molecular pathogenesis of prostate cancer somatic epigenetic and genetic alterations
Báo cáo khoa học: Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells potx
... protein signature of prostate cancer biopsies revealed the overexpression of TPD52 in cancer patient material [22] To date, the main physiological role of TPD52 in prostate cancer progression ... function of TPD52 in prostate cancer progression is still under investigation, the main objective of the present study was the functional characterization of TPD52 alterations in the androgen ... rate of prostate cancer has been decreased significantly In spite of all new treatment strategies to increase survival, PCA is the most common type of cancer found in men in Western countries and...
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Báo cáo y học: "Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications" pps
... made in our understanding of the molecular pathogenesis of AML, and numerous genetic abnormalities in AML have been identified FLT3 is one of the key molecules with a role in the pathogenesis in ... synergistic effects of ATO and MEK inhibition, as well as ATO and FLT3 inhibition, on FLT3-ITD cells [101] The combination of ATO and AG1296, an FLT3 inhibitor, profoundly inhibited the growth and induced ... association of RAC1-GTP binding to phosphorylated STAT5 (pSTAT5), and inhibition of the pSTAT5 level resulted in the decrease of ROS production They concluded that the aggressiveness of the disease and...
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báo cáo khoa học: "Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report" pps
... deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells BMC Biol 2010, 8:6 24 Diaw L, Woodson K, Gillespie JW: Prostate cancer epigenetics: a review ... MF: Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study J Natl Cancer Inst 2007, 99:754-764 Tisman and Garcia Journal of Medical Case Reports ... detection and staging of prostate cancer Clin Cancer Res 2005, 11:6582-6588 21 Hultdin J, Van Guelpen B, Bergh A, Hallmans G, Stattin P: Plasma folate, vitamin B12, and homocysteine and prostate cancer...
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Báo cáo y học: "The molecular basis of lung cancer: molecular abnormalities and therapeutic implications" potx
... Tissue microarrays (TMAs) of lung cancer Tissue microarrays (TMAs) of lung cancer TMAs are comprised of core biopsies of 0.6 mm in diameter of different tumors and of uninvolved lung from the ... having a higher number of packs of cigarettes smoked over years Epigenetic alterations of gene expression in lung cancer Gene function loss can be mediated by deletion of large chromosomal regions ... described and favor the clonal progression of cancer Yet cancer remains a rare event if one considers the total number of bronchial epithelial cells and the proliferation rate of patches of clonal...
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EFFECTS OF CHOLINE KINASE ACTIVITY ON PHOSPHOLIPID METABOLISM AND MALIGNANT PHENOTYPE OF PROSTATE CANCER CELLS
... over-expression of hChK on invasion potential of PC-3 and LNCaP prostate cancer cells 87 Figure 31 Effect of hypoxia and over-expression of hChK on expression of promigratory factor, uPA in LNCaP prostate ... over-expression of choline kinase and hypoxia on invasion potential of prostate cancer cells 86 4.6 Effect of over-expression of choline kinase and hypoxia on expression of pro-invasion ... [14C]acetate and [18F]FDG in prostate cancer cells 31 Figure 12 Uptake of radiolabeled choline in PC-3 prostate cancer cells 41 Figure 13 Uptake of radiolabeled choline in LNCaP prostate cancer...
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Molecular signatures of gastric cancer an integrated approach to molecular cytogenetics, whole genome copy number and transcriptome profiles
... fourth as a cause of cancer mortality, having an ASR of 10.5 in males and 5.6 in females, respectively15 Figure 1-5 Age-standardized cancer incidence and mortality rates of common cancers in Singapore ... identify genetic and genomic aberrations that are causal in the initiation and/ or progression of specific cancer types Discoveries of druggable cytogenetic signatures have advanced prognostication and ... xii List of Figures List of Figures Chapter Figure 1-1 Global incidence and mortality of common cancers Figure 1-2 Global geographic variation in ASR of gastric cancer (GC) among males and females...
