mechanism of action of parathyroid hormone and parathyroid hormone related protein
Báo cáo y học: "Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinscher" potx
Ngày tải lên :
13/08/2014, 13:20
... Quantitative Real-Time PCR of apoptosis and cell proliferation related genes Quantitative Real-Time PCR of apoptosis and cell proliferation related genes mRNA levels of non-copper associated subclinical ... Healthy controls Protein precision marker 10 kDa Figure Western blot analysis of the metallothionein proteins Western blot analysis of the metallothionein proteins Immunoreactive bands of total metallothionein ... in a spectrofluorometric thermal cycler (iCycler®, BioRad, Veenendaal, The Netherlands) For each PCR reaction, 1.67 µl (of the 2× diluted stock) of cDNA was used in a reaction volume of 50 µl containing...
- 13
- 300
- 0
Báo cáo y học: " Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: Implications for transformation" pps
Ngày tải lên :
13/08/2014, 05:20
... necrosis factor β, parathyroid hormone- related protein (PTHrP), macrophage inflammatory protein- 1α (MIP-1α) and receptor activator of nuclear factor-κB ligand (RANKL) that directly and/ or indirectly ... interleukin-1 and parathyroid hormonerelated protein production on adult T-cell leukemia cells in vitro Blood 1995, 86:2257-2267 Dunbar ME, Wysolmerski JJ, Broadus AE: Parathyroid hormonerelated protein: ... Silvestrini A, et al.: Human parathyroid hormone- related protein and human parathyroid hormone receptor type are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived...
- 12
- 199
- 0
Báo cáo hóa học: "Synthesis and Growth Mechanism of Ni Nanotubes and Nanowires" potx
Ngày tải lên :
21/06/2014, 20:20
... (a), (c) and (e) are top views of samples 1, and respectively; (b), (d) and (f) are side views of the samples 1, and respectively are much more than those in Fig 3a A certain amount of Ni nanoparticles ... formation of nanotubes and nanowires Figure illustrates schematic diagrams of the electrodeposition process for Ni nanotubes and nanowires Figure 4a provides a clear understanding of the growth mechanism ... of Ni nanowires and nanotubes for samples under different conditions: (a) sample 1, (b) sample and (c) sample Fig a Schematic diagram of the growth process of nanotubes; b Schematic diagram of...
- 6
- 368
- 0
Báo cáo vật lý: " WEAR MECHANISM OF TiN, TiAlN AND TiCN COATED DRILLS DURING DRILLING OF CARBON STEEL" pptx
Ngày tải lên :
07/08/2014, 14:20
... Wear Mechanism of TiN, TiAIN and TiCN Coated Drills 76 mechanism develops during drilling of TiCN, TiN and TiAlN coated drills on the medium carbon steel work piece The failure mechanism of the ... mixture of wear mechanism of abrasion and adhesion were taken during drilling process Then, the wear mechanism changed to a complex mechanism which involved a mixture of abrasion, severe adhesion and ... result of broken cutting lip and land, and blunting-off chisel wedge ACKNOWLEDGEMENTS The authors are grateful to the Government of Malaysia for the funding of this research The assistance of Amin...
- 11
- 369
- 0
Structural basis for the inhibition mechanism of HUman CSE and a study on c CBL complexes
Ngày tải lên :
11/09/2015, 10:17
... stability, function and intracellular localization of a wide variety of proteins The process of marking a protein with ubiquitin (ubiquitylation or ubiquitination) consists of a series of steps (Figure ... recognition modules of the system and are capable of interaction with both E2 and substrate S stands for substrate Dotted lines represent protein- protein interactions 1.7.7 E3 ubiquitin ligase ... lysine of the target protein and the C-terminal glycine of ubiquitin In general, this step requires the activity of one of the hundreds of E3 ubiquitin -protein ligases (often termed simply ubiquitin...
- 138
- 314
- 0
Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx
Ngày tải lên :
19/02/2014, 02:20
... consists of two related processes ) oxidation of protein- bound sugars (from glycation), and oxidation of free glucose and its products Both processes can generate radicals that modify LDL, and hence ... The time course of cellular uptake of LDL-derived lipid and protein has been characterized, as well as the subsequent turnover of the apoB protein It is shown that both lipid and protein are taken ... rates of uptake of both the lipid and protein components are not matched by the rate of cellular metabolism of these species, resulting in the accumulation of both unmodified cholesteryl esters and...
