mitochondrial dysfunction in insulin insensitivity and type 2 diabetes and new insights for thei
TYPE 2 DIABETES - National clinical guideline for management in primary and secondary care (update) pdf
... (2) : other oral agents and exenatide; 120 from evidence to recommendations 11 11.1 11 .2 11.3 11.4 Glucose control: insulin therapy Oral agent combination therapy with insulin Insulin therapy Insulin ... 2. 4 2. 5 2. 6 2. 7 2. 8 2. 9 2. 10 3.1 3 .2 Introduction Background Definition Prevalence Health and resource burden 4 Methodology Aim Scope Audience Involvement of people with Type diabetes Guideline ... Insulin therapy Insulin detemir Insulin delivery devices 125 130 146 146 12 12. 1 12. 2 12. 3 Blood pressure therapy Clinical introduction Blood pressure lowering – targets and intervention levels...
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Báo cáo y học: "Skeletal muscle sodium glucose co-transporters in older adults with type 2 diabetes undergoing resistance training"
... exercise training to improve glycemic control in older adults with type diabetes Diabetes Care 20 02; 25( 12) :23 35-41 15 Ivy JL Role of exercise training in the prevention and treatment of insulin resistance ... characterized by insulin resistance, and thus the inability of insulin to stimulate glucose utilization in skeletal muscle It has been proposed that insulin resistant individuals have a defect in GLUT4 ... beneficial intervention for diabetes control [24 ] Studies of glucose intolerant and diabetic subjects have demonstrated that increased physical activity enhances insulin sensitivity and insulin- dependent...
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báo cáo hóa học: " A review of methods used in assessing nonserious adverse drug events in observational studies among type 2 diabetes mellitus patients" docx
... Stauch K, Landen H: Effect of add-on acarbose to insulin therapy in routine clinical practice Clin Drug Invest 20 03, 23 : 621 - 627 Hakobyan et al Health and Quality of Life Outcomes 20 11, 9:83 ... prolongedrelease metformin (Glucophage(registered trademark) SR) in individuals intolerant to standard metformin - Results from four UK centres Br J Diabetes Vasc Dis 20 07, 7 :22 5 -22 8 41 Hussein Z, Wentworth ... patients with type diabetes Adv Ther 20 05, 22 : 621 -635 28 Taki H, Maki T, Iso T, Iwamoto K, Kajiura T: Postmarketing surveillance study of nateglinide in Japan Adv Ther 20 05, 22 :513- 526 29 Biswas P,...
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Báo cáo y học: " Ranking candidate genes in rat models of type 2 diabetes" pptx
... increased in obese men J Clin Endocrinol Metab 20 01, 86:1 921 -1 924 Page of (page number not for citation purposes) Theoretical Biology and Medical Modelling 20 09, 6: 12 23 24 25 26 27 http://www.tbiomed.com/content/6/1/ 12 ... tree, certain reference terms are grouped together For example, there is a group of five reference terms that are all associated with insulin ( "insulin action", "insulin resistance", "insulin sensitivity", ... -hyperinsulinaemia ! ! ! + ! ! ! +- 12 + hyperinsulinemia ! ! ! ! ! ! + 14 + -insulinsensitivity ! ! ! ! ! ! ! + -10 + -insulinresistance ! ! ! ! ! + insulinaction ! ! ! ! + -macroangiopathy...
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METFORMIN – MORE THAN ‘GOLD STANDARD’ IN THE TREATMENT OF TYPE 2 DIABETES MELLITUS
... weight gain compared with bedtime insulin plus glibenclamide, bedtime insulin plus metformin plus glibenclamide, or morning and bedtime insulin (17) Metformin and the GLP-agonists exenatide or ... WEIGHT METFORMIN AND LIPID PROFILE While insulin secretagogues, thiazolidinediones and insulin itself promote increased body weight in many patients, treatment with metformin usually results in no ... al Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type diabetes Diabetes 20 02; 51 :20 74 -20 81 13 DeFronzo R, Goodman A Efficacy of metformin in patients...
