minor histocompatibility antigen typing by dna sequencing for clinical practice in hematopoietic stem cell transplantation
Báo cáo y học: "Hematopoietic stem cell transplantation for systemic lupus erythematosus" ppsx
... marrow stem cell transplantation for severe systemic lupus erythematosus of long duration Lupus 1997, 6:545-548 Burt RK, Traynor A, Ramsey-Goldman R: Hematopoietic stemcell transplantation for systemic ... transplantation for active systemic lupus erythematosus Rheumatology 1999, 38:767-772 Burt RK, Slavin S, Burns WH, Marmont A: Induction of tolerance in autoimmune disease by hematopoietic stem cell transplantation: ... hematopoietic stem cells are infused in order to shorten the past transplant neutropenic interval by 4–6 days compared with the same dose of cyclophosphamide without hematopoietic stem cell support,...
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Báo cáo y học: "Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert’s syndrome" pptx
... the conditioning and within 100 days after transplantation, although indirect hyperbilirubinemia repeatedly happened during chemotherapy with daunorubicin, idarubicin, and cytarabine prior to ... days to +28) for GVHD prophylaxis; Caspofungin for prophylaxis of fungal infections] Tropisetron was used during the chemotherapy and conditioning (E) period of acute GVHD [alanine aminotransferase ... http://www.jhoonline.org/content/4/1/9 Page of Figure Bilirubin level during chemotherapy and allogeneic hematopoietic stem cell transplantation Chronological dates of the treatment courses were indicated...
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Báo cáo y học: "Anaplasma phagocytophilum in Danish sheep: confirmation by DNA sequencing" pot
... were initial denaturation at 94°C for followed by 30 cycles of 94°C denaturation for 30 s, 55°C annealing for 40 s and 72°C extension for 45 s with a final 72°C extension for followed by cooling ... the cell pellet was resuspended in 400 μl PBS-BSA A white blood cell preparation was now made on a slide by cytospin preparation at 75 × g for (Shandon Cytospin centrifuge) After drying, the cell ... described in lambs Due to the mainly subclinical and self limiting course [1] the infection may be widespread in animals grazing I ricinus habitats without notice [7] Preliminary results have shown...
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Báo cáo y học: "HIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays" pptx
... protocol Tropism testing on clinical samples using deep sequencing A total of 14 clinical samples from 12 different HAART failing individuals were available Despite the clinical need for alternative ... obtained for all, except for three X4-PSSM predicted minority haplotypes in sample 14 that were predicted to be R5-tropic in G2P, accounting in total for 4% of the population Tropism testing on clinical ... procedures for tropism determination (Vandekerckhove L et al., in preparation), a set of clinical specimens from twelve HIV-1 infected individuals failing HAART therapy and also failing in the Trofile...
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Regulation of spindle behaviour by DNA replication and damage checkpoints in budding yeast
... mediated degradation = Poleward force exerted by plus end motor proteins Cin8, Kip1 etc = Extension resisting force by cohesin = Esp1 Separase = Cohesin ring = Cohesin ring broken due to Esp1 mediated ... fork due to low dNTP levels exposes single stranded DNA (ssDNA) which must first be bound by a single stranded DNA binding protein RPA (Rfa1 in budding yeast) before the Mec1-Ddc2 complex can be ... proteins is thought to increase their affinity for the effector kinase Rad53, which has two Forkhead Associated (FHA) Domains, known for 25 Chapter Introduction their preference for binding phosphorylated...
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Tài liệu New Advances in Stem Cell Transplantation Edited by Taner Demirer ppt
... factors into somatic cells By using these viral delivery systems, 12 New Advances in Stem Cell Transplantation Fig Methods for producing induced pluripotent stem cells (iPSCs) by non-integrating ... factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells Stem Cells 27, 30013011 22 New Advances in Stem Cell Transplantation Rai, K., Huggins, I.J., James, ... cells in the host In conclusion, Cell Transplantation is bridging cell transplantation research in a multitude of disease models as methods and technology continue to be refined The use of stem cells...
