mechanism of action of p glycoprotein in relation to passive membrane permeation

Tài liệu Báo cáo khoa học: Three-dimensional structures of thermophilic b-1,4-xylanases from Chaetomium thermophilum and Nonomuraea ﬂexuosa Comparison of twelve xylanases in relation to their thermal stability pdf

Ngày tải lên : 20/02/2014, 23:20

... comparisons have shown that thermophilic proteins contain more arginines on the protein surface than mesophilic proteins [36–38] The effect of the large-scale increase in the number of arginines ... believed to form Ôsticky patchesÕ on the protein surface that may lead to protein aggregation [16] In addition, introduction of a single tyrosine into the N-terminal region has been reported to improve ... Engineering of multiple arginines into the Ser/Thr surface of Trichoderma reesei endo-1,4-beta-xylanase II increases the thermotolerance and shifts the pH optimum towards alkaline pH Protein...

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báo cáo hóa học: " Self-reported work ability of Norwegian women in relation to physical and mental health, and to the work environment" ppt

Ngày tải lên : 20/06/2014, 00:20

... health of female cleaning personnel in Norway J Occup Med Toxicol 2006, 1(1):24 Gamperiene M, Stigum H: Work related risk factors for musculoskeletal complaints in the spinning industry in Lithuania ... Suppl 1:94-98 Andrea H, Metsemakers JF, Kant IJ, Beurskens AJ, Swaen GM, van Schayck CP: Seeking help in relation to work visiting the Page of (page number not for citation purposes) Journal of ... LR, Lipman RS, Rickels K, Uhlenhuth EH, Covi L: The Hopkins Symptom Checklist (HSCL): a self-report symptom inventory Behav Sci 1974, 19(1):1-15 Winokur G: Psychosis in bipolar and unipolar affective...

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báo cáo hóa học:" Prevalence of visual impairment in relation to the number of ophthalmologists in a given area: a nationwide approach" ppt

Ngày tải lên : 20/06/2014, 15:20

... were applied to all regions It was not the intention of this paper to demonstrate or claim the need for a fixed ratio of ophthalmologists to inhabitants However, investment in healthcare is supposed ... confidence intervals Table 1: Prevalence of low vision in all populations (persons living at home or in institutions) 95% confidence interval n.e not estimable Age (years) Persons living in institution ... over-sampling method made it possible to describe the consequences of impairments in detail, since subjects with impairments were over-represented in the HandicapDependency survey Face -to- face interviews...

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Báo cáo lâm nghiệp: "Chemical composition of the periderm in relation to in situ water absorption rates of oak, beech and spruce fine roots" doc

Ngày tải lên : 08/08/2014, 01:21

... Moreover, comparison among different plant species revealed large differences in Lpr that partly seem to be species-specific According to root pressure probe data, the Lpr of roots of woody species ... sap flow measurements (see below) We applied compressed air (0.2–0.4 MPa) to completely expose the appending root systems without damaging fine rootlets and peridermal surfaces The sampled fine ... These numbers express the water absorption per total surface area of all appending branch roots (including root tips) distal to the gauge measuring point, and are equivalent to 0.38 (beech),...

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Báo cáo sinh học: "Breeding structure of Drosophila buzzatii in relation to competition in prickly pears (Opuntia ficus-indica)" potx

Ngày tải lên : 09/08/2014, 18:22

... irrelevant to explain genetic variation The presence of competition in natural populations of Drosophila has been inferred in several cases (eg, Fellows and Heed, 1972; Atkinson, 1979; Prout and ... does indeed differentially affect the various genotypes We report here an experiment designed to investigate the incidence of competition in Opuntia ficus-indica fruits (prickly pears) in the ... simulations to compare F-statistics from supplemented fruits with the expected values generated by various numbers of mating pairs contributing to a breeding site The main steps of our reasoning for...

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Báo cáo sinh học: "Phenotypic plasticity of body pigmentation in Drosophila: Breeding structure of Drosophila buzzatii in relation to competition in prickly pears (Opuntia ficus-indica)" potx

Ngày tải lên : 14/08/2014, 15:21

... irrelevant to explain genetic variation The presence of competition in natural populations of Drosophila has been inferred in several cases (eg, Fellows and Heed, 1972; Atkinson, 1979; Prout and ... does indeed differentially affect the various genotypes We report here an experiment designed to investigate the incidence of competition in Opuntia ficus-indica fruits (prickly pears) in the ... simulations to compare F-statistics from supplemented fruits with the expected values generated by various numbers of mating pairs contributing to a breeding site The main steps of our reasoning for...

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Báo cáo sinh học: "Reaction norms of size characters in relation to growth temperature in Drosophila melanogaster: an isofemale lines analysis" ppsx

Ngày tải lên : 14/08/2014, 19:22

... norms of reaction of the various lines are not parallel and exhibit different shapes The sex x line interaction means that there is some sexual dimorphism in the norms of reaction Within-line variability ... values are negative, indicating that the ratio decreases with increasing temperature In spite of the broad dispersal it is possible to conclude that the slope varies according to temperature (ANOVA, ... heritability of wing or thorax length (reviewed in Roff and Mousseau, 1987) The isofemale line technique also provides an opportunity to estimate the intrapopulation variability with the coefficient of intraclass...

