microrna regulation in disease
Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"
Ngày tải lên :
03/11/2012, 10:52
... tissue staining intensities
influ-
enced the measured values. Average value density
measurements from individual Vgf immunoreactive
dorsal spinal cord neurons,
reflecting immunostaining
intensity, ... C-terminal epitope of Vgf. Unoccupied
binding sites on the plates were blocked by incubation
with casein. Samples and standards were applied in
duplicate and incubated overnight at 4°C. Following ... in the serum, in the CSF, and in spinal cord
motorneurons may be a biological diagnostic index for
ALS. It remains to be directly tested whether restoring
Vgf expression in spinal cord motor...
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Cell Cycle Regulation in Mammalian Germ Cells
Ngày tải lên :
25/10/2013, 21:20
... Connexin 43 These intracellular signaling molecules in their absence cause Juneja et al. 1999
impaired folliculogenesis resulting in a germ cell deficiency
within the gonads.
Gja4/Cx37 Connexin 37 Intracellular ... absence of which results in vestigial
element binding protein ovaries with immature oocytes arrested at the pachytene stage.
Dazla Dazla protein (Deleted in RNA binding protein that affects translational ... Chaperone protein involved in protein folding, Dix et al. 1996
70 kDa protein 2 (HSP70-2) leads to spermatogenic arrest at metaphase stage in knockouts.
Cell Cycle Regulation in Mammalian Germ...
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Tài liệu Reading Our Lips: The History of Lipstick Regulation in Western Seats ... doc
Ngày tải lên :
16/01/2014, 22:20
... low in England during the nineteenth century, focusing only on lipstick in England could generate a most misleading
image of lipstick’s global status. For example, during the same period in China, ... Members, 16 Law & Ineq. J. 661 (1998) (pointing out that: “a Marine recruit training
manual used after the Gulf War stated that female recruits would be given ‘instruction in hair care, techniques ... well as the continued complaining of religious writers,
makes clear that lipstick remained at least relatively in use by females and entirely free from regulation of
law.
37
In Spain around 500...
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Tài liệu Emotion Regulation in Couples and Families ppt
Ngày tải lên :
19/02/2014, 04:20
... domain plays
an
important
role
in
maintaining
good
interpersonal
relationships.
Managing
Emotions
Before
we
discuss findings supporting
the
importance
of
managing emo-
tions
in
... are
regulated intrapersonally (within individuals)
than
interpersonally (between
individuals).
Investigators
are
only beginning
to
propose
and
test dyadic
models
specifying
how the
emotion
regulation
... emotions, ranging
from
listening
to
music
to
drinking
caffeinated
beverages
to
withdrawing
from
social interaction.
Parkinson
and
Totterdell (1999)
classified
various emotion regulation...
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Tài liệu Báo cáo khoa học: "WORD AND OBJECT IN DISEASE DESCRIPTIONS" doc
Ngày tải lên :
21/02/2014, 20:20
... TICK FRDM SKIN; APPLICA-
TIONS TO SKIN OF TURPENTINE, IODINE,
R~'TONE; REMOVAL OF
TICK BY INSERTION
OF NEEDLE BETWEEN MOUTH PARTS; ASPIRIN
FOR PAIN; ANTIBIOTIC TREATMENT IN-
~-~CTIVE. ...
in CMIT, in order of increasing 'enT.ropy'
The enl=ropy
is
given in P.he
first
column;
,':he ent.ries in ~h~ nezt ii columns are
~he percent of occurrences in the 11
disease ... correspond to the disease
categories represented in CMIT. This is done by assign-
ing terms which occur predominantly in one category to a
single vocabulary and then sorting by entropy. Tables...
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Báo cáo khoa học: Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling pdf
Ngày tải lên :
07/03/2014, 02:20
... against CD3 (1 lgÆmL
)1
, UCHT1;
BD Pharmingen, Franklin Lakes, NJ, USA) and CD28
(5 lgÆmL
)1
, CD28.2; BD Pharmingen), and maintained in
RPMI-1640 standard medium containing recombinant
human interleukin-2 ... domain of INP54p was cloned into the modi-
fied pEGFP-C1 (Clontech, Mountain View, CA, USA)
vector following the C-terminus of GFP. The first 10 amino
acids of Fyn were engineered in frame N-terminal ... Kiessling S, Sansom OJ, Millar CB,
Maddison K, Bird A, Clarke AR & Frisch SM (2003)
Fas-associated death domain protein interacts with
methyl-CpG binding domain protein 4: a potential link
between...
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Rural and Micro Finance Regulation in Ghana: Implications for Development and Performance of the Industry ppt
Ngày tải lên :
22/03/2014, 21:20
... conditions.
