is ccdc26 a novel cancer associated long chain non coding rna
Genomic organization and functional characterization of a novel cancer associated gene u0 44
Ngày tải lên :
14/09/2015, 21:59
... Zona Pellucida – ZP is a thick extracellular coat that surrounds all mammalian eggs and plays a vital role in oogenesis, fertilization and preimplantation development (Wassarman, 1988; Wassarman ... signals can be attenuated and this may be a result of resistance, which is a major limitation of cisplatin-based chemotherapy There are several mechanisms that contribute to cisplatin resistance, ... al., 2004), can improved the prognosis, diagnosis and screening of early stage ovarian cancers 1.3 Treatment of Ovarian Cancers Despite advances in ovarian cancer treatment in the past 40 years,...
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Báo cáo y học: " Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis"
Ngày tải lên :
03/11/2012, 10:52
... Yamaguchi H, Sasaki K, Satomi Y, Shimbara T, Kageyama H, Mondal MS, Toshinai K, Date Y, Gonzalez LJ, Shioda S, Takao T, