nicotinic cholinergic receptors as targets in pain control
Báo cáo khoa học: "Identifying Repair Targets in Action Control Dialogue" pdf
... responses as well as posV has to identify repair target X in (8.5) referred itive responses in the process of grounding Acto as “that” in (5.5) In this case, the repair target cording to their ... quaternary distinction instead of the original binary distinction The notions of partial grounding and mid-discourse unit grounding are also introduced for dealing with action control dialogue ... example, making tea is composed of boiling the water, preparing the tea pot, putting tea leaves in the pot, and pouring the boiled water into it, and so on To analyze actions in dialogue as well as utterances...
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Báo cáo y học: "Bench-to-bedside review: Adenosine receptors – promising targets in acute lung injury" docx
... adenosine deaminase to inosine, or rephosphorylation by adenosine kinase Role of adenosine in inflammation Acknowledgment of adenosine as a potential mediator of inflammatory responses has emerged ... decreased fluid accumulation in the lung of guinea pigs [31] In pigs, administration of adenosine partly prevented the LPSinduced increase in microvascular permeability, as assessed by extravascular ... antagonist reduced I/R injury in the feline lung [40] The same antagonist was examined in endotoxin-induced lung injury in cats In that study, intralobar arterial infusion of endotoxin caused dosedependent...
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Báo cáo khoa học: Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer pdf
... -(CH2)3- with a terminal cationic nitrogen-containing group such as diethylamine, pyrrolidine or piperidine Structure-based drug discovery does have these few structures as starting points [42–47], ... T, Shin-ya K, Sashida G, Sumi M, Okabe S, Ohyashiki JH & Ohyashiki K (2006) Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute ... haematological cancers Notable findings include that of single-agent activity for RHSP4 in a metastatic melanoma model, as well as in a melanoma line resistant to the platinum drug DDP [56] RHPS4 FEBS...
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Báo cáo khoa học: "Oxcarbazepine as monotherapy of acute mania in insufficiently controlled type-1 diabetes mellitus: a case-report" pdf
... DM since the age of 11 For her diabetes, she was initially treated with insulin (Novolente) once and then twice daily for 35 years Subsequently, she was administered an intensified insulin regimen ... (lispro) pre-prandially During the last years the patient has been treated with continuous subcutaneous insulin infusion through a pump, requiring 18–20 units/day as a basal regimen and a total ... self-administered more insulin than required, thus causing the hypoglycemic episodes Over the years she had also developed severe diabetic retinopathy, requiring laser treatments, as well as renal vascular...
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Báo cáo khoa học: "Eag and HERG potassium channels as novel therapeutic targets in cancer" docx
... enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death? FASEB J 2003, 17(2):330-2 96 Rosati B, et al: Glucose- and arginine-induced insulin secretion ... channels Increased expression of K+ channels on cell membrane results in increased influx of Ca2+ ions resulting in increased transition of cells through G1/S phase of cell cycle The channels in presence ... role in prolactin secretion [58] Further investigation of HERG channels in cancer invasion and metastasis revealed that, in addition to the high expression of herg gene and HERG protein in colorectal...
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báo cáo khoa học:" Circulating Immune Complexes and trace elements (Copper, Iron and Selenium) as markers in oral precancer and cancer : a randomised, controlled clinical trial" pot
... enzymes in hydroxylation of proline and lysine This hydroxylation of proline and lysine is catalyzed by proline hydroxylase and peptidyl lysine hydroxylase respectively Peptidyl proline hydroxylase ... glutathione peroxidase, type I iodothyronine deiodinase, metalloprotein, fatty acid binding protein and selenoprotein P therefore selenium is considered as an antioxidant nutrient and the diseases where ... oxidase (Ma R H et al) [32] and thereby causing inhibition of degradation of collagen The rise in serum copper may be due to increased turnover of ceruloplasmin (a copper carrying globulin with...
