mental illness substance abuse and the human immunodeficiency virus
Báo cáo sinh học: " Oligomerization of the human immunodeficiency virus type 1 (HIV-1) Vpu protein – a genetic, biochemical and biophysical analysis" ppt
... MA: The human immunodeficiency virus type (HIV-1) CD4 receptor and its central role in the promotion of HIV-1 infection Microbiol Rev 1995, 59:63-93 Bour S, Schubert U, Strebel K: The human immunodeficiency ... JM: The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release J Virol 1990, 64:621-629 Ewart GD, Sutherland T, Gage PW, Cox GB: The Vpu ... Raja NU, Jabbar MA: The human immunodeficiency virus type Vpu protein tethered to the CD4 extracellular domain is localized to the plasma membrane and is biologically active in the secretory pathway...
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Báo cáo sinh học: " Hepatitis C (HCV), hepatitis B (HBV), the human immunodeficiency viruses (HIV), and other viruses that replicate via RNA intermediaries," pdf
... mosaic [2] and other RNA viruses Importantly, studies of the tobacco mosaic virus confirmed this effect to be host-independent and virus- specific inhibition of viral RNA synthesis and to be quite ... suggests HIV polymerases properties, and those of related retroviruses – for example, simian immunodeficiency virus (SIV) and the feline immunodeficiency virus (FIV) – are influenced by Env proteins ... output depends on the functionality of protein(s) translated from any RNA synthesized by RNApol For viruses, and their polymerase, evolutionary survival – i.e whether the polymerase, and its viral...
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Báo cáo hóa học: " The inhibition of the Human Immunodeficiency Virus type 1 activity by crude and purified human pregnancy plug mucus and mucins in an inhibition assay" ppt
... entry into the cells and therefore prevent the production of p24 antigen To further confirm the hypothesis that mucins inhibit HIV-1 activity by physically aggregating the virus, the CEM SS cells ... 2008, 5:59 of viruses in the filtrates or the failure of the crude pregnancy plug mucus and the media to aggregate the viruses This finding agreed with the report that HIV-1 may bind to the high-molecular ... free virus and cultured for another days in IL-2 rich media This was done to determine if the virus had entered the cells during the initial incubation step and was able to replicate inside the...
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báo cáo hóa học:" Nonopportunistic Neurologic Manifestations of the Human Immunodeficiency Virus: An Indian Study" pptx
... motor and sensory axonal neuropathy They have predominantly been isolated from the microglial cells, giant cells, and capillary endothelial cells.[3] The virus appears to enter the brain via the ... security in their annual meeting The youth of countries across the globe were succumbing to the effects of the HIV infection destroying the economic and social fabric of these countries In the current ... in both of these patients were normal and the spinal MRI revealed subtle signal changes in the posterior columns of the spinal cord None of these patients had any clinical evidence of the AIDS...
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Báo cáo y học: "A single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5α" potx
... presence of human TRIM5α, and a virus with the SIVmac L4/5, L6/7, and G116E substitution (4/5SG116E6/7S) became more sensitive to human TRIM5α (Figure 5B) On the other hand, the virus with the SIVmac ... inefficiently in human cells, we succeeded in rescuing the impaired replicative capability of the virus in human cells Sequence analysis of the MA-CA region of the adapted virus revealed that the there ... shows the template structure of the N-terminal domain of the HIV-1 CA; panel B shows the model of the domain structure with the G116E mutation The ribbons represent the protein backbone; G and...
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Báo cáo y học: " Intragenic transcriptional cis-activation of the human immunodeficiency virus 1 does not result in allele-specific inhibition of the endogenous gene" pdf
... several histone acetyltransferases [21-23] and cyclin T1 [24] On the other hand, the chromatin context at the site of integration should determine whether the provirus is transcriptionally active, poised ... contributions ADM and CB carried out the RT-PCR, ADM and PM carried out the in situ hybridization and quantitative analysis, AK, CV and AM prepared and characterized the cell line, AM contributed to the experimental ... before and after Tat-EGFP transfection is shown C) The ratio between the intensity of the hybridization signals on the transcription spots of the HMBOX1 alleles is shown D) The intensity of the...