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Báo cáo khoa học: " Germination of Pinus pinaster, P. radiata and Eucalyptus globulus in relation to the amount of ash produced in forest fires Otilia" doc

Ngày tải lên : 08/08/2014, 14:21

... massive opening of pine and eucalyptus fruits, and a large amount of seeds are released lyptus Most of the species of the genus Pinus not resprout, nor any of the species we studied: post-fire ... presence of ash is still unknown The aim of this experiment was to analon the seed germination of Pinus pinaster Aiton, Pinus radiata D Don and Eucalyptus globulus Labill and yse the effect of ... behave like opportunistic species which are capable of invading open sites without the presence of aggressive competitors [4, 25, 28, 35] In the event of fire, both the seeds held in the aerial...

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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

Ngày tải lên : 16/02/2014, 09:20

... to understand the precise mechanism by which geﬁtinib induces apoptosis in a Bax-dependent manner Inhibitor of apoptosis protein family Induction of MOMP following apoptotic stimuli results in ... inhibitor of the EGFR tyrosine kinase, has been shown to result in a dose-dependent up-regulation of p2 7KIP1 and in hypophosphorylation of the RB protein in human epidermoid carcinoma cell line ... both protein kinases, such as MAPK kinase (MKK4) or MAPK kinase (MKK7) and protein phosphatases such as MAPK phosphatase (MKP) Mitogen-activated protein kinase phosphatase1 (MKP-1) is a dual-speciﬁcity...

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Tài liệu Rubber plantation performance in the Northeast and East of Thailand in relation to environmental conditions docx

Ngày tải lên : 21/02/2014, 04:20

... also in land preparation for rubber planting Tap: Number of tapping days, Rest: Number of rest days following tapping days Agroforestry 44 Apart from available support, other motives for rubber planting ... seem interesting, from an economical point of view, to delay the opening age for tapping and accept a reduction in latex production in order to improve rubber wood production In the present study, ... tapping practices varied at plantations However, latex tapping was always stopped for the wintering period of rubber trees which falls between January and May This was the practice due to poor...

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Báo cáo khoa học: Conservation of the egg envelope digestion mechanism of hatching enzyme in euteleostean ﬁshes pot

Ngày tải lên : 06/03/2014, 02:20

... from hatching FhZPC3 SVPVVRflTSQAA Pro-X-Y region PSYP QTPSflYPQQ PQYP SKPQflYPNP PQTP PNPQTPPS PSKP TPPSKPQY PQQP SYPQQPQT PQKP QQPQKPSY Fig FHCE1 ⁄ cleavage sites found in the Pro-X-Y repeat region ... (nmolÆ30 min)1Ælg protein)1) Substrate Sequence FHCE1 ⁄ cleavage sites FhZPB1 PSKRPEflAPGVP FhZPB3 YPSKPQflTPTET FhZPC1 QSPPTQflNQQQL FLCE cleavage sites FhZPB2 EVLPLDflNPPPA FhZPC2 VPFELRflYPVPA Cleavage ... supernatant was applied to the reverse phase HPLC system Seven major peaks were obtained and subjected to N-terminal sequencing and MALDI-TOF-MS We obtained sequences such as YPQQPQ, YPSKPQ, YPNPQ,...

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Báo cáo khoa học: Nucleosome positioning in relation to nucleosome spacing and DNA sequence-speciﬁc binding of a protein doc

Ngày tải lên : 16/03/2014, 10:20

... inactivation often involves binding of a single activator molecule to its site in a repressive chromatin structure [37] Thus, the binding of proteins at singular sites in an array of densely packed and ... used to predict whether a positioned nucleosome would be involved in juxtaposing two known distant sites for the productive interaction of the protein factors binding to them Experimental procedures ... that of the wild-type lac repressor but fails to tetramerize [29] Binding of R3 protein to a plasmid DNA pU6LNS (two lac operators at a distance of 183 bp) was reported A B Fig Relative positions...

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Báo cáo khoa học: Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity docx

Ngày tải lên : 23/03/2014, 13:20

... protein accelerates the binding of LPS to CD14 J Exp Med 179, 269–277 Tobias PS, Soldau K, Gegner JA, Mintz D & Ulevitch RJ (1995) Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide ... LBP-mediated intercalation of the synthetic lipid A analogs into phospholipid liposomes corresponding to the composition of the macrophage membrane, derived from the increase of the ratio of the donor ... liposomes corresponding to the composition of the macrophage membrane, phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine and sphingomyelin in a molar ratio of : 0.4 : 0.7 : 0.5 [12]...

