mechanisms and control of regulatory t cells in cancer
Báo cáo sinh học: " Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" docx
... and mature DCs, resulting in tolerogenic interaction with T cells in SIT We found that the combination of DNA vaccination with Fc and OVA had better effects onOVAinduced alterations in the spleen ... pathway of regulation of type immunity in asthma Competing interests The authors declare that they have no competing interests Authors' contributions YL performed all analyses and wrote the initial ... directly to DCs may a new alternative of therapies for patients with allergic asthma These findings suggest that spleen DCs and Foxp3+Tregs prevents the generation and activation of Th2 effector cells...
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báo cáo hóa học:" Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs" pot
... stimulating T cell responses, stability of the phenotype following in vivo administration, the ability to migrate to sites of T cell activation and generation of CTLs Activated and mature DCs results ... concluded that hTERT p540 is not expressed or is cryptic on the surface of tumour cells and that immunization of cancer patients with hTERT p540 leads to the production of T cells that not recognize tumour ... cycles of vaccination (the time point associated with the maximal tetramer + CD8+ response, in patients undergoing vaccination with class I peptides only),, in vitro cytotoxicity against both peptides...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... death, TR cells lead to the induction of T regulator (Tr1) cells and Th3 cells, which feed back to inhibit inflammation, and the TR cells inhibit proliferation of antigen-specific and bystander ... differentiating into TR cells following activation are derived from a separate lineage of CD4+ T cells, and whether their induction is a result of the initial activation early in the inflammatory ... when the body is threatened by infection or injury In this setting T cells will become activated, and will recruit other T cells and other inflammatory cells and mediators to the site As the response...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... GITR-ligand interactions, abrogating the suppressive effect of Treg cells [37] With this in mind, it could be interesting to investigate whether the accumulated Treg cells in patients with arthritis ... one hand, transfer of Treg cells 24 hours after intra-articular antigen challenge might be too late to inhibit activation of effector T cells and their migration to the joint Indeed, T- cell activation ... CD25-expressing cells or transfer of CD4+CD25+ cells, in the present study we demonstrated that Treg cells modulate the onset of AIA but are ineffective at later stages, calling into question their...
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Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... might not be a feasible option treatment decreases the infiltrate in joints Furthermore, RA patients relapse shortly after withdrawal of anti-TNF-α [19] and thus, despite the dampening of joint inflammation ... that Treg isolated from patients with active RA before treatment with anti-TNF-α were unable to suppress proinflammatory cytokine secretion from activated T cells and monocytes After anti-TNF-α treatment ... CD4+CD25+ Treg had a suppressive function and accumulated in the inflamed joint [14–17] One of these studies even reported that CD4+CD25+ Treg isolated from joints of patients with active arthritis...
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Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx
... amounts of IL-4 and IL-10.35 Further studies are required to elucidate the in vivo role of these cells and their subsets Effects of SIT on Dendritic Cells To understand the mechanisms of action of ... applicability that will have persistent clinical effectiveness that can be built within a short duration of therapy time.1 107 Early and Late Effects of SIT on Mast Cells, Basophils, and Eosinophils SIT ... Hence, the oral mucosa represents a unique immunologic unit with the first contact with the allergen within the gastrointestinal tract, where immune tolerance is the natural outcome Freshly isolated...
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Báo cáo y học: "haracterization of regulatory T cells in urban newborns" pptx
... supervised patient recruitment for the study and obtained funding JEG participated in study design, data analysis, and obtained funding All of the authors participated in drafting the manuscript and approved ... using SAS, version (SAS Institute, Cary, NC) and the R system for statistical computing [27] Results Subject characteristics The subjects in this study consisted of a subset of newborns and mothers ... differences in the numbers of CD25+bright cells present in CB and PB, we next sought to establish whether or not these CD25+bright cells expressed distinct patterns of differentiation/activation markers...
