multi scale integrated analysis of farming systems benchmarking and tailoring representations across levels
Particle Toxicology - Chapter 11 pot
... extracts of DEP and PM increase IL-8, TNF and COX2 Organic extracts of DEP increase IL-8 Organic extracts of DEP did NOT alter costimulatory molecules (B7) and MHC class II (CDIa) expression and antigen ... lungs of rats only occurs with DEP and not with carbon black (Ma and Ma 2002) The mechanisms of transfer of organic compounds from particles to the target cells can involve the uptake of particles ... RANTES and chemotactic activity for neutrophils and eosinophils Organic extracts of DEP decrease IP10 and increase MDC production induced by allergen Organic extracts of DEP increase IL-8, RANRES and...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... mRNA levels The mRNA levels of CTGF/CCN2 peaked after h of incubation with S1P and decayed progressively thereafter These experiments revealed a stronger and earlier increase of Cyr61/CCN1 mRNA levels ... SRF of an, as yet, unidentified accessory factor [54] The regulation of c-jun is complex and may involve an increase in the levels of c-jun protein and/ or phosphorylation of specific serines (63 and/ or ... mRNA and protein levels We compared the expression profile of the Cyr61/CCN1 gene to that of the CTGF/CCN2 gene and showed that S1P coordinately regulates the expression of both Cyr61/ CCN1 and...
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Withdrawing from Iraq- Alternative Schedules, Associated Risks, and Mitigating Strategies potx
... behavior of the main opposition groups and their forces—i.e., al-Sadr and Jaysh al-Mahdi (JAM), the Sunni and the Sons of Iraq (SoI), and the Kurds and Summary xxv the Peshmerga and of the GoI and ... advising and assisting by the end of August 2010, and the military com2 Agreement Between the United States of America and the Republic of Iraq on the Withdrawal of United States Forces from Iraq and ... U.S Department of Defense (DoD), the team interviewed key officials in the Office of the Secretary of Defense, the Joint Staff, U.S Central Command (CENTCOM), and, in Iraq, the Multi- National...
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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx
... the effect of cAMP signaling on SUMO pathway is complex and cell type dependent Notwithstanding, the up regulation of E1, the down regulation of E2 or E3 and the increased expression of SENP2 lead ... incubating lL of in vitro 35S-labeled product with lg of Aos1 ⁄ Uba2, 150 ng of UBC9 and lg of SUMO-1 in sumoylation buffer (20 mm Hepes, pH 7.5, mm MgCl2 and mm ATP) SAE1 ⁄ SAE2, UBC9 and SUMO-1 ... lL of serum-free medium were placed in a mm cuvette (Bio-Rad, Hercules, CA, USA) A total amount of lg of DNA (2 lg of Myc-tagged LRH-1 expression plasmid, 1.5 lg of pDsRed-SUMO-1 and 1.5 lg of...
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Erectile Dysfunction – Disease-Associated Mechanisms and Novel Insights into Therapy Edited by Kenia Pedrosa Nunes potx
... Changes of adrenal hormones The role of adrenal hormones and their changes are not well established in the etiology of ED Studies have correlated the low levels of dehydroepiandrosterone with ED Androstenedione ... stress and systemic Mechanisms in Erectile Function and Dysfunction: An Overview 15 levels of NO for many reasons The small diameter of the cavernosal arteries and the eminent amount of endothelium ... etiologies of ED Patients with higher levels of glucose and glycated hemoglobin has higher risk of ED The prevalence of ED in men with DM ranges from 10 to 90% Risk factors for the emergence of ED...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... recruitment of SHP-1 and partial recruitment of SHP-2 The q FEBS 2001 recruitment of SHPs suggests that the function of siglec-10 is similar to that of other siglecs such as siglec-3/CD33 and siglec-7 ... spliced regions (S1 ¼ Ig domain and S2 ¼ Ig domain 5) of siglec-10 b-Actin was also probed as a control for mRNA integrity and loading washed and then twofold dilutions of the GST fusion proteins, ... alpha-2,6-sialylation of adhesion molecules and CD22 ligands J Biol Chem 269, 10637–10643 Razi, N & Varki, A (1998) Masking and unmasking of the sialic acid-binding lectin activity of CD22 (siglec-2)...
