manipulating the fragile x mental retardation proteins in the frog
Tài liệu Essentials of Psychiatric Mental Health Nursing in the BSN Curriculum: Collaboratively Developed by ISPN and APNA, (2007-2008) approved 5/08 ppt
Ngày tải lên :
14/02/2014, 13:20
... families in interpreting and evaluating research findings Utilize research findings in planning and evaluating care practices 9 **DEFINITIONS OF COLUMN HEADINGS CORE NURSING CONTENT –.Evident in general ... of informatics in psychiatric nursing Principles of teaching/learning theories as they relate to patients with psychiatric disorders including psychoeducational approaches Principles of clinical ... Psychiatric -Mental Clinical Nursing Practice (2007) address the trends for an increased awareness of physical health problems in the mentally ill living in the community It is quite clear that the psychiatric/mental...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
Ngày tải lên :
18/02/2014, 16:20
... FDX1 (Fig 9A), confirming the role of endogenous FDX + FDXR in supporting the activity To further confirm the role of endogenous FDX + FDXR in supporting the catalytic activity, we transformed the ... located inside the innermembrane compartment In the third approach, we used alkaline Na2CO3 extraction to determine whether mitochondrial CYP2E1 is a membrane-intrinsic or membrane-extrinsic protein ... ferredoxin (FDX) + ferredoxin reductase (FDXR), homologs of mammalian ferredoxin and ferrodoxin reductase [27,28] Results Expression of intact and truncated rat CYPs in Saccharomyces cerevisiae The...
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Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebrafish pptx
Ngày tải lên :
19/02/2014, 00:20
... of the TGF-b family, binding to and inhibiting these signaling molecules from binding to their receptors in the extracellular space, thus inhibiting ventralizing activities Of these proteins, ... remain unresolved for some time Other factors affecting the BMP pathway Factors inhibiting BMP2b, other than direct binding proteins such as Noggin and Chordin, also affect dorsoventral patterning ... overexpressed in the embryo, cause dorsalization of the embryo chordin, as in Xenopus embryos, is expressed in the dorsal embryonic shield [13] (Fig 2), which corresponds to the organizer region in frog In...
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Tài liệu Báo cáo khoa học: Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae docx
Ngày tải lên :
19/02/2014, 07:20
... the proteins of the outer membrane, we set out to determine what proportion was integral and to identify the major protein species To determine whether the major outer membrane proteins were integral ... the proteins present in the aqueous extract (‘Aq’), the detergent phase (‘D’) and the phospholipid-rich pellet (‘P’) Arrowheads designate the size of proteins enriched in the lipid-rich pellet including ... of the Om14 sequence that predicts two or three a-helical transmembrane segments, in support of the behavior of the protein in Triton X- 114 The transmembrane segments A Integral proteins in the...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
Ngày tải lên :
07/03/2014, 01:20
... STARS-interacting proteins These novel proteins contain four LIM domains and a C-terminal villin headpiece domain, which mediates actin-binding in several proteins, such as villin and dematin [59] ... Direct a-actinin-2 ()) Bundling proteins Coactivator Supervillin NLS F-actin- and membraneassociated scaffolding protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin ... chromatin-remodeling complexes contain actin, actin-related proteins and ⁄ or ABPs Nuclear actin-related proteins (ARP5–9) are associated with actin in chromatin-remodeling complexes of the SWI...
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Báo cáo khoa học: Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway docx
Ngày tải lên :
07/03/2014, 21:20
... of the genes encoding Cg-BMPR1 and Cg-TGFbsfR2 is shown in Fig 2C The serine ⁄ threonine kinase domain in both proteins is encoded by two exons equivalent to kinase subdomains X and XI [22] In ... ancestral kinase gene that encoded sections X and XI of the receptor serine ⁄ threonine kinase domain [22] Another striking point is the phase conservation of the intron– exon boundaries that lie either ... clarify the binding properties of each of these domains we generated synthetic mRNA encoding only the C1 or C2 domains Expression of only the C1 domain resulted in the dorsalization of embryos in...
