ischemia reperfusion injury and oxidative stress the role of mitochondrial atp dependent potassium katp channels on the therapeutic potential for the treatment of cardiac dysfunction

Báo cáo sinh học: "Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction" ppt

Ngày tải lên : 18/06/2014, 19:20

... regarding the source and safety of allo- and xeno-grafting has become important concern in the clinical setting On the other hand, the use of adipose-derived (AD) MSCs has the distinct advantages of ... Study Limitations This study has limitations First, since the present study focused on the therapeutic impact of ADMSC on acute renal injury using a rodent model of renal IR, the effects of ADMSC ... Zimmermann A, Davis G, Wheatley AM: Effect of ischemia- reperfusion injury on the microcirculation of the steatotic liver of the Zucker rat Transplantation 2001, 72:1625-1631 Sun CK, Zhang XY, Sheard...

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Báo cáo sinh học: "The combined transduction of copper, zincsuperoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury" ppt

Ngày tải lên : 18/06/2014, 19:20

... this condition allows the rapid return of blood flow to the ischemic zones of the myocardium However, reperfusion may cause further complications such as decreased cardiac contractile function and ... ischemia- reperfusion injury To observe whether transduced PEP-1-SOD1 and PEP-1CAT protect myocardial ischemia- reperfusion injury in Page of 11 vivo, we established the model of myocardial ischemiareperfusion injury ... preventing the generation of OH- Therefore, we hypothesize that combination of PEP-1-SOD1 and PEP1-CAT fusion proteins is more useful in preventing myocardium from ischemia- reperfusion injury Page of...

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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"

Ngày tải lên : 26/10/2012, 09:07

... regulation of enzyme production and increased clearance along with the modulation by NO The figure shows the concentration of NOx, TAS and TBARS in this study The concentration of NOx and TBARS ... damage in anoxia The increased concentration of TBARS and decreased concentration of TAS supports the oxidative stress in anoxia and reperfusion and suggests a possible role for anti oxidants ... concentration of TBARS and decreased concentration of TAS supports the oxidative stress in anoxia In this study the results of citrulline – NO cycle enzymes and NOx, TAS and TBARS indicating the...

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Báo cáo khoa học: The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster Implications for cellulose synthase complex formation and oxidative stress response potx

Ngày tải lên : 17/03/2014, 03:20

... redox reactions and might constitute the molecular basis of oxidative stress response by annexins Materials and methods Puriﬁcation of recombinant protein Cloning and construction of an N-terminal ... shows separation of the two modules (I/IV and II/III) leading to greater accessibility of the intermodular space than in the case of AnxA5 and to formation of a Table Conservation of salt bridges ... Anx(Gh1) from cotton emphasizes the high conservation of the unique annexin fold even among the members of the plant subfamily of annexin proteins The fold is comprised of the arrangement of four a-helical...

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Báo cáo khoa học: The molecular chaperone a-crystallin incorporated into red cell ghosts protects membrane Na/K-ATPase against glycation and oxidative stress ppt

Ngày tải lên : 17/03/2014, 03:20

... regeneration system, nor by loss of ATP or by changes in concentrations of Na+ and K+ levels These experiments were performed in the absence of a-crystallin, suggesting that the chaperone function of ... [12,14] and prevention of inactivation of enzymes by small molecules [7,8] a-Crystallin has also been shown to decrease the degree of thiol oxidation of other lens crystallins under conditions of oxidative ... concentrations or Na+ and K+ levels three control experiments were performed The efﬁciency of the ATP regenerating system was checked: ATP levels over h were measured, as were concentrations of...

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Báo cáo khoa học: "Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation" pps

Ngày tải lên : 07/08/2014, 18:21

... snoitidnoc eseht rednu ON fo ytitnauq eht desaercni nac dica cibrocsa taht deveileb si ti ,yduts siht ni derusaem ton saw noitartnecnoc ON eht hguohtlA ]72,62 ,41[ SOR dna ON devired-muilehtodne ... a rof nekat erew yendik tfel eht morf selpmas eussit ehT ld/gm 8.1< ot dezilamron dah seulav eninitaerc mures eht fi keew tnalpsnart-tsop driht eht retfa seninac gnivivrus eht gnizinahtue rof ... noitatnalpsnarT noitatnalpsnartotua yb dewollof puorg tnemtaert eht ni desufrep erew )aeroK ,mrahP naH iaD ;gk/gm 001( dica cibrocsa dna enilas lamron dloC enilas lamron dloc htiw desufrep erew puorg lortnoc...

