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Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf
... Sigma-Aldrich (St Louis, MO, USA).Statistical analysisThe data were expressed as the means ± standard devia-tion (SD) and statistical analysis utilized a two-tailed Stu-dent’s t-test. Statistical significance ... from cell lines, we also detectedthe expression of IL6R mRNA in nine other pairs oftissue samples. Figure 5B shows that, compared withnormal tissue samples, IL6R mRNA was consistentlydownregulated ... gastric adenocarci-noma tissue samples and matched normal gastric tissuesamples. miR-23a was consistently upregulated in gas-tric adenocarcinoma tissues (Fig. 1A). This result indi-cated that...
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Cách sử dụng (Something) is down to (a number of something) pdf
... it’s down to just me, Claire, and Maria - Hiện giờ chỉ còn tôi, Claire và Maria. Lưu ý rằng khi sử dụng down to” thường kèm “now”, ở đâu đó trong câu. Với bài viết Daily English Speaking ... cho chúng ta hiểu ro hơn về cách sử dụng " is down to " trong giao tiếp thường ngày. Hãy cùng xem và thực hành cho đúng nhé ! “We’re down to only 3 people now.” Công ty của bạn vừa ... nhân viên nữa. Bạn nói chuyện với bạn của mình về tình huống này. “We’re down to only 3 people now” (something) is down to (a number of something) ...
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Báo cáo khoa học: An estrogen receptor a suppressor, microRNA-22, is downregulated in estrogen receptor a-positive human breast cancer cell lines and clinical samples pptx
... collection. ERa proteinexpression status was confirmed at diagnosis using standardimmunohistochemistry procedures. Total RNA was isolatedand then converted to cDNA using miR-22 RT primer(Ribobio) ... MicroRNAs: genomics, biogenesis,mechanism, and function. Cell 116, 281–297.2 Lu M, Zhang Q, Deng M, Miao J, Guo Y, Gao W &Cui Q (2008) An analysis of human microRNA anddisease associations. PLoS ... mRNA by quantitative RT-PCR.This supplementary material can be found in theonline version of this article.Please note: As a service to our authors and readers,this journal provides supporting...
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Báo cáo khoa học: Double-stranded RNA-dependent protein kinase (PKR) is downregulated by phorbol ester ppt
... andthat this activity is not cell line specific.Poly I:C is a potent inducer of PKR expression andactivity in different types of cells. We examined theeffect of poly I:C on the downregulation ... thatPKC-a and b may play a role in this event.The degradation of certain proteins by PMA treat-ment is via a proteasome-dependent mechanism [27]. Totest if the downregulation of PKR levels in L929 ... treatment (Fig. 6). This observation suggeststhat PKC is involved in the downregulation of PKRautophosphorylation in the cells. To determine furtherthe role of PKC in the downregulation of PKR...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... show that HO-2 knock- down is associated with the induction of HO-1 expres-sion in human cancer cell lines. HO-2 knockdown maymimic a certain physiological change that is importantin the maintenance ... relevant cis-acting element is not presentin the 4.5-kb promoter region. It is therefore conceiv-able that HO-2 knockdown may induce HO-1 expres-sion through not only the heme-independentmechanism ... Bach1 is aheme-responsive repressor, and its repression activity is lost when Bach1 is bound by heme, which in turnleads to transcriptional activation of the HO-1 geneABFig. 8. Knockdown...
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Báo cáo Y học: Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line pptx
... for proteolysistargetingThe role of TPH phosphorylation is that it down regulatesthe TPH level in the cell by serving a tag for targeting fordigestion by proteasomes. This idea is based on ... (Fig. 1B,32P, lane 4) and was coincidentwith the TPH visualized by Western blot analysis(Fig. 1B, WB, lane 3 and 4). This operation visualizes32P-incorporation into the specific proteins which ... theenzyme protein in a tissue-specific way.We have demonstrated with RBL2H3, an established cell line that expresses TPH in culture while retaining many ofthe characteristics of mast cells, that:...
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Cancer Research UK’s strategy 2009–2014: Cancer Research UK’s aim is to reduce the number of deaths from cancer. Our future plans are ambitious, but they are in line with the challenge and the responsibility we face. docx
... more promising. This optimism is fuelled by the ever-increasing knowledge and understanding of the disease that research provides andin which Cancer Research UK is leading, both in this countryand ... Diagnosis Initiative (NAEDI), whichbrings together a wide range of experts and organisations tounderstand what causes delay in diagnosis, establish the bestways of helping the public to recognise ... metastasis and genetic pre-disposition to cancer. Scientists at Cancer Research UK and across theworld are building on these discoveries to develop newtreatment approaches.• We have discovered...
