management of brain metastasis in melanoma patients

Báo cáo khoa học: " Whole brain radiation therapy in management of brain metastasis: results and prognostic factors" ppsx

... risk of developing brain metastases varies according to primary tumor type, with lung cancer accounting for approximately one half of all brain metastases [2] The prognosis of patients with brain ... randomized trial of surgery in the treatment of single brain metastases to the brain N Engl J Med 1990, 322:494-500 Wronski M, Arbit E, McCormick B: Surgical treatment of 70 patients with brain metastases ... one to three brain metastases In the RTOG 95-08, SRS after WBRT has been validated with level evidence as a standard of care option in the management of patients with single brain metastases...

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Báo cáo y học: "Management of HBV Infection in Liver Transplantation Patients"

Danh mục: Y học thưởng thức

... absence of detectable HBV DNA at the time of OLT and absence of reinfection for a minimum of months post-OLT After one year, reinfection occurred in 20% of patients in each group, but the finding of ... prospective study of indefinite LAM pre-OLT therapy, 32 of 154 patients (21%) died and 25 of the 32 deaths occurred within months of initiating therapy [52] Bilirubin, creatinine and detectable ... of HBV, a lower trough level of 100-150 IU/L has been considered protective if maintained indefinitely [7,72] In the initial multicenter, European report, the rate of recurrent infection in patients...

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báo cáo hóa học:" Validation of a HLA-A2 tetramer flow cytometric method, IFNgamma real time RT-PCR, and IFNgamma ELISPOT for detection of immunologic response to gp100 and MelanA/MART-1 in melanoma patients" doc

Danh mục: Hóa học - Dầu khí

... their intended use: detection of CD8+ T cell response in melanoma patients Post-treatment PBMC obtained from three melanoma patients treated in an IRB approved melanoma vaccine protocol of the ... recovery of an analyte in biological matrix (matrix effect) is defined as the direct or indirect alteration or interference in response due to the presence of unintended analytes or other interfering ... presenting cells (APC) in real time RTPCR and ELISPOT analysis Proof of principle studies were performed using frozen PBMC from three melanoma patients (kindly provided by Dr Francesco Marincola,...

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Báo cáo sinh học: "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pot

Danh mục: Hóa học - Dầu khí

... Neuroserpin was used as a continuous variable since there was a linearity of the odds ratios for outcome The influence of neuroserpin decrease at 24 h on serum levels of molecular markers of brain injury ... defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints The primary endpoint was the decrease of ... http://www.translational-medicine.com/content/9/1/58 our group obtained after investigating neuroserpin effects using an in vitro model of brain ischemia [40] The information reported here regarding biomarkers...

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báo cáo hóa học:" Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pdf

Danh mục: Hóa học - Dầu khí

... Neuroserpin was used as a continuous variable since there was a linearity of the odds ratios for outcome The influence of neuroserpin decrease at 24 h on serum levels of molecular markers of brain injury ... defined as neuroserpin decrease All determinations were carried out in a laboratory blind to the clinical outcome and neuroimaging findings Endpoints The primary endpoint was the decrease of ... http://www.translational-medicine.com/content/9/1/58 our group obtained after investigating neuroserpin effects using an in vitro model of brain ischemia [40] The information reported here regarding biomarkers...

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Báo cáo khoa học: " Neuropsychological testing and biomarkers in the management of brain metastases" doc

Danh mục: Báo cáo khoa học

... or urine levels in patients with brain metastases MMPs are not only involved in tumor invasion but can also be a sign of CNS vascular injury as indicated by an increase in plasma levels of MMP9 ... functioning of patients treated with radiation for brain metastases For many patients with brain metastases, controlling neurological symptoms, preventing cognitive dysfunction, and maintaining functional ... modifier of hemoglobin that works by decreasing the binding affinity of hemoglobin to oxygen thus permitting greater oxygenation of hypoxic tumor cells and enhancing the effect of radiation In addition...

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Báo cáo y học: " An integrated approach to diagnosis and management of severe haemoptysis in patients admitted to the intensive care unit: a case series from a referral centre" ppsx

Danh mục: Báo cáo khoa học

... either maintaining conservative measures in patients or to surgery in six; of these 15 patients died within the first month (4/9 patients managed conservatively and 1/6 undergoing surgery) In another ... cause of bleeding was identified in 69% (n = 111/162) of patients at bedside when combining history, comorbid conditions, physical examination, chest-X-Ray and fiberoptic bronchoscopy findings, ... consequences of bleeding in 73 patients (37%) leading to the following interventions prior to the referral or during the first 24 hours of ICU admission: local (n = 23) or systemic (n = 56) terlipressin,...