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báo cáo hóa học:" Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells" potx
... of the suppressive effect of the PGSE on CXCL-10 induction, we measured the activities of MAP kinases, including ERK1/2 and p38MAPK, by Western analysis Intense activation of phospho-ERK1/2 and ... Cheng of Yale University and Prof Paul Tam of University of Hong Kong for their valuable advice and insightful comments We also thank Genome Research Centre of The University of Hong Kong for the ... (Applied Biosystems) and the levels of CXCL-10, IL-8 and TNFAIP3 mRNA as well as the reference gene 18S rRNA were assayed by the gene-specific TaqMan gene expression assays (Applied Biosystems)...
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báo cáo hóa học: " Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury" potx
... expression of proinflammatory cytokines in the brains of Gsn-H mice was determined Significant reductions in brain levels of early cytokines, including IL-1b and IL-6 mRNA expression, and late ... [47] A number of markers such as S100B and NSE can serve as general markers of brain injury Consistent with our observation of morphological improvement, cerebral S100B and NSE levels were diminished ... Better understanding of the improvement of neurological outcome with gelsolin may allow an in-depth understanding of the mechanisms by which gelsolin attenuates the acute response, and to what...
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Báo cáo hóa học: " Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain" pptx
... activation of AMPK (Figure 3A) and a reversible inhibition of both ERK (Figure 3B and C) and mTOR signaling (Figure 3D–H) Hence, resveratrol dose- and time-dependently activates AMPK and inhibits ERK and ... (Ser473, cat# 4058), total AKT, GAPDH and eIF4A Statistical Analysis and Data Presentation Data are shown as means and the standard error of the mean (± SEM) of eight independent cell culture wells, ... activation of mTOR’s negative regulator, TSC2 [49] This results in a profound inhibition of mTOR and its downstream targets involved in translation control (e.g 4EBP and ribosomal S6 kinase and rS6p...
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Associated Technologies And Milling Cutter by J Smith_2 doc
... effectiveness of the production process This latter point, not only influences method of component clamping, dictating: how, where and what will be the optimum method of ‘location and restraint’17 of the ... other important factors [Courtesy of Sandvik Coromant] Milling Cutters and Associated Technologies 163 Table 7: The ratio of cut width-to-diameter (W/D) Number of inserts in-cut Zc W/D: 0.88 0.80 ... life’ somewhat, but this is only part of the problem of off-centre cutting Returning to the cutter positioned centrally (i.e Fig 84g), here the direction of the radial component cutting forces...
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Associated Technologies And Milling Cutter by J Smith_4 pptx
... A Practical Handbook AB Sandvik Coromant Pub., 1994 Oxley, P.L.B Mechanics of Machining Ellis Horwood Pub., 1989 Shaw, M.C Metal Cutting Principles Oxford Univ Press, 1989 Society of Manufacturing ... Manufacturing Eng’rs., Tool and Manufacturing Engineers Handbook – Vol – Machining 4th Ed., SME Pub., Dearborn, Mich., 1983 Smith, G.T Advanced Machining – The Handbook of Cutting Technology, IFS/Springer ... 1989 Smith, G.T CNC Machining Technology Springer Verlag, 1993 Tlusty, G Manufacturing Processes and Equipment Prentice Hall, 2000 Usui, E Modern Machining Theory [i.e In Japanese] Kyoritu-shuppan...
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Molecular and Cellular Signaling docx
... brought in and out of the cell, and moved back and forth to the surface There is a continual flow of outbound traffic of cargo from the ER and Golgi to organelles and the cell surface, and there ... Role of Rho, Rac, and Cdc42, and Their Isoforms 11.16 Ran Family Coordinates Traffic In and Out of the Nucleus 11.17 Rab and ARF Families Mediate the Transport of Cargo ... signals in multicellular plants and animals that allow cells in tissues and organs to work together In humans, there are several systems of tissues, organs, and glands that continually send and receive...
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ERECTILE DYSFUNCTION – DISEASE-ASSOCIATED MECHANISMS AND NOVEL INSIGHTS INTO THERAPY pdf
... Changes of adrenal hormones The role of adrenal hormones and their changes are not well established in the etiology of ED Studies have correlated the low levels of dehydroepiandrosterone with ED Androstenedione ... stress and systemic Mechanisms in Erectile Function and Dysfunction: An Overview 15 levels of NO for many reasons The small diameter of the cavernosal arteries and the eminent amount of endothelium ... etiologies of ED Patients with higher levels of glucose and glycated hemoglobin has higher risk of ED The prevalence of ED in men with DM ranges from 10 to 90% Risk factors for the emergence of ED...