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STUDIES ON DIABETIC PERIPHERAL NEUROPATHY IN THE DB DB, TYPE 2 DIABETES MOUSE
... factors of type diabetes Lack of insulin is the main pathogenesis and therapeutic option is exogenous insulin injection combined with life style control 1.1 .2 Type Diabetes Mellitus Type diabetes ... (BMNCs) 20 1.6 .2 Endothelial progenitor cells (EPCs) 21 1.6.3 Mesenchymal stem cells (MSCs) 21 1.7 Missing Link and Our Approach 22 CHAPTER 2: MATERIALS AND METHODS 23 2. 1 Animals 24 2. 2 Study ... hyperglycemia and a relative or absolute lack of insulin Depending on the nature of disease, there are two major types of diabetes: type diabetes known as insulin dependent diabetes mellitus (IDDM) and type...
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báo cáo hóa học: " Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes" docx
... I enjoy 12 Insulin means my health will deteriorate 13 Injecting insulin is embarrassing 14 Injecting insulin is painful 15 It is difficult to always inject insulin correctly 16 Insulin makes ... Fear of needle injection Insulin will increase the risk of hypoglycaemia Insulin will improve health Insulin will cause weight gain 10 Insulin will be demanding to administer 11 Insulin means I have ... (SD) Insulin signifies failure with pre -insulin therapy Insulin signifies diabetes has worsened Insulin will improve prognosis Insulin will make others perceive greater sickness Insulin will make...
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báo cáo hóa học:" Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes" pdf
... I enjoy 12 Insulin means my health will deteriorate 13 Injecting insulin is embarrassing 14 Injecting insulin is painful 15 It is difficult to always inject insulin correctly 16 Insulin makes ... Fear of needle injection Insulin will increase the risk of hypoglycaemia Insulin will improve health Insulin will cause weight gain 10 Insulin will be demanding to administer 11 Insulin means I have ... (SD) Insulin signifies failure with pre -insulin therapy Insulin signifies diabetes has worsened Insulin will improve prognosis Insulin will make others perceive greater sickness Insulin will make...
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Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"
... pre-existing increased insulin resistance and dysfunction of beta cells Insulin resistance is present in the acutely ill [13,15,18 ,28 ] in different intensity, but the factors determining the extent ... Curr Opin Clin Nutr Metab Care 20 02, 5:551-559 14 Marette A: Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings Curr Opin Clin Nutr Metab Care 20 02, 5:377-383 ... disease during pregnancy Jama 20 05, 29 4 :27 51 -27 57 49 Kim C, Newton KM, Knopp RH: Gestational diabetes and the incidence of type diabetes: a systematic review Diabetes Care 20 02, 25 :18 62- 1868 50...
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Tài liệu Báo cáo khoa học: Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects Implications for a mechanism linking obesity and type 2 diabetes pdf
... Palmitoyl-CoA and control of mitochondrial function Fatty acid-induced insulin resistance in liver is one of the main causes of hyperglycemia in type diabetes [15], and the role of mitochondria in this dysfunction ... Teerlink T, Westerhoff HV & Heine RJ (20 01) The potential role of adenosine in the pathophysiology of the insulin resistance syndrome Atherosclerosis 155, 28 3 29 0 FEBS Journal 27 3 (20 06) 528 8–53 02 ... Grigiene J (20 02) Multiple effects of 2, 2,5,5-tetrachlorbiphenyl on oxidative phosphorylation in rat liver mitochondria Toxicol Sci 65, 22 0 22 7 FEBS Journal 27 3 (20 06) 528 8–53 02 ª 20 06 The Authors...
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Effectiveness of PRECEDE model for health education on changes and level of control of HbA1c, blood pressure, lipids, and body mass index in patients with type 2 diabetes mellitus docx
... inhibitors Insulin 14 .2 (10.4-18) 14.4 (10.4-18.4) 0.94 Diuretics 27 .4 (22 .5- 32. 3) 23 .1 (18.3 -27 .9) 0 .23 Beta blockers 12. 9 (9 .2- 16.6) 9.7 (6.4-13.1) 0 .22 ACE inhibitors 30.6 (25 .5-35.7) 29 .1 (24 -34 .2) ... Control PRECEDE 12. 7 12. 3 12. 5 12. 3 0.90 -0 .2 0.85 SBP (
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Long-term Exposure to Traffic-related Air Pollution and Type 2 Diabetes Prevalence in a Cross-sectional Screening-study in the Netherlands pdf
... 20 02, 23 :599- 622 10 Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM: C-reactive protein, interleukin 6, and risk of developing type diabetes mellitus JAMA 20 01, 28 6: 327 -334 11 Ko K-P, Min ... contributed to inconsistent findings For instance, the interquartile range for NO2-exposure in this study was only 2. 3 μg/m3, while in previous studies on air pollution and type diabetes [2, 3] this ... 1,795 (22 %) 110 (18%) 38 (18%) 1,685 (23 %) 60-65 1,446 (18%) 122 (20 %) 45 (21 %) 1, 324 (18%) ≥ 65 2, 024 (25 %) 29 1 (47%) 1 02 (48%) 1,733 (24 %) BMI (kg·m -2) < 18.5 51 (1%) (1%) (1%) 48 (1%) 18.5 -25 .0...
