... on the firms, including the decrease in expected future earnings andthe increase in cost of capital (Hribar and Jenkins, 2004) We are interested to examine the role of financial analysts in ... suppliers, and its industry warrants them the service fee However, the growing number of earnings restatements andthe accompanying problems in financial reporting bring about many criticisms on the financial ... perception ofthe management’s credibility andthe financial reporting quality, and thereby increases the firms’ cost of capital (Hribar and Jenkins 2004) We are interested to investigate whether the...
... Thus, the node N-1 immediately dominates N, the node N-2 dominates N-I, and so on The nodes subordinate to each ofthe nodes dominating N are indexed beginning with the left-most node and proceeding ... about the nature of dialogue structures, about the validity and usefulness ofthe concept of a dialogue structure, about the role ofthe task structure in determining dialogue structure, andinthe ... attempt to find evidence linking the dialogue structure to the task structure The main point is that the structure ofthe intentions conveyed inthe discourse should mirror to some extent the task...
... actively exploring some of these exciting avenues of investigation Chemotherapy We have investigated this hypothesis further by examining the timing of chemotherapy doses with respect to the LCRP immune ... of colorectal cancerand independently associated with the increased risk of colorectal cancerin men [14], and overall cancer risk [15] Interleukin-6 (IL-6) has been used for the diagnosis of ... substantiate the current observations Examining the Hypothesis Vaccinations We have examined this hypothesis by taking L-CRP measurements over the weeks surrounding the vaccination times of patients...
... that pain and appetite loss are independent determinants of overall survival One found that a 40-point increase inthe pain subscale ofthe EORTC QLQ-C30 was associated with a 27% increase inthe ... each other, in many instances when one includes both physical functioning and performance status inthe regression models, the likelihood of finding inconsistent results can be expected In other ... study sample, type ofcancer (where relevant data were available), instrument used to measure quality of life, andthe main findings or conclusions The findings were then sorted and presented chronologically...
... pattern of care and main outcomes, and a discussion ofthe feasibility of this kind of approaches inthe specific setting, the second about the effects (effectiveness) of treatments on patients (and ... expected: the first reporting on the results ofthe "epidemiological" part ofthe study, including a description of patients' characteristics in terms of baseline socio-demographic and clinical ... to conduct and monitor the progress ofthe trial for the patients' safety and according to the World Medical Association Declaration of Helsinki andthe European and Italian Good Clinical Practice...
... needle is introduced into the last portion of internal jugular vein This vein was reached through the transducer placed at the point of insertion ofthe sternocleidomastoid muscle into the clavicular; ... removal ofthe CVC The follow-up consisted of: patient’s clinical examination, catheters flushed with heparinized solution and catheter exit side dressing Assesment of endpoints The primary endpoints ... allowed the completion ofthe therapeutic program for 1,930/ 1,978 (97.6%) ofthe catheters inserted The absence of pneumotorax and other major complications indicates that US guidance should be mandatory...
... inthe design ofthe study and writing ofthe manuscript MN and NH assembled the data TM and YK performed the statistical analysis HI and HK performed the study of flowcytometry YN designed the ... Distribution in Th1 and Th2 subsets of CD4+T cells in peripheral blood of colorectal cancer patients and involvement incancer establishment and progression Cancer Immunol Immunother 1996, 42:1-8 ... IFN-γ+T cells were not seen other than the reduction on POD inthe hepatic resection group found On the other hand, there were also no significant differences inthe percentage of CD4+IL-6+ T cells...
... both in monomeric (active) and dimeric (inactive) state [16] The protein contains several important domains such as 1) the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding ... assess the possible functional effect of a sequence variation inthe coding regions ofthe ATM gene resulting in an amino-acid substitution inthe protein sequence The online tool scores the effect ... substrate binding domains and ATPbinding domains, is illustrated in Figure Single marker associations Risk for developing breast cancerThe association between any variant inthe ATM gene and risk of...
... anticoagulation over the course ofthe increased risk of VTE (during and postsurgery) with the minimum of adverse events such as post-operative bleeding For cancer patients, there is also increasing evidence ... variety of patient-, cancer- and treatment-related factors including age, race and immobility status, together with site or stage ofthe cancer, whether or not the patient is receiving chemotherapy, ... bleeding Given theperiodof post-operative VTE risk, data increasingly support extended-duration prophylaxis beyond theperiodof hospitalization The practical and pharmacokinetic advantages of the...
... a fishy taste inthe mouth might certainly cause detection bias Assessment ofthe trial reporting in terms of risk of bias, the use of random assignment, and subsequent concealment of allocation ... Aalborg, Denmark Competing interests The funding agencies (The Oak Foundation andThe Danish Rheumatism Association) had no role in writing the report or inthe decision to submit the manuscript for ... the taste of fish oil during a 3-month trial, probably as difficult as it is to hide the taste of ginger [5] Finally, deviations from protocol and loss to follow-up often lead to the exclusion of...