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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx

Ngày tải lên : 09/08/2014, 01:23

... days before hospitalisation The baseline evaluation was performed on the morning of admission after hour of rest at room temperature The duration of the wash-out period is long enough for calcium-channel ... [24] The improvement of all these markers and the correlation between the values before and after treatment suggest a powerful general action on endothelial injury Calciumchannel blockers of the ... VEGF signalling We confirm herein the high concentration of VEGF in serum and its association with the early phase of the disease [9] Moreover, we report high concentrations of the sVEGFR-1 in patients...

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Báo cáo y học: "Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rat" pptx

Ngày tải lên : 10/08/2014, 09:22

... Ischemic preconditioning decreases the reperfusion related formation of hydroxyl radicals in a rabbit model of regional myocardial ischemia and reperfusion: the role of K (ATP) channels Free ... ischemia and days of reperfusion Group 2- Preconditioning plus I/R with long duration (7dR+IP): The same preconditioning protocol with the group IV, and then, hours of ischemia with following days of ... minutes of short ischemia with minute's intervals), and then hours of ischemia with hours of reperfusion Part 2: Long time effetcs of I/R and IP Group 1- I/R with long duration (7dR):4 hours of ischemia...

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Báo cáo y học: "Ipsilateral common iliac artery plus femoral artery clamping for inducing sciatic nerve ischemia/reperfusion injury in rats: a reliable and simple method" doc

Ngày tải lên : 10/08/2014, 10:20

... carried out for the sham-operated group except for arterial clamping After certain time intervals of reperfusion, the function of the hind limb was assessed for each animal in terms of behavioral ... another model introduced by Saray and his colleagues [2], only femoral artery and vein – just distal to the inguinal ligament – are clamped for hrs followed by reperfusion The former is time consuming ... Discussion The results of our experiment promised of a newly introduced method for induction of I/R injury in peripheral Figure microscopy level (left panel) and group days reperfusion (right...

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Báo cáo y học: "Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits" docx

Ngày tải lên : 10/08/2014, 10:20

... 15 after the administration of the reagent (phase7), and just before the end of the experiment (phase 8) Serum Ca2+ level measured in all groups at the onset (phase 1) and at the end of the experiment ... The method is based on the reaction between superoxide radical and Hydroethidine that results in the formation of the specific product 2-OH-ethidium, the formation rate of which is measured and ... macrophage influx, and) activation of the calcium-activated cysteine protease calpain which is mediating axonal damage in SCI One of the consequences of mitochondrial dysfunction, COX and lipoxygenase...

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Báo cáo y học: "CXC-chemokine regulation and neutrophil trafficking in hepatic ischemia-reperfusion injury in P-selectin/ICAM-1 deficient mice" docx

Ngày tải lên : 11/08/2014, 08:21

... analysis of the cytokine data and the preparation of the manuscript EC was responsible for conceiving, supervising the design and performance of the project, as well as preparation of the manuscript ... (B) Control, P/I null mouse, (C) Wild-type mouse after 90 minutes of ischemia and h of reperfusion, (D) P/I null mouse after 90 minutes of ischemia and h of reperfusion ischemia followed by and ... [25] Other factors such as swelling of the endothelial lining cells, vasoconstriction of the sinusoids, and, stiffening and decreased deformability of the neutrophils, may also contribute to the...

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Báo cáo y học: "Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice" potx

Ngày tải lên : 13/08/2014, 16:21

... alterations in afterload have a significant impact on measures of cardiac performance The uncertainty as to the in vivo action of AVP on the heart provides the rationale for this study Further, as the ... control to assure good absorption of the intra-peritoneal medication as well as a standard of care arm with which to compare cardiac function and mortality Vasopressin, on the other hand, demonstrated ... group were studied Ischemia- reperfusion of the LAD An open-chest model of I/R using ligation and reperfusion of the LAD was modified from Michael and colleagues [36] Mice were anesthetized using...