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Questions & Answers About Prostate Cancer, Bone Metastases, and Treatment-Related Osteoporosis pot
... with prostate cancer and 27,050 men will die from prostate cancer in the U.S Q How is prostate cancer diagnosed? A Prostate cancer is most often diagnosed by needle biopsy of the prostate gland ... urinary bladder in men Q How common is prostate cancer? A Prostate cancer is the most common form of cancer in men (except for skin cancer) and a leading cause of cancer death worldwide In 2007, close ... General Information about Prostate Cancer Q What is prostate cancer? A Prostate cancer is an abnormal (malignant) growth of the prostate, a walnut-sized gland at the base of the urinary bladder...
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Báo cáo khoa học: Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation potx
... Biosciences) Standards consisted of lL aliquots of serial dilutions of the reaction mixtures, with the moles of phosphate defined using the ATP concentration Division of the signal per mole of substrate ... higher levels of expression than the midbrain and 3550 B Sahin et al (Eur J Biochem 271) Ó FEBS 2004 Fig Deduced amino acid sequence alignment of the long and short isoforms of human and mouse AK ... more prominent TH band to be visible likely to represent the long and short isoforms of the enzyme Many of the tissues included in this analysis also showed a prevalence of one isoform over the other...
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INTENSIVE LIFESTYLE CHANGES MAY AFFECT THE PROGRESSION OF PROSTATE CANCER docx
... tumor growth and the underlying prostate cancer disease process However, recent articles failed to show any effect of INTENSIVE LIFESTYLE CHANGES AND PROSTATE CANCER a diet low in fat and high in ... care and promote an attitude of optimism and hope Paul H Lange Department of Urology University of Washington Seattle, Washington REPLY BY AUTHORS Changes in diet and lifestyle are of profound ... in PSA and differences in progression or survival, PSA is used as a primary end point meausre of virtually all standard treatments of prostate cancer Also, it is unusual for prostate cancer to...
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scientific american - 1994 04 - the dilemmas of prostate cancer
... of detecting prostate cancer, and it can signal the presence of cancer in individuals who display no symptoms of prostate abnormalities This test measures the level of a glycoprotein called prostate- speciÞc ... field of molecular and physical gastronomy since 1989 Kurti, emeritus professor of physics at the University of Oxford and a former vice president of the Royal Society, was born in 1908 and educated ... Dilemmas of Prostate Cancer Do the risks of aggressive treatment for early prostate cancer outweigh the benefits? This question is one of several unresolved issues faced by those who treat, and those...
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Báo cáo sinh học: "A novel multiplex assay combining autoantibodies plus PSA has potential implications for classification of prostate cancer from non-malignant cases" docx
... Identification and validation of B cell epitopes from PCAA Similar to NY-ESO-1, XAGE-1b and SSX-2,4 are cancer/ testis antigens shared among cancers of the prostate, lung, breast and others [20,21] ... SSX-2, and XAGE-1b were less than 0.001 and the pvalues of NY-ESO-1 and AMACR autoAb were 0.029 and 0.134, respectively A combined A+PSA index was created as the predicted probability of prostate cancer ... in prostate cancer diagnosis Thus, patients with lung cancer and colon cancer, two common cancers for elder men will also be included in the crossvalidation in order to enhance the prostate cancer...
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báo cáo hóa học:" A novel multiplex assay combining autoantibodies plus PSA has potential implications for classification of prostate cancer from non-malignant cases" ppt
... Identification and validation of B cell epitopes from PCAA Similar to NY-ESO-1, XAGE-1b and SSX-2,4 are cancer/ testis antigens shared among cancers of the prostate, lung, breast and others [20,21] ... SSX-2, and XAGE-1b were less than 0.001 and the pvalues of NY-ESO-1 and AMACR autoAb were 0.029 and 0.134, respectively A combined A+PSA index was created as the predicted probability of prostate cancer ... in prostate cancer diagnosis Thus, patients with lung cancer and colon cancer, two common cancers for elder men will also be included in the crossvalidation in order to enhance the prostate cancer...
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Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps
... for prostate cancer1 7, and was the most powerful indicator of disease activity in men under observation alone.18 When pretreatment variables in patients with androgen-independent prostate cancer ... pectin (MCP) increases the prostate- specific antigen doubling time in men with prostate cancer: a phase II pilot study Prostate Cancer and Prostatic Dis 2003; 6: 301 Sokal RR and Rohlf FJ Introduction ... standard error of the mean Discussion In a previously published, prospective, randomized trial, patients with pathologically proven prostate cancer in advanced stages (M1), osseous metastasis and...