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Management of ventricular arrhythmia in patients with chronic stablle angina LV function improvement or ablation

Danh mục: Tổng hợp

... Ablation is indicated in patients with bundle-branch reentrant VT Ablation is indicated as adjunctive therapy in patients with an ICD who are receiving multiple shocks as a result of sustained VT ... Anti-anginal & anti-ischemic effects without clinically significant effect on HR or BP • Approved for treatment of chronic angina –  exercise time,  angina in selected pts • Novel mechanism of action ... Ranolazine in Ischemic Heart Disease Background • Ranolazine associated with an  in QTc (average ~5 msec) • However, experimental data suggest suppression of pro-arrhythmic markers • Indication in...

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Báo cáo y học: "PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells"

Danh mục: Y học thưởng thức

... localization of claudin-1 Nuclear claudin-1 does not increase melanoma cell motility We have previously shown that increasing the levels of CLDN-1 increases the invasion of melanoma cells (4) To determine ... isoforms using bryostatin instead increased the expression of claudin-1 in the tight junction complex, and increased tight junction barrier integrity (9) In melanoma, we have shown that claudin-1 expression ... localization of claudin-1 is evident in nevi, and less metastatic melanoma cells (4) To determine if the nuclear localization of claudin-1 was related to the increased invasive capacity of melanoma...

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Risk Management of Water Environment in New Paradigm

Danh mục: Môi trường

... of the earth and returns to the surface again as a rain Originally rainwater itself does not contain any contaminants, however, in the process of precipitation, flowing, it takes some contaminants ... Therefore, we have been trying to harmonize these cities and villages in the usage of fresh water resource and the discharging of wastewater as well, by using an engineering means of water treatment ... energy in total TASKS FOR RISK MANAGEMENT Unlike the safe drinking water act in the United States of America or WHO drinking water quality guidelines, water works law in Japan does not only provide...

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Tài liệu Risk Characterization, Assessment, and Management of Organic Pollutants in Beneficially Used Residual Products pdf

Danh mục: Hóa học - Dầu khí

... the incorporation of multiple conservative assumptions in deterministic risk assessment It is not intended to judge the validity of the assumptions In 1998, the State of Wisconsin began developing ... eliminated, with management practices shifting to either landfilling or incineration The financial impact associated with a shift in management practices for biosolids alone was estimated to be in ... sample Each cleanup step is intended to eliminate interfering compounds by using physical or chemical properties that differ between interfering compounds and the analyte of interest The analytical...

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Tài liệu Hypertension - Clinical management of primary hypertension in adults pdf

Danh mục: Cao đẳng - Đại học

... need Interventions might include: suggesting that patients record their medicine-taking encouraging patients to monitor their condition simplifying the dosing regimen using alternative packaging ... hypertension offer to: test for the presence of protein in the urine by sending a urine sample for estimation of the albumin:creatinine ratio and test for haematuria using a reagent strip take a blood sample ... hypertension [new 2011] NICE clinical guideline 127 – Hypertension Initiating and monitoring antihypertensive drug treatment, including blood pressure targets Initiating treatment Offer antihypertensive...

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INTERNET ADDRESS SPACE: ECONOMIC CONSIDERATIONS IN THE MANAGEMENT OF IPv4 AND IN THE DEPLOYMENT OF IPv6 pptx

Danh mục: Quản trị mạng

... informed policy-making  Monitor IPv6 readiness, including by monitoring information on national peering points offering IPv6 connectivity, Internet Service Providers offering commercial IPv6 ... MAIN POINTS .4 INTRODUCTION I AN OVERVIEW OF INTERNET ADDRESSING 12 Overview of major initiatives in Internet addressing and routing to-date ... Network management software (upgrade) Network testing Installation effort Maintaining network performance Training (sales, marketing, and technical staff) Distribution of Total Transition Costs Internal...

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Rheumatoid arthritis - The management of rheumatoid arthritis in adults doc

Danh mục: Cao đẳng - Đại học

... Approximately one third of people stop work because of the disease within years of onset, and this prevalence increases thereafter The total costs of RA in the UK, including indirect costs and work-related ... indicated 1.4 Pharmacological management 1.4.1 DMARDs Introducing and withdrawing DMARDs 1.4.1.1 In people with newly diagnosed active RA, offer a combination of DMARDs (including methotrexate and at ... their disease and its management should be offered the opportunity to take part in existing educational activities, including self -management programmes NICE clinical guideline 79 – Rheumatoid...

