m blaco sequeiros m krause u neonatal symptomatic hypoglycaemia a follow up study of 151 children dev med child neurol 1972 14 603 14
mechanisms of type 2 diabetes
... problems • More than 60% of nontraumatic lowerlimb amputations in the United States occur among people with diabetes Diabetic Retinopathy • Diabetic retinopathy is the most common cause of new cases ... 10 -14 15+ Years T2DM Harris,S et al CDA 2003; Type Diabetes and Associated Complications in Primary Care in Canada: The Impact of Duration of Disease on Morbidity Load UKPDS: the benefits of improved ... alone Mechanisms of Action of Diabetes Medications Decreased digestion of complex sugars Alpha-glucosidase Sulfonylureas inhibitors and CBAs Biguanides Thiazolidinediones Decrease in hepatic glucose...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... delivers a square wave bipolar current with a voltage ranging from 5V up to a maximum of 40 V The device produces a current range of mA down to 100 nA Electrodes are applied in layers, and tap water ... jolt as produced by a Transcutaneous Electrical Nerve Stimulator Whereas Transcutaneous Electrical Nerve Stimulator device can produce a current varying from 1uA to 100 mA, the EPRT ranges from ... in another study that microcurrent stimulates dermal fibroblasts and U9 37 cells to secrete transforming growth factor-β1, a major regulator of cell-mediated inflammation and tissue regeneration...
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Tài liệu ECCENTRIC MECHANISM OF FOUR-BAR LINKAGE pptx
... Save the assembly CREATE AN SUB-ASSEMBLY arm_asm.asm Click , Enter the name of arm_asm OK 20 Click Then open arm.prt and assemble it at default location by selecting Open clip-1.prt and place ... eccentric_mechanism.asm Click , Enter the name of eccentric_mechanism OK Click Then open sub-assembly base_asm.asm and assemble it at default location by selecting 24 Open sub-assembly eccentric_asm.asm and assemble ... the assembly Save the assembly 15 CREATE AN SUB-ASSEMBLY base_asm.asm Click , Enter the name of base_asm OK Click Then open base.prt and assemble it at default location by selecting 16 , and...
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Tài liệu Báo cáo " Mechanism of forming the Dien Bien basin " pdf
... Lai Chau fault zone is one of the most active fault zones in Indochina This fault zone is a part of the Lai Chau – Luong Pha Bang – Pursat fault system, extending from the border between China ... regime: Dien Bien Lai Chau fault was left-lateral and Sop Cop Lang Chanh was right-lateral one, producing an extensional field, associating secondary faults The secondary faults played a role of ... Chau fault zone and of Sop Cop - Lang Chanh fault plays an important role in forming the Dien Bien basin Fig Diagram illustrating the mechanism of forming the Dien Bien basin Chu Van Ngoi, Luong...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... tuberculosis Structural analyses Analysis of the sites of substrate binding from NMR data, and structural comparison of the E coli, M tuberculosis and A thaliana PSs with nPS, was performed using vmd [60] ... bacterial enzyme Enzymatic and other biochemical studies have shown that for PS from M tuberculosis, pantoate, ATP and b-alanine have Km values of 0.13 mm, 2.6 mm and 0.8 mm, respectively Enzymatic ... coli, M tuberculosis and A thaliana was achieved using clustalw2 [58] Finally, modeller [59] was used to model the A thaliana PS structure, using the structures of PSs from E coli and M tuberculosis...
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Tài liệu Báo cáo khoa học: Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) ppt
... tRNA to form aminoacyl-tRNA In the aminoacylation reaction of class I aaRSs with aminoacyl-AMP, the 2¢-OH group of the ribose of A7 6 tRNA attacks the carbonyl carbon atom of the –Ca–(CO)–O– moiety ... group of the Arg molecule can assume such a conformation that O2 forms a hydrogen bond with the 2¢-OH group of the ribose moiety of A7 6 of tRNAArg by rotation around Ca–C When Pa of ATP gains access ... of Arg, ATP coordinated by Mg2+ and A7 6 of tRNAArg assisting the Arg-AMP formation reaction A model of NH2OH, enzymatically synthesized Arg-AMP and A7 6 of tRNAArg in the ArgNHOH formation reaction...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... examination of the articular cartilage after experimentally induced OA Articular cartilage of the femoral condyles from the experimental joints was examined to assess any macroscopic damage caused ... arthrotomy was performed The cranial cruciate and the medial collateral ligaments were transected and a medial meniscectomy was performed The experimental animals were given intravenous crystalloid ... inflammation; 7382 grade 1, slight inflammation; grade 2, strong inflammation The cartilage damage severity of the femoral condyles and tibial plateau was graded from to 4: grade 0, smooth surface;...
