is there any association of angiogenic activity with the histopathologic pattern of the iip
Báo cáo y học: "Participation of the PI-3K/Akt-NF-κB signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 " pot
... expression of Flk-1 is highly restricted to endothelial cells and tightly controlled during angiogenesis, further understanding of the potential factors that regulate the expression of Flk-1 in the ... Madison, WI), with or without HIMF protein stimulation, and then treated with passive lysis buffer according to the dual-luciferase assay manual (Promega) The luciferase activity was measured with ... chemiluminscent detection of the signals with autoradiography film (Amersham) Statistical analysis Unless otherwise stated, all data were shown as mean ± standard error of the mean (SEM) Statistical significance...
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Báo cáo sinh học: "Time-course of sFlt-1 and VEGF-A release in neutropenic patients with sepsis and septic shock: a prospective study" pptx
... consequence of the cascade of events that leads to septic shock This hypothesis is supported by the intuitive assumption that VEGF-A acts as one of the final downstream elements in the pathogenesis of ... cells Rather than an independent function, this barrier-breaking property is indeed an important part of VEGF-A’s role in the regulation of angiogenesis, as the disassemble of an intact endothelial ... associated with a variety of conditions that share the disruption of the endothelial barrier as a common pathogenic mechanism, including sepsis [19,20] In intensive care unit patients with sepsis, levels...
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báo cáo hóa học:" Time-course of sFlt-1 and VEGF-A release in neutropenic patients with sepsis and septic shock: a prospective study" pdf
... consequence of the cascade of events that leads to septic shock This hypothesis is supported by the intuitive assumption that VEGF-A acts as one of the final downstream elements in the pathogenesis of ... cells Rather than an independent function, this barrier-breaking property is indeed an important part of VEGF-A’s role in the regulation of angiogenesis, as the disassemble of an intact endothelial ... associated with a variety of conditions that share the disruption of the endothelial barrier as a common pathogenic mechanism, including sepsis [19,20] In intensive care unit patients with sepsis, levels...
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Báo cáo y học: "Characterization of N200 and P300: Selected Studies of the Event-Related Potential Salil H. Patel 1 and Pierre N. Azzam 2"
... and this change is further filtered in relation to the sex of the subject The effect of cortical perfusion and metabolic activity on the P300 is still poorly understood P300 amplitude is 151 ... which deviated from the standard in the intensity of the first component and the glide direction of the second constituent The number of distinct MMN components elicited by this double deviation ... schizophrenia is nonetheless a clinicallydiagnosed disease Beginning in the 1970s, attempts have been made to objectify various aspects of the disease and its pathogenesis via analysis of the P300...
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Agile Web Application Development with Yii 1.1 and PHP5
... this simplified format for the purposes of this example The ControllerID in the URL refers to the name of the controller By default this is the first part of the controller class name, up to the ... version 1.1.2 for the purposes of this book, which is the latest stable version as of the time of writing Though most of the sample code should work with any 1.1.x version of Yii, there may be some ... relieves us of the tedium of having to write any SQL or otherwise deal with the underlying database Active Record does even more than this It integrates seamlessly with many other aspects of the Yii...
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listen and speaking 1 and 2
... Florida is a There are as many women as men in this class b There are fewer men in this class than there are women a The ice cream isn’t as good as the cake b The cake is good, but the ice cream is ... points) Listen and check off what you hear The mother has to cook the dinner pay the bills empty the dishwasher The father must wash the dishes cook the dinner empty the dishwasher the shopping They ... Rachel isn’t the same height as Yoko My car is in better shape than his is Texas is farther than Florida is There are fewer men in this class than there are women The cake is good, but the ice...
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Tài liệu ADC’s HDSL Interface Panel combines HDSL termination, DSX-1 and DSX-3 into a single shelf doc
... Minneapolis, Minnesota USA 55440-1101 Specifications published here are current as of the date of publication of this document Because we are continuously improving our products, ADC reserves the ... splicing for feeder and distribution cables • Splitters provided with 2mm pigtails ready to patch into distribution ports • Extensive cable management • Preterminated with OSP cable; loose tube ... connector cleanliness is maintained • 1x4, 1x8, 1x16, or 1x32 splitters can be preinstalled or ordered separately ADC Fiber Distribution Hub – ACE-200 (576 Homes) Front of cabinet Rear of cabinet Base...
