lost on the moon group activity
Organic chemitry t8 nucleophilic substitution on the carbonyl group
... oxygen of the alcohol attacks the carbonyl carbon. In the second step, the proton bonded to the oxygen from the alcohol transfers to the oxygen that was the carbonyl oxygen. This proton transfer ... case, is the carbonyl carbon. In the carboxylic acid family, the leaving group (the electronegative group bonded to the carbonyl carbon) is a base, but is generally a weaker base than the nucleophile. ... a leaving group. In reactions with a leaving group, the behavior of the leaving group significantly affects the course of the reaction. The reactivity of the various members of the carboxylic...
- 60
- 2,092
- 0
Báo cáo khoa học: Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases pot
... inhibition potency on the polymerase function; and (c) the K-61 analogueshowed a fourfold reduction in its RDDP activity inhi-bition potency. By contrast, when the AQ derivativeswere tested on the ... similar conformation (RMS 0.57), on the other hand, in the crystal reported by Pata et al. [30] the NNRTI binding pocket most closely resembles the RT unliganded conformation. Therefore, the AQ ... steric modifications occur. The binding modeof K-49 in the Y181C RT is different, and the contribu-tion of the p–p stacking interaction is lost. Furthermore, the low number of good contacts with...
- 14
- 425
- 0
Tài liệu The Influence of Human Activity on the Environment ppt
... rise.• This leads to disruption of the weather patterns eg drought, floods• Some weeds may thrive on the extra carbon dioxide while other plants are killedBiological Control of Pests• This means ... from the water• This means the fish suffocate and die• This process is called Eutrophication• Raw sewage pumped into rivers has the same effect The Influence of Human Activity on the EnvironmentBenefits ... cars and power stations produces carbon dioxide, sulphur dioxide and other greenhouse gases• carbon dioxide traps heat in the atmosphere and causes the temperature of the earth to rise.•...
- 23
- 690
- 0
Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx
... proposed for the binding of the SRL to the active site of RTA in which the principal difference lies in the conformation of the second ÔGÕ in the target GAGA motifin the 28S rRNA substrate. In one model, ... of RTA resulted in different effects on the activity of RTA. Whereas, one had no effect on the activity of the enzyme (R258A), others reduced activity by one(R213A, R258D, R48A) or by two (R213D) ... hydrogen bonds to be formed between the base G4and the sidechain of Asn122. In the second model(Fig. 1B) the structure of the hexanucelotide is, on the whole, unchanged and the majority of the interactions...
- 10
- 616
- 0
Tài liệu Báo cáo khoa học: Coordination chemistry of iron(III)±porphyrin±antibody complexes In¯uence on the peroxidase activity of the axial coordination of an imidazole on the iron atom ppt
... to the iron(III) of Fe(ToCPP)and Fe(ToCPP))13G10 The second part of our results concerns the binding ofimidazole d erivatives on the iron of Fe(ToCPP) either alonein solution or inside the ... thisinhibition was due to the binding of the imidazole ligand on the iron atom. In addition, measurement of the kineticparameters for the oxidation of ABTS by H2O2catalyzed byFe(ToCPP))13G10 in the ... (Table 1). The bind-ing of the ®rst CN±ligand to the iron was thus more easy in the hydrophobic binding pocket of the antibody than the binding of the second one, most probably because of the steric...
- 11
- 470
- 0
Đề tài " Harmonic analysis on the infinite-dimensional unitary group and determinantal point processes " doc
... in a convex set X consisting of certain positive definite functions on the group. In our concrete situation, the elements of the set X are positive definitefunctions on U(∞), constant on conjugacy ... By Proposition 5.3 the kernel K describes the correlationfunctions of the L-ensemble in question. On the other hand, the same correla-tion functions are also expressed in terms of the kernel ... through the correlation kernel of the original process. Thus, one wayto obtain the correlation functions for the two-component log-gas is to apply the complementation principle to the (one-component)...
- 105
- 321
- 0
Báo cáo khoa học: Effect of annealing time of an ice crystal on the activity of type III antifreeze protein pdf
... that the TH valuereflects the fraction of ice-bound AFPs on the flat iceplane. Indeed, TH increases in proportion with the total concentration of nfeAFP8, as can be seen inFig. 3A. The fraction ... AFP based on the ‘adsorption–inhibition’ model [3,4]. (A) Aconvex ice front is created after primarybinding of type III AFP onto the flat iceplane. (B) Overgrowth of the convex icefront, giving ... value. (C) Possiblesecondary ice binding of type III AFP onto the convex ice front during the annealingperiod (2–3 h). (D) AFPs bound onto the convex ice front narrow the growth area(dashed...
