mechanisms underlying the effects of pro inflammatory cytokines on learning and memory
Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
... expression CB-R activation Protection Protection Protection Protection Toxicity Protection [28] [30] [31] [37] [48] [38] Protection NT Protection Protection Protection NT Protection Toxicity Toxicity ... CB receptor agonists and antagonists have both been demonstrated to produce either protective or toxic responses in ischemia, depending on a number of factors Among these, two of the most important ... possible mechanism underlying the neuroprotective effects of endocannabinoids Warming the animals to the body temperature of controls prevented the neuroprotective effects of CB1 agonists in some...
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Báo cáo khóa học: Collectins Players of the innate immune system docx
... depend on the density of carbohydrate ligands on the microbial surface [83] on the one hand, and on the degree of oligomerization of the collectin [66], on the other Clustering of glycoproteins ... the production of proinflammatory mediators, such as TNF-a and NO, while others observed inhibition by SP-A of the production of these mediators (reviewed in [117–119]) A partial explanation of ... inhibition of IgE binding to allergens, suppression of histamine release from basophils in the early phase of allergen provocation, and inhibition of lymphocyte proliferation in the late phase of bronchial...
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Paradoxical roles of the immune system during cancer development docx
... is probably a consequence of their inherent capacity to produce both pro- inflammatory T-helper-1 cytokines and anti -inflammatory T-helper-2 cytokines7 4; therefore, the nature and balance of surrounding ... promotion — first, by preventing apoptosis of cells with malignant potential, and second, by stimulating production of pro- inflammatory cytokines by cells of myeloid origin in tumours These pro- inflammatory ... pro- inflammatory cytokines then contribute in a paracrine fashion to neoplastic cell proliferation and increase survival of initiated, and/ or otherwise ‘damaged’, epithelial cells These elegant approaches offer...
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Cancer of the Brain and Other Central Nervous System doc
... Peace BB Analysis of patterns of care of brain tumor patients in the United States: a study of the Brain Tumor Section of the AANS and the CNS and the Commission on Cancer of the ACS Clin Neurosurg ... occurring in the frontal lobes (25.8% of total), temporal lobe (20.1% of total), parietal lobe (14.6% of total) and overlapping lesions of the brain (19.8% of total) were the most common Relative ... grade and primary site The combinations of particular interest were: race and sex, histologic type and sex and histologic type and race Size of tumor information was not analyzed because of the...
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Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf
... esters and ethers of long-chain polyunsaturated fatty acids that are synthesized on demand Anandamide (arachidonoylethanolamide) (AEA) was the first member of this family to be discovered [1], and ... (FAAH), which cleaves the amide bond to form arachidonic acid and ethanolamine [5] Taken together, AEA, its congeners and the proteins that bind, synthesize or transport them form the ‘endocannabinoid ... MCAo-induced brain insult on AEA regional level, metabolism, and receptor binding and expression The putative neuroprotective action of agonists and antagonists of cannabinoid receptors has also...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... and monocytes were binding the fusion protein but T-cells were not Possible binding of the fusion protein to the Fc receptors on B-cells and monocytes was ruled out by comparison to two fusion ... the 597 position), GST–cyto-Y641F (Y !F mutation at the 641 position), GST– cyto-Y667F (Y !F mutation at the 667 position), GST–cyto-Y691F (Y !F mutation at the 691 position), and GST alone proteins ... high expression (Fig 3) Blots were probed with three labeled oligonucleotides spanning a common region (L3) and the two spliced regions (S1 and S2) The tissue distribution of the three probes was...
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brain facts a primer on the brain and nervous system - the society for neuroscience
... where they can either provoke or prevent the generation of a new signal The regulation of this transmission at synapses, and the integration of inputs from the thousands of synapses each neuron ... Hurd VISION The cornea and lens help produce a clear image of the visual world on the retina, the sheet of photoreceptors and neurons lining the back of the eye As in a camera, the image on the retina ... acetylcholine Since all neurons have genes containing the information for the production of these molecules, it is the turning on of a particular set of genes that begins the production of specific neurotransmitters...
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Design of a near infrared spectrophotometry brain imaging system
... the upper bit and the lower bits when it is received The program combines them together and divides the resulting value by 0xFFFF The reason for this is the output from the ADC on the microcontroller ... would be put on the PCB rather than on the sensor to reduce the size of the sensor Figure 4.5: The schematic of one sensor 27 CHAPTER DESIGN PROCEDURES 4.2.1 Building the sensor Building the sensor ... since the Brother laser printer toner have a high melting point, making it hard to melt the toner from the paper onto the copper The glossy paper was then placed onto the copper board and ironed...
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scientific american - 1993 09 - special issue - life, death, and the immune system
... walls, the convection was weakened In further tests the workers used a conical container of their own design In this case, the beads flowed in the opposite direction, confirming that convection accounted ... damaged The next wave, which appears between the 15th and 20th days of gestation, takes up residence mainly in the lining of the reproductive organs in females and in the epithelium of the tongue ... a gross deÞcit of mature B cells and the antibodies they secrete Another is the consequence of a mutation in the gene for one of the three chains that make up the receptor for the growth factor...
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báo cáo hóa học:" Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target" docx
... induction of IL-12 production is a key component of the anti-angiogenic properties of angiostatin in vivo Removal of the Figure AST induction of IL-12 mRNA production by macrophages AST induction of ... identify the effects of AST on endothelial cells AST has been demonstrated to produce an array of events ranging from apoptosis/activation of endothelium to inhibition of endothelial cell migration, ... expression of IL-12 mRNAs for both the p40 and p35 IL-12 subunits (Fig 4), in the case of p40 to levels close to that induced by differentiation with IFNγ and LPS The expression of other markers of...
