manual whole cell patch clamping of the herg cardiac k channel
Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
... not block the activity of another IKK isoform, IKK1 Consequently, IjBa may still be phosphorylated by the IKK1 isoform when the IKK1 isoform is present and activated in the system Another could ... 2588325891 50 Huynh QK, Kishore N, Mathialagan S, Donnelly AM & Tripp CS (2002) Kinetic mechanisms of IkappaBrelated kinases (IKK) inducible IKK and TBK-1 differ from IKK-1 IKK-2 heterodimer J ... in the NF-jB activation cascade typically consists of two catalytic subunits [24,25], IKKa (IKK1) and IKKb (IKK2) [2629] and a regulatory unit NF-jB essential modulator (NEMO, IKKc) [3033] The...
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Báo cáo hóa học: " The role of single N-glycans in proteolytic processing and cell surface transport of the Lassa virus glycoprotein GP-C" ppt
... we determined the effect of the individual N-glycans on the maturation cleavage by analysing the presence of the cleaved subunit GP-2 Disruption of the N-glycosylation sites within the GP-1 mutants ... In order to investigate the importance of the individual N-glycosylation sites of Lassa virus GP-C for intracellular trafficking we analysed cell surface expression of the mutated glycoproteins ... is also transported to the cell surface of SKI-1/S1P deficient cells (data not shown) The finding that only an endo H-sensitive form of Lassa virus GP-C was found at the cell surface suggests...
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Báo cáo lâm nghiệp: "Leaf and whole-plant water relations of the Patagonian conifer Austrocedrus chilensis (D. Don) Pic. Ser. et Bizzarri: implications on its drought resistance capacity" ppt
... representative of the environmental extremes of the species distribution They were bred in a greenhouse in the EEA INTA Bariloche, Argentina In addition, we carried out some of these measurements ... 7.79 ± 0.45 kg m–1 MPa–1 s–1, respectively) and lower (P < 0.05) for the mesic site (4.34 ± 0.67 kg m–1 MPa–1 s–1) Differences between plants of the mesic site and those of the other two sites ... Picea abies (L.) Karst [12] In this group of trees the value of ψxylem which provokes 10% loss of hydraulic conductivity also lead to a 90% of stomatal closure In conclusion, these and previous...
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Báo cáo y học: "B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren''''s syndrome" ppt
... Tsunawaki S, Nakamura S, Ohyama Y, Sasaki M, Ikebe-Hiroki A, Hiraki A, Kadena T, Kawamura E, Kumamaru W, Shinohara M, et al.: Possible function of salivary gland epithelial cells as nonprofessional ... fibroblast-like synoviocytes of patients with RA [45] Our results agree with findings of the absence of a major role of TNF-α in the pathogenesis of pSS, as illustrated by the lack of efficacy of TNF-α ... the possibility of contamination with myeloid cells, B cells, T cells or myoepithelial cells (Figure 2d–h) The HSG cell line had exactly the same staining pattern as epithelial cells from patients...
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Báo cáo khoa học: "Extrapulmonary small cell sarcinoma: involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans" ppsx
... version to be published Acknowledgements The reporting of this case was approved by the Ethics committee of St Louis University as the consent of the patient or the next of kin could not be obtained ... small cell carcinoma: A single-institution experience and review of the literature Ann Oncol 1994, 5(10):909-913 Kim JH, Lee S, Park J, Kim HY, Lee SI, Nam EM, Park JO, Kim K, Jung CW, Im YH, Kang ... blood cell count are the major prognostic factors that correlate with mortality [4,10] Optimal management is not well characterized because of the rarity of these tumors, and the lack of randomized...
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Báo cáo y học: "Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study" pptx
... 59:225-49 The data base of Japanese Ministry of Health, Labor and Welfare [http:// www.mhlw.go.jp/toukei/saikin/hw/jinkou/geppo/nengai09/kekka3.html] The data base of National Cancer Institute at the ... common characteristics of LCNEC and SCLC The preferential expression of the cancer stem cell markers in LCNEC over SCLC suggests that the mechanism of increasing the extent of malignancy in LCNEC ... another, we noticed that AL1A1 [16,17], AK1C1 [18], AK1C3 [19] and CD44 [20] have been proposed to be the markers of cancer stem cells Their expression in tumor cells could correlate with their...
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Báo cáo y học: " Small cell neuroendocrine tumor of the breast in a 40 year-old woman: a case report" pps
... Shimazaki H, Aida S, Tamai S, Tamaki K, Hiraide H, Mochizuchi H, Matsubara O: Primary small cell (oat cell) carcinoma of the breast: report of a case and review of the literature Histopathology 2001, ... revisions of the samples, one by the Pathology Department of "M Malpighi" Hospital in Bologna and one by the Pathology Department of the Oncologic Institute in Milan (IEO) confirmed the diagnosis ... Discussion Small cell (oat cell) neuroendocrine cancer of the breast is a rare tumor with fewer than 30 cases reported in the literature The morphological and immunohistochemical patterns of this tumor...