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Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx
... develop antimicrobial agents specifically against DHNA from S aureus or E coli Because many DHNAs from Gram-positive and Gram-negative bacteria are highly homologous within their own groups but ... developing antimicrobial agents specifically against Gram-positive or Gram-negative bacteria Results NMR analysis Although it is reasonable that the epimerase reaction follows the same reaction intermediate ... and products in the supernatants were separated by HPLC using a Vydac RP18 column The column was equilibrated with 20 mm NaH2PO4 made with MilliQ water and eluted at a flow rate of 0.8 mLÆmin)1...
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Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf
... 3.4.11.10] and M2 8E Aeromonas proteolytica aminopeptidase [(AAP) EC 3.4.11.10] In addition, the M2 8 family includes important human aminopeptidases such as M2 8B glutamate carboxypeptidase II (N-acetylated, ... griseus A Fig Rate ratio (Vn ⁄ V1) as a function of atom fraction of deuterium (n) for SGAP and its mutant E131D Vn is the kcat value obtained at a particular fraction of deuterium (n), whereas ... significantly more freedom compared with the catalytic mutant Conclusions The results of the present study substantiate several catalytic features that characterize the mechanism of action of SGAP Taking...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... open-channel states of the same amplitude (O1 and O2) Eventually, an abrupt increase in membrane leakage took place (c), which led to membrane rupture (d) and to the disappearance of ion channel activity ... Catalano M, Zetta L, Schaller G, Urech K, Giannattasio M, Ragona L & Molinari H (2003) NMR solution structure of viscotoxin C1 from Viscum album species Coloratum ohwi: toward a structure-function ... eliminated under vacuum in the dark for more than h Then, mL buffer containing 10 mm Tris ⁄ HCl, 20 mm NaCl, pH 7.4, and 5-carboxyfluorescein at a concentration of 40 mm was added, and multilamellar vesicles...
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Tài liệu Báo cáo khoa học: Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc
... 5¢-UCAUCACACUGAUAACCAACACUGA-AG-3¢; #2578, sense 5¢-GGAUCAAAGAGAACACUGGGGUAUA-AG-3¢; and #1513 sense, 5¢-AGUUCACGUGCAAGAACAAG UUCUG-AG-3¢ The forward sequence of the scrambled RNA was 5¢-GAUCCAAGUAAUACAGAGAUGGGAG ... 21, 140 147 14 Mutaguchi K, Yasumoto H, Mita K, Matsubara A, Shiina H, Igawa M, Dahiya R & Usui T (2003) Restoration of insulin-like growth factor binding protein-related protein has a tumor-suppressive ... carcinoma cells Biochem Biophys Res Commun 198, 1046–1053 Akaogi K, Okabe Y, Sato J, Nagashima Y, Yasumitsu H, Sugahara K & Miyazaki K (1996) Specific accumulation of tumor-derived adhesion factor...