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Approach to Internal Medicine A Resource Book for Clinical Practice Third Edition ppt
... edition, fifth printing, November 2008 Second edition, sixth printing, June 2009 Third edition, first printing, January 2011 Approach to Internal Medicine: A Resource Book for Clinical Practice Additional ... high yield clinical information and can be particularly useful when one is all alone assessing a patient at o’clock in the morning Other sections contain many clinical pearls that are intended ... appro priate clinical resources prior to applying information in this manual for direct patient care This is ix x Preface particularly important since patterns of practice and clinical evidence...
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Principles for Best Practice in Clinical Audit pot
... Chairman National Institute for Clinical Excellence Clinical audit in the NHS: a statement from the National Institute for Clinical Excellence The clinical audit challenge facing the NHS The NHS ... best practice in clinical audit throughout the NHS David Pink, Audit Programme Director National Institute for Clinical Excellence January 2002 Stage One: preparing for audit Key points Clinical ... Criteria for Clinical Audit, published by the National Centre for Clinical Audit (Dixon, 1996) Key points From the review of the literature, we identified a set of key points for best practice in clinical...
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Báo cáo sinh học: "Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib" potx
... both for refining clinical research and for clinical decision-making Page of 14 A phase II study of sunitinib 50 mg/day on Schedule 4/2 (4 weeks on treatment, followed by weeks off treatment) in ... between clinical outcome and both elevated VEGF-C levels at baseline and greater reductions in VEGF-C In contrast, sunitinib-induced increases in VEGF-A were reduced in patients with high baseline ... performed on baseline soluble protein levels as discriminators in predicting disease control (PR or SD > 12 weeks) versus PD, as assessed by RECIST (Figure 3) The soluble protein cut-point for...
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báo cáo hóa học:" Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib" pot
... both for refining clinical research and for clinical decision-making Page of 14 A phase II study of sunitinib 50 mg/day on Schedule 4/2 (4 weeks on treatment, followed by weeks off treatment) in ... between clinical outcome and both elevated VEGF-C levels at baseline and greater reductions in VEGF-C In contrast, sunitinib-induced increases in VEGF-A were reduced in patients with high baseline ... performed on baseline soluble protein levels as discriminators in predicting disease control (PR or SD > 12 weeks) versus PD, as assessed by RECIST (Figure 3) The soluble protein cut-point for...
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Báo cáo y học: "Stem cell transplantation for rheumatic autoimmune diseases" potx
... histocompability antigens DCs, specialised in presenting antigens to donor effector cells, are mainly involved in this setting and probably also in autoantigen (cross)presentation in AD In most tissues, ... Figure Resetting of the immunological clock following hematopoietic stem cell transplantation Hematopoietic stem cell transplantation (HSCT) is a complex multistep procedure involving mobilisation ... autoantigen-presenting cells are postulated to be attacked and eliminated by the allograft [62] Donor precursor T or NK cells are attracted by host antigen- presenting cells, presenting so-called host minor...
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Báo cáo y học: "Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cell" ppsx
... Immunohistochemistry staining for human mesenchymal stem cells in whole brain sections of mice Whole brain sections of each mice (4 μm) were proceeded immunohistochemistry staining of b2 microglobulin for hMSCs ... showed that in utero transplantation of hMSCs in mice contributed to numerous tissues, including the brain and spinal cord [24] Donor hMSCs engrafted into murine tissues originating from all ... similar findings Many recent clinical studies which adopt systemically administered MSCs also implicate paracrine signaling as the primary mechanism of action [32] Although clinical trials of MSC transplantation...
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báo cáo khoa học: " Comparison of KRAS and EGFR gene status between primary non-small cell lung cancer and local lymph node metastases: implications for clinical practice" pdf
... is stable during the metastatic progress and to investigate the clinical usefulness of mutational analyses in primary tumor versus in metastases for planning EGFR-targeted therapies for the treatment ... NSCLC were included Patients who had been exposed to TKI before surgical treatment were excluded from this study In each case, hematoxylin and eosin-stained sections of formalin-fixed paraffinembedded ... received gefitinib as first-line treatment after being identified to harbor EGFR-TKI sensitive mutations in mediastinal lymph nodes metastases obtained by mediastinoscope One tablet of gefitinib (250...