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Báo cáo y học: "Undifferentiated giant cell type carcinoma of the gallbladder with sarcomatoid dedifferentiation: a case report and review of the literature" ppsx
... osteoclast-like giant cells Am J Gastroenterol 1995, 90(7):1177-1179 Ikeda T, Seki S, Maki M, Noguchi N, Kawamura T, Arii S, Igari T, Koike M, Hirokawa K: Hepatocellular carcinoma with osteoclast-like ... suggestive of their probable histogenesis CAM5.2 is a keratin mixture, containing a range of cytokeratins between 39 kd and 50 kd, which is a strong marker for the epithelial origin of a tumour ... to explain the origin of osteoclast-like giant cells Immunohistochemical analysis has demonstrated the giant cells to be of histiocytic origin lacking of epithelial differentiation These findings...
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Báo cáo y học: "Perivascular epitheloid cell tumour (PEComa) of the retroperitoneum – a rare tumor with uncertain malignant behaviour: a case report" ppsx
... revision of the article KAG contributed to the clinical management of the patient and gave approval for the final write up YKV assisted in performing the surgery and helped in drafting the article ... impression of an old haematoma On frozen sections, it became obvious that the wall of the cystic mass consisted of nests of tumour cells with a uniform, spindle shape There were no overt signs of malignancy ... D2-40 decorated the endothelial linings of the numerous vessels The diagnosis of a tumour with perivascular epitheloid cell differentiation, a so-called PEComa, was made Based on the histological...
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Single channel and whole cell electrophysiological characterizations of l type cav1 2 calcium channel splice variants relevance to cardiac and nervous system functions
... highlight the advantages of the cell attached mode of single -channel recordings in relation to the whole cell technique 1.5 Single -channel vs whole cell recordings in cardiovascular studies Studying the ... To detach the adherent cells from the flask, ml of a 0.05% trypsin was pipetted into the flask and removed immediately after The HEK 293 cells were trypsinised for at 37 °C, 5% CO2 and the reaction ... at the single -channel level is a powerful tool to help further dissect the mechanisms to account for alterations in whole- cell channel properties in alternative splice variants of the CaV1.2 channels...
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Báo cáo hóa học: " Prognostic utility of the acute cardiac ischemia time-insensitive predictive instrument (ACI-TIPI)" pptx
... the hospital This likely explains the higher event rate and lower sensitivity of ACI-TIPI seen in the data presented here Thirty-day MACE was not assessed in either of these studies The aim of ... infarction was defined as the ‘’detection of rise and/or fall of cardiac troponin with at least one value above the 99th percentile of the upper reference limit together with evidence of myocardial ischemia ... performed the statistical analyses, and edited the manuscript UH participated in the study design and edited the manuscript VN participated in the design of the study, provided oversight of the primary...
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Báo cáo hóa học: "Research Article An MMSE Approach to the Secrecy Capacity of the MIMO Gaussian Wiretap Channel" ppt
... det I + SKr − log det I + SKe 2 (13) Kx S Kr Ke = = ≤ Ke Kr Ke Kr Ke Kr Ke K 1 (EG − E0 )K 1 dK K 1 EG K 1 dK, −1 + det Ke log det Kr 1 − − log det I + SKr − log det I + SKe 2 Kr (16) The General ... I(U; Ye ) ≤ ≤ −1 K0 Ke K0 Ke −1 K EL K M = CT C2 − CT C1 CT C1 2 dK K 1 Kx − Kx (Kx + K) −1 Kx K 1 dK = 1 − − log det I + Kx K0 − log det I + Kx Ke 2 ≤ (B.7) C Proof of Lemma Since the sub-matrix ... function G with gradient ∇G the line integral (type II) [18] is given by K0 K0 Ke K 1 EK −1 dK K 1 EL − E0 K 1 dK K 1 EL K 1 dK Ke (B.1) K 1 E0 K 1 dK K 1 EL K 1 dK, where the last inequality is again...
