monoclonal antibodies in paediatric acute lymphoblastic leukemia
Relapse prediction in childhood acute lymphoblastic leukemia by time series gene expression profiling
... typically involving grouping genes with correlated expressions into bins and then selecting representatives from each bin, have also been used One of the more interesting recent developments in gene ... effects of the training data, and result in prediction failures In contrast, unsupervised learning targets on classifying cases in a dataset into several subgroups by evaluating the major variance ... similarity is calculated between two clusters Candidates include single linkage, complete linkage, average linkage, and centroid linkage Single linkage takes the similarity of the nearest samples between...
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báo cáo hóa học: " Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" potx
... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the ... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is...
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báo cáo hóa học: " Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia: an exploratory study" pdf
... Health-related quality of life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy Int J Oncol 1997, 11(2):333-339 ... frequently been used in pediatric oncology studies [22,32-34] and includes subscales with age-specific questions for determining problems in relevant areas during cancer treatment such as pain, nausea, ... confirm these findings and provide more detailed information on the relationship between sleep and QoL, and on factors affecting sleep in pediatric ALL and in children with cancer in general Abbreviations...
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báo cáo hóa học:" Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" docx
... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the ... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is...
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Báo cáo khoa học: "Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy" ppt
... cell lines (such as human skin fibroblasts, glioblastoma and colon carcinoma lines) and primary lymphocytes [13-15] Furthermore, CD was induced by IR in human hepatoblastoma cell line performing ... irradiation; IR, ionizing radiation; HVR2, hypervariable region 2; nDNA, nuclear DNA; ALL, acute lymphoblastic leukemia; MGB, minor groove binder; ROS, reactive oxygen species; Competing interest: The ... (ALL) patients undergoging total body irradiation (TBI) precondionting as human beings in vivo irradiation model The advantage of using this model lies in full view of in vivo microenvironment,...
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báo cáo khoa học: " Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia" docx
... insulin and leptin receptors are located in key brain areas, such as the hypothalamic arcuate nucleus In some cells of hypothalamus, leptin and insulin activate both JAK-STAT and PI3K signaling ... may be the reason of leptin resistance The closed-loop leptin/insulin feedback makes the GH/insulin/leptin relations understandable [30,31] According to Link et al leptin might serve as a good ... their relationship to serum growth hormone-binding protein and leptin levels in children with acute lymphoblastic leukemia: a prospective study Eur J Endocrinol 2000, 143:243-250 26 Karaman S, Ecran...
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báo cáo khoa học: "Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study" doc
... clinical significance of TEL-AML1 as MRD in CD 10 positive ALL is needed to determine how to best integrate TEL-AML1 testing into routine patient care Abbreviations ALL: Acute lymphoblastic leukemia; ... rearranged in a wide variety of hematological malignancies In particular, TEL is fused to the platelet-derived growth factor receptor β in CMML, to the ABL tyrosine kinase in acute myeloid leukemia ... Endo C, Oda M, Nishiuchi R, Seino Y: Persistence of TEL-AML1 transcript in acute lymphoblastic leukemia in long-term remission Pediatr Int 2003, 45:275-280 McLean TW, Ringold S, Neuberg D, Stegmaier...
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báo cáo khoa học: "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines" ppsx
... expressed in myeloid leukemias [7,8] Conclusion We demonstrated the presence of the SET-NUP214 gene in the T-ALL cell line LOUCY and in the AML cell line MEGAL by genomic sequencing In both cell lines, ... SET-NUP214 screening in cell lines SET-NUP214 screening in cell lines SET-NUP214 expression screening performed with a SET exon forward primer and a NUP214 exon 18 reverse primer Cell lines LOUCY and ... recurrent deletion, del(9)(q34.11q34.13) in patients with T-cell acute lymphoblastic leukemia (T-ALL) [4] It has also been reported in a single case of acute myeloid leukemia (AML) [5] SETNUP214 positive...
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báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc
... showed that the inhibition of BCL11B expression by siRNA selectively inhibited proliferation and effectively induced apoptosis in human T-cell acute lymphoblastic leukemia (T-ALL) cell lines (Jurkat, ... other four genes of interest in the healthy controls Discussion Increasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11B mRNA expression in most T-ALL cases ... of caspases BCL2L1 may inactivate caspase-8 by decreasing death-inducing signaling complex (DISC) formation in the plasma membrane, nucleus, and Golgi complex while diverting DISC formation to...
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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report." doc
... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in longterm safety monitoring of the drug [11] Hartmut Geiger et al ... Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S: Treatment-related myelodysplasia and acute leukemia in non-Hodgkin’s lymphoma patients J Clin Oncol 2003, 21:897-906 Macdonald...
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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report" potx
... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in longterm safety monitoring of the drug [11] Hartmut Geiger et al ... Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S: Treatment-related myelodysplasia and acute leukemia in non-Hodgkin’s lymphoma patients J Clin Oncol 2003, 21:897-906 Macdonald...