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Báo cáo y học: "Dynamic features of the selective pressure on the human immunodeficiency virus type 1 (HIV-1) gp120 CD4-binding site in a group of long term non progressor (LTNP) subjects" pptx
... on the surface of gp120 (the internal portion and the CD4 binding region) dN/dS score visualization on the surface of gp120 (the internal portion and the CD4 binding region) Visualization of the ... visualization on the surface of gp120 (the 'silent' face of the molecule) dN/dS score visualization on the surface of gp120 (the 'silent' face of the molecule) Visualization of the dN/dS score (the posterior ... infers dN and dS for each site and also tests whether dN = dS or not for the sites [36] All the sites identified with the FEL approach were also identified with the previous methods, further confirming...
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Báo cáo y học: "Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum" doc
... designed and performed all the experiments and contributed to the writing of the manuscript MD provided reagents, participated in the design of some experiments and in the revision of the manuscript ... step in the process of CD4 degradation and precede the transport of the viral receptor through the ER membrane for proteolytic degradation by the cytosolic proteasome To investigate the role ... expressing human CD4 together with Vpu and human β-TrCP [34] They found that Vpu-mediated proteolysis of CD4 involved dislocation of ubiquitinated intermediates in the cytosol as we found in the present...
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Báo cáo y học: " Association between disruption of CD4 receptor dimerization and increased human immunodeficiency virus type 1 entry" pdf
... at the cell surface of T lymphocytes and monocytes/macrophages [3-5] The equilibrium established between these different forms may vary according to the cell type, the activation state of the ... of the receptor More precisely, residues in the CC' loop and the CDR3like region of the D4 domain were shown to be part of a putative dimer interface, with residues Q344 and Q344' having the ... viral entry in the A201 cell transfectants The CD4 dimer to monomer ratio was then evaluated in the different A201 CD4 cell populations to confirm the dimerization defect of the D1 and D4 mutants...
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Báo cáo y học: " Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates" ppt
... expression The activity of the intrinsic protease was inactivated by a D25A substitution of the catalytic aspartate The location of the Gag NC/p1 [53] and pl/p6 [54] sites and the Gag-Pro-Pol NC/ TF and ... PR/RT), and these are indicated with small arrows The slower cleavages at these sites (labeled and 5) give rise to the later paired products The molecular masses shown of the intermediates and final ... part, by the dimerization of the protease and RT domains We and others have shown that timed and ordered cleavage of the HIV-1 Gag precursors is highly regulated and is necessary for the production...
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Báo cáo y học: " Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatin" pot
... purification and isolation of HIV1 DNA FK participated in the design of the study and contributed to drafting of the manuscript MB conceived of the study, participated in its design and coordination and ... of RTCs and their conversion into PICs is completed in the cytoplasm This study adds to HIV-1 RTC/PIC characterization and advances our understanding of RTC maturation Methods Cells and viruses ... cells, as 33% of these cells are in G2/M phase (Fig 2A) and may lack the nuclei However, accounting for these cells would not significantly change the cytoplasm/nuclear ratio of early and late DNA-containing...
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The Prevention of Substance Abuse And Misuse Among the Elderly pot
... Summary October 31, 1994 SUBSTANCE ABUSE AND MISUSE The Washington State Division of Alcohol and Substance Abuse has identified the prevention of substance abuse and misuse among the elderly as a priority ... for the Division of Alcohol and Substance Abuse Olympia, WA September 30, 1994 The Washington State Division of Alcohol and Substance Abuse has identified the prevention of substance abuse and ... the extent of substance misuse and abuse/ dependence problems; to summarize the effects of alcohol and other licit and illicit drugs on the elderly and their social, behavioral, and psychological...
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Báo cáo sinh học: " The simultaneous presence and expression of human hepatitis C virus (HCV), human herpesvirus-6 (HHV-6), and human immunodeficiency virus-1 (HIV-1) in a single human T-cell" docx
... level, their presence is only seen outside the cells The assembly and synthesis of HHV-6A begins in the nucleus, the virion acquires a membrane as it passes through the nuclear membrane, and it ... same individual, the development of a system to study the effects of the interactions among these viruses at the level of a single cell is important Our experience in human viruses allowed us ... reported in the brain environment [25-27] These observations may partly explain the diminished cognitive function, depression and fatigue in these individuals The presence of HIV1 and HCV in the same...