- 12
- 604
- 0
báo cáo hóa học: " The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism" pot
Ngày tải lên :
19/06/2014, 22:20
... levels of neurokinin A and anti-ribosomal P protein antibodies were found in 57.1% and 44.3%, respectively of autistic children There was significant positive correlations between serum levels of ... levels of neurokinin A and CARS in autistic patients, P < 0.001 This may indicate that the extent of the elevation of serum neurokinin A was closely linked to the degree of the severity of autism ... in accumulation of lipids inside the cell, and downregulation of the total protein synthesis P proteins are post-translationally modified (dephosphorylated) during apoptosis, and a dysregulation...
- 30
- 522
- 0
Báo cáo y học: "Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study" ppt
Ngày tải lên :
12/08/2014, 15:22
... role-physical score of 35.0 and PCS value of 34.2 for a population with a Page 10 of 13 mean age of 59 years and experiencing 0.6 flares per month [18], while Strand et al reported reductions of 30 to 32 ... PS, DR, VM and UA, and data were gathered and analyzed by Novartis All authors vouch for the accuracy of the data and the analysis, and contributed to the interpretation of the data and were involved ... impact on acute Gouty Arthritis and the risk of recurrent flares, but also because of the possible role of elevated CRP and SAA levels and IL-1b in the development of cardiovascular disease [52-54]...
- 13
- 419
- 0
Báo cáo y học: " Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication" potx
Ngày tải lên :
13/08/2014, 13:20
... Further study of the interactions of EIF4G1, CBP80 and EIF4A1 may thus be important in elucidating Rev function and viral RNA export, as well as the synthesis of viral proteins While some of the differentially ... expression profiles of genes encoding DDX18 and DDX39, which were up regulated during viral latency and during latency and early lytic replication Panel D shows the expression profile of genes encoding ... initiation and may also be involved in mediating nuclear export of RNA In addition, genes encoding other proteins involved in nucleic acidprotein interactions were also upregulated, such as members of...
- 5
- 255
- 0
Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
Ngày tải lên :
26/10/2012, 09:39
... mellitus High levels of free radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance ... effects on diabetes, hypertension and wound healing Presumably, one of mechanisms of action is its antioxidant activity The action of EPRT is to produce electrical pressure rather than an electrical ... continued to improve and heal, and her remaining gangrenous toes eventually fell off Her blood pressure at admission was 166/53 with use of Lisinopril, which was dropped and eventually ceased...
- 7
- 813
- 0
Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
Ngày tải lên :
19/02/2014, 07:20
... generation of H2O2 in spores [9,15–18] In this work we have gained more information on the cellular targets and the mechanism of action of vis- cotoxins, by examining the interaction of VtA3 with ... monochromator, and Glan-Thompson polarizers using quartz cuvettes with continuous stirring of the suspension, bandwidths of nm for excitation and nm for emission, and excitation and emission wavelengths of ... [3,16] To further explore the interaction of the most cytotoxic viscotoxin isoform, VtA3, with biological membranes and obtain information on its mechanism of action, we have applied different...
- 12
- 530
- 0
Báo cáo y học: "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel." ppt
Ngày tải lên :
11/08/2014, 03:20
... neutrophils, and is a biomarker for inflammation Furthermore, to clarify the LA mechanism of action, we studied the participation of pentoxifylline, a PDE5 and TNF-alpha inhibitor, and morphine, a mu and ... pre-treatment of mice with LA (12.5 and 25 mg/kg, i.p) significantly reduced the volume (μL) of the edema in the 2nd (31 and 41%), rd (30 and 50%) and 4th (23 and 27%) hours after administration of dextran, ... light/dark cycle and food and water supplied ad libitum The experiments were carried out according to the Guide for the Care and Use of Laboratory Animals of the U.S Department of Health and Human Services...