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Role of cyclic AMP signalling mechanisms in heart protection against ischemia reperfusion injury

Ngày tải lên : 30/08/2015, 13:58

... binding of Hexokinase II to the mitochondrial membrane and inhibition of mitochondria permeability transition pore (MPTP) opening Cyclic AMP-induced activation of PKA by (due to heart perfusion with ... 2007;581:1147-61 Study of the signalling mechanisms of cardioprotective effect of temperature preconditioning have revealed that this intervention is mediated by consecutive activation of PKA and PKC as ... Coronary Artery Occlusion and Heart Attack Heart Attack Myocardium Atheroslcerosis Reperfusion Thrombosis Risk Zone IschaemiaReperfusion INJURY Experimental Protocol...

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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf

Ngày tải lên : 07/03/2014, 12:20

... 1140–1149 21 Anderson MF & Sims NR (2002) The effects of focal ischemia and reperfusion on the glutathione content of mitochondria from rat brain subregions J Neurochem 81, 541–549 22 Cai J & Jones DP ... contribution of each ROS-forming site, because inhibition of ROS production in the one may aggravate ROS formation in the other, and vice versa The observation that KGDHC generates and is also ... mitochondria: the ﬁrst wave of efﬂux is attributed to the activation of the DAG-sensitive nonselective cationic channels; the second wave is due to opening of the PTP It is not yet known how activation of...

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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc

Ngày tải lên : 14/03/2014, 23:20

... the induction of GhMPK2 On the one hand, GhMPK2 was strongly induced in response to MV, which can cause continuous formation of OÀ (Fig 1), suggesting that ROS participate in the activation of ... comprehensive understanding of the functional roles and mechanisms of action of GhMPK2 in plant defense As we learn more about MAPKs and their regulation, the design of efﬁcient strategies for crop improvement ... Discussion The role and signiﬁcance of group C MAPKs in response to biotic and abiotic stresses have only recently begun to emerge [22–24] In the present study, we describe the characterization of the...

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Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw potx

Ngày tải lên : 30/03/2014, 16:20

... Induction of the Msn2 ⁄ target genes in response to one form of stress gives rise to the phenomenon of cross-protection against an aggravated form of the same stress or to a different type of environmental ... chaperoning the formation of disulfide bonds through the guiding of Orp1 Cys36SOH to Yap1 Cys598, and ⁄ or preventing the formation of the competing Orp1 Cys36-Cys82 disulfide bond Once activated, the ... proteins and the yeast response to stress expression programmes common to all environmental stress responses are at play [1] Specific forms of stress such as heat shock and some forms of oxidative stress...

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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx

Ngày tải lên : 19/06/2014, 22:20

... addition to the deposition of Aβ in brain [13,14] Despite this evidence, and the considerable theoretical and therapeutic interest, the relationship between brain inflammation responses and oxidative ... Chronic neuroinflammation is another constant feature of AD, and this also is thought to play a significant role in the onset and progression of AD Support for this hypothesis comes from epidemiological ... more restricted therapeutic target to provide further evidence that both oxidative stress and inflammation are indeed functionally relevant in the development of the phenotype of these animals...

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Báo cáo khoa học: " Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury" pps

Ngày tải lên : 07/08/2014, 18:21

... etartsnomed ot deliaf evah ew ,yllanoitiddA NUB naht segnahc deirav hcum wohs ton did rC fo sleveL egnahc rof hguone gnol ton saw emit yrujni cimehcsi taht tseggus gnidnif siht ,suhT NUB seod naht ... esaercni tpurba detartsnomed nim 09 rof aimehcsi gniwollof noisufreper laner ,yduts suoiverp a nI puorg lortnoc ni detartsnomed erew noisufreper retfa syad 41 dna erofeb yletaidemmi seulav erapmoc ... tnacifingis on saw ereht dna puorg detaert ni 36.0 ot 55.0 morf dna puorg lortnoc ni 36.0 ot 25.0 morf degnar seulav IR kaep ehT egnar lamron erew yregrus retfa syad 41 ,7 ,5 ,3 ,1 dna erofeb ta...

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