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Tài liệu Chapter 4: Configuring Layer 1 and Layer 2 Features docx
... SONET 9/0/0 • SigType NA NA NA NA Mode/QL NA/Dis Sync/Dis NA/Dis NA/Dis Prio 251 1 QL_IN NA NA NA NA ESMC Tx Dis Dis Dis Dis ESMC Rx Dis Dis Dis Dis You can use show network-clocks synchronization ... AT8/1/0 SONET 9/0/0 SigType NA NA NA NA Mode/QL NA/Dis Sync/Dis NA/Dis NA/Dis Prio 251 1 QL_IN NA NA NA NA ESMC Tx Dis Dis Dis Dis ESMC Rx Dis Dis Dis Dis Interface: Local Interface: ... the BITs interface The cleaned up clock is received back from the SSU This clock is used as Tx clock for the SyncE ports For 7600 router, the interface from which the clock is recovered and the...
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Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx
... < GST B OXI1 lof lof - MPK3 MPK6 7255- 15 15 15 μg - < GST-MAPK < HIS-OXI < HIS-PTI < HIS-OXI < HIS-PTI GST-MPK3 > < MBP 55- HIS-OXI > < HIS-OXI < HIS-PTI HIS-PTI > < HIS-OXI < HIS-PTI < MBP Fig ... The kinase-deficient mutant, OXI1K45R, in which the lysine residue of the ATP binding domain is mutated to arginine, still interacted with PTI1-4 These data indicate that the kinase activity of ... proteins were then detected by western blot analysis with an anti-HIS IgG GST alone was used as a negative control One tenth of the input was loaded on to the gel and represents the amount of HIS-tagged...
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Tài liệu Báo cáo khoa học: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor pdf
... inhibition of the protease activity of TMPRSS13 (Fig 2C) These results suggest the characteristic association of HAI-1–NK1 with TMPRSS13, the mechanism of which remains to be investigated The in ... representation of the structure of the full-length HAI-2 (1) and a soluble form of HAI-2 tagged at the C-terminals with myc-His (2) (C) Dose dependence of the inhibitory activity of soluble forms of HAI-1 ... exclusively in the injured tissue This conversion is mediated by serine protease activity, which is induced in the injured tissue [28] The two-chain form is required for the biological activity of HGF...
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Tài liệu Báo cáo khoa học: The two Caenorhabditis elegans metallothioneins (CeMT-1 and CeMT-2) discriminate between essential zinc and toxic cadmium docx
... absorber–scatterer distance in A (± 0.02 A, inner shell; ± 0.05 A, outer shell), N is the number of scatterers around ˚ the central atom, 2d2 is the the Debye–Waller factor in A2, ± 25%, and the R factor is the ... and other MTs (Table 2), even when the effect of the over-metallated species is taken into account To date, the overall stability of cadmium binding to CeMT-1 is the lowest value reported for any ... homeostasis [15], and response to oxidative stress [16] There is growing evidence that the existence of multiple MT isoforms is associated with functional differentiation, for example in snails...
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Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx
... whereas this was not the case in the absence of PMA (Fig 3) Furthermore, the ratio between the ERK-PP concentration after stimulation with EGF and PMA together on the one hand, and the sum of the ERK-PP ... Synergistic ERK activation by EGF and PMA (Eur J Biochem 271) 3911 of its precise mechanism, the transient oscillation is one aspect of complexity that is observed in the dynamics of this signal ... accurately the synergistic effect EGF concentration-dependency of synergistic activation To investigate the synergistic activation in the second phase of the time profile further, we measured the ERK-PP...
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Tài liệu Báo cáo khoa học: Characterization of promoter 3 of the human thromboxane A2 receptor gene A functional AP-1 and octamer motif are required for basal promoter activity docx
... subjects is currently unknown but in view of the extensive differences between the TP isoforms in terms of their mechanisms of signaling [18,19], modes of regulation ⁄ desensitization [20–23] and patterns ... also play a critical role in the assembly of the preinitiation complex within TATA-less promoters [47] The AP-1 complex is comprised of a group of proteins encoded by the jun (c-Jun, JunB, JunD) ... regions of Prm3 The following lists the identities of the Prm3 gene fragments and corresponding plasmids generated in either pGL3Basic (pGL3b) or pGL3Enhancer (pGL3e) vectors and the identity of the...
