mesenchymal stem cell treatment for ischemic brain injury
Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer doc
... glioma brain cancer cells selectively and protects normal lymphocytes by inducing cell division in blood-forming cells This homeopathic medicine could be prescribed for optimum treatment of brain ... treatments MGR1 brain cancer cells treated for 24 and 48 h showed durationdependent G1 arrest (data not shown) Ruta induced reproducible and significant levels of cell death in brain cancer cells, ... intracranial cancer cells, by either inducing cell death or preventing further proliferation; b) to explore the molecular mechanism of cell death by Ruta + Ca3(PO4)2 treatment of brain cancer cells in vitro;...
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Báo cáo sinh học: "Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction" ppt
... adipose-derived mesenchymal stem cells (ADMSCs) After culturing for 14 days, majority of isolated adipose-derived stem cells expressing CD29 and CD90 characteristic of mesenchymal stem cells (n = ... availability of various cellular sources for experimental investigations [6,7,10-15] including bone marrow-derived mesenchymal stem cells (BMDMSCs), hematopoietic stem/ progenitor cells, and cells of embryonic ... have emphasized stem cell therapy as an effective treatment modality for acute kidney injury, the mechanistic basis underlying the observed improvement in renal function after stem cell therapy...
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Báo cáo khoa học: " Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin''''s disease: a case report" doc
... relapsed and two cycles of DexaBEAM with stem cell harvest were applied We performed high-dose chemotherapy according to the BEAM protocol On day twelve after stem cell reinfusion he developed mental ... allogeneic stem cell transplantation, severe disease is rare in patients after autologous stem cell transplantation Nevertheless, in patients with severe complications of infections after autologous stem ... hematopoietic stem cell transplantation Leukemia 2002, 16:958-959 Vu T, Carrum G, Hutton G, Heslop HE, Brenner MK, Kamble R: Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell...
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Báo cáo khoa học: " Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin''''s disease: a case report" ppsx
... relapsed and two cycles of DexaBEAM with stem cell harvest were applied We performed high-dose chemotherapy according to the BEAM protocol On day twelve after stem cell reinfusion he developed mental ... allogeneic stem cell transplantation, severe disease is rare in patients after autologous stem cell transplantation Nevertheless, in patients with severe complications of infections after autologous stem ... hematopoietic stem cell transplantation Leukemia 2002, 16:958-959 Vu T, Carrum G, Hutton G, Heslop HE, Brenner MK, Kamble R: Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell...
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Dynamic mechanical stimulation for mesenchymal stem cell chondrogenesis in an elastomeric scaffold
... particular that of stem cells, and the biomaterials, for cartilage tissue engineering will be addressed 2.3.1 Stem cell based Approaches for Cartilage Tissue Engineering The aforementioned weaknesses ... hypertrophy and cell dedifferentiation, but donor site morbidity and fibrocartilage formation are still inevitable drawbacks Thus, mesenchymal stem cell (MSC) as an alternative cell source is ... clinical treatments and chondrocyte based approaches encourage the investigation on stem cells with chondrogenic potential for articular cartilage repair Both pluripotent and multipotent stem cells...
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Exploring mesenchymal stem cell derived exosome and tocotrienol (t3) as therapeutic agents in drug induced liver injury (DILI)
... Lai, W Wong, Y Y Dan, S K Lim and H K Ho, Mesenchymal stem cell- derived exosomes promote hepatic regeneration in drug-induced liver injury models, Stem Cell Research and Therapy, 5(3):76 (2014) ... 49 2.3.4 In vitro treatment of APAP-induced liver injury model 49 2.3.5 In vitro treatment of hydrogen peroxide (H2O2)-induced liver injury model 50 2.3.6 Cell viability assay ... in cell viability after APAP- and H2O2-induced injury in TAMH hepatocytes 114 Figure 29 Pre -treatment effects of -TP, -T3, -T3 and -T3 in cell viability after APAP- and H2O2-induced injury...
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Mesenchymal stem cell differentiation on biomimetic surfaces for orthopaedic applications
... stromal cells (BMMSC) 57 Culture of bone chip-derived osteoblasts (BC-OB) 58 Culture of human mesenchymal stem cells (hMSC) 59 (Lonza, USA) Culture of human osteoblasts (hFOB) (ATCC, USA) 59 Cell ... marrowderived mesenchymal stem cells and osteoblast differentiation on titanium with surface-grafted chitosan and immobilized bone morphogenetic protein-2, 2nd International Congress on Stem Cells and ... amount of useful information for the fabrication of PLGA-based biomaterials, like controlled release devices 37 Introduction to the biological aspects of implants Mesenchymal stem cells (MSCs) MSCs...
