mitochondria and bcl 2 family proteins regulate self induced cell death in mammals
Báo cáo khoa học: Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics pptx
Ngày tải lên :
16/03/2014, 00:20
... (20 04) Role of Bim in the survival pathway induced by Raf in epithelial cells Oncogene 23 , 24 31 24 41 22 Ewings KE, Wiggins CM & Cook SJ (20 07) Bim and the pro-survival Bcl- 2 proteins: opposites attract, ... BCL- 2 proteins [14] (Fig 1); because BIM promotes cell death by binding to prosurvival BCL- 2 proteins, this alteration in the binding properties of BIMEL serves as a cell- survival mechanism In ... gefitinib alone being more efficacious in H 325 5 cells [54] CML with BCR-ABL Prosurvival BCL- 2 family proteins such as MCL-1, BCL- 2 and BCL- xL are often expressed at high levels in CML cells [ 62, 63,78,79],...
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Báo cáo y học: "Coaggregation of Fc RI with Fc RIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells" ppsx
Ngày tải lên :
08/08/2014, 21:20
... aggregate Fc␥RIIB in cells sensitized with 2. 4G2 rat Ab, and (as a consequence) coaggregate Fc⑀RI and Fc␥RIIB in cells sensitized with both IgE and 2. 4G2 rat Ab Since aggregation using 2. 4G2 rat Ab together ... Mol Cell Biol 20 01 ;21 :854–64 18 Alfredsson J, Puthalakath H, Martin H, et al Proapoptotic Bcl- 2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl- XL ... Immunol 1997;158:1803–9 24 Hemmings BA Akt signaling: linking membrane events to life and death decisions Science 1997 ;27 5: 628 –30 25 Coffer PJ, Jin J, Woodgett JR Protein kinase B (c-Akt): a multifunctional...
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Báo cáo khoa học: " AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis" pdf
Ngày tải lên :
09/08/2014, 10:20
... M: BCL- 2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy J Cell Biochem 1996, 60 :23 - 32 Simonian PL, Grillot DA, Nunez G: Bcl- 2 and Bcl- XL ... phosphorylates and inactivates anti-apoptotic Bcl- 2 family members, including Bcl- 2, Bcl- XL and Mcl-1 [49-51] Finally, other investigators have recently shown that Bcl- 2 antagonists like gossypol, can increase ... is through its interaction with the BH3binding groove in Bcl- XL and to a lesser extent in Bcl- 2, thereby preventing their interaction with pro-apoptotic proteins and allowing mitochondrial permeabilization...
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Báo cáo khoa học: Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression pdf
Ngày tải lên :
16/03/2014, 04:20
... Pattou F (20 02) 1 ,25 -dihydroxyvitamin D3 protects RINm5F and human islet cells against cytokine -induced apoptosis: implication of the antiapoptotic protein A20 Endocrinology 143, 4809–4819 22 Konarkowska ... of porcine intestinal heptacosapeptide and vasoactive intestinal polypeptide on insulin and glucagon secretion in rats Endocrinology 1 12, 1469–1473 FEBS Journal 27 5 (20 08) 55 42 5551 ª 20 08 The ... implied in b cell death with use of the RIN-m5F cell line, a model currently used for the study of pancreatic cell death [21 ] RIN-m5F cells have been identified as continuous cell lines that retain...
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Báo cáo khoa học: The proapoptotic member of the Bcl-2 family Bcl-2 / E1B-19K-interacting protein 3 is a mediator of caspase-independent neuronal death in excitotoxicity pot
Ngày tải lên :
22/03/2014, 17:20
... Greenberg AH (20 00) BNIP3 heterodimerizes with Bcl- 2 ⁄ Bcl- X(L) and induces cell death independent of a Bcl- 2 homology (BH3) domain at both mitochondrial and nonmitochondrial sites J Biol Chem 27 5, 1439–1448 ... permeability, and DNA fragmentation [17] These features of BNIP3 -induced neuronal cell death are indistinguishable from those of BNIP3 -induced non-neural cell death [17] BNIP3-regulated cell death appears ... Bad, a heterodimeric partner for Bcl- XL and Bcl- 2, displaces Bax and promotes cell death Cell 80, 28 5 29 1 Kroemer G & Reed JC (20 00) Mitochondrial control of cell death Nat Med 6, 513–519 Chen G,...
