nanoparticles for drug delivery

nanoparticle technology for drug delivery, 2006, p.427

Ngày tải lên : 04/06/2014, 15:15

... discussed in Chapter for injectable delivery, Chapter for oral delivery, Chapter 10 for brain delivery, Chapter 11 for ocular delivery, and Chapter 12 for gene delivery Finally, the fourth section ... applications of nanoparticles in drug delivery Depending on the route and purpose of drug delivery, the requirements for nanoparticulate systems can vary These aspects are discussed in Chapter for injectable ... experience force in the magnetic ﬁeld Such materials are useful for targeted delivery of drugs and heat For example, interaction of electromagnetic pulses with nanoparticles can be utilized for enhancement...

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Báo cáo hóa học: "Single-component Polymer Nanocapsules for Drug Delivery Application" docx

Ngày tải lên : 22/06/2014, 01:20

... polypeptide -drug conjugates [PGA-Doxorubicin (Dox)] The researchers also investigated the applicability of thick-walled polymer nanocapsules for tumor therapy via drug delivery They prepared drug- loaded ... cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death Bansal notes that it is highly desirable for antitumor applications, that the size of the delivery vehicle ... attachment of targeting ligands to the drug- conjugated capsules through established coupling protocols will further provide functional capsules for targeted drug delivery applications 267 Overall,...

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Báo cáo y học: "Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice" doc

Ngày tải lên : 09/08/2014, 14:20

... investigated magnetically retainable drug delivery systems, an approach as yet clinically unexploited despite the intense need for the development of novel i-a delivery modalities Thus, our aim ... per group, Page of 10 (page number not for citation purposes) was necessary for at least two reasons First, there was a need to perform these control tests for the correct evaluation of the action ... and SPION suspension The test drug delivery system consisted of 10-μm microparticles containing DXM and SPIONs ("complete microparticles") Five animals were used for each group Joint inflammation...

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Controlled release alginate based microparticulate systems for drug delivery and chemoembolization

Ngày tải lên : 13/09/2015, 20:39

... INTRODUCTION delivery of drug In time-controlled delivery, the drug is released in a pre-determined rate while in target-controlled delivery, the drug is delivered to a specific site The delivery ... been developed as a drug delivery system (DDS) for many peptide and protein drugs (Chan and Heng, 1998) An ideal DDS is able to control the drug concentration at the target site for a desired period ... The successful formulation of a stable and effective dosage form therefore depends on the careful selection of excipients The use of polymers in the formulation of controlled drug delivery systems...

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Design and fabrication of microneedles for drug delivery

Ngày tải lên : 14/09/2015, 11:17

... Microneedles 2.1 Microneedles in Transdermal Drug Delivery Transdermal drug delivery is an alternative method for delivery of DNA/protein based drugs These drugs which have sophisticated compounds ... are designed for transdermal therapies to deliver drugs such as insulin and heparin On the other hand, microneedles can also be used for local delivery of other drugs, for example, drugs in anti-restenosis ... varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic system and the continuous delivery...

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Particle development for drug delivery

Ngày tải lên : 17/09/2015, 17:19

... Rationale for the Choice of Equipment and Method Employed 112 A1.1 Rationale for Choosing FB Hammer Mill 112 A1.2 Rationale for Choosing Laser Diffraction for Particle Sizing 113 A1.3 Rationale for ... rate of drug appearance in the blood is determined by the absorption rate of the drug whereas for Class II drugs, the rate of dissolution plays a greater role In the case of Class IV drugs, both ... B FBO Jet Mill 136 B1 Rationale for the Choice of Equipment and Method Employed 136 B1.1 Rationale for Choosing FBO Jet Mill 136 B1.2 Rationale for Choosing SEM for Particle Sizing 137 B1.3 Choice...

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In vitro and in vivo evaluation of transferrin conjugated lipid shell and polymer core nanoparticles for targeted delivery of docetaxel

Ngày tải lên : 09/10/2015, 11:18

... insufficient drug loading, faster drug release and storage instability Meanwhile, nanoparticles can provide high drug encapsulation efficiency for hydrophobic drugs and controlled drug release ... 2009; Liu et al., 2010) Therefore, lipid shell and polymer core nanoparticles with antitumor targeting would be an ideal nanoscale drug delivery system for hydrophobic drugs such as docetaxel and ... synthesize nanoparticles to encapsulate a variety of therapeutic compounds (Feng, 2006) PEGylation, which refers to polyethylene glycol conjugated drugs or drug carriers, is essential for drug delivery...

