jak signal transducers and activators of transcription stat pathway and cytokine signaling
Studies on the anti cancer potential of sesquiterpene lactone parthenolide
... 1.1.3.4 Effects on Janus Kinase (JAK) -Signal Transducers and Activators of Transcription (STAT) pathway and cytokine signaling As discussed above, NF-κB-regulated cytokines play a critical role ... mainly regulated via disruption of nuclear factor - kappaB (NF-κB) signaling pathway (Hehner et al., 1999) and signal transducers and activators of transcription (STAT) pathway (Sobota et al., 2000) ... In addition to NF-κB, the JAK- STAT signaling pathway also plays an important role in cytokine signaling and inflammatory response (Pfitzner et al., 2004) The IL-1 type cytokines (IL-1, TNFα etc.)...
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Human telomerase reverse transcriptase (hTERT) overexpression modulates intracellular redox balance and protects cancer cells from apoptotic cell death
... successes and failures and for being a huge source of support for me Thank you all loads I would also like to give special mention to Dr Jayshree and Kartini for taking care of the needs of the lab and ... been shown to be a suppressor of hTERT whilst SP1 and Nf-kB have been shown to be activators of TERT Given that activation or suppression of these transcription factors of TERT are redox regulated, ... peptidases (Anderson, 1998; Meister and Anderson, 1983) cysteine glycine glutamate Figure 4: Structure of Glutathione (Anderson, 1998) GSH is ubiquitously expressed in animal tissues, plants and micro...
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Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf
... pumping of the agents out of the cells and their passive uptake [10,31] and (b) competition between the active pumping of the agents out of the cells and their intracellular binding to receptors and ... responsible for the exclusion of rhodamine dyes from cells, we surveyed a variety of agents known to interfere with the transport of anticancer drugs and dyes in and out of cells (Table 2) 4-Chloro-7-nitro-2,1,3-benzoxadiazole ... allowing the enhanced uptake of rhodamine dyes inhibited the efflux of these dyes from the cells The efflux of rhodamine 123 and TMRM was inhibited by NBD-Cl and MK571 and, to a lesser extent, by...
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Tài liệu World Economic outlook - Financial Stress, Downturns and Recoveries ppt
... sources of support for the U.S economy are the quick and strong reaction of the Federal Reserve to lower policy rates and the robust state of the U.S nonfinancial corporate sector Low indebtedness and ... example of this approach 26 ingly careful measures of inputs—for example, by adjusting labor inputs for the impact of education and training on the quality of labor and by introducing a measure of ... Inventories, and OPEC Spare Capacity 86 3.3 Grain and Oil Demand, Production, and Inventories in Comparison 87 3.4 Oil Supply Developments 95 3.5 Price Trends of Major Foods 97 3.6 Duration and...
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Tài liệu Báo cáo khoa học: Osmotic stress sensing and signaling in fishes doc
... role of aquaporins as effector proteins of osmosensory signal transduction pathways and the potential role of these proteins in osmosensing of fish cells has yet to be addressed As a result of recent ... conservation of orthologs of the putative osmosensors TRPV4 and aquaporin and the osmosensory signal transcription proteins TonEBP and TSC22D2 in vertebrates The human sequences of TRPV4 (871 ... stabilization and transcriptional mechanisms and on the presence of an osmotic gradient between the extracellular and intracellular fluid of tilapia gill cells [32] A role of Ostf1 in osmosensory signal...
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Tài liệu Báo cáo Y học: Regulated expression and intracellular localization of cystatin F in human U937 cells pptx
... antibody with an excess of recombinant cystatin F [5] a total absorption of the signal was apparent Fig Double staining of cystatin F and ER (A) Cystatin F was stained with a human cystatin F specific ... cystatin C, we measured the cystatin contents in cell lysates and culture media of cells grown for and days with cystatin F and cystatin C specific ELISAs Generally, the total cystatin F amounts were ... cystatin F, through analysis of the expression, distribution and properties of the native human inhibitor in U937 cells MATERIALS AND METHODS In silico cloning and sequencing of the human cystatin...