- 11
- 367
- 0
Báo cáo y học: "The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study" pdf
Ngày tải lên :
12/08/2014, 23:21
... study furthers our understanding of the mechanism of action for anti-HIV drug interactions and the efficacy observed for the TDF+FTC+EFV triple combination for the treatment of HIV infection Methods ... Where and represent the individual action of drug or drug 2, while 1,2 represents the combined action of the drug combination The CI values of < 1, = 1, and > indicate synergy, additive effect, and ... and FTC-TP [30]; and (2) DEC or DEC-like complex formation by TFV-terminated DNA and HIV-1 RT in the presence of the FTC-TP or EFV, and by FTC-MP-terminated DNA and HIV-1 RT in the presence of...
- 16
- 377
- 0
Structure and mechanism of hormone perception and signal transduction by abscisic acid receptors
Ngày tải lên :
10/09/2015, 09:26
... of recombinant proteins 55 3.2 ABA-dependent interactions of PYLs with PP2Cs 57 3.3 Large scale purification and crystallization of PYLs 60 3.4 Molecular features of PYL ABA interaction ... contribute to the understanding of similar intracellular signalling mechanisms in humans LIST OF TABLES LIST OF TABLES Table List of crystallization conditions .43 Table List of proteins in the ... domain proteins 125 Figure 47 Multiple sequence alignment of the START domains of Arabidopsis PYL and human STARD proteins .126 Figure 48 Structures of human STARD proteins and their...
- 171
- 350
- 0
Discovery and mechanism of action study of anti viral compounds for dengue virus
Ngày tải lên :
10/09/2015, 15:51
... need to determine its mode of mechanism During the studies to determine the mode of mechanism of NITD770, host lipid rafts (as suggested by chemogenomic profiling data) and cholesterol were confirmed ... compartments of host cells DENV is an enveloped virus which contains a lipid bilayer that has 180 copies of E protein and M protein embedded in it The E proteins are arranged in an icosahedral scaffold of ... N-myristoylated proteins (Farazi et al 2001) or Spalmitoylated proteins (Linder and Deschenes 2007) Myristoylation of structural proteins of viruses is required for targeting these modified viral proteins...
- 175
- 512
- 0
Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants sugar metalbolic pathway
Ngày tải lên :
11/09/2015, 09:08
... filtration profile of FRK Crystal of SeMet FRK 3.4 Sample diffraction pattern of SeMet FRK crystal 81 3.5 Crystal structure of HoFRK 85 3.6 Structure based sequence alignment of HoFRK 90 3.7 Stereo ... and the actual UDP ligand Superimposition of one docked-ADP ligand and the actual ADP ligand Superimposition of the catalytic regions of the open SPS-F6P complex (cyan) and the closed SPS-S6PUDP ... (magenta) Schematic diagram of the reaction between F6P and UDP-Glc in the binding cleft of SPS A schematic diagram of the reaction involving FRK and Fructose Top a) SDS-GEL image of purified FRK Bottom...
- 136
- 309
- 0
Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high throughput techniques
Ngày tải lên :
11/09/2015, 09:18
... comparison of transcriptome profiles of MV411 and THP-1 75 Figure 4.3 Hierarchical clustering of transcriptomic profiles of microarray data 78 Figure 4.4 Linear regression analysis of fold-changes of ... the FRB and the FATC domains, at the C-terminus of 17 the protein The HEAT domain mediates protein- protein interactions, and the FATC domains mediate the kinase activity of mTOR (Yang and Guan, ... understanding the mechanism of action of drugs (Li, et al., 2007; Frolov, et al., 2003) (Nunoda, et al., 2007) Transcriptomic techniques can survey the expression levels of thousands of genes and...
- 202
- 319
- 0
The mechanism of action of sprouty2 characterization of the interaction between sprouty2 and PKCdelta
Ngày tải lên :
14/09/2015, 14:06
... effect of Spry2 on ERK phosphorylation, and that its point of action is upstream of Ras 31 1.6.6.2 Upstream of Raf Some other studies offer an alternative view of the point of action of Spry ... the point of receptor-ligand binding, upstream of Ras, upstream of Raf, and at the level of or downstream of Raf (Guy et al., 2003; Kim and Bar-sagi, 2004) The study conducted by Casci and colleagues ... interacting partner of Spry2 The interaction between Spry2 and PKCδ was also found to be both specific and direct, and it depends on the conformation of the two proteins The binding of Spry2 and PKCδ does...
- 209
- 984
- 0