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Báo cáo y học: " Upregulation of Bax and Bcl-2 following prenatal cocaine exposure induces apoptosis in fetal rat brain" doc
Ngày tải lên :
08/08/2014, 17:20
... cocaine on Bax and Bcl- 2 protein levels To determine whether cocaine leads to changes in Bcl- 2 family protein levels in fetal brain, we examined the Bcl- 2 and Bax protein expression As shown in ... protein kinase and mitochondrial/cytochrome c pathways J Pharmacol Exp Ther 20 05, 3 12: 1 12- 119 24 25 26 27 28 29 Xiao Y, He J, Gilbert RD, Zhang L Cocaine induces apoptosis in fetal myocardial cells ... neural cells upon cocaine insult Previous study [40] found that total Bcl- 2 protein is increased in injured brain after traumatic brain injury Neurons are resistant to ischemic injury when Bcl- 2 protein...
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báo cáo khoa học:" Expression of caspase-3, p53 and Bcl-2 in generalized aggressive periodontitis" ppsx
Ngày tải lên :
11/08/2014, 23:22
... fashion using a scale of to 3+: (0) = no staining; (1+) = stained cells comprising >10% of the inflammatory infiltrate (2+ ) = stained cells comprising 30% of the inflammatory infiltrate, and (3+) ... carboxylic acidsdecrease humangingival keratinocyte proliferation and increase apoptosis and necrosis J Clin Periodontol 1999, 25 :311-315 23 24 25 26 27 28 29 30 31 32 33 34 35 Kurita-Ochiai , Fukushima ... from becteria -induced cell death? Trends in Microbiology 1997, 5 :20 1 -20 4 Ekert PG, Silke J, Vaux DL: Caspase inhibitors Cell Death Differ 1999, 6:1081-1086 Reed JC: Bcl- 2 family proteins Oncogen...
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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
Ngày tải lên :
19/06/2014, 22:20
... review and meta-analysis of observational studies Bmj 20 03, 327 : 128 Page 15 of 16 (page number not for citation purposes) Journal of Neuroinflammation 20 06, 3:6 19 20 21 22 23 24 25 26 27 28 29 30 ... Sci 20 03, 991 :27 2 -27 7 Minghetti L: Cyclooxygenase -2 (COX -2) in inflammatory and degenerative brain diseases J Neuropathol Exp Neurol 20 04, 63:901-910 Minghetti L, Levi G: Microglia as effector cells ... oxidereleasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice J Neurosci 20 02, 22 :22 46 -22 54 West MJ: New stereological methods for counting neurons...
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Báo cáo y học: "Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment" pptx
Ngày tải lên :
13/08/2014, 11:22
... 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 Vol 12 No Li et al 23 9063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung Am J Physiol Lung Cell ... occurs early in ventilator -induced lung injury, and neutrophil infiltration occurs later [20 ] aSerine/threonine kinase/protein kinase B, extracellular signal-regulated kinase 1 /2, S100A4positive ... phospho-serine/threonine kinase-protein kinase B staining of lung sections via immunohistochemistry after days in bleomycin-treated wild-type (WT) mice or serine/threonine kinase-protein kinase B...
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Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
Ngày tải lên :
23/03/2014, 17:20
... Debatin, 20 06) The mitochondrion plays a crucial role in sensoring and regulating intrinsic signaling pathway, in particular, by providing a platform for normal functioning of the Bcl- 2 family proteins ... pro-apoptotic members of Bcl- 2 family and adaptors that link death signal sensors and caspases Finally, introduction of apoptotic executioners, in 30 Targeting New Pathways and Cell Death in Breast Cancer ... higher in these cells than in the parental MCF-7 cells Estradiol induced apoptosis occurs in a LTED breast cancer cell line named MCF-7:5C by neutralization of the Bcl- 2 /Bcl- XL proteins, and upregulation...