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Báo cáo y học: "A randomised controlled comparison of early post-pyloric versus early gastric feeding to meet nutritional targets in ventilated intensive care patients" ppsx
... received their feeding tubes as soon as possible ICU nursing staff were trained by the principle researchers or the ICU clinical facilitator to insert the post-pyloric tubes using a blind insertion technique ... emptying using paracetamol absorption in intensive care patients Intensive Care Med 1997, 23:256-260 36 Boivin MA, Levy H: Gastric feeding with erythromycin is equivalent to transpyloric feeding in ... There was also evidence that higher APACHE II score was associated with increased daily average nasogastric aspirate (by 3% for each unit increase in APACHE II score) A comparison of average daily...
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Báo cáo y học: "Retroperitoneal packing as part of damage control surgery in a Danish trauma centre – fast, effective, and cost-effective" pot
... studies and clinical guidelines support damage control surgery Retroperitoneal packing is being increasingly recommended as a lifesaving procedure to be used in the hyper acute phase where the ... with uncontrollable bleeding caused by pelvic fractures [5] Before the course, packing had only been applied in two cases, but was indicated in a number of cases where it was not performed During ... doctors trained within six months We evaluated the course by asking the doctors about their approach to deciding on and performing retroperitoneal packing Finally, we monitored the changes in the...
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Báo cáo sinh học: " HCV entry receptors as potential targets for siRNA-based inhibition of HCV" ppt
... the inhibition of HCV entry via cellular receptors using siRNA against CD81, LDLR, SRBI, CLDN1 was observed, which we interpreted as confirmation of the role of these receptors in mediating HCV ... individually and in combination using siRNA against two receptors simultaneously To determine whether siRNA against each HCV receptor can reduce viral load in HCV-infected cells, Huh-7 cells were infected ... surface receptors mainly include the tetraspanin proteins CD81, SR-BI, and LDLR and the tight junction protein CLDN1 [62-66] In this study, we have targeted HCV host cell surface receptors that interact...
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
... IkappaB kinase kinases IL Interleukin JNK c-Jun N-terminal kinases LPS Lipopolysaccharide MAPK Mitogen-activated protein kinases XIV MCP-1 Monocyte chemotactic protein-1 MIP-1a Macrophage inflammatory ... feeding also induces a decrease in caspase expression and an increase in cathepsin B expression, indicating that ethanol abuse may prevent apoptosis of pancreatic cells and activate trypsinogen ... pancreas The pro-inflammatory cytokines including Tumor necrosis factor- (TNF), Interleukin (IL)-1, IL-6, anti-inflammatory mediators including IL-10, IL-1 receptor antagonist, chemokines including...
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INTERLEUKIN 6 RELEASE FROM t98g HUMAN GLIAL CELL LINE AS a PREDICTIVE MARKER FOR CHRONIC PAIN, AND THE CHARACTERIZATION OF SUBSTANCE(S) INVOLVED IN PAIN
... are involved in the early development of chronic pain, while astrocytes function in sustaining the pain (Vallejo et al., 2010) An interesting finding was that nerve injury induces an increase in ... Peroxidase xiv IL-1 Interleukin-1 IL-1β Interleukin-1β IL-6 Interleukin-6 IL-8 Interleukin-8 IL-10 Interleukin-10 IL-18 Interleukin-18 i.t Intrathecal L-PGDS Lipocalin-type Prostaglandin D Synthase ... 2007) Amino acids including aspartate, arginine, asparagine, tyrosine and valine were also demonstrated to be elevated in the CSF of chronic pain patients as compared to that of acute pain patients...
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Báo cáo y học: "Autofluorescent Proteins as Photosensitizer in Eukaryonte"
... http://www.medsci.org Int J Med Sci 2009, d) pKillerRed Lamin B1 vector - Lamin B1-localized KRED protein Figure Physical map of the vector expressing the fusion protein KRED-Lamin B1 The Lamin B1 was inserted into ... as a response to caspase activation as documented by the Barros Okada group22 With increasing duration of light exposure of HeLa cells expressing the KRED-Lamin B1 protein, the cell number was ... and their influence on downstream targets in vascular cells ROS influence a multifaced range of cellular activities e.g of protein tyrosine phosphatases (PTP) ROS influence gene and protein expression...