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Báo cáo khoa học: Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the 1 level of phosphorylation of IRS1 in type 2 diabetes pot
... postoperative insulin resistance Insulin resistance in type diabetes Tyrosine phosphorylation of the insulin receptor increased over the same concentration range of insulin in cells from patients with type ... & James DE (20 00) Signalling through the insulin receptor Curr Opin Cell Biol 12, 22 2 22 8 Saltiel AR & Kahn CR (20 01) Insulin signalling and the regulation of glucose and lipid metabolism Nature ... molecular basis for insulin resistance Elevated serine ⁄ threonine phosphorylation of IRS-1 and IRS -2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability...
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báo cáo hóa học: " A comparison of EQ-5D index scores using the UK, US, and Japan preference weights in a Thai sample with type 2 diabetes" pdf
... 6.53 4.10 300,000 2. 43 123 ,457 1 .23 6.94 4.40 300,000 2. 54 118,110 5.51 6.68 4 .21 300,000 2. 47 121 ,457 2. 83 6. 62 4.17 300,000 2. 45 122 ,150 2. 28 7.05 4.49 300,000 2. 56 117,096 6. 32 Decision tree ... Literature review and proposed guidelines J Clin Epidemiol 1993, 46:1417-14 32 16 17 18 19 20 21 22 23 24 25 26 Kaplan RM, Feeny D, Revicki DA: Methods for assessing relative importance in preference ... patients for providing their valuable data, and nurses and physicians for their assistance in collecting the data References Gold MR, Russell LB, Siegel JE, Weinstein MC: Cost-effectiveness in health...
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báo cáo hóa học: " Fatness and fitness: how do they influence health-related quality of life in type 2 diabetes mellitus?" docx
... recruited between 7/1/99 and 11/30/03 for the study in people without type diabetes and between 5/1/04 and 12/ 28/07 for the study in people with type diabetes Study design and sample This study ... control in type diabetes: a randomized trial Ann Intern Med 20 07, 147(6):357-69 Hamdy O, Goodyear LJ, Horton ES: Diet and exercise in type diabetes mellitus Endocrinol Metab Clin North Am 20 01, ... VO2peak (SD), mL/kg·min Mean total cholesterol level (SD), mg/dL Mean hemoglobin A1c (SD), % 63.8 (5.6) 46 .2 85.7 38 .2 (9 .2) 24 .1 (5.1) 21 5 .2 (37.5) N/A 56.9 (5.9) 63.3 60 .2 36.0 (7.1) 21 .2 (5.1)...
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báo cáo hóa học: " Additional impact of concomitant hypertension and osteoarthritis on quality of life among patients with type 2 diabetes in primary care in Germany – a cross-sectional survey" doc
... (18.84) 46.93* (19. 42) 77.69 (23 . 82) 81.47 (22 . 52) 71.60* (26 .99) 74 .25 (26 .78) 66.83 (43.91) 82. 52 (35.08) 62. 45 (44.46) 68.06 (44. 92) 69 .21 (21 .25 ) 72. 79 (17.88) 65.68 (18.33) 66.35 (20 .83) 43.45 ... 72. 21 (40 .26 ) 41.46* (44.56) 45.50* (45. 12) 66.94 (30 .26 ) 72. 89 (27 .01) 44 .21 *** (21 .54) 44.60*** (23 .99) 55. 82 (20 .17) 57.79 (17.15) 50.46* (17.06) 49.13** (18. 02) 52. 09 (23 .78) 58.33 (21 .05) 47.98 ... Life Outcomes 20 09, 7:19 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 Moritz D, Ostfeld A, Blazer D, Curb D, Taylor J, Wallace R: The health burden of diabetes for the elderly in four communities...
