... blood pressures and
resting heart- rates from baseline to the ending test for
each of the five study groups. The average baseline
blood pressures and resting heart- rates for the study
cohort were ... supported by a grant from Nu-
tratech Inc., West Caldwell, NJ.
Conflict of Interest
HM is an employee of Nutratech, Inc. SJS and
GHP have served as consultants for Nutratech, Inc.
References
1. ... different amounts of hesperidin and nar-
ingin on: (1) resting metabolism rate, (2) blood pres-
sure, (3) resting heart- rate, and (4) self-reported
mood/energy levels in healthy human subjects....
... differences were observed for
heart rates or blood pressures between the experi-
mental and placebo control groups. However, there
was a small but significant change in RER data for the
low caffeine ... significant effects of
either treatment on heartrate were noted over the first
three hours after ingestion of the products. However,
a significant increase in heartrate over control was
noted at the ...
after treatment ingestion. After eating, an increase in
heart rate occurred in all three treatment groups. The
increase in heartrate does not coincide with the
pharmacokinetics including...
... mm
increasing probability
increasing probability
of restenosis
of restenosis
Late loss of 1.2 mm
associated with a 50%
chance of binary restenosis
Probability for
Restenosis
Probability for ...
probability of TLR
Probability for TLR
Probability for TLR
Popma J . TAXUS IV Angiographic Results 2003.
Late loss of 1.6 mm
associated with a 50%
chance for TLR
Mak Heart
Late Loss in TAXUS Trials
Consistent ... Endpoint: 8-month Restenosis Rate
9.6
7.0
11.1
8.3
0
2
4
6
8
10
12
In Stent In Segment
P=0.32
P=0.32
P=0.31
P=0.31
Sirolimus (n=684)
Paclitaxel (n=699)
Restenosis Rate (%)
Mak Heart
Mechanisms of Late...
... (young and elderly separated)
were divided into three groups, which were given different
information on the samples for the home-use. One group in
both age cohorts was informed about the organic ... received information about
the sample’s healthiness and low fat content. A third group
served as control, receiving no additional information,
except for the list of ingredients. The written information
was ... presence of health-related information. Since the effects
of information were negligible, and not relevant enough for
this study, the data were pooled together over the
information conditions.
Olfactory...
... m
http://www.fastcocreate.com/1682625/the-myth-of-marketing-ho w-research-reaches -for- the -heart- but-only-co nnects-with-
the-head
The Myth of Marketing: How Research Reaches For The
Heart But Only Connects With The Head
Marketers ... want to generate action, you have to generate emotion.
Take f or instance a commercial we created f or Volkswagen f or the Super Bowl. Traditional ad testing
indicated that the spot generated a below-average ... us.
For too long, standard marketing theory has had it backwards. The most startling truth is we don’t even
think our way to logical solutions. We f eel our way to reason. Emotions are the substrate,...
... 2008
For product and ordering information:
World Wide Web: http://www.usgs.gov/pubprod
Telephone: 1-888-ASK-USGS
For more information on the USGS the Federal source for science about the Earth, ... held for 3 minutes, then ramped
at 9 °C/min to 320 °C and held at 320 °C for 3 minutes.
Identification of the targeted chemicals was performed using
full-scan MS, and quantification was performed ... with the Friends of the North Fork of the Shenandoah River
Investigation of Organic Chemicals Potentially Responsible
for Mortality and Intersex in Fish of the North Fork of the
Shenandoah River,...
... The deposit rate is Norges Bank’s
key rate, and forms the floor for short money market
rates.
• Overnight lending rate: Interest rate on overnight
loans from Norges Bank.
• Fixed -rate loans: ... the deposit rate is banks’ marginal
investment rate. The deposit rate is thus Norges Bank’s
key rate. The overnight lending rate has limited monetary
policy significance. The interest rate on Norges ... international
practice.
As the article illustrates, many central banks use the
interest rate on market operations or a market rate target
as their key rate. Norges Bank’s key rate is the deposit
rate, which is a standing...
... except for
UDP-GlcNAc acyltransferase, responsiblefor lipid A biosynthesis in
M. catarrhalis, have been identified. By bioinformatics, two late acyltrans-
ferase genes, lpxX and lpxL, responsiblefor ... were responsible for
the addition of secondary laurate (C12:0) chains at the
2-position and 2¢-position of lipid A [29,38]. Our
results showed that the lpxX gene product in O35E
was responsiblefor ... m HCl at 80 °C for 18 h.