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Development of a Regional Risk Management Framework for APEC Economies for use in the Control and Prevention of Introduced Marine Pests
... Within APEC little is known on the introduction of marine pests Little practical information on measures to prevent introductions Lack of knowledge in what individual countries are doing ... enhance the effectiveness of existing instruments within APEC Institutional arrangements for managing the marine environment is fragmented in most economies Baseline surveys to identify IMP are ... Conclusions, including the results of the November 2001 Workshop Management Framework - Introd uced Marine Pests Management capabilities and approaches APEC and the MRCWG have a role in liaising with...
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The interference of mother tongue as vietnames in learning english souds and stress at high school = ảnh hưởng của tiếng mẹ đẻ đối với việc học âm và trọng âm tiếng anh ở trường phổ thông
... English in forming grammatical endings, and in pronouncing of grammatical endings Vietnamese learners have difficulties in pronouncing suffixes showing grammatical meanings that are not 33 present in ... consonants in final position such as student, steak, assistant, top, pop, like, look, work Thirdly, linking exercises in which ending in these consonants are followed by words beginning with vowels ... Consonant Clusters in English 25 2.2.6.2 Consonant Clusters in Vietnamese 26 2.3 Sound Linking .26 2.3.1 Sound Linking in English .26 2.3.2 Sound Linking in Vietnamese...
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A course in robust control theory 3
... course as a major theoretical and computational tool 1.1 Linear spaces and mappings In this section we will introduce some of the basic ideas in linear algebra Our treatment is primarily intended as ... done by taking a basis fv1 : : : vk g for V , and associating each vector v in V with the vector of coordinates in the given basis, Fk : k Equivalently, each vector vi in the basis is associated ... discussing convexity 1.2.2 Convex sets Let us begin by de ning the line segment that joins two points in V Suppose that v1 and v2 are in V , then we de ne the line segment L(v1 v2 ) between them as...
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Tài liệu Core Topics in Pain ppt
... developing curricula for training in pain management The International Association for the Study of Pain (IASP) has been at the forefront in promoting education in pain management If you are interested ... pancreatitis) as well as chronic pain and pain in patients with cancer The range of topics dealt with in this book bear testament to the ubiquity of pain and the way in which pain impinges itself into ... Neurokinin Neurokinin – receptor for neurokinin A Neurokinin – receptor for neurokinin B Neurokinin A – peptide related to substance P Neurokinin B – peptide related to substance P N-methyl-D-aspartate...
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Tài liệu Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors ppt
... has yet to be determined As the side chain length increases the ratio between a3b2 and a7 increases up to > 100 for EpI containing a methionine at this position The recent discovery of GID has ... of PnIA showing the residues important for binding is shown in Fig The increase in potency for [A10L]PnIA has been attributed to the longer side chain of the leucine at position 10 In general, ... vital role in correctly orienting key binding residues Arg7 was suggested to have a functional role in binding as the structure of R7A only differs from the native in the side chain position...
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Tài liệu Báo cáo khoa học: "Humor as Circuits in Semantic Networks" doc
... visualizing opinions and sentiments in a multi-dimensional vector space Knowledge-Based and Intelligent Information and Engineering Systems, pages 385–393 E Cambria, R Speer, C Havasi, and A Hussain ... categories (12 two-liners in each): priest, woman, computer, robot, and to normalize against individual humor biases, humanmade two-liners were mixed in in the same categories Two-liners generated ... sense disambiguation using wordnet domains In Emerging Trends in Engineering and Technology, 2008 ICETET’08 First International Conference on, pages 1187–1191 IEEE H Liu and P Singh 2004 Conceptneta...
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Tài liệu Báo cáo khoa học: A synthetic weak neurotoxin binds with low affinity to Torpedo and chicken a7 nicotinic acetylcholine receptors docx
... I-labelled a-Bgtx binding Varying amounts of toxins were incubated with nM of active sites of receptors and nM of 125I-labelled a-Bgtx for at least h With a7 receptors, the toxin was incubated at different ... [29] In vitro binding experiments and electrophysiological assays showed that this toxin has a low affinity (IC50) in the range of 4–15 lM for these receptors On the basis of competition binding ... sequences have an asparagine, Wntx-5 has a lysine at position 29 whereas other sequences have a methionine, and Wntx-9 has an asparagine at position 65 whilst other sequences have a serine They all...
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