... Ankrom MA, Shapiro JR: Paget'sdiseaseofbone (osteitis deformans) J Am Geriatr Soc 1998, 46:1025-1033 Thomas DW, Shepherd JP: Paget'sdiseaseof bone: current concepts in pathogenesis and treatment ... techniques of internal fixation This unusual case of delayed union ofthe femur fracture associated with Paget'sdiseaseofthebone for which functional bracing was ultimately successful illustrates ... Paget'sdiseaseofthebone This would be especially useful in the elderly and those considered at high risk from major corrective surgery In recent years, the concept of biological osteosynthesis...
... other sclerosing bone dysplasia [2,3] To monitor disease activity andthe effects of treatment, we measured T-ALP and uNTX levels of our patients every three to six months and assessed their bone ... TP: Update on the epidemiology ofPaget'sdiseaseofbone J Bone Miner Res 2006, 21(Suppl 2):3-8 Siris ES, Lyles KW, Singer FR, Meunier PJ: Medical management ofPaget'sdiseaseof bone: indication ... the treatment ofPaget'sdiseaseofbone J Clin Endocrinal Metab 1996, 81:961-967 12 Woo S- B, Hellstein JW, Kalmar JR: Systematic review: bisphosphonates and osteonecrosis ofthe jaws Ann Intern...
... Paget'sdiseaseofthe penis and scrotum: excision, reconstruction and evaluation of occult malignancy J Urol 2001, 166(6):2112-2117 Chanda JJ: Extramammary Paget's disease: prognosis and relationship ... CKs, have consistently been proven to be the most useful diagnostic markers [2] This observation was confirmed in our case A recent classification based on the origin ofthePaget's cells has ... Vulvar Pagetdiseaseof urothelial origin: a report of three cases and a proposed classification of vulvar Pagetdisease Hum Pathol 2002, 33(5):549-554 Lai YL, Yang WG, Tsay PK, Swei H, Chuang SS,...
... for Paget'sdisease is to control disease activity with bisphosphonates This is the first reported case ofPaget'sdisease affecting pituitary gland function by involvement ofthe sphenoid bone ... function Discussion Erectile dysfunction is a common disorder and is an important health-care issue as it acts as a surrogate marker of other diseases of more concern, such as diabetes mellitus and ... fossa The hypothesis was that the hyperprolactinaemia may have been consequent upon the increased vascularity and blood flow through the sphenoid secondary to the activity ofthePaget's disease...
... nuclei [1,2] The pathogenesis ofPagetsdisease is still a subject of debate with two main hypotheses The epidermotropic hypothesis proposes that Pagets cells originate from ductal epithelium, ... where they migrate towards the epidermis This hypothesis is supported by the association between Pagetsand an underlying breast carcinoma in the majority of patients The second hypothesis, the ... [9] Several differential diagnoses should be considered when Pagetsdisease is suspected including malignant melanoma, pagetoid dyskeratosis, Bowen sdiseaseand inflammatory skin conditions of...
... HC: Paget'sDiseaseofBone London: E & S Livingstone; 1969 Huvos AG, Butler A, Bretsky SS: Osteogenic sarcoma associated with Paget'sdiseaseof bone: a clinicopathologic study of 65 patients ... was not performed on this subject; the skeletal extent of PDB is on the basis of X-ray evaluations bone biopsy showed the presence of an osteogenic sarcoma on the Pagetic bone already metastasized ... Bone scintigraphy showed signs ofdisease in the right pelvis, the right proximal femur and left ribs IV and VIII Three years after the diagnosis of PDB, bone pain in the right pelvis increased...
... can spread to any part ofthe skeleton, tumor cells most often affect the bones that have the greatest blood supply These include the ends ofthe arms and legs (nearest the torso), the pelvis, the ... involves thebone • Provide information and serve as a resource for physicians, nurses, and other health professionals regarding the management of cancer that spreads to theboneTheBoneand Cancer ... therapy for lung cancer is essential to minimize further bone loss and to improve symptoms related to bonedisease • Bisphosphonates Bisphosphonates are drugs that help stop abnormal bone loss...
... running the dorsal aspect ofthe anastomosis The other suture is used to finish the remaining anastomosis The distal anastomosis is performed in the same way The laparoscopic clamps are then removed ... interpretations ofthe results of these trials with some authors still advocating in favour of early repair of small AAA using the justification that a policy of early EVAR is as safe as a policy of US Surveillance42 ... diluting the benefits of screening Despite these criticisms the Chichester study remains a land mark as it demonstrated the feasibility of US screening for AAA and its potential value and remains a...
... this purpose) or hysteroscopic lysis of intrauterine adhesions Other caLises of Asherman 's syndrome relevant in particular parts ofthe world are tuberculosis and schistosomiasis Complications of ... ofthe pelvis, pjrlicukrly the ovarian fb&sa Laparnscopy allows direct visuali?^!ion of endomelriolic lesions andthe possibility nf biopsy of snspicinus *rtj& and" alsu blaming ofthedisease ... arises through a separate pathway of chromosomal deletions (see the box above) andthe real possibility of malignant change in a fibroid is vanishingly small menstrual disturbance and pressure symptoms,...
... diseases such as tuberculous lymphadenitis, skin diseases, thyroid diseases and spondylitis, however, at present, RT is mainly used to treat malignancies The limitation ofthe prior disease treated ... (3 cycles of CHOP) The pathological diagnosis ofthe second HNC in all the cases (2 cases of cancer ofthe gum, case of tongue cancer, and case of maxillary sinus cancer) was SCC (fig 2) The median ... by the nature ofthe tumor, but also by several patient factors, mainly the extent ofthe existing tissue damage Because ofthe small number of cases, we could not estimate the prognosis of second...