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báo cáo hóa học:" Factors associated with psychological and behavioral functioning in people with type 2 diabetes living in France" pptx
... 0.98 1 .22 0. 42 0.008 - 2. 16 1.10 0.05 0. 02 - 2. 20 1 .28 < 001 0.09 < 001 0.10 Insulin - 9.49 1 .23 < 001 - 8.54 1.94 < 001 - 3.35 1.61 0.04 Insulin & OHAs - 8.79 1. 32 < 001 - 2. 43 1.97 0 .22 - 1.64 ... life in type diabetes Diabetologia 20 06, 49:1489-1497 Boini et al Health and Quality of Life Outcomes 20 10, 8: 124 http://www.hqlo.com/content/8/1/ 124 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 ... 10-19 years 866 (29 .6%) 20 years and more 615 (21 .0%) 2, 565 (83.0%) Diabetes treatment Oral hypoglycemic agents (29 .7%) Insulin 307 (9.9%) Insulin & Oral hypoglycemic agents 21 8 (7.1%) At least...
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báo cáo hóa học:" Health-related quality of life and self-related health in patients with type 2 diabetes: Effects of group-based rehabilitation versus individual counselling" pot
... Microalbuminuria was defined as a urine Albumin:Creatinine Ratio (ACR) ≥ 2. 5 - 25 mg/mmol in men and ≥ 3.5 - 25 mg/mmol in women Macroalbuminuria: ARC > 25 mg/mmol Peripheral neuropathy was defined ... Van der Does FE, De Neeling JN, Snoek FJ, et al: Symptoms and well-being in relation to glycemic control in type II diabetes Diabetes Care 1996, 19 :20 4-10 21 25 26 27 28 29 Testa MA, Simonson DC: ... 0 .2 (-5.3 to 5.6) 0.96 63 (23 ) 69 (20 )¶ 1.5 (-5.6 to 8.6) 0.68 85 (24 ) 89 (17) 89 (18) 2. 4 (-5 .2 to 10.0) 0.53 78 (33) 81 (29 ) 74 (39) 82 (34) 2. 2 (-8.8 to 13 .2) 0.69 77 (19) 80 (18) 79 (18) 82...
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báo cáo hóa học:" Determinants of quality of life in adults with type 1 and type 2 diabetes" pdf
... (40.6) 22 0 (19 .2) 138 (28 .2) 329 (28 .7) 85 (17.3) 377 ( 32. 9) 44 (9.0) 147 ( 12. 8) 20 (4.1) 62 (5.4) (0.8) BMI (kg/m2) Lifestyle factors 12 (1.0) 26 .2 (4.6) 29 .1 (5.7) < 0.0001 Smoking 0.81 Nonsmoking ... the increased prevalence of diabetes in the United States: 1976 -20 04 Prev Med 20 07, 45(5):348-3 52 Kaufman RF: Type diabetes in children and young adults: A New Epidemic.” Clinical Diabetes 20 02, ... pancreatic beta-cell death in type and type diabetes: many differences, few similarities Diabetes 20 05, 54(Suppl 2) :S97-107 Loghmani E: Diabetes mellitus: type and type In Guidelines for Adolescent Nutrition...
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TOPICS IN THE PREVENTION, TREATMENT AND COMPLICATIONS OF TYPE 2 DIABETES pptx
... from 20 03 to 20 52 2003 2. 5 1.5 20 52 0.5 0 10 20 30 40 50 60 age [years] 70 80 90 100 Fig 15 Number of people in Slovenia from 20 03 to 20 52 6000 5000 20 52 number 4000 20 03 3000 20 00 1000 0 10 20 ... July 25 -29 , 20 04 (Oxford, England), Hoppensteadt, F C & Peskin, C S (20 02) Modeling and Simulation in Medicine and the ... juvenile diabetes) , results from the body's failure to produce insulin, and presently requires the person to inject insulin Type diabetes (referred to as non -insulin- dependent diabetes mellitus, and...
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