... FTI -27 7 (Figures 3A and 3B) These findings indicate a predominant involvement of GGT1, but not FT, in the TGFb1-induced profibrotic response of human airway fibroblasts In line with these findings, ... anti-inflammatory effects of statins in murine and rat models of allergic asthma [ 32 ,33 ] and COPD [11, 12] Moreover, statins reportedly suppress ex vivo airway responsiveness in animal models [34 ,35 ] ... et al: Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer J Clin Oncol 20 00, 18: 927 -941 22 Standards for the diagnosis and care of patients with...
... (CCN3) regulation in the growth plate and CCN FEBS Journal 27 4 (20 07) 1655–1665 ª 20 07 The Authors Journal compilation ª 20 07 FEBS T Yanagita et al 19 20 21 22 23 24 25 family member expressionin ... proliferation and differentiation, but CCN4 splicing variants in chondrocytes 26 27 28 29 30 31 32 33 34 not hypertrophy of cultured articular chondrocytes J Cell Physiol 1 92, 55– 63 Rachfal AW ... CCN2 ⁄ CTGF, thus result in increased proteoglycan synthesis [22 , 23 ] Moreover, rCCN2 ⁄ CTGF effectively increased both the ALPase activity and the matrix calcification of RGC cells [24 ,25 ] In...
... of transforming growth Page of (page number not for citation purposes) Respiratory Research 20 09, 10 :36 20 21 22 23 24 25 http://respiratory-research.com/content/10/1 /36 factor-beta (1) and interferon ... Foundation of China (30 500 23 2 ); the Specialized Research Fund for the Doctoral Program of Higher Education (20 060159006); and the Liaoning Provincial Natural Science Foundation (20 0 721 02) 18 19 ... USA) at 37 °C, in 5% CO2 To detect quantities of TGF-β1 in BALF, CCL-64 cells were plated at × 1 03 cells/well in 96-well plates and cultured in FBS-free DMEM at 37 °C in 5% CO2 for h Ten μl of untreated...
... F2-R2, F3-R2 and F4-R2 (Fig 3) , containing the first exon of the ZC3H12A gene, first intron and first three codons of the ZC3H12A coding sequence, were prepared with F2, F3, F4 and R2 primers and ... Community’s FP6: MTKD-CT -20 06-0 425 86 and LSHM-CT -20 06 036 9 03and Polish Ministry of Scientific Research and Information Technology: 63 ⁄ 6PR-UE ⁄ 20 07 ⁄ and 33 9 ⁄ 6PR-UE ⁄ 20 07 ⁄ 5904 References ... constructs (F2-R4, F2-R6, F2-R7 and F2-R8, Fig 3) were prepared in a two-step manner First, the F2-R2 promoter region was cloned into the pGL4.17[luc2 ⁄ Neo] vector using F2 and R2 primers and XhoI...
... 19 20 21 22 23 24 25 26 27 28 29 30 31 32 Griffin WS, Yeralan O, Sheng JG, Boop FA, Mrak RE, Rovnaghi CR, Burnett BA, Feoktistova A, Van Eldik LJ: Overexpression of the neurotrophic cytokine ... role of cytokines in the pathophysiology of epilepsy Brain Behav Immun 20 08, 22 :797-8 03 Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, 3rd, Araoz C: Brain interleukin and ... aging, the brain shows increased microglial activation andexpressionof IL-1 [21 ], as well as neuronal expressionof both ApoE and βAPP [35 ] The ability of IL-1β to induce βAPP expression [30 ,...
... 1999, 1 32 4 : 32 80 - 32 93 Cheshire JL, Williams BRG, Baldwin AS Jr: Involvement of 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 double-stranded RNA-activated protein kinase in the synergistic ... resulted in a small, but not significant, increase in levels of proMMP -2 and active MMP -2 in the media C2-ceramide-induced regulation of MMP -2 is abrogated by inhibition of PKR R48 To determine a ... increases levels of MT1-MMP (data not shown) The increased expressionand activation of MMP -2 and -9, induced by C2-ceramide treatment of chondrocytes, is a novel finding and the significant inhibitory...