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Báo cáo sinh học: " Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" docx
... function and ultimately the induction of anti-virus immunity [12], pre- vents the differentiation of DC from monocytes [5], and inhibits the down regulation of receptor-mediated endocytosis and ... experimental work and drafting of the manuscript Abdel-Moneim conceived the study, designed and carried out the experimental work and drafted the manuscript All authors read and approved the final manuscript ... and procedures of statistics New York: McGraw-Hill Book Comp Inc Toronto, London; 1960:99-131 Steinmassl M, Wolf G: Formation of interleukin-2 and interferon alpha by mononuclear leukocytes of...
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Báo cáo hóa học: " Effectiveness of a Wii balance board-based system (eBaViR) for balance rehabilitation: a pilot randomized clinical trial in patients with acquired brain injury" ppt
... rehabilitation of the patients, achieving a system that reinforces the motivation of the patients during the rehabilitative process and providing the therapists with objective data of the evolution of the ... remarked on the ease and the speed of use This makes it possible to spend most of the session on the treatment As a token of their satisfaction, the therapists now continue using the eBaViR system on ... the therapist to parameterize the game to suit the needs of each patient There are two sets of parameters: a set that configures the rehabilitation session (such as the duration of the session...
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Báo cáo hóa học: " Brain-Computer Interface Controlled Functional Electrical Stimulation System for Ankle Movement" doc
... means of the MCU The FES device then stimulates the TA muscle of the foot, thereby causing contralateral dorsifiexion The inset shows the MCU connected to the neuromuscular stimulator and the placement ... requests carried the information on whether to turn the stimulator on or “off” (as determined by the prediction model), and the intensity of electrical stimulation (as determined by the experimenter) ... dorsifiexion was then defined as: x[i] = Figure Histograms of the posterior class probabilities for subject B Based on the known underlying action (idling or dorsifiexion), the distributions of the...
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báo cáo hóa học: " Application of a hybrid wavelet feature selection method in the design of a self-paced brain interface system" pptx
... integers) The contracted versions of the wavelet function will match the high-frequency components of the original signal and the dilated versions will match the low-frequency oscillations Then by ... over the number of cross-validation sets) The low standard deviation obtained for all cases shows the robustness of the proposed method over different runs of the algorithm Discussion and conclusions ... able-bodied), the experimental protocols, the evaluation protocol and the neurological phenomenon differ from one study to another In addition, the number of available EEG epochs, as well as the degree of...
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báo cáo hóa học: " Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis" docx
... balance probably exits between the anti -inflammatory/ protective responses to protect the brain against the rather proinflammatory/toxic response in severe bacterial meningitis The severity of the ... (PGs) Together these compounds may profoundly affect the plasticity of the brain epithelial cells and potentially driving robust expression of regulatory proteins to protect from bystander complement ... regional specificity and independent regulation of Cregs between epithelial cells of the choroid plexus and the ependyma of the ventricle which may be due to the local inflamed microenvironment The...
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báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc
... the injured brains of MT-I/II-/mice is due to the absence of the neuroprotective effects of MT-I/II in the CNS or the absence of the modulatory effects that MT-I/II has on the immune system The ... represent the standard error of the mean (SEM) Results Histological comparison of the extent of injury in wild type and MT-I/II-/- mice The area of the injury site in a μm section taken from the widest ... Th1 cytokines are responsible for the generation of caMFs and Th2 cytokines are responsible for the generation of aaMFs We have previously shown that exogenous application of MT-I/II to the injured...
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báo cáo hóa học:" Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" doc
... function and ultimately the induction of anti-virus immunity [12], pre- vents the differentiation of DC from monocytes [5], and inhibits the down regulation of receptor-mediated endocytosis and ... experimental work and drafting of the manuscript Abdel-Moneim conceived the study, designed and carried out the experimental work and drafted the manuscript All authors read and approved the final manuscript ... and procedures of statistics New York: McGraw-Hill Book Comp Inc Toronto, London; 1960:99-131 Steinmassl M, Wolf G: Formation of interleukin-2 and interferon alpha by mononuclear leukocytes of...
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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
... exceptionally susceptible to either infection or pathology, and a deeper understanding of the intimate co-evolution of pathogens and the immune system 10 11 12 13 14 Acknowledgements The author’s ... above the bifurcation generally determine T cell activation, and those below down-regulation, although the distinction is blurred: for example, IL-2 promotes both effector T cell proliferation and ... encoding cytokines controlling both innate immune responses (such as the IL-1 family) and adaptive Th2 responses (such as IL-4 and IL-4R) Strikingly (in terms of the hygiene hypothesis) out of alleles...
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Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx
... physiological impact of AhR expression on other cells of the immune system and the consequences of exposure to AhR ligands for these Given the complexity of cellular interactions that underlie specific ... for protecting the epithelial surfaces of the gut, lung and genitourinary system; TH17 cells, which produce early inflammatory responses; and TREG cells, which inhibit the responses of the other ... function They then proliferate and differentiate into different functional subsets, distinguished by the different cytokines they produce (indicated under each CD4 T cell type): the cytokines act on...
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Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)" pdf
... recognize epitopes expressed on the majority of WC1+ cells and also epitopes expressed only on the N3 or N4 isoforms of WC1 These findings suggest that the distribution of WC1− and WC1+ cells will be ... of young and adult animals has revealed the composition of leukocyte populations in water buffalo is similar to the composition in cattle One of the unique features to emerge from the study of ... lymphocytes Comparison of the patterns of expression of MHC and leukocyte differentiation molecules by FC has shown the patterns of expression of orthologous molecules in the water buffalo are...
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