... cysts with an associated increase in the risk of renal cell carcinoma (see front cover) However, successful renal transplantation results in a gradual regression of cysts, a shrinking of diseased ... long-term dialysis One of these involves polycystic changes and their malignant transformation in diseased kidneys Since I have studied these polycystic changes and their malignant transformation ... years and months This study showed that diseased kidneys shrink for years after the initiation of dialysis, but some of them begin to enlarge thereafter due to multiple cyst formation Thus, the...
... Acquired Cystic Diseaseofthe Kidney The designation of “acquired cystic diseaseofthe kidney”: This disease is called “acquired cystic diseaseofthe kidney,” “acquired renal cystic disease, ” or ... electron microscopy ofthe cyst wall The cyst epithelium has a brush border and shows the characteristics ofthe proximal tubules Figure 11 shows a cross section of a kidney with ACDK Most ofthe renal ... [22], and that there are fewer cysts in hypoplastic kidneys Figure 10 shows the relationships between primary diseases and ACDK Histology of Acquired Cystic Diseaseofthe Kidney With ACDK, the...
... time -of- flight mass spectrometer (SELDI-TOFMS) and ProteinChips These findings are being analyzed (Fig 30) Table Hypotheses ofthe pathogenic mechanisms of acquired cystic diseaseofthe kidney Epithelial ... follow-up of acquired cystic diseaseofthe kidney The graphs show the frequencies ofthe grades of cysts during the follow-up Severe grade-4 cystic changes were observed in many ofthe male patients ... function persists [54] (Fig 29) The clinical characteristics of acquired cysts in ACDK are summarized in Table Diagnosis of Acquired Cystic Diseaseofthe Kidney Acquired cystic diseaseofthe kidney...
... of dialysis of 10 years or less and those with a history of dialysis of 20 years or longer (Reproduced from [90], with permission from S Karger AG) Less than 10 years n Age (years) Males Presence ... or dialysis modality, and increases as the duration of dialysis increases (SIR = 3.2 at year, 3.7 at 3–5 years, and 6.8 at 10 years or longer) 32 Acquired Cystic Diseaseofthe Kidney and Renal ... 0.000 NS NS NS words, the duration of dialysis was 10 years or longer in about half the dialysis patients with renal cell carcinoma When the results ofthe surveys were compared, the number of renal...
... of its CpG island) may be acting as a tumor suppressor gene [123] In the epithelium of atypical cysts, the HGF and c-met of its receptors were intensely stained, andthe staining of Bcl-2 was ... [126] Furthermore, Ca oxalate crystals are often found in tissues of acquired cystic diseaseofthe kidney, andthe plasma oxalate level is increased in dialysis patients The differentiation and proliferation ... cystic diseaseofthe kidney and renal cell carcinoma (hypothesis) 58 Acquired Cystic Diseaseofthe Kidney and Renal Cell Carcinoma Fig 72 Causes of renal cell carcinoma in dialysis patients seen...
... rapidly progressive glomerulonephritis and with a history of dialysis of years and 11 months This is the first clinical case in the world in which acquired cystic diseaseofthe kidney was complicated ... glomerulonephritis and with a history of dialysis of years and months This was a case of metachronous bilateral renal cell carcinoma, also with a lesion in the opposite kidney (Figs 91 and 92) An opposite lesion ... glomerulonephritis and with a history of dialysis of years and months Renal cell carcinoma was detected at an unexpected site (Figs 103 and 104) In this patient, who had a long history of dialysis, the mass...
... 121 Case 25 A 64-year-old woman with ADPKD and with a history of dialysis of 12 years and months This is a case of ADPKD in which oncocytoma was found at autopsy (not observed in the cross section) ... glomerulonephritis and with a history of dialysis of 11 years and months This is a case of oncocytoma Fig 116 Case 22 HE stain, ×200 Case 23 A 41-year-old man with chronic glomerulonephritis and with a history ... contrast enhancement was observed (white arrows), andthe diagnosis of renal cell carcinoma was uncertain However, diagnosis became possible after renal transplantation because cysts regressed...
... glomerulonephritis and with a history of dialysis of 25 years and month (the same patient as Case 30) This is a possible recurrence at the same site years and months after the resection of renal cell ... nationwide questionnaire surveys which were carried out during the past 24 years, andthe results of our studies on the etiology ofthediseaseThe history of this research is summarized in Table ... glomerulonephritis and with a history of dialysis of 21 years and months A renal cell carcinoma had metastasized to the lymph nodes (Figs 135 and 136) In this patient with a long history of dialysis, a mass...
... Maisonneuve P (2003) Cancers ofthe kidney and urinary tract in patients on dialysis for end-stage renal disease: analysis of data from the United States, Europe, and Australia and New Zealand ... hemodialysis-associated acquired cystic diseaseofthe kidney (in Japanese with English abstract) J Jpn Soc Dial Ther 36:1289–1293 71 Kamoshida T, Yamada S, Saito K, Miura K, Ando Y, Takada S, Honma S, ... 24 Ishikawa I (1990) Comparison of cyst characteristics in acquired and inherited renal cystic disease In: Carone FA, Dobbie JW (eds) Advances in the pathogenesis of polycystic kidney disease...