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Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"
... traumatic brain injury, part 1: Guidelines for the management of severe traumatic brain injury J Neurotrauma 2000;17:451-533 Piek J Decompressive surgery in the treatment of traumatic brain injury ... severe traumatic brain injury Injury 2006;37:1125-1132 Coplin WM Intracranial pressure and surgical decompression for traumatic brain injury: biological rationale and protocol for a randomized ... intervention for severe traumatic brain injury J Trauma 2001;50:1050-1059 28 Fagiji AA, Fieggen AG, Argent A, et al Surgical treatment for Brain compartment syndrome” in children with severe head injury...
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Tài liệu Báo cáo khoa học: Expression and secretion of interleukin-1b, tumour necrosis factor-a and interleukin-10 by hypoxia- and serum-deprivation-stimulated mesenchymal stem cells Implications for their paracrine roles ppt
... human mesenchymal stem cells Science 284, 143–147 Porada CD, Zanjani ED & Almeida-Porad G (2006) Adult mesenchymal stem cells: a pluripotent population with multiple applications Curr Stem Cell ... marrowderived mesenchymal stem cells and mononuclear cells Stem Cells 25, 1166–1177 Li L, Zhang S, Zhang Y, Yu B, Xu Y & Guan Z (2009) Paracrine action mediates the antifibrotic effect of transplanted mesenchymal ... Ingwall JS et al (2005) Paracrine action accounts for marked protection 10 11 12 13 14 15 of ischemic heart by Akt-modified mesenchymal stem cells Nat Med 11, 367–368 Kinnaird T, Stabile E, Burnett...
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NGHIÊN CỨU SỬ DỤNG TẾ BÀO GỐC TRUNG MÔ (MESENCHYMAL STEM CELL - MSC) TRONG ĐIỀU TRỊ UNG THƯ ĐẠI - TRỰC TRÀNG TRÊN CHUỘT (SPRAGUE DAWLEY) ppt
... Therapeutic potential of mesenchymal stem cells producing interferonalpha in a mouse melanoma lung metastasis model, Stem Cells 26, (2008), 2332-8 Satija, N K et al., Mesenchymal stem cell- based therapy: ... therapy: a new paradigm in regenerative medicine, J Cell Mol Med 13, 2009 STEM CELL RESEARCH USING MESENCHYMAL (MESENCHYMAL STEM CELL - MSC) IN THE TREATMENT OF CANCER AGENCY - RECTUM RATS (SPRAGUE ... some characteristics of mesenchymal stem cells in cancer immunotherapy in mice Research results show that the mesenchymal stem cells injected into mice at the dose of 107 cells/ml can inhibit the...
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báo cáo hóa học: " Interleukin-1alpha expression precedes IL-1beta after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues" pdf
... [13], although functional evidence for a role of microglia-derived IL-1α in brain injury is not provided here In cerebral ischemia the primary injury to brain cells is caused by the lack of blood ... whole cell fluorescence (F) All images are representative of n ≥ mice Quantification is of n=4 CX3CR1-GFP +/- mouse brains, with each data point representing an individual cell, n ≥ 30 cells per brain ... presence in the brain parenchyma indicates BBB disruption and injury [9] Staining of coronal brain sections from C57BL6/H mice (Figure 2C) and CX3CR1-GFP+/- mice (not shown) 24h after MCAo for IL-1α...
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Báo cáo y học: "Hematopoietic stem cell transplantation for systemic lupus erythematosus" ppsx
... marrow stem cell transplantation for severe systemic lupus erythematosus of long duration Lupus 1997, 6:545-548 Burt RK, Traynor A, Ramsey-Goldman R: Hematopoietic stemcell transplantation for systemic ... with the same dose of cyclophosphamide without hematopoietic stem cell support, and also to hasten stem cell regeneration of the immune system under the umbrella of the ATG effect Based on the same ... hematopoietic stem cells are not necessary for re-engraftment While intensely immune suppressive, the regimen is not myeloablative and endogenous hematopoiesis would recover The hematopoietic stem cells...
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Báo cáo y học: "Stem cell transplantation for rheumatic autoimmune diseases" potx
... hematopoietic stem cell transplantation Hematopoietic stem cell transplantation (HSCT) is a complex multistep procedure involving mobilisation and harvesting of hematopoietic stem cells (HSCs) ... without stem cell rescue has been tested in SLE and scleroderma patients [37-39] The rationale for that procedure is a rapid eradication of autoreactive effector cells while sparing stem cells ... European Group for Blood and Marrow Transplantation, et al.: Autologous stem cell transplantation for systemic lupus erythematosus Lupus 2004, 13:168-176 Saccardi R, Kozak T, Bocelli-Tyndall C,...