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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt

Ngày tải lên : 21/06/2014, 02:20

... design of nanoparticles for therapeutic applications Nat Rev Drug Discov 2010, 9:615-627 Davis ME, Chen Z, Shin DM: Nanoparticle therapeutics: an emerging treatment modality for cancer Nat Rev Drug ... Pt(IV) prodrug-PLGA-PEG nanoparticles Proc Natl Acad Sci USA 2008, 105:17356-17361 Rieter WJ, Pott KM, Taylor KML, Lin WB: Nanoscale coordination polymers for platinum-based anticancer drug delivery ... transition metals and any drug molecule in general from a delivery are major factors that ultimately determine the success or failure of that vector when applied to targeted drug delivery One of the...

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Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx

Ngày tải lên : 20/06/2014, 22:20

... photoluminescence, afford additional advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, in vitro ... suitable candidates for a nanoparticle-based drug delivery system to improve their pharmacological performance For this purpose, a “longboat delivery system” has been prepared for the platinum warhead ... as the molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems targeted to the...

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Báo cáo hóa học: " Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery" doc

Ngày tải lên : 21/06/2014, 03:20

... the drug In order to overcome these limitations, a suitable formulation was needed to maximize the potential of DCU in vivo Several formulations strategies for SC dose have been assessed Formulations ... discovery: the potential impact of formulation on pharmacokinetic parameters Curr Op Drug Discov Devel 2002, 5(1):59-71 17 Barrett R: Nanosuspensions in drug delivery Nat Rev Drug Discov 2004, 3:785-796 ... Liu Y, Miyoshi H, Nakamura M: Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles Int J Cancer 2007, 120(12):2527-2537...

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Báo cáo hóa học: " Oral Delivery of DMAB-Modified DocetaxelLoaded PLGA-TPGS Nanoparticles for Cancer Chemotherapy" potx

Ngày tải lên : 21/06/2014, 08:20

... peak of 5.2 and 1.69 ppm for PLA, 4.82 ppm for PGA and at that of 3.65 ppm for TPGS, respectively Characterization of Drug- Loaded Nanoparticles Size, Zeta Potential and Drug Entrapment Efficiency ... The morphology of the nanoparticles formed was recorded as smooth and spherical in shape In vitro Drug Release The in vitro drug release profiles of the 5% DMAB-modified PLGA nanoparticles (ANP),unmodified ... DMABmodified PLGA-TPGS nanoparticles (CNP) >the unmodified PLGA-TPGS nanoparticles (BNP) >the Taxotere® formulation is also dependent on the drug concentration The higher the drug concentration,...

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Báo cáo hóa học: " Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Leve" pptx

Ngày tải lên : 22/06/2014, 00:20

... experiments The CNT array owns a forest-like structure that could be exploited for the deposition of a polymeric thin ﬁlm acting as drug delivery device For drug release kinetics investigation, ... can form extended neural network upon differentiation [5] In this study, we propose a combination of drug delivery system with such CNT array, exploiting a thin ﬁlm of calcium alginate as drug ... be used for controlled drug delivery: any bioactive factor could be released in a spatially and temporally controlled manner The proposed approach represents an interesting solution for building...

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Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps

Ngày tải lên : 09/08/2014, 06:22

... for investigating in vitro binding and internalization contained 0.1 mol% Texas red-phosphatidylethanolamine (Molecular Probes Europe) Liposomes used for studying drug delivery in vitro and for ... Diego, California, USA) For statistical analysis of CD134 expression in vivo and liposomal drug delivery in vitro, a one-way analysis of variance with Dunnett's post-hoc test was used For analysis ... internalization determined the strategy of drug delivery We here employed the mechanism of lipid-coupled drug transfer between membranes to achieve intracellular drug delivery When anti-CD134 liposomes...

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báo cáo khoa học: "Cationic nanoparticles for delivery of amphotericin B: preparation, characterization and activity in vitro" potx

Ngày tải lên : 11/08/2014, 00:22

... (Figure 10) For the less tightly packed drug particles at high P, drug delivery was more efficient leading to drug release and cell death at lower zeta-potentials (Figure 10) The reason for this ... and drug were allowed to interact for 10 minutes Thereafter, CMC was added and allowed to interact for 20 minutes before adding PDDA, which was also allowed to interact for 20 minutes, before ... integrity of red blood cells [28] Therefore, similar studies should be performed for the formulations described in this paper Conclusion At the chosen condition for the AmB/DODAB BF/CMC assembly,...

