nature of law role and function of law in society
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
Ngày tải lên :
14/02/2014, 19:20
... full-length
v-KIND; DKIND1, deletion of KIND1;
DKIND2, deletion of KIND2; DKIND1 + 2,
deletion of both KIND1 and KIND2; DRasN,
deletion of RasN; DGEF, deletion of
RasGEF; KIND1, KIND1 domain; KIND2,
KIND2 ... v-KIND KIND2 binding resides within
residues 702–744 of MAP2.
Residues 456–487 in the KIND2 domain of v-KIND
contain the core MAP2 binding module
To identify the core MAP2-binding site within ... sequence for v-KIND binding.
To evaluate the v-KIND KIND2-binding specificity
of residues 702–744 of MAP2, we performed a pull-
down assay of combinations of EGFP-fused KIND1
or KIND2 of v-KIND with...
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Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
Ngày tải lên :
14/02/2014, 18:20
... [238–240]. Even in the absence of pro-
tein–protein interactions, factors can assist each other’s
binding to DNA within nucleosomes. This principle is
illustrated in the model shown in Fig. 7A. In this ... considerable varia-
tion and complexity in the number of nucleosomes dis-
rupted, the histone composition of the remaining
nucleosomes, and the number and nature of protein
complexes they interact with.
Much ... transcribed
regions of active genes in human T cells [124]. In a
study in yeast, mutations were introduced alone or in
combination in lysines 5, 8, 12 and 16 in the gene for
histone H4 [125]. Of these,...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
Ngày tải lên :
17/02/2014, 19:20
... predicting,
measuring and understanding the roles of different kinds of organisms in the flux
and storage of elements in ecosystems. The total biomass per unit area, W,is
simply the sum ofthe ... size, in
comparison to a linear increase in gain as the driving force for the development
of gelatinous bodies. As seen above, however, the same principle of costs
increasing more rapidly than gains ... 28557 and Virginia Institute of
Marine Science, The College of William and
Mary, Gloucester Point, VA 23062.
Michael C. Marshall Department of
Zoology and Physiology, University of
Wyoming, Laramie,...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
Ngày tải lên :
19/02/2014, 06:20
... (PX)
domain in the N-terminus. PX domains occur in a
variety of proteins involved in cell signaling, mem-
brane trafficking, and polarity establishment, and func-
tion as phosphoinositide-binding modules ... in the testis and fetal brain. The Noxo1c protein contains an
additional five amino acids in the N-terminal PX domain, a phosphoinosi-
tide-binding module; the domain plays an essential role in ... domains with p22
phox
[25–
27]. Although the SH3 domain of Noxo1 participates in
regulation of Nox3, the role of the PX domain in Nox3
activity remains unknown.
In the process of cloning of human...
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Tài liệu Báo cáo khoa học: Structure and function of plant aspartic proteinases pptx
Ngày tải lên :
19/02/2014, 12:20
... and C-terminal domain in red. (B) Ribbon representation of the structure of the PSI domain of barley prophytepsin [25] (N-terminal domain,
blue; C-terminal domain, red). (C) Model structure of ... family includes
saposins, which are lysosomal sphingolipid-activator pro-
teins [37], NK-lysin, granulysin, surfactant protein B,
amoebapores and domains of acid sphingomyelinase and
acyloxyacyl hydrolase ... folding, stability
and intracellular sorting of several zymogens [16], the PSI is
an insertion only identified in plant APs, which is highly
similar to saposins and saposin-like proteins and whose
biological...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
Ngày tải lên :
19/02/2014, 12:20
... structure of
an ACh-binding protein reveals the ligand-binding domain of
nicotinic receptors. Nature 411, 269–276.
6. Dutertre,S.&Lewis,R.J.(2004)Computationalapproachesto
understand a-conotoxin interactions ... (Table 1). Interestingly, Vc1.1 was able to inhibit
in vivo a vascular response to pain and was effective in
alleviating chronic pain and accelerating functional recovery
in an animal model of neuropathy. ... transmembrane domain of each subunit contri-
butes to the formation of the hydrophilic pore. ACh binding protein
has structural and functional homology to the extracellular ligand
binding domain of the...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
Ngày tải lên :
19/02/2014, 16:20
... freeze-intolerant insects
The structure and function of b-helical antifreeze proteins
Steffen P. Graether and Brian D. Sykes
CIHR Group in Protein Structure and Function, Department of Biochemistry and Protein ... so, a considerable number of questions remain
before we can solve the interaction at the atomic level and
understand t he role of the threonine side chains in ice
binding. The contradiction between ... f
isoform 337 with the structure o f th e l onger i soform CfAFP-501 using
the main chain of residues Thr23fiAsn90 in i soform 337 and residues
Thr54fiMet121 in CfAFP-501. (B) Overlap of isoforms...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
Ngày tải lên :
06/03/2014, 09:22
... contained a 30 bp insertion in the
ORF, beginning at nucleotide 516. This resulted in
insertion of a 10 amino acid segment (TREIDYPETI)
and one substitution (Ser fi Gly) at the C-terminal
end of ... residue
cystine-knot domain. Injection of Spa
¨
tzle-C108, but not proSpa
¨
tzle-1A, into
larvae stimulated expression of several antimicrobial peptides and proteins,
including attacin-1, cecropin-6, moricin, lysozyme, ... development and in the antimicrobial immune response in larvae
and adults. We have investigated the function of Spa
¨
tzle in a lepidopteran
insect, Manduca sexta, in which hemolymph proteinases activated...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
Ngày tải lên :
06/03/2014, 11:20
... minidomain and the zinc-binding domain
of the zinc finger protein Ynr046w [25] (Fig. 8). The fit
of the heavy atoms (Ca, C, and N) from three
b-strands and the a-helices of both the closed and the
open ... specificity of the factor. The results provide new insights
into the possible role of the C-domain in the process of translation termi-
nation.