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Management of breast cancer in women: A national clinical guideline ppt

Danh mục: Cao đẳng - Đại học

... following dissection There should be national coordination of trials of sentinel node biopsy management of ductal carcinoma in situ Ductal carcinoma in situ (DCIS) covers a heterogenous group of ... Optimal role of adjuvant taxanes Defining the role of capecitabine and vinorelbine in advanced disease Identifying sub-groups of patients who get most benefit from adjuvant therapy: which patients ... following breast conserving surgery (BCS) in reducing the risk of invasive and non-invasive breast recurrence in the ipsilateral breast The trials reported an increased risk of developing contralateral...

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Diagnostic and Therapeutic Problems of Pulmonary Tuberculosis in Elderly Patients doc

Danh mục: Sức khỏe giới tính

... diagnosis of TB in the elderly A positive sputum AFB smear was obtained in 57.1% of elderly and in 57.5 % of young TB patients, and a positive AFB culture was obtained in 70.6% of the elderly and in ... data included the following: demographic characteristics, presenting symptoms and body temperature, underlying illnesses, laboratory findings (including microbiologic study at the time of diagnosis), ... (including alcoholic liver disease) composed the majority of underlying illnesses in both groups Elderly had significantly higher frequencies of cardiovascular and chronic lung disease including...

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Management of Unscheduled Bleeding in Women Using Hormonal Contraception pot

Danh mục: Sức khỏe phụ nữ

... Levonorgestrelreleasing intrauterine system Irregular bleeding without heavy bleeding 2 Heavy or prolonged bleeding (includes regular or irregular) 2 Initiation Unexplained vaginal bleeding (suspicious of serious ... evidence reducing interval for or implants, injectableDMPA injection interval for DMPA bleeding, however intrauterine system improves bleeding, however injection can be given up the injection can ... (unlicensed) of the bleeding duration of the bleeding duration of the bleeding no long-term interval, no long-term interval, no long-term No evidence reducing benefit interval for DMPA benefit injection...

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Management of Bipolar Disease in the Elderly ppt

Danh mục: Sức khỏe người cao tuổi

... illness Evaluation of Function Functional assessment Activities of daily living Feeding, Bathing, Dressing, Transferring, Toileting Instrumental activities of daily living Finances, Telephone, ... Subtlety in interview style Inability of patient to recognize symptoms Lack of insight Depressive symptoms bring patient in Poor memory of manic symptoms Greater stigma than diagnosis of depression ... Phillipe Pinel, physician 1806 Citizen Pinel Orders Removal of the Chains of the Mad at the Salpêtriére Tony Robert-Fleury (1838–1911) 1876 painting Resources American Association of Geriatric...

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Neuropathic pain - The pharmacological management of neuropathic pain in adults in non-specialist settings pot

Danh mục: Cao đẳng - Đại học

... Dosulepin (dothiepin) Doxepin Imipramine Lofepramine Nortriptyline Trimipramine Citalopram Fluoxetine Paroxetine Sertraline Duloxetine Venlafaxine Carbamazepine Gabapentin Lamotrigine Oxcarbazepine ... multi-modal management of all types of pain, including neuropathic pain NICE clinical guideline 96 – Neuropathic pain 11 1.1 List of all recommendations Key principles of care 1.1.1 Consider referring ... Dosulepin (dothiepin) Doxepin Lofepramine Trimipramine Citalopram Fluoxetine Paroxetine Sertraline Phenytoin Buprenorphine Co-codamol Codeine phosphate Co-dydramol Dihydrocodeine Fentanyl NICE clinical...

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Guidelines for the Diagnosis and Management of Food Allergy in the United States docx

Danh mục: Cao đẳng - Đại học

... HowweretheGuidelinesdeveloped? The Guidelines are the culmination of a 2-year effort in which the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, ... slow heartbeat in anaphylaxis) Low blood pressure Dizziness Fainting Loss of consciousness Other GI, gastrointestinal Uterine contractions Sense of “impending doom” — — DIAGNOSIS OF FOOD ALLERGY ... Whataretherecommendationsforvaccinesfor patients witheggallergy? Several vaccines are made using chicken eggs These vaccines contain varying amounts of egg protein Although these egg-based vaccines contain very low amounts of egg protein, people with a...

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