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Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
... inhibit the LBS function of either K1 [34] or K4 [35] and have used them to analyse, in functional isolation, the role of these LBS on plasmin(ogen) binding and activation The effect of these mAbs ... possibility of steric hindrance The reproduction of similar results with Fab fragments is in agreement with this concept We demonstrate that the selective neutralization of the K1-LBS with mAb 34D3 ... fibrinolysis C As fibrinolysis is the main physiological function of fibrin-bound plasmin, we explored the effect of the two anti-LBS mAbs on this process Both anti-LBS mAbs decreased fibrinolysis in...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
... fgl2 mRNA The left side of the figure is the sequence ladder using the same primer and the pM166 clone as template Arrow indicates the nucleotide that is matched to the band present in the primer ... (pCR3.1) Mutation of the Sp1/Sp3 (mut4) site completely abolished this activation Discussion Evidence indicates that inducible expression of fgl2 correlates with the vascular thrombosis of the liver ... mutation of any of the above fragments significantly affected basal expression of fgl2, it is possible that the nucleoprotein complexes that form upon this PRD cis region interact with the core...
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Tài liệu Báo cáo Y học: Binding of gelsolin domain 2 to actin An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin pptx
... 10 mM ) to 226–375 of actin As the affinity for S2 to the entire actin molecule is within this range (Kd 1.4–7.9 mM ) [14,32] perhaps there is no other region on the surface of the actin molecule ... extent the identity of these residues within S2 is less certain The first 10 residues of S2 in addition to S1 is the minimal requirement for filament severing [41] The standard explanation for this is ... (Eqn 1) was drawn The plot gives the number of binding sites which is the value of C/(XE) for 1/(1–X) ¼ The slope of the same curve directly gives the value of the affinity constant Analytical...
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Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors pdf
... of the sequence of the promoter of the murine Muc5b mucin gene The sequence covering 1210 nucleotides upstream of the transcription initiation site is shown in Fig 1A It is characterized by the ... co-transfected with the empty expression vector pCMV4 The luciferase activity for each cotransfection is represented as the fold activation compared with the activity obtained with the empty pCMV4 vector The ... mutant of interest was transfected with 0.25 lg of the expression plasmid encoding the transcription factor of interest The results were expressed as the fold activation of luciferase activity of the...
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Báo cáo khoa học: Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans pot
... known as PTS1, is present at the C-terminal end of the C elegans GSTK-1 protein PTS1 is involved in protein import into peroxisomes, and the importance of this signal for peroxisome targeting ... complexed with glutathione (GSH), showed a different folding topology from that of the other GST classes, and revealed that the enzyme shows similarity with the protein disulfide bond isomerase, ... human and rodent Tissue distribution, analysed by RT-qPCR, showed that the hGSTK1 gene is expressed in the 24 different human tissues examined [4] In the mouse, the mGSTK1 protein is present in large...
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Báo cáo khoa học: Complexes of Thermoactinomyces vulgaris R-47 a-amylase 1 and pullulan model oligossacharides provide new insight into the mechanism for recognizing substrates with a-(1,6) glycosidic linkages docx
... the binding of pullulan to the catalytic site This hydrophobic wall is suitable for the binding of amylose with a helical structure, where the O2 atoms form hydrogen bonds with the O3 atoms of ... for the hydrolysing activity As the first step in the proposed mechanism behind the hydrolysis of a-(1,4) glycosidic linkage, the OE atom of Glu396 protonates the O4 atom (glucoside oxygen) at the ... Technology of Japan The author (A A) is supported by Research Fellowship for Young Scientists (17–6519) from Japan Society of the Promotion of Science This research was performed with the approval of the...
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Handbook of Residue Analytical Methods for Agrochemicals VOLUME 1 and VOLUME 2 doc
... compendia as the FDA Pesticide Analytical Manual15 or the Of cial Methods of Analysis of the Association of Official Analytical Chemists’.30 In addition to regulatory agencies, the US Department of Agriculture ... Chemists [later named the Association of Official Analytical Chemists (AOAC) and now AOAC International], the American Chemical Society’s Division of Pesticide Chemistry (now the Agrochemical Division), ... Execution of the field portion of the worker exposure/re-entry study Observations of the volunteers during the conduct of the field study Data collection and the use of field forms Storage and shipping of...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25