- 8
- 520
- 0
Report of the Task Group on Social Audit potx
... 74thAmendments to the Constitutionand the recommendationsof the XIFinanceCommission.Further,CentralGovernmenthasbeenentrusting the implementationofvarioussocio‐economicdevelopmentalschemestoautonomousagencies/societies.Moreoftenthannot,CentralGovernmentschemeshavealsoenvisageddirecttransferoffunds ... of the audits by the CAG of India. On our part,one of the biggest limitations of not being able to reach the beneficiaries for their perception andverificationofdeliveryof the programmes,including the existenceof the communityassetsand ... SynergyandPartnershipbetweenSocialAuditandCAG’sAudit The Task Group isof the opinionthatrecognisingthatsocialauditsaffordanopportunitytostrengthen the micro level scrutiny of the programme planning, implementation andmonitoring,...
- 15
- 472
- 0
Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... iden-tified as the major and the minor forms of the holo-ACP structure, on the basis of their percentage contri-butions (65% and 35%, respectively) to the overallstructure of the protein. The structures ... mCm, the two-state assumption for the unfolding reaction, and linear pretransition and post-transition baselines, which are dependent on the concentra-tion of guanidine hydrochloride by the ... interactions, and the blue lines denote CH–O hydro-gen bonds. The 4¢-PP group is linked to the protein by the Ser37 O-c atom. Only residues 31–38 of the protein make extensive contactswith the cofactor....
- 14
- 419
- 0
Báo cáo khoa học: The potent inhibitory activity of histone H1.2 C-terminal fragments on furin doc
... cloned through the flanking NcoI and XhoI restrictionsites into the expression vector pET28a. The sequences of the constructions were verified by DNA sequencing. The primer pairs for the cloning ... column, the highest inhibi-tory activity was found in the unbound fraction (datanot shown). The unbound fraction was then furtherpurified on a Superdex-75 column (Fig. 2A) and then on a Hamilton ... fractionswere finally obtained and assayed for their inhibitory activity. Among them, the major fractions P2, P3 andP4 have a strong inhibitory activity against furin. The homogeneity of the three...
- 11
- 286
- 0
Reforming Internet Govermernance- Perspectives from the Working Group on Internet Governance pptx
... record, as contained in papers published on the WGIG web site and in e-mails exchanged among the members of the group. A concluding section provides some personal views on the principal themes that ... in the consultations. By April 2005 the Group had started talking about recommendations, but the real discussion was to be at the final June meeting. Usually the group met in the United Nations’ ... that they had to listen and respond to the doubts and questions raised. Instead of talking at one another, the members started talking with one another. The members of the group were there...
- 285
- 367
- 0
Báo cáo khoa học: Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase pdf
... both the ini-tiation and elongation of DNA replication [13], andthese proteins migrate on the genome together with the replication forks [14,15]. One of the intricacies relatedto the function ... solution (0.4 lL) containing or lackingheliquinomycin was added to the reaction mixture. The final con-centrations of heliquinomycin added to the reaction mixture areindicated at the top. The ... DNA was considered to be100% in the control reaction mixture lacking heliquinomycin, and the proportions in the mixtures containing heliquinomycin were cal-culated in relation to the control...
- 10
- 538
- 0
Báo cáo khoa học: Effect of magnesium ions on the activity of the cytosolic NADH/cytochrome c electron transport system pptx
... Fig. 1 on the oxidation of exo-genous NADH as the expression of the activity of the complete system.Discussion The data presented provide new insights into the roleof magnesium ions in the permeability ... provides direct evidence that, inthese latter conditions, the addition of magnesiummimics the results obtained with the addition ofcyto-c, the only difference being that the potentialis lower and ... mitochondria, activates the oxida-tion of extramitochondrial NADH and the generation of a membranepotential, both linked to the activity of the cytosolic NADH/cyto-c electrontransport pathway. The...
- 12
- 441
- 0
Báo cáo khoa học: The ‘pair of sugar tongs’ site on the non-catalytic domain C of barley a-amylase participates in substrate binding and activity potx
... agreement with the reduced DMA of the AMY1 Y380A ‘sugar tongs’mutant, these effects may stem from allosteric regula-tion. The mutational analysis of the ‘sugar tongs’ in barleyAMY1 explored the role ... Thisis the first demonstration of a function for a C domainfrom the large GH clan-H. The work contributes to the unraveling of the molecular basis of multivalentenzyme–polysaccharide interactions. ... connects b5 and a5 of the catalytic (b ⁄ a)8-barrelat the end of the aglycon-binding area of the active sitecleft. Earlier, significant deviation was found in thisregion between the backbone...
- 13
- 385
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008