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Báo cáo " Characteristics of Quaternary sedimentary facies in relation to water bearing capacity of aquifers and aquicludes in the Red River Delta, Vietnam " ppt

Ngày tải lên : 28/03/2014, 15:20

... clay of lagoonal facies in the central part passing into silty clay of flood plain, oxbow, coastal swamp and peat facies in the direction from the plain to the modern coastline. ... sand of plain river bed facies and changing upwards into finer sediments consisting mainly silty clay mixed with fine sand of flood plain facies and clay of lagoonal facies. Depth ... swamp facies of Hai Hung Formation in the upper sequence and the fine sediments of deltaic and marine facies of Vinh Phuc Formation in the lower sequence. The sediment of Vinh Phuc ...

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LEGENDS OF BABYLON AND EGYPT IN RELATION TO HEBREW TRADITION doc

Ngày tải lên : 29/03/2014, 02:21

... he was put in a coffin in Egypt" Since it formed the subject of prophetic denunciation, I refrain for the moment from citing the notorious adoption of Assyrian customs at certain periods of the ... (1916), pp 161 ff.; and cf Gardiner, Journ of Egypt Arch., III, pp 143 ff., and Petrie, Ancient Egypt, 1916, Pt III, pp 114 ff (2) Cf Petrie, op cit., pp 115, 120 From the fragment of the stele preserved ... Crown of the South We have then to with kings of Upper Egypt, not the Delta, and it is no longer possible to suppose that the predynastic rulers of the Palermo Stele were confined to those of Lower...

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Báo cáo khoa học: Modulation of P-glycoprotein-mediated multidrug resistance by acceleration of passive drug permeation across the plasma membrane potx

Ngày tải lên : 30/03/2014, 04:20

... lipid matrix into the protein that may permit access of substrates to the core of the protein [24–28] The anesthetics could facilitate the incorporation of drugs into the inner leaflet of the plasma ... subline was maintained in the presence of 0.5 lm doxorubicin Continuous monitoring of daunorubicin cellular transport Uptake and efflux of the anthracycline daunorubicin was assayed by monitoring ... The extent of fluorescence quenching upon binding of daunorubicin to DNA was determined by exposure of daunorubicin to saturating amounts of DNA, which resulted in quenching of 94% of the fluorescence...

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Báo cáo khoa học: "A CONSIDERATION ON THE CONCEPTS STRUCTURE AND LANGUAGE IN RELATION TO SELECTIONS OF TRANSLATION EQUIVALENTS OF VERBS IN MACHINE TRANSLATION SYSTEMS" doc

Ngày tải lên : 31/03/2014, 17:20

... a pair of verb and associated translation equivalent ( D o , Play : ~ - & ) that can be associated in common to a part of the structure of the categories as in Fig.l, and then find appropriate ... determined by pairs of verbs and nouns to each other So we need to study the problem of selection of translation equivalent also from this point of view Reference (i) Sho Yoshida : Conceptual ... the nouns belonging to nearby categories in the given concepts structure and find a nouns group to which we associate the translation equivalent In this manner, we can find pairs of verb and its...

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báo cáo hóa học: " Sense of coherence as a resource in relation to health-related quality of life among mentally intact nursing home residents – a questionnaire study" pot

Ngày tải lên : 18/06/2014, 19:20

... face -to- face interviews The interview took place in the respondent's room or at another appropriate location in the nursing home The principal investigator (JD) recorded the demographic information ... by supporting them in maintaining their close relation- Page of (page number not for citation purposes) Health and Quality of Life Outcomes 2008, 6:85 ships and by providing emotional support, ... tested for interaction with SOC using the corresponding interaction term in the general linear model We performed an exploratory examination of the interactions because we suggest, according to the...

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báo cáo hóa học: " The assessment of health-related quality of life in relation to the body mass index value in the urban population of Belgrade" potx

Ngày tải lên : 18/06/2014, 19:20

... divided into two major categories: any form of exercise, excluding walking, lasting a minimum of 30 minutes per day, and walking alone, again for a minimum period of 30 minutes Both groups where ... (p < 0.001; p < 0.01; p < 0.05) In obese women, scores for physical functioning (p < 0.001), role-physical (p < 0.001), bodily pain (p < 0.001), social functioning (p < Page of 10 (page number ... a nutritional status, appears to have little impact on the subjective perception of physical health in male subjects, except in the realm of physical functioning, a finding also borne out by other...

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báo cáo hóa học: " Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia" docx

Ngày tải lên : 19/06/2014, 22:20

... Leonoudakis D, Zhao P, Beattie EC: Rapid tumor necrosis factor alphainduced exocytosis of glutamate receptor 2-lacking AMPA receptors to extrasynaptic plasma membrane potentiates excitotoxicity J Neurosci ... apoptotic changes such as membrane blebbing and formation of apoptotic bodies Apoptosis due to forced loss of intracellular K+ can be induced by ionophores or K+ channel activators [24-26] In ... with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder Neuropsychobiology 2002, 46:76-84 12 Singh VK: Plasma increase of interleukin-12...

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