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Stress symptoms and coping strategies in healthy elderly subjects pot
... with normal cognitive function, randomly chosen from a group of elderly who were registered at the University of São Paulo School of Nursing Secretary of Culture and Community Services (SCEU -EEUSP) ... scores All data were coded and inserted in SPSS software (12.0 version) and significance was 5% RESULTS AND DISCUSSION The sample of the current study was composed of 41 elderly subjects, predominantly ... studies, and the nature of stressor events present in the daily life of elderly individuals should be analyzed The observation of the relationship between stress, coping and the nature of a stressor...
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Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx
... ligand and changes in the flexibility of the FG loop (residues 86–96) in the protein when the redox state of the heme iron is changed [6] For the Fe(III) heme, the axial ligands are His77 and ... compilation ª 2006 FEBS 1211 Heme electronic states of Leu mutants of Ec DOS N Yokota et al Fig Partial sequences of amino acids of the PAS domains of Ec DOS and other related heme-bound PAS proteins ... ligand binding kinetics of the PAS domain of Ec DOS, as it does in myoglobin and hemoglobin Examination of the effects of these hydrophobic amino acids on the kinetics of O2 and CO binding to the...
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Báo cáo Y học: A Ca2+/CaM-dependent kinase from pea is stress regulated and in vitro phosphorylates a protein that binds to AtCaM5 promoter ppt
... differential effects of EGTA and W7 on low temperature- and salinity-mediated expression of PsCCaMK indicate that their responses are mediated by different signaling pathways and that Ca2+/CaM signaling ... affect the level of same kinase and in turn different kinases are modulated by the same signal, depending on the specificity of calcium signal and position of the kinase in the signaling cascade ... form DISCUSSION Role of PsCCaMK in stress signaling Protein kinases and phosphatases are important components of signaling cascades, which by changing the phosphorylation status of the target proteins...
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Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka pptx
... the calculated signal intensity of relaxin-3 mRNA Data are shown as the mean ± SD of photostimulated luminescence (PSL) [12] (B) A schematic representation of the intracellular signaling that ... expression Downstream of CRFR1, the cAMP-PKA pathway is involved in the activation of relaxin-3 gene transcription Regulation of relaxin-3 gene expression Concerning the regulation of relaxin-3 gene ... brain Regul Pept 145, 54–59 24 Osheroff PL & Ho WH (1993) Expression of relaxin mRNA and relaxin receptors in postnatal and adult rat brains and hearts Localization and developmental patterns J Biol...
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oxidative stress biomarkers and antioxidant protocols
... Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, MN MULCHAND S PATEL • Department of Biochemistry, School of Medicine and Biomedical Sciences, State University of ... calibrations of 18 Browne and Armstrong Fig Simultaneous chromatograms of LHP and LOH standards at 236 nm (A) and native unoxidized PUFA standards at 25 nm (B) See Subheading 3.3 for HPLC conditions and ... Afzal and Donald Armstrong 32 Designing Safer (Soft) Drugs by Avoiding the Formation of Toxic and Oxidative Metabolites Nicholas Bodor and Peter Buchwald 33 Statistical Correction of...
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báo cáo hóa học: " Occurrence of post traumatic stress symptoms and their relationship to professional quality of life (ProQoL) in nursing staff at a forensic psychiatric security unit: a cross-sectional study" potx
... the central and northern parts of Norway with about 1.1 million inhabitants The unit consists of wards with a total number of 21 beds One of the wards (ward F) is specialised to serve offenders ... attacks on staff Assessments of professional quality of life were made with the Professional Quality of Life Scale (ProQOL) [16], which is a validated development of the Compassion Fatigue Test ... Discussion and conclusion Occurrence of any symptoms of PTSD was related to the variables length of psychiatric nursing experience, which of the wards you were working at (as categorical variable) and...
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báo cáo hóa học: " Prevalence of stress, anxiety and depression in with Alzheimer caregivers" ppt
... direct and indirect costs of care also play a major role in influencing the social, psychological and physical wellbeing of the caregiver and of his/her family Caring is held to be very demanding and ... interviewed, 29% claim to be unable to accept the situation and wish to abandon their home Mean values of MMSE, ADL and IADL of the patients and CBI of the caregivers are outlined in Table At the same ... psychological condition, and, therefore, anxiety and depression of the caregiver, are closely related to the values of the MMSE, ADL, IADL and to the several phases of the cognitive and physical deterioration...