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Báo cáo hóa học: " The simultaneous presence and expression of human hepatitis C virus (HCV), human herpesvirus-6 (HHV-6), and human immunodeficiency virus-1 (HIV-1) in a single human T-cell" pptx
... level, their presence is only seen outside the cells The assembly and synthesis of HHV-6A begins in the nucleus, the virion acquires a membrane as it passes through the nuclear membrane, and it ... same individual, the development of a system to study the effects of the interactions among these viruses at the level of a single cell is important Our experience in human viruses allowed us ... reported in the brain environment [25-27] These observations may partly explain the diminished cognitive function, depression and fatigue in these individuals The presence of HIV1 and HCV in the same...
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Báo cáo y học: " Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo" pptx
... been instrumental in prolonging the lives of adults and saving the lives of thousands of children [1-4] However, concern regarding mitochondrial and other toxicities in adults [5,6] and in HIV-1-uninfected ... designed to examine virus replication with the combination of AZT and WR1065, the standard curve for AZT included concentrations between and 23.0 ηM and WR1065 was used at either 18.7 or 26.0 μM ... and mM EDTA, and run through a magnetic column The flow-through material contained PBMC depleted (>99%) of CD8+ T-cells, which were then counted and cultured using the same media as for the human...
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Báo cáo y học: "Human immunodeficiency virus infection and autoimmune hepatitis during highly active anti-retroviral treatment: a case report and review of the literature" potx
... for the patient and edited the manuscript HN reviewed and provided legends for the pathological images MH reviewed the pathological specimens and made the initial diagnosis All authors read and ... Authors’ contributions HD wrote the manuscript, collected the images and obtained consent from the patient to publish this case report RK reviewed the literature and edited the manuscript FK coordinated ... anti-cardiolipin and anti-ribosomal antibodies; anti-double-stranded DNA (anti-dsDNA) titer, 1:160; and immunoglobulin G level, 4600 mg/dL Her antibodies to hepatitis viruses A, B and C and hepatitis...
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báo cáo khoa học: " Substance abuse and pharmacy practice: what the community pharmacist needs to know about drug abuse and dependence" ppsx
... another Rather it is frequently the case that an individual uses many different drugs often in combination The issue is further complicated by the co-occurrence of substance abuse and mental illness ... the substance abuse of the husband or wife When the opportunity arises, the pharmacist should recommend spousal participation in a support program designed for their needs These are Al-Anon and ... self-esteem, and eventual ill health are the sequelae of substance abuse and, taken together, may evolve into a perverted justification for self-medication While the question of the magnitude of the problem...
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Báo cáo y học: "Phenotypic and genotypic characterization of Human Immunodeficiency Virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China" pot
... B' viruses The number and location of the potential N-linked glycosylation sites in the V1–V5 regions in gp120 of the CRF07_ BC and subtype B' viruses were analyzed The results showed that the ... virus with that the replication kinetics of the CRF07_BC Comparison of of the subtype B' R5 and R5/X4 viruses R5 Comparison of the replication kinetics of the CRF07_BC R5 virus with that of the ... glycosylations in other variable loops The CRF07_BC viruses have lower net charge value in the gp120 V3 loops than those from the subtype B' viruses The net charge value of the V3 loop in gp120 of the CRF07_BC...
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Báo cáo y học: "Mutations in matrix and SP1 repair the packaging specificity of a Human Immunodeficiency Virus Type 1 mutant by reducing the association of Gag with spliced viral RN" ppsx
... TCID50 was calculated by the Reed and Muench method The same aliquot of virus was quantified with p24 ELISA and used to normalize the titer of the virus stock Means and SD of three independent ... reverse-transcribed and amplified the 4-kb singly spliced viral RNA using primers targeting the U5 and vpu of the HIV-1 genome and analyzed the products by agarose gel electrophoresis The PCR products from the ... very close to the major splice donor of the SL2 in the 5′ leader sequence We determined whether dimerization and splicing of the RNAs were affected by the deletion in SL1 Because the SL1 contains...
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