Abbreviations
C-domain, C-terminal domain (or domain 3) of ... most of the residues of the protein rigid core
could be successfully fitted using models 1 and 2. For a few
residues of the minidomain (330–332, at the beginning of
the central b-strand) and residues...
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Báo cáo khoa học: Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein doc
Ngày tải lên :
07/03/2014, 00:20
... various organisms,
and the evolution of TLP and transthyretin.
The identification of TLPs and
transthyretins in nature
The evolution of transthyretin and its distribution in
nature have been well ... b-strands A, G and H [17].
Structural nature of the TLP and
transthyretin active sites
One of the striking features of transthyretin is the cen-
tral channel of the protein into which the THs bind.
This ... transthyretin dimers associate, via
nonpolar interactions, between the loops joining stands
G and H with the loops joining strands A and B, mak-
ing the transthyretin tetramer a ‘dimer of dimers.’
Recently,...
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Báo cáo khoa học: Synthesis and function of ribosomal proteins – fading models and new perspectives pptx
Ngày tải lên :
07/03/2014, 01:20
... FEBS
synthesis involving small modifying peptides (ubiquitin
and NEDD8) affecting protein stability. The most
intriguing recent finding is the phenotype resulting
from mutations in RPs in zebrafish, mice, and ... elusive. In Xenopus , two
proteins have been identified, La and cellular nucleic
acid-binding protein (CNBP) ⁄ zinc finger protein 9
(ZNF9), which bind the 5¢-UTRs of RP mRNAs in vitro.
La interacts ... mitogen-induced signal transduction path-
ways acting through TSC1–TSC2 and involving
mTORC1, as suggested by the rapamycin effect.
Rapamycin, which inhibits mTORC1 by binding to
mTOR in a complex...
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Báo cáo khoa học: Structure and function of KH domains docx
Ngày tải lên :
07/03/2014, 05:20
... poly(C)-bind-
ing proteins: a multiplicity of functions and search for
mechanisms. RNA 8, 265–278.
32 Gamernik AV & Andino R (2000) Interactions of viral
protein 3CD and poly(rC) binding protein ... nucleotide at the 3¢-end of the ssDNA
strand (dC in 2AXY; dT in 2PQU) is participating in base-stacking interactions with the preceding cytosine base.
Structure and function of KH domains R. Valverde ... sequences.
Although in both examples the coupling of two
RNA-binding domains will effectively increase the
specificity and affinity of the RNA–protein interaction,
the two different binding modes have...
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![Báo cáo khóa học: Selective release and function of one of the two FMN groups in the cytoplasmic NAD + -reducing [NiFe]-hydrogenase from Ralstonia eutropha pptx](https://media.store123doc.com/images/document/14/rc/gg/medium_ggg1394180403.jpg)
Báo cáo khóa học: Selective release and function of one of the two FMN groups in the cytoplasmic NAD + -reducing [NiFe]-hydrogenase from Ralstonia eutropha pptx
Ngày tải lên :
07/03/2014, 15:20
... work and [36,37]). (f) It is proposed that the
FMN-a is bound to the inwards-pointing end of the
flavodoxin fold in the HoxY subunit. Such a flavodoxin fold
is conserved in the small subunit of all ... part that holds two of the Fe-S clusters in the small subunit of
the D. gigas enzyme is missing in HoxY of the SH, suggesting an
exposure of part of the hydrophobic surface of the HoxH subunit. ... used in all experiments. The
purity of the samples was examined by SDS/PAGE [29].
Protein concentrations were routinely determined by the
Bradford method [30] using bovine serum albumin as a
standard.
Activity...
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Báo cáo khoa học: The metabolic role and evolution of L-arabinitol 4-dehydrogenase of Hypocrea jecorina potx
Ngày tải lên :
07/03/2014, 15:20
... Irina Druzhinina
1
and Christian P. Kubicek
1
1
Division of Gene Technology and Applied Biochemistry, Institute of Chemical Engineering, TU Wien, Vienna;
2
Institute of Ecology,
University of ... significant differences in
amino acids flanking the active site. The 3D
model of Lad1 was fitted, according to the 2D
structure of SDH [25]. Amino acids involved
in binding of
D
-sorbitol [25] and conserved
between ... alignment of mammalian and fungal sorbitol dehydrogenases. Amino acids involved in binding of
D
-sorbitol [25] are marked by
asterisks, amino acids conserved between Lad1 and SDH in % are indicated...
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Báo cáo khoa học: Structure and function of N-acetylglucosamine kinase Identification of two active site cysteines pptx
Ngày tải lên :
08/03/2014, 10:20
... align-
ments of glucokinase and GlcNAc kinase and the common
ATP-binding domain, the GlcNAc kinase was fitted into the
glucokinase model using RasMol software. Figure 5 shows
the predicted structure of ... alignment of glucokinase and GlcNAc kinase. The amino acid sequences are numbered beginning with the first amino acid of the
N-terminus. Both amino acid sequences share the ATP binding subdomains (Phosphate1, ... for hexokinase
[30]. Binding of the sugar results in a strong conforma-
tional change allowing the binding of ATP. Mutations of
amino acids involved in this mechanism therefore result in
lower...
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