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Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx
... novelPKC (nPKC) isoform, is characterized both by itsunique tissue distribution (in skeletal muscle, lymphoidorgans, and hematopoietic cell lines, particularlyT cells [21]) and by its isoenzyme-specific ... apoptosis in the humanT-cell line, L-MAT, because AhR does not exist inL-MAT [7,8]. In view of our previous findings and thevery high susceptibility to TCDD among T-cell lines(A. Hossain, unpublished ... this apoptosis was mediated byPKCh, although we cannot completely rule out theparticipation of PKCd in the apoptosis. Therefore,even if PKCd is involved in TCDD-induced L-MATT-cell apoptosis,...
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Báo cáo khoa học: Downregulation of protease-activated receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E2 receptor EP2 through cAMP elevation and protein kinase A pot
... receptor A2B, can induce down- regulation of the PAR-1 level. We treated fibroblastswith the b2-AR agonist isoproterenol (ISO) and withthe adenosine receptor agonist adenosine-5¢-N-ethyl-carboxamide ... reduced inresponse to bleomycin-induced fibrosis [8,9]. Moreover,the PAR-1 protein level is increased in lung tissues ofpatients with pulmonary fibrosis [8] and in early stagesKeywordscAMP; E ... mediatedmainly by PKA.Downregulation of PAR-1 is likely to be regulatedat the transcriptional level rather than by an alteredmRNA degradation rate. As we showed that de novoprotein synthesis is not required...
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– ACT READING TEST PRACTICE – 67. The word exhausted, as it is used in line 23, most nearly doc
... stated in lines 42–43, that he“detested the grind of the real-estate business.” This makes it clear that Babbitt hates his job. Andalthough the next line refers to his dislike of his family, ... is taking a roommate because she is running out ofmoney, choice c is the best choice.68. Question type: detailChoice g is correct. It is true that Sylvia could not afford the rent, but this ... Thereforehis desire to learn how things worked was stronger than his affection for nature.49. Question type: generalizationChoice b is correct. Lines 56–59 describe Leonardo’s reaction to his punishment....
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The Complete IS-IS Routing Protocol potx
... imple-menter of the IS- IS protocol, once with Cisco Systems, noted on the NANOG Mailing List: IS- IS is defined in ISO document 10589. It defines the base structures of the protocol (adjacencies,flooding, ... the IS- IS specification. And that is thewhole reason for this book.Real-world IS- IS implementations are the main focus of this book. The two vendorsshipping all but a tiny fraction of the IS- IS ... Exchange Protocol (to give IS- IS its official name) was published as ISO specification ISO 10589.First-time readers tend to get confused by the sometimes arcane “ISO-speak” used in thedocument. IS- IS...
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3 Reasons Why Building a Lazy Downline is Smarter and More Profitable! Written By James 2 ppt
... the reason is, you and most of the members arehaving a hard time growing your downlines. And there are probably numerousreasons why this is the case Nevertheless, what if you discovered a ... say there is a quicker way to building a largedownline on the internet. The idea in the pages that follow will hopefully open youreyes to this easier, and more profitable method of downline building. ... of this for us net marketers is a product that my friend ChrisZavadowski created. It’s called InstantMLMSalesLetters.com. Chris’ product is a perfect example of "Giving Them The Fish!"...
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The Complete IS-IS Routing Protocol- P1 pps
... differentiating IS- IS and CLNP more difficult. Henk Smit, a well-respected imple-menter of the IS- IS protocol, once with Cisco Systems, noted on the NANOG Mailing List: IS- IS is defined in ISO document ... “ISO-speak” used in thedocument. IS- IS itself, in contrast to its specification, is actually a fine, lean protocol. Afterlearning which sections of ISO 10589 to avoid, readers find that IS- IS is ... basedon IS- IS.1.2.6 IETF ISIS-WGFrom 1999, most of the IS- IS extensions for IP are done within the IETF and not withinITU-T or ISO committees. Most of the basic IS- IS protocol is maintained in ITU-T,...
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The Complete IS-IS Routing Protocol- P2 pot
... Show the IS- IS link-state databasehostname Show IS- IS hostname databaseinterface Show IS- IS interface informationroute Show the IS- IS routing tablespf Show information about IS- IS SPF calculationsstatistics ... instance, a show isis database Londonjust shows a single link-state database (LSDB) entry, while show isis databaseshows all LSDB entries.hannes@Frankfurt> show isis database London IS- IS level ... harm any transit trafficThis is from a router running JUNOS andMunich>show isis% Incomplete command. is from an IOS-based router. However, there is an easy way to discover what kinds ofcommands...
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