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Báo cáo y học: " Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia" ppt
... and outlined in numerous publications, but in spite of extensive research within almost all areas of medicine, few outcome predictors are implemented in routine clinical decision-making [2] Hence, ... we face in individualized medicine, and how they can be addressed Childhood acute lymphoblastic leukemia In the industrialized countries cancer is the most common medical cause of death in children ... medicine and childhood acute lymphoblastic leukemia for implementing individualized medicine the following issues need to be addressed: The patients exhibit variable treatment responses in terms...
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CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC docx
... hypotheses concerning an infectious origin of childhood leukemia ‘Population mixing’ hypothesis by Kinlen In early 1980, an unusual increase in the incidence of childhood leukemia was observed in young ... Identifying the Etiology of Acute Lymphoblastic Leukemia in Children http://dx.doi.org/10.5772/52716 [37] Infante-Rivard C, Krajinovic M, Labuda D, Sinnett D Childhood acute lymphoblastic leukemia ... of the population mixing studies had failed to find an increase in a symptomatic infection in adults or children, paralleling the increase in leuke‐ mia incidence Considering that there are viruses...
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Báo cáo y học: "Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF-κB binding activity and TNF-α secretion of T cell" pot
... anti-CD4 mAbs in the treatment of RA, i.e promising initial efficacy in open anti-CD4 trials [6,7], subsequent disappointing double-blind clinical trials (reviewed in [8]), and, finally, a revival ... degree (Fig 3) Interestingly, preincubation with the accelerating anti-CD4 mAb, RIB5/2, induced a significantly higher binding activity of NF-B than did preincubation with the ameliorating W3/25 and ... [34], it was revealing that the accelerating mAb, RIB5/2, besides inducing TNF- secretion, also strongly upregulated NF-B binding activity This was especially striking because binding of another...
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báo cáo khoa học: "The frequency of NPM1 mutations in childhood acute myeloid leukemia" doc
... motif inserted at the C-terminus and are thought to play a significant role in the abnormal cytoplasmic localization of the NPM protein The other mutation obtained in the present study, involved individual ... mutations in 1485 adult patients with acute myeloid leukemia Blood 2006, 107:4011-4020 Ahmad F, Mandava S, Das BR: Mutations of NPM1 gene in de novo acute myeloid leukemia: determination of incidence, ... TCTG-tandem duplication in NPM1exon 12 Leukemia 2007, 21:366-367 Rau R, Brown P: Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukemia: towards definition of a new leukemia entity...
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Báo cáo y học: " Precursor B-cell acute lymphoblastic leukemia presenting as obstructive jaundice: a case report" pdf
... rare presentation of acute lymphoblastic leukaemia in an adult JOP 2010, 11:72-74 Takamatsu T: Preferential infiltration of liver sinusoids in acute lymphoblastic leukemia Rinsho Ketsueki 2001, ... report any recent change in his medications and was tolerating his aspirin, sitagliptin, fosinopril, metformin and repaglinide without reported side effects His physical examination was significant ... biopsy of the liver showing small to medium-sized lymphoblasts infiltrating the hepatic parenchyma Page of Figure Bone marrow biopsy showing lymphoblastic infiltration instructions to follow up...
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In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization
... Phosphoinositide 3-kinase Promyelocytic Leukemia Zinc Finger protein Phosphatase of Regenerating Liver Retinoblastoma Protein Red Fluorescence Protein RNA interference Receptor Tyrosine Kinase ... Shock Protein 90 Indirubin Derivative Interferon gamma-inducible gene 16 Immunohistochemistry Intraperitoneally Internal Tandem Duplication c-Jun N-terminal Kinase Kinase Insert Domain Receptor ... CCAAT/enhancer-binding protein α Chromatin Immunoprecipitation Combination Index Chronic Myelogenous Leukemia Colorectal Carcinomas C-terminal Src Kinase 4'-6-Diamidino-2-phenylindole Disease...
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Báo cáo y học: "Monoclonal Antibodies against Nucleophosmin Mutants: Potentials for the Detection of Acute Myeloid Leukemia" ppt
... raised a mAb (T26) only against NPM1 mutants by using a 19-aminoacid polypeptide immunogen (CLAVEEVLSRK) containing the unique C-terminus of the NPM-mA protein It indicated that the specific ... electrophoresis in acute myeloid leukemia Leukemia 2005; 19:1479-82 Falini B, Mason DY Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection ... for protein purification The supernatant was loaded to His-Bind-Resins affinity column (Novagen, Darmstadt, Germany) to purify the fusion protein The purified protein was dialysed against phosphate-buffered...
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Báo cáo khoa học: Role of CCP2 of the C4b-binding protein b-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies docx
... measured in a c-counter Results Selection of amino acids in CCP2 to be mutated In this study, we were interested in investigating which regions within CCP2 of the C4BP b-chain are involved in protein ... protein S C4b–binding protein interactions by homology modeling and inhibitory antibodies Biochemistry 33, 11073–11078 ´ Fernandez, J.A & Griffin, J.H (1994) A protein S binding site on C4b-binding ... bind 125 I-labeled protein S in solution (Fig 2C) All variants yielded binding patterns similar to that of wild-type b-chain In the binding assay, the recombinant proteins were immobilized in...
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