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Báo cáo khoa học: Esculentin-1b(1–18) – a membrane-active antimicrobial peptide that synergizes with antibiotics and modifies the expression level of a limited number of proteins in Escherichia coli doc
Ngày tải lên :
16/03/2014, 00:20
... £ 0.5 indicates synergy; see Experimental procedures] To obtain insights into the mode of action underlying the synergistic activity, we investigated the bactericidal action of the combination ... (p0), the peptide (0.1–2 lm) was injected into the subphase, and the increment in surface pressure of the LPS film upon intercalation of the peptide dissolved in the subphase was monitored for the ... modify, within 20 min, the expression levels of a limited number of bacterial proteins, at either lethal or sublethal concentrations These findings rule out the possibility that variations in the production...
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Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx
Ngày tải lên :
16/03/2014, 11:20
... signal peptide in the 24-kDa a-zein and the 19-kDa a-zein endosperm storage proteins, respectively These mutant proteins are translocated into the lumen of the ER, but remain anchored to the membranes ... pivotal role of the UPR is to maintain ER homeostasis Therefore, the presence of mutated proteins that are unable to fold into their native conformation in the ER induces the UPR in an effort to ... transcriptional response in fl-2 may be induced by the UPR, as the change in the pattern of gene expression was restricted to the endosperm in which the mutant a-zein was synthesized The expression pattern...
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Báo cáo khoa học: The consensus motif for N-myristoylation of plant proteins in a wheat germ cell-free translation system ppt
Ngày tải lên :
29/03/2014, 21:20
... corresponding to the N-terminal fragment of either protein that retained the initiating Met in the presence or absence of myristic acid These results thus confirmed removal of the initiating Met ... N-myristoylated proteins contain a myristoylation motif, generally defined as Met1-Gly2-Xaa3Xaa4-Xaa5-Ser ⁄ Thr6-Xaa7-Xaa8 (where Xaa indicates any amino acid), at their N-terminus [18] This motif interacts ... N-terminal sequence conservation We examined the N-terminal sequences of these 80 proteins, and categorized them into four groups: 18 proteins (22.5%) without Ser6 and Lys7, designated the Met-Gly-Xaa-Xaa-Xaa-[^Ser]-[^Lys]...
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Báo cáo khoa học: New insights into Fragile X syndrome Relating genotype to phenotype at the molecular level docx
Ngày tải lên :
30/03/2014, 15:20
... consensus in the Fragile X field on either the structural or functional consequences of the mutation Because of the limitations in working with humans, Fragile X studies have expanded to other organisms ... of dFXRP resembles the combined expression pattern of mammalian FMRP and FXR proteins [20,22], adding support to the hypothesis that dFXRP is a functional homolog of human FMRP and FXR proteins ... pheonotype in Fragile X syndrome Dreyfuss and colleagues introduced the I307N point mutation in dFXRP (the equivalent of I304N in human FMRP) [20] Wild-type dFXRP and dFXRP(I307N) were overexpressed in...
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báo cáo hóa học:" Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patients" potx
Ngày tải lên :
18/06/2014, 15:20
... receptor; (IGFBP-3): Insulin-like Growth Factor Binding Protein-3; (IGFBP-4): Insulin-like Growth Factor Binding; Protein-4; (MAPK): Mitogen-activated protein kinase; (IMCG): Interdisciplinary Melanoma ... Cohen P: The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action Endocrinol Metab Clin North Am 1996, 25(3):591-614 Rajaram S, Baylink DJ, ... antibodies, or tyrosine kinase inhibitors Several of these drugs are currently in Phase I trials as single agents or in combination with chemotherapy [7-11] A critical aspect in the design of these trials...
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Báo cáo y học: "Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff" pptx
Ngày tải lên :
09/08/2014, 08:22
... present between the lobular elements in the supporting reticular tissue of the bursa and the supraspinatus tendon fibers reaching into the basal portion of the organ, in addition to the dense connective ... standardization The regression curve has the function f (x) = -3. 9x + 42.5 The dashed lines indicate the 95% confidence intervals Moreover, two aliquots were prepared containing cDNA from a bursa sample, in ... towards or within the tendon Elements staining positive included reticular fibers, dense connective tissue fibers proximal to the tendon, and the tendon (Figure 2c) Safranin O staining, an indicator...