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Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt
... the molecular mechanisms of chain length determination, we built structural models of Rv1086 and of LLLH mutant of M luteus UPP synthase using the E coli UPP synthase-E,E-FPP complex structure as ... 5¢-CAGTTGACAATAAGTACAGCG-3¢ (for A7 2L ⁄ F73L); 5¢-CTTTAGGTCGACTCAAATTTTCAGTTGACAATAA GTACAGCG-3¢ (for A7 2L ⁄ F73L ⁄ W78L); 5¢-CCGGCCAG TGTTCATCGATAAATAC-3¢ (for F223H); 5¢-CTTTAGG TCGACTCAAATTTTCAGTTGACAATAAGTACAGCG-3¢ ... from the complex structure of IPP and the D2 6A mutant of E coli UPP synthase (Protein Data Bank No 1X09), were superimposed on the structural models Amino acid residues mutated in the LLLH mutant...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... from malate by use of NAD+ and malate dehydrogenase (MDH) from pig heart A typical assay in a final volume of mL contained (mM) 50 potassium phosphate, pH 7.0; 10 L-malate, 0.2 CoASH, NAD+, ATP, ... concentration of acetate from the growth medium A 1-mL assay contained 50 mM potassium phosphate, pH 7.0; 10 mM L-malate, mM NAD, 0.5 U MDH, 0.5 U citrate synthase, 0.5 U methylcitrate synthase and ... mean value of 20 independent samples Partial purification of ATP-citrate lyase and succinyl-CoA synthetase from A nidulans A nidulans strain SMB/acuA [2] was grown for 20 h on glucose minimal medium...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... The Luria–Bertani medium for E coli, and the yeast peptone dextrose medium and buffered minimum methanol medium (BMM) for P pastoris were prepared according to the manufacturer’s recommendations ... SalI ACGTACTGCTgTCCGGAAAGtACtCCATGGCCGC ScaI TCCAATCCGTtAGTCTGgCCaTAGAACGCGC MscI GGAGAATGGTgCCAGGGTACATTTcCAATCCGTCA KpnI AATACATCTTaAGGCCGTCGTtGTCGGTGTGG A II AATACATCTTaAGGCCGTtGCGTCGGTG A II ... (1961) Untersuchungen an pullulan Biochem Z 334, 180–187 Shimizu, M. , Kanno, M. , Tamura, M & Suekane, M (1978) Purification and some properties of a novel a- amylase produced by a strain of Thermoactinomyce...
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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc
... formed The anchoring of a- carboxylate and a- amino group in the external aldimine defines automatically the positions of the a- proton and the side chain of any bound amino acid The lability of ... preliminary formation of a hydrogen bond between the Lys257 amino group and a water molecule providing a favorable mutual orientation of the amino group, the water, and the a- proton of the external ... Kainosho, M. , Ajisaka, K., Kamisaku, M & Murai, A (1975) Conformational analysis of amino acids and peptides using specific isotope substitution Conformation of 1-phenylalanylglycine Biochem Biophys...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
... highly unstable at room temperature and can only be detected at low temperature after rapid freezing of the sample (E Ghibaudi and E Laurenti, unpublished observation) The same arguments offered earlier ... catalytic mechanism of MPO and LPO A brief survey of the absorption features of MPO, LPO and their intermediates The absorption spectrum of MPO is characterized by an intense Soret peak at kmax ... behaviour of LPO and MPO A critical examination of these data resulted in a model that offer a solution to some of these opened questions It re-evaluates the role of superoxide ion as a reductant in the...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... MSSG (lane 3), MSSAE from a lysate performed in the presence of mM iodoacetamide (lane 4), BS-RNase from a lysate performed in the presence of mM iodoacetamide (lane 5), MSSAE as in lane after ... incubation with isolated PM from SVT2 cells The incubation was performed (A) in the absence of iodoacetamide (IAM), (B) in the presence of 10 mM IAM, or (C) of 50 mM IAM D and M mark the elution ... the role of plasma membranes (PM) in the transformation of MSSAE into a dimeric protein 125I-labelled MSSAE was incubated with isolated membranes from SVT2 broblasts (0.45 mgặmL)1 of total protein)...
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Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx
... Mannheim) was supplied by infusion of a 0.1 M NADH solution into the reaction mixture through a capillary whose tip was below the surface of the liquid The infusion was mediated by a Harvard Apparatus, ... concentrates on the mechanism of inactivation of the enzyme by free radical intermediates and the role of aromatic species in this mechanism The mathematical model described here has been submitted ... [12], the simulations reveal that although the maximum concentration of superoxide during oscillations is much higher than the values observed in a steady state, the average concentration of this...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... calculated using the averaged distance template of 1CEV and 1RLA, and then a full hydrogen bond network optimization was performed again Agmatine was added to agmatinase using the same superposition matrix ... characterization of human agmatinase Genet Metabol 75, 209–218 Mistry, S.K., Burwell, T.J., Chambers, R .M. , Rudolph-Owen, L., Spaltmann, F., Cook, W.J & Morris, S .M (2002) Cloning of human agmatinase ... for the activating metal ion, are not the explanations for the greatly decreased catalytic activity of the D153N variant To evaluate possible structural changes that may result from mutation,...
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