minimal residual disease in acute lymphoblastic leukemia
Báo cáo khoa học: "Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy" ppt
... cell lines (such as human skin fibroblasts, glioblastoma and colon carcinoma lines) and primary lymphocytes [13-15] Furthermore, CD was induced by IR in human hepatoblastoma cell line performing ... irradiation; IR, ionizing radiation; HVR2, hypervariable region 2; nDNA, nuclear DNA; ALL, acute lymphoblastic leukemia; MGB, minor groove binder; ROS, reactive oxygen species; Competing interest: The ... with minor groove binder (MGB) groups, which is more sensitive and appropriate than nonspecific dsDNA-binding dye PCR methods previously used [16] Besides, we taken the acute lymphoblastic leukemia...
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báo cáo khoa học: "Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study" doc
... of minimal residual disease in T-cell acute lymphoblastic leukemia using polymerase chain reaction Blood 1991, 78:739-747 Yamada M, Wasserman R, Lange B, Reichard BA, Womer RB, Rovera G: Minimal ... Masera G, Bartram CR: Minimal residual disease in childhood acute lymphoblastic leukemia: analysis of patients in continuous complete remission or with consecutive relapse Leukemia 1992, 6:282-288 ... clinical significance of TEL-AML1 as MRD in CD 10 positive ALL is needed to determine how to best integrate TEL-AML1 testing into routine patient care Abbreviations ALL: Acute lymphoblastic leukemia; ...
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báo cáo hóa học: " Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" potx
... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the ... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is...
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báo cáo hóa học: " Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia: an exploratory study" pdf
... Health-related quality of life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy Int J Oncol 1997, 11(2):333-339 ... frequently been used in pediatric oncology studies [22,32-34] and includes subscales with age-specific questions for determining problems in relevant areas during cancer treatment such as pain, nausea, ... confirm these findings and provide more detailed information on the relationship between sleep and QoL, and on factors affecting sleep in pediatric ALL and in children with cancer in general Abbreviations...
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báo cáo hóa học:" Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" docx
... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the ... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is...
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báo cáo khoa học: " Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia" docx
... insulin and leptin receptors are located in key brain areas, such as the hypothalamic arcuate nucleus In some cells of hypothalamus, leptin and insulin activate both JAK-STAT and PI3K signaling ... may be the reason of leptin resistance The closed-loop leptin/insulin feedback makes the GH/insulin/leptin relations understandable [30,31] According to Link et al leptin might serve as a good ... their relationship to serum growth hormone-binding protein and leptin levels in children with acute lymphoblastic leukemia: a prospective study Eur J Endocrinol 2000, 143:243-250 26 Karaman S, Ecran...
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báo cáo khoa học: "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines" ppsx
... expressed in myeloid leukemias [7,8] Conclusion We demonstrated the presence of the SET-NUP214 gene in the T-ALL cell line LOUCY and in the AML cell line MEGAL by genomic sequencing In both cell lines, ... SET-NUP214 screening in cell lines SET-NUP214 screening in cell lines SET-NUP214 expression screening performed with a SET exon forward primer and a NUP214 exon 18 reverse primer Cell lines LOUCY and ... recurrent deletion, del(9)(q34.11q34.13) in patients with T-cell acute lymphoblastic leukemia (T-ALL) [4] It has also been reported in a single case of acute myeloid leukemia (AML) [5] SETNUP214 positive...
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báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc
... showed that the inhibition of BCL11B expression by siRNA selectively inhibited proliferation and effectively induced apoptosis in human T-cell acute lymphoblastic leukemia (T-ALL) cell lines (Jurkat, ... other four genes of interest in the healthy controls Discussion Increasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11B mRNA expression in most T-ALL cases ... of caspases BCL2L1 may inactivate caspase-8 by decreasing death-inducing signaling complex (DISC) formation in the plasma membrane, nucleus, and Golgi complex while diverting DISC formation to...
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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report." doc
... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in longterm safety monitoring of the drug [11] Hartmut Geiger et al ... Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S: Treatment-related myelodysplasia and acute leukemia in non-Hodgkin’s lymphoma patients J Clin Oncol 2003, 21:897-906 Macdonald...
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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report" potx
... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in longterm safety monitoring of the drug [11] Hartmut Geiger et al ... Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S: Treatment-related myelodysplasia and acute leukemia in non-Hodgkin’s lymphoma patients J Clin Oncol 2003, 21:897-906 Macdonald...
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Báo cáo y học: " Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia" ppt
... refined by adding monitoring of the early response to induction chemotherapy (i.e monitoring of minimal residual disease) However, due to the high frequency of toxicity, general treatment intensification ... we face in individualized medicine, and how they can be addressed Childhood acute lymphoblastic leukemia In the industrialized countries cancer is the most common medical cause of death in children ... medicine and childhood acute lymphoblastic leukemia for implementing individualized medicine the following issues need to be addressed: The patients exhibit variable treatment responses in terms...
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Relapse prediction in childhood acute lymphoblastic leukemia by time series gene expression profiling
... typically involving grouping genes with correlated expressions into bins and then selecting representatives from each bin, have also been used One of the more interesting recent developments in gene ... effects of the training data, and result in prediction failures In contrast, unsupervised learning targets on classifying cases in a dataset into several subgroups by evaluating the major variance ... of childhood ALL, including minimal residual disease (MRD), which is considered as the most powerful relapse predictor among all biological and clinical features tested to date In our study, GSS...