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báo cáo khoa học: "Current status of haploidentical stem cell transplantation for leukemia" pps
... haploidentical T -cell- replete hematopoietic stem cell transplantation Hematologica 2007, 92:414-417 Bignon JD, Gagne K: KIR matching in Hematopoietic stem cell transplantation Curr Opin Immunol 2005, ... to increase stem cell numbers in graft With the pioneering work of Reisner[15], Aversa and his group produced a series of clinical trials, administered "megadose" of donor hematopoietic stem cells ... techniques for positive selection of CD34 cells by using the CliniMACS system has provided enriched CD34+ stem cells with a powerful and reproducible TCD (median 4.5 logs) in grafts The median cell...
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Báo cáo khoa học: " Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin''''s disease: a case report" doc
... Bilateral interstitial infiltrates clinical studies have to be performed to examine the frequency of clinically relevant HHV-6 infections in these patient cohorts Consent statement Written informed ... Human herpesvirus DNA in plasma after allogeneic stem cell transplantation: incidence and clinical significance J Infect Dis 2006, 193:68-79 Volin L, Lautenschlager I, Juvonen E, Nihtinen A, Anttila ... after hematopoietic stem cell transplantation Clin Infect Dis 2005, 40:932-940 Bissinger AL, Einsele H, Hamprecht K, Schumacher U, Kandolf R, Loeffler J, Aepinus C, Bock T, Jahn G, Hebart H: Infectious...
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Báo cáo khoa học: " Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin''''s disease: a case report" ppsx
... Bilateral interstitial infiltrates clinical studies have to be performed to examine the frequency of clinically relevant HHV-6 infections in these patient cohorts Consent statement Written informed ... Human herpesvirus DNA in plasma after allogeneic stem cell transplantation: incidence and clinical significance J Infect Dis 2006, 193:68-79 Volin L, Lautenschlager I, Juvonen E, Nihtinen A, Anttila ... after hematopoietic stem cell transplantation Clin Infect Dis 2005, 40:932-940 Bissinger AL, Einsele H, Hamprecht K, Schumacher U, Kandolf R, Loeffler J, Aepinus C, Bock T, Jahn G, Hebart H: Infectious...
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Cardiovascular Imaging A handbook for clinical practice - Part 1 pptx
... Imaging A handbook for clinical practice BCIPR 6/17/05 9:53 PM Page ii BCIPR 6/17/05 9:53 PM Page iii THE ESC EDUCATION SERIES Cardiovascular Imaging A handbook for clinical practice EDITED BY ... Congress Cataloging -in- Publication Data Cardiovascular imaging : a handbook for clinical practice / edited by Jeroen J Bax [et al.] p ; cm — (ESC educational series) Includes index ISBN-13: ... book is focused on the use of non-invasive imaging in clinical cardiology Currently, the main non-invasive imaging modalities include echocardiography, nuclear imaging, cardiac magnetic resonance...
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Cardiovascular Imaging A handbook for clinical practice - Part 2 pps
... department for further evaluation Diagnosis and grading of severity In general, aortic regurgitation (AR) is detected by physical examination or incidentally by echocardiography Clinical presentation includes ... as a basis of clinical decision-making Alternative imaging tools Although grading is possible by Doppler echocardiography in the vast majority of patients, uncertainty may remain in some, particularly ... volume overload Initially, end-systolic diameter remains unaffected, thus leading to an increased shortening fraction, reflecting a hyperkinetic, volume-loaded ventricle Increase in the end-systolic...
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Cardiovascular Imaging A handbook for clinical practice - Part 3 pptx
... provide information on branch vessel involvement Although it does not provide information regarding aortic insufficiency, this can be obtained with TTE or TEE while the operating room is being prepared ... additional useful information in treatment planning Conclusions In the IRAD study, the first diagnostic test used was TTE and TEE in 33%, CT in 61%, MRI in 2%, and angiography in 4%, reflecting the current ... extends for a variable distance beyond the ascending aorta, while in type II the dissecting hematoma is confined to the ascending aorta In type III, the dissection originates in the descending aorta,...
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