... in oncology and/ or R195 intensive care, and take part in regular training of oncology and intensive care nurses The nurse/patient ratio ranges from 1.2 to 1.7 Routine clinical rounds, including ... the impact of missing data on the performance of models; inthe present study prothrombin time, and serum albumin and bilirubin were not obtained in all patients The differences between the predicted ... patients (with a diagnosis of cancer) may be admitted because of life-threatening illness identified during assessment ofthe extent of their cancer and/ or consideration ofthe therapeutic options This...
... cytoreductive therapy and develops in 20% to 40% of BMT recipients [47] Amphotericin during conditioning Acyclovir during conditioning Vancomycin during conditioning The main site of liver damage in this ... with many anti -cancer agents, including gemcitabine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α [25] Lastly, the association ... chains bind to a specific peptide domain on the Tamm-Horsfall protein [17]; variations in CDR3 in both the κ and λ light chains influence binding [20] Additionally, hypovolaemia, sepsis, urinary...
... during the ICU stay: age and gender; chronic health status as evaluated using the Charlson comorbidity index [15]; characteristics ofthe malignancy, including the number of previous courses of ... that they have no competing interests Authors' contributions DM collected and analyzed the data and reviewed and coordinated the study AS and MF collected and analyzed the data J-PB, J-LB, DB, and ... consent ofthe patients or next of kin, we performed the study in 51 consecutive adult cancer patients with medical septic shock Septic shock was defined according to the criteria ofthe American...
... study, individual organ failures were diagnosed in case of a SOFA score ≥ points in each domain [14] In addition, patients receiving dialysis inthe context of acute kidney injury and invasive ... according to the suspected primary focus of infection Demographic, clinical and laboratory data were collected using standardized case report forms during the first day of ICU stay including main ... in patients with febrile neutropenia to assess their performance inthe diagnosis of infection [18-24], inthe identification ofthe underlying agents [18-20,22,24], inthe characterization of...
... with those obtained in other studies that have investigated the addition of another drug inthe taxane-based chemotherapy Inthe study of Albain et al [28], the addition of gemcitabine to paclitaxel ... following steps: definition ofthe outcomes (definition ofthe question the analysis was designed to answer), definition ofthe trial selection criteria, definition ofthe search strategy, and ... the combination of clinical and molecular factors will guide the clinician in identifying the most effective therapy for a given patient, leaving more space and giving more importance to the molecular...
... separates the aminoterminal DNA-binding domain ofthe enzyme from the carboxy-terminal catalytic domain resulting inthe loss of normal PARP1 function Although the role of PARP in apoptosis remains ... photodynamic therapy for the derivation of molecules of interest incancer therapy including photofrin, purpurins, xanthenes, phthalocyanines, oxazines, cyanines, chlorines (Pervaiz, 2001; Pervaiz and ... associated proteins, and intermediate filament proteins including vimentin keratin and nuclear lamins (Luthi and Martin, 2007; Taylor et al., 2008) Caspase mediated clevage ofthe protein kinase ROCK1...
... for binding to proteins containing LXCXE motifs while the pocket-domain andthe C-domain are involved in binding E2F proteins Mdm2 (as well as c-Abl) binds to the C-domain All pocket proteins ... made in cells lacking pRb inthe retina Somatic inactivation of pRb, even inthe absence of p107 and p53, inthe outer nuclear layer had no obvious consequences, indicating that in some settings ... elucidated the function of pRb in controlling cell cycle progression, providing a platform to understand the relevance of pRb loss indevelopmentofcancer (reviewed in Weinberg 1995; Hanahan and Weinberg...
... Visbal AL, Horgan AM, Guindi M, Hornby J, Xu W, Ringash J, Keshavjee S, Chen E, Haider M, Darling G: Phase trial of preoperative irinotecan plus cisplatin and conformal radiotherapy, followed by ... Mayer R: Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781 J Clin Oncol 2008, 26(7):1086-92 ... Oncology Group; Australasian Gastro-Intestinal Trials Group: Surgery alone versus chemoradiotherapy followed by surgery for resectable cancerofthe oesophagus: a randomised controlled phase III trial...
... clavicular fossa and above the seventh rib Any relapse involving the axillary lymph nodes, and/ or other nodes inthe infra or supraclavicular fossa or inthe internal mammary chain was considered ... supraclavicular and internal mammary lymph nodes alone) Local recurrence was defined as any relapse inthe area of surgery between the sternum andthe anterior axillary line, and below the inferior ... time, the role of PMRT for women with to positive lymph nodes remains uncertain and is being examined in a randomized clinical trial” Many surgeons and radiation oncologist are not recommending...
... various cancercell lines, including gastric cancer cells, colon cancer cells, breast cancer cells, lung cancer cells, bladder cancer cells, renal cancer cells, and melanoma cells [22] Inthe present ... expression of these splicing variants was shown only inthe thymus [22] We then analyzed the survivin expression inthe protein level In all the oral cancercell lines examined inthe present ... blotting analysis of survivin protein in oral cancercell lines Western blotting analysis of survivin protein in oral cancercell lines Lysates from oral cancercell lines or normal oral mucosal...