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báo cáo hóa học:" Psychosocial stress, demoralization and the consumption of tobacco, alcohol and medical drugs by veterinarians" ppt
... type of work, weekly working hours and the number of years of professional work • „Over the past few years, my job has become more and more demanding.“ (ERI6) • „During my work I am afraid of injuries ... women of intermediate (14%) or lower status (9%) The influence of socioeconomic status is apparently less marked for the male consumers (higher status: 35%, intermediate status: 29%, lower status: ... in the study and it was shown that the mean number of hours worked per week was 51.5 h and that there was a correlation between the high number of working hours and stress Gardner and Hini [4]...
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báo cáo hóa học: " Quality of life in Croatian Homeland war (19911995) veterans who suffer from post-traumatic stress disorder and chronic pain" doc
... multidimensional nature of the determinants of quality of life in these patients The use of more advanced statistical analytic methods indicated the existence of several cluster of quality of life, suggesting ... et al Health and Quality of Life Outcomes 2011, 9:56 http://www.hqlo.com/content/9/1/56 Page of Table The comparison of quality of life among study groups using analysis of variance and post-hoc ... Health and Quality of Life Outcomes 2011, 9:56 http://www.hqlo.com/content/9/1/56 Page of 26 Clapp JD, Beck JG, Palyo SA, Grant DM: An examination of the synergy of pain and PTSD on quality of life:...
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Stress, Strain, and Structural Dynamics ppt
... learning of various topics in science and technology, and surely help increase the efficiency and accuracy of engineering designs The recent technological advancements in computers, software, and ... allows instant solution of a variety of engineering problems and in-depth exploration of the physics of deformation, stress, and motion by analysis, simulation, graphics, and animation Interactive ... engineering education and engineering practice Examples include static analysis of Euler-Bernoulli beams (Chapter 2), stress and deformation of elastic bodies (Chapters and 15), and rigid-body dynamics...
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Tài liệu tiếng anh tham khảo stress coping and health
... availability of sufficient resources (internal and external) to meet the demands of the situation, and (c) meaningfulness—the degree to which life’s demands are worthy of the investment of energy ... measurement of multiple variables of psychological state (depressive symptomatology, positive states, and positive and negative affect), coping, and religious or spiritual beliefs and activities ... diagnosis and treatment of disease Public health professionals and government agencies commonly adopt the biomedical model and use morbidity and mortality statistics as an index of the population’s...
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Devaluation and the trade balance
... and E are the values of imports and of exports of the devaluing country expressed in foreign exchange I' and E' are the same imports and exports expressed in domestic currency r is the rate of ... elasticities of demand for f o r e i ~ n exchange as distinct from elssticities of demand for imports and exports in volume terms - does not necessari!~rest on the assumption of constant costs or of infinite ... one-tenth of total imports While the postwar predominance of balanceof-payments problems requires watching of the balance expressed in foreign exchange and, secondarily, of the ratio of exports...
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Báo cáo sinh học: " Genome degeneration affects both extracellular and intracellular bacterial endosymbionts" pot
... reduced genome sizes of 160-800 kb, a complete stasis of genome structure, an extreme reduction in the numbers of transcriptional regulators, and recombination and DNA repair factors, and high mutation ... genome size of S glossinidius is comparable to that of free-living Enterobacteriaceae, but it is in an early state of degeneration, as exemplified by the massive presence of pseudogenes and a coding ... 31.2 Journal of Biology 2009, Volume 8, Article 31 Feldhaar and Gross http://jbiol.com/content/8/3/31 Table Comparison of basic features of endosymbiotic and free-living bacteria...
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Báo cáo sinh học: " Oxidative stress, thermogenesis and evolution of uncoupling proteins" doc
... characterization of the biochemical activity and regulation of fish and marsupial UCP1 orthologs, which are likely to be different from that of eutherian UCP1 Interestingly, the expression of the carp ... ancestor of vertebrate UCP1-3 first duplicated into UCP1 and the common ancestor of UCP2-3, which subsequently duplicated into UCP2 and UCP3 Each of the three paralogs is found in fish, amphibians, and ... shows animal UCP4 and UCP5 (also termed BMCP1) as a sister group of plant UCPs and animal UCP1-3 The other members of the superfamily analyzed - PiC, ANT, OGC (oxoglutarate carrier) and DIC (dicarboxylate...
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