Innovative microfinance institutions have had
substantial success in making financial services
accessible to the poor in many parts of the
world, and microfinance is increasingly
provided ... Ethiopia was a leader in Africa in moving to treat MFIs as financial intermediaries, it
has only gradually moved toward promoting financial self-suffic iency. The interest rate was initially fixed ... Union Law.
• The informal financial system covers a range of activities known as susu, including
individual savings collectors, rotating savings and credit associations, and savings and
credit...
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Báo cáo khoa học: Gene regulation by tetracyclines Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes Christian Berens and Wolfgang Hillen pptx
Ngày tải lên :
23/03/2014, 21:20
... and screening systems in
E.coli [104,105] and in S. cerevisiae [88] have lead to a
profound understanding of how DNA binding, inducer
binding and dimerization function in TetR. This informa-
tion ... the inducer-binding and dimerization domain is in dark gray, activation domains are
black boxes, and the silencing domain is stippled. The conformational change leading to the loss of DNA-binding ... disorders. In a conditional model of Hunting-
ton’s disease, mice expressing a mutated huntingtin
fragment in the brain demonstrated that its continuous
supply was needed to maintain the characteristic...
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Better Regulation In Europe Better Regulation In Europe - Austria 2010 pptx
Ngày tải lên :
28/03/2014, 23:20
... responsibility.
Binding guidelines for all federal ministries and the Lände
r relating to the negotiation,
transposition and infringement phases have been in place since 2003. In 2003, the Ministry of ... co-ordination of rule-making is weak in Austria, with regulations being
autonomously conceived within each responsible ministry. As a result forward planning policies vary from
ministry to ministry. ... existing IT systems in the
preparation of regulation including a clear link between public consultation
and the drafting process. Develop a single consultation portal for use by all
ministries...
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Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer ppt
Ngày tải lên :
29/03/2014, 08:20
... by
activating DAPK activity [40]. Indeed, bosutinib, an
investigational Src kinase inhibitor, has been shown to
inhibit the migration and invasion of breast cancer
cells [48]. In addition, dasatinib, ... are now being tested in combination therapies
[47].
Tyrosine kinase inhibitors are widely and success-
fully used in the treatment of cancer, and in the
context of this review, may inhibit tumour ... revealed that DAPK protein was inactive, sug-
gesting that the kinase activity of DAPK was inacti-
vated in cancer cells [38]. Our own studies assessing
protein expression of DAPK in freshly isolated...
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Báo cáo khoa học: Function of microRNA-375 and microRNA-124a in pancreas and brain doc
Ngày tải lên :
29/03/2014, 22:21
... important role in the differentiation
of progenitor cells to mature neurons by directly
regulating polypyrimidine tract-binding protein 1, which
is involved in alternative pre-mRNA splicing in non-
neural ... RNaseIII-type protein, Dicer,
which acts in concert with another double-stranded
RNA-binding protein (the HIV transactivating
response RNA-binding protein) and Argonaute pro-
teins to liberate the ... 3¢-UTR of myotrophin
mRNA was shown to repress myotrophin translation
and result in the inhibition of insulin secretion. In
addition to its role in exocytosis control, myotrophin
is also known...
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Báo cáo khoa học: Impact of cyclic hypoxia on HIF-1a regulation in endothelial cells – new insights for anti-tumor treatments doc
Ngày tải lên :
30/03/2014, 02:20
... gain in endothelial cell survival, thereby
mirroring the effects of a PI3K ⁄ Akt inhibitor. However, combination of
both drugs resulted in a net reduction in HIF-1a and a dramatic in
decrease in ... alterations occurring during the
reoxygenation periods. These observations also indicate the potential of
combining Akt-targeting drugs with anti-angiogenic drugs, in particular
those interfering with ... dependency of the COX-2 induction
was shown using echinomycin, a pharmacological
hypoxia-responsive element-interfering drug [27], which
completely prevented the increase in COX-2 transcript
abundance...
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transcriptional regulation in eukaryotes
Ngày tải lên :
11/04/2014, 10:37
... immunoglobulin heavy-chain protein
IL-2, interleukin-2
IL-12, interleukin-12
Inr, initiator elements
int, integrase
IPTG, isopropyl-β-
D-thiogalactoside
IRE, iron-responsive element
IRP, iron-regulating ... different affinities for core promoters (e.g., TBP binding to consensus and non-
consensus TATAs; TFIIB binding to a consensus vs. a degenerate BRE; TFIID binding to an
Inr-containing vs. Inr-less ... The
gypsy insulator binds the suppressor of hairy wing (su[Hw]) proteins (in one case the
insulator comprises 12 su[Hw] binding sites). Unlike BEAF32, mutations in su(Hw) inac-
tivate insulator activity.
Most...
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