... time-dependent gene expression patterns and involves Page 12 of 13 (page number not for citation purposes) 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 intracellular calcium and cyclic ... II in constructs cultured under free-swelling conditions in the presence and absence of the p38 MAPK inhibitor SB2 035 80 In the absence of the cytokine, the expression levels of iNOS and COX -2 ... increase in the expression levels of both iNOS and COX2 (Figure 2) COX -2 expression appeared to be more sensitive to the cytokine and to the presence of SB2 035 80 (Figure 2b), suggesting that COX -2 activation...
... day in splenocytes of mice with GPI-induced arthritis (Figure 2c, left panel) In the joints of the same mice, upregulation of TIARP mRNA and protein was noted at days 14 and 28 , and the expression ... expressed mainly in CD11b+ cells in the spleen, and TIARP mRNA level was increased in the joints (accompanied by joint swelling), especially in hyperplastic synovium Overexpression of the human ... arthritis Serial changes in TNFα concentrations in (a) serum and (b) arthritic joints and (c) TIARP mRNA and protein expressionin spleens (left and middle panels) and arthritic joints (right panel)...
... washed in PBS, incubated in biotinylated secondary antibody for 60 min, washed again in PBS, and then incubated in an avidin-rich solution for 60 After a final wash, positive biotin-avidin binding ... Patterson C: Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins J Clin Invest 20 07, 117 : 32 11 - 32 23 Sharma S, Ying J, Razeghi P, ... implicated in skeletal muscle catabolic conditions andin the development of cardiac fibrosis [29 ,30 ] Interstitial and myocardial fibrosis has been reported in HIV-infected patients [31 , 32 ], and while...
... categories in plants Trends Plant Sci 20 05, 10:117- 122 22 23 24 25 26 27 Giuliani C, Consonni G, Gavazzi G, Colombo M, Dolfini S: Programmed cell death during embryogenesis in maize Ann Bot 20 02, 90 :28 7 -29 2 ... member of the Band 7-domain-containing proteins (Figure 1) Many of these proteins are lipid raft -associated and may cluster to form membrane micro-domains, andin turn recruit multi-protein complexes ... pollination-induced petal senescence in petunia Plant Physiol 20 00, 122 : 1 32 3- 133 4 Cacas JL: Devil inside: does plant programmed cell death involve the endomembrane system? Plant Cell Environ 20 10,...
... representation of pEGFP-N3 vector containing pre-miR29a and 29 b (B) Expressionof hsa-mir -29 a and 29 b confirmed by quantitative real-time PCR Data show the expression levels of mir -29 a and 29 b from ... stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR 93 expression Immunity 20 07, 27 :1 23 - 134 Matskevich AA, Moelling K: Dicer is involved in protection against influenza ... 20 07, 27 : 435 -448 21 22 23 24 25 26 27 28 29 30 Lecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, Himber C, Saïb A, Voinnet O: A cellular microRNA mediates antiviral defense in human cells...
... (LSHM-CT -20 06- 036 9 03, MTKD-CT -20 06-0 425 86 and COST Action BM06 02) and by the Polish Ministry of Scientific Research and Information Technology (2 P05A01 127 , 63 ⁄ 6PRUE ⁄ 20 07 ⁄ and 33 9 ⁄ 6PR-UE ⁄ 20 07 ... (D141, E185, D 226 , D244) in PIN domains involved in binding Mg2+ ions are conserved in all three sequences Other conserved residues are R2 63, V 139 and N144 Determination of the MCPIP domain architecture ... equivalent levels of IL-1beta MCPIP protein as an RNase 19 20 21 22 23 24 25 26 27 28 mRNA show unequal IL-1beta protein accumulation but similar polyribosome profile J Immunol 1 53, 27 7– 28 6 Dinarello...
... effects of PEP-1–HSP27 against brain ischemia 20 21 22 23 24 25 26 27 28 29 30 31 Cu,Zn -superoxide dismutase mediated by an HIV-1 Tat protein basic domain into mammalian cells FEBS Lett 485, 1 63 167 ... against brain ischemia 32 33 34 35 36 37 38 39 40 J J An et al damage in different brain regions following transient cerebral ischemia in gerbils Neurosci Res 41, 23 3 24 1 Wang Q, Sun AY, Simonyi ... prostaglandins and cytokines [34 36 ] Ionized calciumbinding adaptor molecule (iba-1) is a calcium-binding protein that is specifically expressed in microglia in the brain and plays an important role in...