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Báo cáo toán học: "A Presentation of the Elements of the Quotient Sheaves Ωk /Θk in Variational Sequences" pdf
... · + k We denote by pk : k → k the morphism of sheaves defined by pk ρ = ρq , r,q r r+1 r,q for ≤ q ≤ k k = ker pk , ≤ k ≤ n, is the sheave of contact k- forms r,0 r(c) k = ker pk r ,k n , ... ∧ k n + t=1 l=1 σ σ t+1 k n−1 ∧ wit+1 ∧ ∧ wik−n−1 ∧ w k n ∧ wik−n i i σ σ k n k n−1 Since fσ1 k n wi11 ∧ ∧ wik−n−1 ∧ w k n ∧ wik−n ∈ k 1 , we have σ σ1 k n k i1 ik−n τ3 pk 2 ,k n (fσ1 k n ... ik−n d(wi11 ∧ ∧ wik−n−1 ∧ w k n ∧ wik−n ) k n k n−1 σ σ σ t−1 i (−1 )k n+t fσ1 ik−n wi11 ∧ ∧ wit−1 ∧ dwitt ∧ k n + t=1 σ σ t+1 k n−1 ∧ wit+1 ∧ ∧ wik−n−1 ∧ w k n ∧ wik−n k n = (−1) (14) k n−1...
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Báo cáo toán học: "A refinement of the formula for k-ary trees and the Gould-Vandermonde’s convolution" pps
... , an = n k n k= 0 −ak − m −an − m bk z n k , −an − m n k (9) we obtain Corollary 3.6 For n > 0, n (−1)n Cβ,γ (n) = k= 0 (1 − β )k − α (1 − β)n − α (1 − β)n − α n k the electronic journal of combinatorics ... Figure 1: An example of above involution for n = 6, α = 1, β = 3, the tree on the left side is of the first class while the other belongs to the second class For simplicity of the remaining presentment, ... 0: • The first class consists of trees in which there is at least one colored leaf in the lowest two levels (the two levels furthest to the root) and to the left of which all vertices in the same...
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Characterisation of alternative splicing of the cav1 4 calcium channel gene
... student) for the work rendered during the course of the attachment ii TABLE OF CONTENTS ACKNOWLEDGEMENTS i TABLE OF CONTENTS iii LIST OF PUBLICATIONS vii ABSTRACT viii LIST OF TABLES x LIST OF FIGURES ... depolarisation of an excitable cell activates VGCC The opening of the channel pore allows an influx of calcium ions into the cytosol that coordinates a plethora of responses like neurotransmitter ... engineered truncations of the CaV1.4 after the IQ motif also restored CDI to this channel The CDI of both the K1 591X mutant and the truncated Cav1.4 are CaM-dependent as coexpression with the dominant-negative...
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core competence of the corp C k prahalad g hamel
... residents of an underdeveloped country hiding most of their cash under their mattresses The benefits of competencies, like the benefits of the money supply, depend on the velocity of their circulation ... as on the size of the stock the company holds Western companies have traditionally had an advantage in the stock of skills they possess But have they been able to reconfigure them quickly to ... terms of the price/performance of end products are courting the erosion of core competencies—or making too little effort to enhance them The embedded skills that give rise to the next generation of...
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Báo cáo y học: "Formulation of a killed whole cell pneumococcus vaccine - effect of aluminum adjuvants on the antibody and IL-17 response" pps
... of mice with a whole cell pertussis vaccine induced Th17 cells, whereas these cells were not induced by the acellular vaccine [29,30] The role of adjuvants was not specifically addressed in these ... These studies for the first time demonstrate that the type of aluminum-containing adjuvants (AH vs AP) affects the magnitude and quality of the antibody response as well as the Th17 CD4 + T cell ... form of the Langmuir equation The adsorptive coefficient was calculated as the slope/intercept and the adsorptive capacity was calculated as the reciprocal of the slope Statistical analysis The...
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Báo cáo y học: "Spindle Cell Lipoma of the Hypopharynx"
... is possible, as the histological characteristics of SCL are similar to those of liposarcoma 2,8; however, uniformity of the spindle cells, lack of lipoblasts, and presence of thick mature collagen ... L Benign neoplasms of the larynx Otolaryngol Clin North Am 1984; 17: 151-178 Wenig BM Lipomas of the larynx and hypopharynx: a review of the literature with the additional of three cases J Laryngol ... indistinct symptoms5,7 481 In this case, the feeling of a mass in the throat without dysphagia was the only symptom of large pyriform sinus lipoma The preferred method of treatment for laryngeal and hypopharyngeal...
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Tài liệu Publication Manual of the American Psychological association_1 docx
... the general class of methods being discussed; the essential features of the proposed method; the range of application of the proposed method; and in the case of statistical procedures, some of ... requesting the data, it may be used by the person requesting the data and individuals the requestor directly supervises, or there are no limits on the further distribution of the data) Furthermore, the ... results is the scientific journal The scientific journal is the repository of the accumulated knowledge of a field The findings and analyses, the successes and failures, and the perspectives of many...
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