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Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites potx
Ngày tải lên :
09/08/2014, 20:20
... in saline at 37°C, washed × in saline and × in RPMI1640 containing 100 µg/ml penicillin and 100 U/ml streptomycin Worms were incubated with 10% gentamicin for 20 and then washed a further × in ... parasite secreted proteins indeed acquired signal peptides, or have free-living lineages lost these motifs in the genes in question? Is more rapid diversification of secreted proteins a specific ... compartments within the worm However, the extent to which signal-peptide-bearing proteins are truly exported by these multicellular organisms will be clarified by current proteomic analyses on proteins secreted...
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báo cáo khoa học: "Search for age-dependent as compared to mutagen-induced mutations on the X-chromosome affecting viability in" pdf
Ngày tải lên :
09/08/2014, 22:22
... lines derived from middle-aged mothers Rapid extinction occurred in the line maintained by senile mothers In spite of an extensive search for such « Lansing effects in Drosophila (COMFORT, 1953 ; ... mutations in the gametes of aged parents ANSING L (1954) using the rotifer Philodina citrina showed that the mean life span of offspring decreased successively in each generation in lines derived ... occur no or a The observed decline in both male and female offspring with increased paternal and the dramatic increase in sterility, may reflect the general decline in vitality and age increased...
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báo cáo khoa học: "Structure and expression of the maize (Zea mays L.) SUN-domain protein gene family: evidence for the existence of two divergent classes of SUN proteins in plants" pot
Ngày tải lên :
11/08/2014, 11:21
... proteins reside or function in the NE remains to be determined In addition to their difference in size and SUN domain locations, these protein subfamilies are distinct in other interesting ways ... NE-associated proteins The plant proteins that most closely resemble the founding members of the SUN-domain protein family are those encoded by the CCSD genes The plant CCSD proteins exhibit conserved ... ancient divergence of these two classes These data also suggest that the PM3 proteins originated early in the life of the plant kingdom, predating the origin of flowering plants The second, four orthologous...
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Báo cáo y học: " Risk of malnutrition is associated with mental health symptoms in community living elderly men and women: The Tromsø Study" pdf
Ngày tải lên :
11/08/2014, 15:22
... included in the invitation to the survey The questionnaire was completed by participants at home and handed in at the study centre The SCL-10 questions explored the presence and severity of the ... described, whereas the medium and high risk categories are combined in the analyses in Figure BMI was divided into six categories in order to include the World Health Organization definitions of overweight ... included in the analysis The mean age of the participants included in the study sample was lower than that of the non-attending persons, and the mean age was also lower than that of the participants...
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Báo cáo y học: " Standards of lithium monitoring in mental health trusts in the UK" pot
Ngày tải lên :
11/08/2014, 16:22
... may influence monitoring rates These include variation in the willingness of patients to have blood tests [15,16], and either receiving inadequate information about lithium treatment and the ... tests in the previous year, thus meeting the QOF standard, while 30% had or more tests in the last year, reaching the NICE standard With respect to tests of renal function, which included creatinine, ... also indicates the relationship between each these variables and the extent to which the audit standards derived from the NICE guidance were being met The sample Four hundred and thirty six clinical...
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Báo cáo y học: " Study protocol for the development of a European measure of best practice for people with long term mental health problems in institutional care (DEMoBinc)" pptx
Ngày tải lên :
11/08/2014, 17:20
... standard setting agencies in the participating countries including the practicalities of incorporating the toolkit into existing review systems for institutional care The development of a computerised ... nature of the unit/institution being assessed This does not restrict scores being used for individual domains The toolkit will be further refined in response to suggestions from the Principal Investigators ... http://www.biomedcentral.com/1471-24 4X/ 9/36 face interview with the institution's manager The toolkit is refined in response to inter-rater reliability testing, feedback from interviewers and interviewees regarding its utility,...
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báo cáo khoa học: " The Puf family of RNA-binding proteins in plants: phylogeny, structural modeling, activity and subcellular localization" potx
Ngày tải lên :
12/08/2014, 03:21
... gene locus name (Atxxxxxxx) The rice clones are identified by their gene locus name only (Osxxxxxxxx), as standardized Pum gene designations have not yet been established Maximum likelihood bootstrap ... PUM-HD binding to the NRE1 (Kd ~0.5 nM; [34]), but within the range observed for other Puf protein interactions with their cognate RNAs [21,28] The binding affinity of the protein to the mutant ... present in the 1000 nM and 2000 nM samples, indicating that the low affinity binding of the AtPum-HD to the RNA resulted in a dissociation of the complex during electrophoresis Thus, the instability...
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