The FAMEs were recovered into the organic phase by
three-fold extraction with 50% NaCl ⁄ chloroform (1 : 1
v ⁄ v). A new volume of chloroform was used for each of
the...
... post-hydrolysis. Therefore, the dissoci-
ation of phosphate and ⁄ or ADP is likely to be responsiblefor resetting
of the transporter. The data indicate that, like ABCB1 and ABCC1,
the ‘power stroke’ for translocation ... Although early cellu-
lar studies failed to generate a consensus for the sub-
strate profile, the discrepancies were attributed to a
mutation generated during long-term selection in the
presence ... within
NBDs. The best evidence for an interaction between
the two domains is the ability of numerous substrates
and modulators of ABCG2 (and the R482G isoform)
to stimulate the rate of ATP hydrolysis...
... HSV1-TK show a similar binding mode for
the substrates in the active site. Three key residues in
Dm-dNK, identified and proposed as being responsible
for substrate specificity [4], were mutagenized ... charged residues are
expected to influence catalytic rate rather than sub-
strate binding.
Two further active site residues responsible for
substrate binding were investigated, these being Y70
and ... twofold for
dThd and dCyd, respectively, supporting a role in substrate binding. These
observations give insight into the mechanisms of substrate binding and
catalysis, which is important for developing...
... characterization of the
enzymes is slow [2,4], p robably because the substrate for
the enzyme assay, 2-aminomuconic 6 -semialdehyde, which i s
formed by ring cleavage of 2-aminoph enol, is unstable and is
converted ... coupled assay was
identified as 2-hydroxymuconic 6-semialdehyde by GC-MS
analysis. A mechanism for the formation of 2-hydroxy-
muconic 6-semialdehyde via enzymatic deamination and
nonenzymatic decarboxylation ... A novel coupled enzyme assay reveals an enzyme responsiblefor the
deamination of a chemically unstable intermediate in the metabolic
pathway of 4-amino-3-hydroxybenzoic...
... There-
fore, analysis o f their transcripts could have been rather
difficult because of the occurrence of at least nine different
forms of messenger arising from the F allele [9]. Finally, t o
integrate ... & M artin [6], we also n eeded to obtain
information ab out relevant noncoding regions in which
specific and informative mutations are localized.
For these reasons, we d ecided to analyse the ... M/B).
Interestingly, the mutation s pecific for the M allele affects
the same nucleotide as that which is deleted in the F allele,
and shown to be responsiblefor the internal deletion of 37
amino-acid...
... the GIRK1 protein
was also demonstrated to be a direct target for PKA-
catalysed phosphorylation [17,22,23]. Despite several
efforts undertaken to identify the responsible structural
determinant ... determinant responsiblefor PKA
phosphorylation in vitro
To identify the structural determinants that are respon-
sible for phosphorylation of GIRK1 by PKA, fusion
proteins comprising truncated forms ... substrate for PKA itself. Recently,
using a different experimental approach employing
mass spectroscopic methods, Rusinova et al. [30] has
identified S385 as a prominent and specific target for
PKA-catalysed...
... may
cooperate in targeting the mSMOl isoform to the nuc-
leus. By means of transient expression of the deletion
mutant, mSMOlD, in the murine neuroblastoma cell
line, N18TG2, we demonstrated that ... nuclear
targeting of the mSMOl isoform.
Results
Structural analysis and modeling of vertebrate
SMO proteins
Comparison of the derived amino acid sequences of
vertebrate SMO proteins has revealed ... mSMOl
have been reported previously [9,10]. The recombinant
mSMOlD isoform also shows catalytic activity. The
substrate specificity of mSMOlD for Spm, Spd and
N
1
-acetylpolyamines has been investigated...
... corporate tax rate and the system for depreciating investment in tangible property.
The noncorporate tax rate and the tax depreciation system are includes in the modeling of the
noncorporate ... changes in tax rates. For
example, Feldstein (1995) and Auten and Carroll (1999) examined the 1986 tax reform. Carroll (1998) and Heim
(2009) examined the 1993 tax rates increases. For an extensive ... modeled for four production sectors – corporate-manufacturing, corporate-
nonmanufacturing, noncorporate, and housing. Production is represented by the standard
Cobb-Douglas functional form with...