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CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC docx
... hypotheses concerning an infectious origin of childhood leukemia ‘Population mixing’ hypothesis by Kinlen In early 1980, an unusual increase in the incidence of childhood leukemia was observed in young ... Identifying the Etiology of Acute Lymphoblastic Leukemia in Children http://dx.doi.org/10.5772/52716 [37] Infante-Rivard C, Krajinovic M, Labuda D, Sinnett D Childhood acute lymphoblastic leukemia ... of the population mixing studies had failed to find an increase in a symptomatic infection in adults or children, paralleling the increase in leuke‐ mia incidence Considering that there are viruses...
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báo cáo hóa học:" Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells" potx
... able to induce apoptosis in leukemia cells via caspase activation and involvement of both intrinsic and extrinsic pathways of apoptosis Background The Endocrine Disrupting Compounds are defined ... FLIP: FLICE Inhibitor Protein; TRAIL: TNF Related Apoptosis Inducing Ligand; RA: Retinoic Acid; RB: Retinoblastoma Competing interests The authors declare that they have no competing interests ... sub-G1 peack in all the cell lines tested, HL60 being the most resistant one In NB4 cells, a model from promyelocytic leukemia containing the fusion protein PMLRARα and sensitive to retinoids, the...
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Báo cáo y học: "Current findings for recurring mutations in acute myeloid leukemia" pdf
... that encode poorly characterized proteins involved in the regulation of chromatin remodeling The ASXL proteins contain a C-terminal plant homeodomain (PHD) finger and belong to the polycomb and ... on OS and EFS in patients with t(8;21) but not in patients with a normal karyotype [66,68,69] 1.7% in AML 22-45% in t(8; 21) 2948% in inv(16) CBL n d [72,73] 1.1% in AML/MDS 16% in inv(16)AML associations ... family of guanine nucleotidebinding proteins that regulate signal transduction upon binding to a variety of membrane receptors, including KIT and FLT3, and play important roles in proliferation,...
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báo cáo khoa học: "CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation" potx
... protein/protein interaction CD7 exon also contains an E2F binding site according to TFSEARCH results To test whether C/EBPα acts as direct or indirect transcriptional repressor for CD7 - by protein/DNA ... resulting in four (instead of three) histidine-proline repeats in the transactivation domain of the protein However, this mutation is considered insignificant for leukemogenesis as it was detected in ... mutations of CEBPA, encoding CCAAT/enhancing binding protein-α (C/EBPα), in acute myeloid leukemia Nature Genet 2001, 27:263-270 Wouters BJ, Jordà MA, Keeshan K, Louwers I, Erpelinck-Verschueren CAJ,...
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báo cáo khoa học: "Ring chromosome 18 abnormality in acute myelogenous leukemia: the clinical dilemma" ppt
... Double minute chromosomes in a patient with myelodysplastic syndrome transforming into acute myeloid leukemia Cancer Genet Cytogenet 1999, 109(1):76-8 11 Sawyer JR, et al: Cytogenetic findings in ... Sinai School of Medicine, New York, NY, USA Page of 14 Mrozek K, et al: Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including ... than gain in acute myeloid leukemia with complex aberrant karyotype: a detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color...
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Báo cáo y học: " Precursor B-cell acute lymphoblastic leukemia presenting as obstructive jaundice: a case report" pdf
... rare presentation of acute lymphoblastic leukaemia in an adult JOP 2010, 11:72-74 Takamatsu T: Preferential infiltration of liver sinusoids in acute lymphoblastic leukemia Rinsho Ketsueki 2001, ... report any recent change in his medications and was tolerating his aspirin, sitagliptin, fosinopril, metformin and repaglinide without reported side effects His physical examination was significant ... biopsy of the liver showing small to medium-sized lymphoblasts infiltrating the hepatic parenchyma Page of Figure Bone marrow biopsy showing lymphoblastic infiltration instructions to follow up...
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Targeting PI3KAKTmTOR signaling in Acute Myeloid Leukemia
... protein kinase 1; Akt: Protein kinase PKB/Akt Akt, a serine/threonine protein kinase also known as protein kinase B (PKB), is recruited to the inner surface of plasma membrane through the interaction ... including agents that target individual protein kinases and drugs that target multiple kinases in the pathway (44, 45) TABLE 1: Therapeutic targets in the PI3K/Akt/mTOR signaling pathways Following ... pathway including rapamycin, CCI-779, RAD001 and AP23573 Rapamycin has shown activity against many types of cancer in phase I and II clinical trials (30) Moreover, combination treatment of rapamycin...
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Diagnosis and management of acute rheumatic fever and rheumatic heart disease in Australia pptx
... developing in children receiving salicylates, who develop certain viral infections, particularly in uenza It is recommended that children receiving aspirin during the in uenza season (autumn/winter) ... management of acute rheumatic fever and rheumatic heart disease in Australia Reducing the pain of BPG injections The pain of BPG injections is usually not a critical factor in determining adherence ... symptoms improve Consider ceasing in the presence of acute viral illness, and consider in uenza vaccine if administered during autumn/winter Naproxen po Arthritis (if aspirin intolerant) 10–20mg/kg/day...
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