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Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc
Ngày tải lên :
29/03/2014, 08:20
... Chem 27 7, 127 10– 127 17 14 Lee ER, Kang YJ, Kim JH, Lee HT & Cho SG (20 05) Modulation of apoptosis in HaCaT keratinocytes via 16 17 18 19 20 21 22 23 24 25 FEBS Journal 27 7 (20 10) 2 21 ª 20 09 The ... activation involved in radiation -induced cell death in NIH3T3 cells Biochim Biophys Acta 1593, 21 9– 22 9 Wang X, Martindale JL & Holbrook NJ (20 00) Requirement for ERK activation in cisplatin -induced ... caspases and nucleases leading to the death of the injured cells without affecting neighboring cells The intrinsic pathway of apoptosis regulates the activity of the Bcl- 2 family proteins that...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
Ngày tải lên :
29/03/2014, 09:20
... tumors and tumoral cell lines Mol Carcinog 16, 165–1 72 Heddi A, Faure-Vigny H, Wallace DC & Stepien G (1996) Coordinate expression of nuclear and mitochon- 28 66 14 15 16 17 18 19 20 21 22 23 24 25 ... measured ADF cell viability 24 h after treatment with H2O2 (10, 25 , 50, 75, 100, 125 , 150, 175 and 20 0 lm) ANT1-silencing results in a sustained sensitization to H2O2 treatment (IC50 = 56 ± 12) with ... thus allowing us to exclude a autophagic-like cell death FEBS Journal 27 7 (20 10) 28 53 28 67 ª 20 10 The Authors Journal compilation ª 20 10 FEBS 28 55 ANT1-silencing induces glioblastoma cell death A...
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Báo cáo sinh học: "Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
Ngày tải lên :
18/06/2014, 19:20
... VX-680 treated cells VX-680 suppresses cell growth and induces cell apoptosis in NB4-R2 cells Next, we studied if VX-680 could suppress proliferation in NB4-R2 cells in vitro NB4-R2 cells were treated ... 20 10 0 10 VX-680(nM) Figure VX-680 suppresses the proliferation of NB4-R2 cells and induces cell apoptosis NB4-R2 cells were incubated with increasing doses of VX-680 (1, 2, and 10 nM) for 24 ... site Thr288, therefore suppressing phosphorylation of mitotic Histone H3 at Ser10, arresting cell cycle in G2/M phase and blocking proliferation in multiple tumor cell types [22 -24 ,34] In addition,...
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báo cáo hóa học:" Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
Ngày tải lên :
20/06/2014, 03:20
... VX-680 treated cells VX-680 suppresses cell growth and induces cell apoptosis in NB4-R2 cells Next, we studied if VX-680 could suppress proliferation in NB4-R2 cells in vitro NB4-R2 cells were treated ... 20 10 0 10 VX-680(nM) Figure VX-680 suppresses the proliferation of NB4-R2 cells and induces cell apoptosis NB4-R2 cells were incubated with increasing doses of VX-680 (1, 2, and 10 nM) for 24 ... site Thr288, therefore suppressing phosphorylation of mitotic Histone H3 at Ser10, arresting cell cycle in G2/M phase and blocking proliferation in multiple tumor cell types [22 -24 ,34] In addition,...
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TARGETING NEW PATHWAYS AND CELL DEATH IN BREAST CANCER pot
Ngày tải lên :
27/06/2014, 11:20
... Debatin, 20 06) The mitochondrion plays a crucial role in sensoring and regulating intrinsic signaling pathway, in particular, by providing a platform for normal functioning of the Bcl- 2 family proteins ... pro-apoptotic members of Bcl- 2 family and adaptors that link death signal sensors and caspases Finally, introduction of apoptotic executioners, in 30 Targeting New Pathways and Cell Death in Breast Cancer ... higher in these cells than in the parental MCF-7 cells Estradiol induced apoptosis occurs in a LTED breast cancer cell line named MCF-7:5C by neutralization of the Bcl- 2 /Bcl- XL proteins, and upregulation...