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Báo cáo khoa học: "Early clinical experience of radiotherapy of prostate cancer with volumetric modulated arc therapy" pps
... neck, anal canal, cervix uteri cancer and other indications [3-9] The potential role of RA in the treatment of prostate cancer has been investigated by the Danish group of Rigs Hospitalet [6], by ... resolution of 2.5 mm Technical features of treatments have been reported in terms of main delivery parameters (field and control point (CP) size, MU, MU/deg and MU/Gy, Dose Rate Page of (DR), Gantry ... results of the DVH analysis Table records the clinical outcome of the treatments as early acute reactions and PSA values From the summary of main technical features it derives that treatment of prostate...
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Báo cáo khoa học: "Reproducibility of patient setup by surface image registration system in conformal radiotherapy of prostate cancer" pdf
... 6, and The positioning error detected by AlignRT along the axes X, Y, and Z exceeded the value of mm in 14.1%, 2.0%, and 5.1% of measurements and the value of mm in 36.9%, 13.6%, and 27.8% of ... positioning errors measured by AlignRT and EPID images that ranged from 0.77 to 0.92 with a mean of 0.85 and SD of 0.13 The analysis of systematic and random errors showed that the mean largest ... AlignRT along the axes X, Y, and Z exceeding the values of and mm Positioning errors detected by AlignRT along the axes X, Y, and Z exceeding the values of and mm Page of 10 (page number not for...
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Báo cáo khoa học: " Distinct effects of rectum delineation methods in 3D-confromal vs. IMRT treatment planning of prostate cancer" pdf
... DVH, DWH and DSH in 3D-CRT and IMRT treatment planning for prostate cancer A literature review of the association of these dose parameters with late rectal toxicity was conducted Materials and methods ... 80 IMRT Figure tate cancer rectal DVH of rectal volume and relative difference between Correlation and DWH in IMRT treatment planning of prosCorrelation of rectal volume and relative difference ... Impact of volume and location of irradiated rectum wall on rectal blood loss after radiotherapy of prostate cancer Int J Radiat Oncol Biol Phys 2004, 58(4):1072-1082 Lee CM, Lee RJ, Handrahan...
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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps
... protein in PIN and CaP, in contrast to those of the sham and vehicle controls Scale bars: 50 μm in upper (d) of panel A; 10 μm in lower (d) of panel A and in (d) of panel C CaP: prostate cancer; HE: ... of P63 + cancer cells in the metastatic loci and generation of prostate- like glandular structures Our data support the prostate cancer stem cell characteristics observed in previous studies and, ... loss -of- function mutations has been reported in some androgen-refractory prostate cancers [13,41] Therefore, both AR + and AR - cells were capable of forming androgen-independent prostate cancer...
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báo cáo khoa học: "Co-expression and impact of prostate specific membrane antigen and prostate specific antigen in prostatic pathologies" ppt
... Page of secretory epithelial cells of prostate gland, both PSMA and PSA transcriptions are androgen-dependent [39,40] The emergence of androgen-insensitive tumor cells arising as a consequence of ... and/ or progression of prostate cancer? Prostate 2007, 67:312-329 23 Oesterling JE: Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate ... MUC1 Overexpression and Loss of Prostate- specific Antigen Expression in Prostate Cancer Clin Cancer Res 2001, 7:1533-1538 33 Hernes E: Advanced prostate cancer Selected aspects of human pathology,...
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báo cáo khoa học: "Angiogenesis inhibitors in the treatment of prostate cancer" pdf
... anti -prostate cancer Hwang and Heath Journal of Hematology & Oncology 2010, 3:26 http://www.jhoonline.org/content/3/1/26 65 66 67 68 69 70 71 Page 12 of 12 efficacy of androgen ablation and taxotere ... growing body of evidence that angiogenesis plays a role in prostate cancer in particular It has been demonstrated that prostate cancer cells express VEGF [22,23] and that the expression of VEGF by ... VEGFR-2, VEGFR-3 and PDGFR kinases Results of three phase II studies in prostate cancer have been recently reported Twentytwo patients with metastatic androgen independent prostate cancer were enrolled...
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