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... determining immunity or immune tolerance; this determination is based on the maturation or activation state and the subset of DCs, and cytokine profiles in the microenvironment at the time of antigen ... expression and inhibit T- cell proliferation In this regard, it will be interesting to investigate IDO expression in different subsets of DCs from tolerized mice and to characterize their role in the induction ... PCR using IDO sense (5'-CACTGTACCAGTGCAGTAG-3') and antisense (5'-ACCATTCACACACT CGTTAT-3') primers, and using Foxp3 sense (5'-CAGCTGCCTACAGTGCCCCTAG-3') and antisense (5'CATTTGCCACGAGTGGGTAG-3')...
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Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot
... intact in cultures without antigen-presenting cells The functional activity of both patient and healthy control Tregs, however, was decreased in the presence of the patient’s antigen-presenting ... Overproduction of type I interferons in SLE matures dendritic cells (DCs) into immunogenic antigen-presenting cells that strongly contribute to the T- cell and B-cell hyperactivity characteristic of this ... not be able to overcome the strength of T- cell stimulation or the inhibitory effects of proinflammatory cytokines produced by other cells It is known that strong Toll-like receptor stimulation...
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Báo cáo y học: "Japanese Encephalitis Virus wild strain infection suppresses dendritic cells maturation and function, and causes the expansion of regulatory T cells" doc
... IFN-a and TNF-a was independent on viral replication DCs infected with P3 attenuated allostimulatory activities to T cells To test whether P3 infection will impair the ability of DCs to activate ... 0.05 Treg in vivo The results also demonstrated the expansion of Treg population after the co-culture of P3infected DCs and T cells It suggested that JEV infection of DCs might influence the mode ... function of DCs, including reducing expression of costimulatory molecules, modulating secretion of crucial cytokines, suppressing activation of T cells, and stimulating differentiation of regulatory...
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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses
... Abstract In this study, we showed that activated human CD8 T- cells could induce DCs to produce IL-12p70 in vitro and this interaction also resulted in the production of a cytokine milieu that ... each individual lymphocyte B cells and T cells are the major types of lymphocytes T cells provide important cell mediated immunity by participating in the cytolysis of infected cells through the ... unprecedented ability to activate naive T cells (Steinman and Cohn, 1974) These cells are now known as the primary instigators of the adaptive immunity as they are vital for detecting, alerting and...
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Báo cáo nghiên cứu khoa học " Development of an Improved Capability in support of National Bio-security for the Surveillance and Control of Foot & Mouth Disease in Cattle and Pigs " pptx
... productivity Executive Summary The main focus of this reporting period was to commence the project, begin the training of the field veterinarians in the South, Centre and North of Vietnam and also the ... Veterinary laboratories in Vietnam and the training of DAH veterinarians in disease investigation and control This will strengthen the profile of DAH which will play a vital role in making Vietnam ... be taken up by laboratories Little risk Training carried out in the North, Centre and South of Vietnam for veterinary field and laboratory staff Training carried out in the North, Centre and...
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Báo cáo nghiên cứu khoa học " Development of an Improved Capability in support of National Bio-security for the Surveillance and Control of Foot & Mouth Disease in Cattle and Pigs - Milestone 3 " pptx
... support and training to other laboratories in the network The project has highlighted the need for training of field veterinarians in the collection of data and how to ensure the correct information ... capability of the veterinary laboratories in Vietnam and the training of DAH veterinarians in disease investigation and control This will strengthen the profile of DAH which will play a vital role in ... the currently active National FMD Control Program The project highlighted the need to have coordination between the laboratory and the field staff in the control of FMD and in understanding the...
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Báo cáo nghiên cứu khoa học " Development of an Improved Capability in support of National Bio-security for the Surveillance and Control of Foot & Mouth Disease in Cattle and Pigs - Milestone 6 " ppt
... this reason accurate recording of not just the manufacturer and the name of the vaccine, but the serotypes contained in it is absolutely vital for determining the level and effectiveness of the ... training to other laboratories in the network The project has highlighted the need for training of field veterinarians in the collection of data and how to ensure the correct information is obtained ... internationally through the training programs and also through the achievements in understanding FMD in Vietnam FMD is a disease of importance in Vietnam and the region and this put this project into the...