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báo cáo khoa học: "Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis" pptx

Ngày tải lên : 11/08/2014, 00:22

... nanotechnology–implications for drug targeting and gene therapy Trends Biotechnol 1997, 15:217-224 11 Panyam J, Labhasetwar V: Biodegradable nanoparticles for drug and gene delivery to cells and tissue Adv Drug Deliv ... selective delivery of this class of compounds for treatment of CF lung disease We evaluated the efficacy of PLGA based nano-systems for selective drug delivery A major drawback of PLGA nanoparticles ... vehicles for bronchial epithelial cell delivery targeted delivery into specific sites and across complex biological barriers The development of novel nano-systems for pulmonary gene or drug delivery...

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báo cáo khoa học: " Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts" potx

Ngày tải lên : 11/08/2014, 11:21

... following the use of CPN -delivery, which causes only 5-20% loss of viability within the first 24 h of delivery (Table 1) Unlike the CPN delivery method, the optimal conditions for delivery of siRNAs ... FM4-64 for 10 min, showed uniform red fluorescence in the plasma membrane, and bright spots where vesicles begin to form (Figure 2A, arrowheads) Few internal vesicles appear Following staining for ... obtain new information about these pathways Conclusions CPNs represent a significant advance in technology for the delivery of siRNAs to plant protoplasts Other methods of siRNA delivery include...

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ROMP based polymer nanoparticles for the targeted delivery of antitumor agents

Ngày tải lên : 23/08/2015, 18:48

... Institute for BioNanotechnology in Medicine Requirements for Drug Delivery • Drug delivery particle should self-assemble from drug molecules, components for targeting, and components for stability ... Components of drug delivery system should easily be removed from the organism Institute for BioNanotechnology in Medicine Polymeric Nanoparticles as Model Drug Delivery Vehicles Institute for BioNanotechnology ... penetration in target tissue and cells (< 400 nm for tumor tissue) • Drug delivery particles should be stable and biologically inert before reaching their target • Drug release should result from interactions...

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COAXIAL DOUBLE WALLED MICROSPHERES FOR DRUG AND GENE DELIVERY APPLICATIONS

Ngày tải lên : 10/09/2015, 09:05

... penetration into the inner drug- loaded core on various time scales, and therefore control the drug release from the microspheres For both microsphere formulations, the drug release profiles were ... doxorubicin from formulation B microspheres, (b) chi-p53 nanoparticles from formulation C microspheres, (c) doxorubicin from formulation D microspheres, and (d) chi-p53 nanoparticles from formulation ... Chapter Drug Administration (FDA) Some representative drug delivery systems which have received regulatory approval have been summarized in Table 2.1 2.1.1 Drug delivery systems Two key aims most drug...

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Drug delivery systems for antiangiogenesis and anticancer activities

Ngày tải lên : 11/09/2015, 09:58

... Integrin targeted drug and gene delivery Expert opinion on drug delivery 2010; 7(2), 159-171 Wang Z., Chui WK Ho PC Nanoparticulate delivery system targeted to tumor neovasculature for combined anticancer ... functionalization for targeted doxorubicin delivery (93) Later on, they further made this delivery system multifunctional by adding iron oxide nanoparticles in the system for simultaneous MRI imaging and drug ... Antiangiogenesis inhibitors 10 1.3 Drug delivery system for vascular targeted antiangiogenesis or antitumor therapy 15 1.3.1 Conjugation of drug with ligand for vascular targeting 15 1.3.2...

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Application of HCRSV protein cage for anticancer drug delivery

Ngày tải lên : 11/09/2015, 14:22

... 1.2 Targeted delivery systems 1.2.1 Rationale 1.2.2 Targeting strategies 1.3 Nano-scale drug delivery systems 10 1.3.1 Rationale 10 1.3.2 Classification 11 1.4 Virus-based drug delivery systems ... could be reassembled in vitro into uniformly sized and precisely structured virus-like protein cages (PC) The PC could be an attractive platform for drug delivery as its cavity could serve as ... anticancer drug delivery systems The hypothesis for this project was that PC derived from the Hibiscus Chlorotic Ringspot virus (HCRSV) could be developed into a targeting anticancer drug delivery...

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