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Báo cáo y học: "A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes." ppsx
... repeats were performed for each biological replicate: this comprises gels for E6 and gels for E7 For each clone we ran three replicates for t0 (control) and three replicates for t48 hours Corresponding ... mES cells, this system allows the efficient and long-term overexpression of the transgene in a dose- and time-dependent manner It is therefore suitable for systematic expression of HSA21 cDNAs Cell ... state (that is, cells grown in the presence of Tc) with those derived from cells grown in a medium deprived of Tc for 48 hours (in other words, cells overexpressing the protein Runx1) For each of...
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Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines ppt
... serum free conditions for 14 days (Figure 3B) For co-cultured CD34+ hematopoietic stem cells with 3A6 cells, we noted the formation of cobblestone areas from hematopoietic cells that transmigrated ... hMSCs converges toward embryonic stem cells Principal component analysis comparing the gene expression profiles of 3A6, embryonic stem cells (ESC), mesenchymal stem cells (MSC), and various tissues ... of mesenchymal stem cell in vitro BMC cell biology 2006, 7:14 Hung SC, Chen NJ, Hsieh SL, Li H, Ma HL, Lo WH: Isolation and characterization of size-sieved stem cells from human bone marrow Stem...
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Báo cáo y học: "Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cell" ppsx
... human mesenchymal stem cells generate osteosarcoma-like lesions in the lung Stem Cells 2007, 25:1586-1594 doi:10.1186/1423-0127-18-54 Cite this article as: Chang et al.: Mesenchymal stem cell ... Infusion of allogeneic-related HLA mismatched mesenchymal stem cells for the treatment of incomplete engraftment following autologous haematopoietic stem cell transplantation Leukemia 2007, 21:568-570 ... Yarmush ML: Mesenchymal stem cells: mechanisms of immunomodulation and homing Cell Transplant 2010, 19:667-679 Lee PH, Kim JW, Bang OY, Ahn YH, Joo IS, Huh K: Autologous mesenchymal stem cell therapy...
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Báo cáo y học: " Ceftriaxone attenuates hypoxic-ischemic brain injury in neonatal rats" potx
... conclusion, pre -treatment with ceftriaxone for 48 hrs prior to hypoxic -ischemic brain injury in neonatal rats reduced brain injury score, improved myelination, decreased hippocampal apoptotic cell death, ... induced brain damage Ceftriaxone attenuated hypoxic -ischemic white matter injury in neonatal rats White matter damage was also observed in this rodent model of hypoxic -ischemic brain injury The ... ceftriaxone treatment could offer neuroprotection against the hypoxic -ischemic brain injury Our results indicate that pretreatment with ceftriaxone in neonatal rats can reverse hypoxic-ischemic...
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báo cáo khoa học: "The research on the immuno-modulatory defect of Mesenchymal Stem Cell from Chronic Myeloid Leukemia patients" pdf
... activated state leading to self injury Besides HSCs, there also existed another kind of stem cells called MSCs (Mesenchymal Stem Cells), they could differentiated into stroma cells and acted as the “niche” ... Immunocytometry Systems, Mountain View, CA) For intracellular antigen detection, cells were first fixed in 2% paraformaldehyde (Sigma) for 15 minutes at 4°C and permeabilized with 0.1% saponin (Sigma) for ... (1-20 nM) cells cultured for up days were used as templates for PCR reactions using specific primers for MMP-9 and ICAM-1 (B) The cDNAs from snc-RNA (20 nM) and ds-RNA (20 nM) cells cultured for up...
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Báo cáo y học: "Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert’s syndrome" pptx
... for conditioning; Phenytoin for prophylaxis of busulfan’s side affect Tacrolimus; methotrexate and mycophenolate mofetil (0.5 g twice a day on days to +28) for GVHD prophylaxis; Caspofungin for ... Figure Bilirubin level during chemotherapy and allogeneic hematopoietic stem cell transplantation Chronological dates of the treatment courses were indicated (A) the first cycle of chemotherapy ... phenytoin, were used in the diagnosis and treatment of GS [8,9] List of abbreviations GS: Gilbert’s syndrome; allo-HSCT: Allogeneic hematopoietic stem cell transplantation; AML: acute myeloid...
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