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Báo cáo nghiên cứu khoa học " Development of Improved Capability in Support of National Biosecurity for the upport Surveillance and Control of Foot & Mouth Disease in Cattle and Pigs - Milestone 8" pptx
... in the field in Vietnam, the determination of the efficacy of vaccine coverage and has facilitated the identification of the risks associated with specific FMD serotypes in target areas in Vietnam ... results from vaccine efficacy testing demonstrated that the FMD vaccine response rate in cattle surveyed increased from 29% in 2006 to 68% in the second half of 2008 [Attachment 3] In addition, the ... surveillance and control of FMD in the field in Vietnam During the course of this project, successful laboratory capacity development has resulted in the attainment of FMD Reference Laboratory status...
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Báo cáo nghiên cứu khoa học " Development of an Improved Capability in support of National Bio-security for the Surveillance and Control of Foot & Mouth Disease in Cattle and Pigs " ppt
... own antigen and this is now in use for FMD ELISA PT testing was carried out to shown the laboratories were operating the tests correctly and obtaining the correct result Achieved Training in cell ... strategies Completing these objectives will improve the diagnostic capability of veterinary laboratories in Vietnam and achieve training of DAH veterinarians in disease investigation and control ... by training and education, will give Vietnam a more integrated animal health network and greatly facilitate disease control This will directly increase the competitiveness and productivity of the...
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Báo cáo nghiên cứu khoa học " Development of an Improved Capability in support of National Bio-security for the Surveillance and Control of Foot & Mouth Disease in Cattle and Pigs - Milestone 5 " ppt
... NAVETCO and DAH not only maintains the diagnostic capability developed at that time, but on its own initiative and unassisted by AAHL is conducting training courses and technology transfer to other ... labs in Vietnam Next Critical Steps In the next months AAHL staff will review the project outputs and to examine the information collected so far in the project and continue to provide support to ... Veterinary laboratories in Vietnam and the training of DAH veterinarians in disease investigation and control This will strengthen the profile of DAH which will play a vital role in making Vietnam...
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Báo cáo nghiên cứu khoa học " Development of an Improved Capability in support of National Bio-security for the Surveillance and Control of Foot & Mouth Disease in Cattle and Pigs - Milestones 7 " docx
... conducting training courses and technology transfer to other labs in Vietnam Next Critical Steps In the next months AAHL staff will review the project outputs and to examine the information collected ... recipient laboratory for support and fine tuning A useful indicator of likely success is the initiative and ability of the trainees to make a useful attempt at implementation by themselves DAH and ... collected and submitted to the laboratory The project has provided training and technology transfer of FMD diagnostics to each laboratory involved in the project Reagents and standard methods...
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Báo cáo y học: "Association of chemokine receptor gene (CCR2CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians" pdf
... represents a one-half to two-thirds reduction in transmission following joint testing and counseling Statistical analysis of genetic variants of CCR2 and CCR5 consisted of testing hypotheses derived ... cohort to 1) the date of HIV-1 infection (first seropositive visit) of the initially uninfected exposed partner or 2) the most recent seronegative visit prior to administrative censoring date (December ... Further confirmation of the effect of HHE highlights its potential impact on clinical HIV-1 disease control in diverse populations, in contrast to that of the protective Δ32 variant whose distribution...
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Báo cáo y học: "Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo" doc
... two distinct protein interaction surfaces to facilitate the depletion of CD4+ T lymphocytes in HLAC To determine the molecular determinants that govern Nef's activity in this ex vivo-model, tonsil ... Nefmediated increase in CD4+ T lymphocyte death identified the C-terminal di-leucine motif and the interaction site for the NAKC signalosome as two distinct protein interaction sites involved in this ... Competing interests The authors declare that they have no competing interests Authors' contributions SH and NT performed the experimental work OTK and OTF conceived the experimental strategies and...
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