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Báo cáo sinh học: "The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling" potx
... by the activation of any of the known cell-death pathways Expression of the caspase inhibitors p35 or DIAP1, or of p21, an inhibitor of p53-induced apoptosis [42], and loss of eiger, which encodes ... females and then screened the F1 generation for reversion of the strong gain -of- function phenotype and its associated semilethality Several loss -of- function alleles of dFOXO were isolated and molecularly ... conditions and were of identical age (2 d) at the time of the experiment The sizes of ommatidia and rhabdomeres were quantified with the program NIH Image 1.61 [76] Clonal analysis To induce loss -of- function...
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Báo cáo sinh học: "Dishevelled and Wnt signaling: is the nucleus the final frontier" potx
... complex induces the stabilization of -catenin via the DIX and PDZ domains of Dishevelled (Dsh) and a number of factors including Axin, glycogen synthase kinase (GSK3) and casein kinase (CK1) -catenin ... subcellular localization of Dsh and the choice of effector molecules downstream of Dsh govern the selectivity of specific pathway activation Dsh-localization studies in Drosophila [21] and recently Caenorhabditis ... localization of Dsh in this pathway See text for further details domains of Dsh to induce the stabilization of cytosolic -catenin; this allows for cytoplasmic accumulation and subsequent translocation of...
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Báo cáo y học: " Eph Receptors and Ephrin Signaling" pps
... exception of EphA4 which can bind to ephrinA and ephrinB ligands, and ephrinA5 which can 264 also bind to EphB2 [2, 3] Figure Domain structure of Eph receptors and ephrinA and ephrinB ligands Eph ... expression and thus disruption of the normal coupling of bone resorption and bone formation [92] Bone is a frequent site of metastasis for prostate cancer, and tissue microarray analysis of metastatic ... in elongation of actin filaments and morphogenesis and maturation of dendritic spines In addition to Rho GTPases, Eph receptors can also regulate the activity of the Ras family of GTPases, including...
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Báo cáo y học: "Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury" potx
... upregulation of BMP-2 mRNA after injury Several factors can determine activation of BMP signaling independently of the expression of one ligand, including secretion and solubility of the ligand(s), ... different time-points and the knees dissected for histological and histochemical analysis The same procedure has been performed in month old mice of the same strain and sex and produced analogous ... avoid spreading of cells from the explants After days, the medium was replaced and one of each pair of adjacent samples was cut using a scalpel at mm intervals The other explant of each pair was...
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Báo cáo y học: "Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study" pot
... acquisition of data, analysis and interpretation of data, statistical analysis, and manuscript preparation NA participated in acquisition of data, analysis and interpretation of data, statistical analysis, ... analysis, and manuscript preparation JMP and JPP participated in study design, analysis and interpretation of data, and manuscript preparation ND participated in study design and in analysis and interpretation ... MMP-13, and COX-2 of 29%, 20%, and 18% compared with means of 73%, 44%, and 40% for PAR2-AP PAR-2-induced signalling pathways The effect of PAR-2 activation on the phosphorylated levels of three...
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Báo cáo y học: "Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells" doc
... mRNA and protein expression of dermal fibroblasts (Figures 13a and 13c) As shown in Figures 13b and 13c, the respective osteoprotegerin expression levels were reduced after one and two days of ... also increased expression of RAGE, NFκB p65 and of the proinflammatory cytokines TNF-α and IL-6 In contrast, AGE-BSA decreased expression of RANKL and osteo- Page 14 of 19 (page number not for ... temperature and consisted of μg of nuclear proteins, binding buffer (15 mM Tris-HCl, pH 7.9, 60 mM KCl, mM MgCl2, mM EDTA, mM EGTA, 10% glycerol, mM DTT), μg of poly(dIdC), μg BSA and 40 fmol of labelled...
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báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt
... correlated with expression of NF-B, Notch1 and VEGF-C, independent of T stage, sex, age, and differentiation status of tumor cells Moreover, a multiple factors analysis of VEGF-C, which is a key ... ZC and HL conceived of the study; CS, YS, YL, YL and BZ performed experiments; ZC and LC analyzed data and prepared the figures; CS, ZC and HL drafted the manuscript All authors have read and ... dehydrated, and mounted Negative controls were prepared by substituting PBS for primary antibody Assessment of immunohistochemical staining Nuclear staining of NF-B and cytoplasmic staining of Notch1 and...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25