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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
Ngày tải lên :
09/08/2014, 09:20
... of Bcl- 2 were intermediate (LNCaP-cells) or low (PC3-cells) (Figure 3C and 3D) Treatment with ErPC3 did not affect the protein levels of Bcl- xL and Bcl- 2 in LNCaP and PC3 cells, whereas ionizing ... LNCaP and PC3 cells expressed the anti-apoptotic Bcl- 2 proteins Bcl- xL, Mcl-1, and Bcl- 2, although at different levels: Both cell lines expressed a high amount of Bcl- xL, and an intermediate amount ... in the levels of Bcl- 2 in both cell lines Moreover, ErPC3treatment decreased the levels of Mcl-1 in LNCaP cells Thus, in LNCaP cells the down-regulation of the two anti-apoptotic Bcl- 2 proteins...
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báo cáo khoa học: "Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells" pptx
Ngày tải lên :
11/08/2014, 00:22
... 20 06, 28 1 (2) :1196- 120 4 Beyaert R, Van Loo G, Heyninck K, Vandenabeele P: Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas Int Rev Cytol 20 02, 21 4 :22 5 -27 2 ... vitro [ 12] , and induce death in various cell types [14,15] Oxidative stress -induced cell death, both apoptosis and necrosis, can involve a number of cellular mechanisms, one of which includes ... expression in neuroblastomas Fas expression was assessed by FACS in untreated cells (grey line) and in cells exposed to cysteamine-QDs for 24 hours (black line) Dotted line shows background staining...
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Báo cáo y học: "Cell death in sepsis: a matter of how, when, and where" potx
Ngày tải lên :
13/08/2014, 18:22
... Mol Cell Biol 20 01, 2: 589598 Hotchkiss RS, Nicholson DW: Apoptosis and caspases regulate death and inflammation in sepsis Nat Rev Immunol 20 06, 6:813- 822 Hotchkiss RS, Swanson PE, Freeman BD, Tinsley ... polymerase-1-deficient mice Shock 20 02, 17 :28 629 2 Vandenabeele P, Declercq W, Berghe TV: Necrotic cell death and ‘necrostatins’: now we can control cellular explosion Trends Biochem Sci 20 08, 33:3 52- 355 Page of ... factorinduced shock via oxidative stress and phospholipase A2 Nat Immunol 20 03, 4:387-393 Scott AM, Saleh M: The inflammatory caspases: guardians against infections and sepsis Cell Death Differ 20 07,...
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Báo cáo khoa học: " Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death" docx
Ngày tải lên :
09/08/2014, 10:20
... 17 18 19 20 21 22 23 24 25 26 27 28 He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X: Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha Cell 20 09, 137:1100-1111 ... constructs cloned in the vector pRc/ CMV (Invitrogen) encoding wildtype Bcl- 2 (Bcl- 2 WT), cytosolic Bcl- 2 lacking the transmembrane domain (Bcl- 2 ΔTM) and Bcl- 2 mutants restricted to the outer mitochondrial ... specifically at the ER by binding to the autophagy-inducing protein Beclin-1 [15] Even though the role of Bcl- 2 has been most intensively studied in mitochondria and the ER, Bcl- 2 also localizes to...
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Báo cáo y học: "A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history" pptx
Ngày tải lên :
12/08/2014, 04:20
... programmed cell death interacting protein (PDCD6IP/ALIX), which has been involved in apoptosis regulation, cytokinesis and HIV-1 budding VACV C6 also interacted with keratin (KRT4) and troponin I, ... Reed JC, Liddington RC: Vaccinia virus N1L protein resembles a B cell lymphoma -2 (Bcl- 2) family protein Protein Sci 20 07, 16:118- 124 13 Chen RA, Jacobs N, Smith GL: Vaccinia virus strain Western ... its N-terminus, alpha-helix and a nonhelical segment equivalent to alpha-helix in Bcl- 2- like proteins Interestingly, this region corresponds to the Page of 12 dimerization interface in A 52, which...
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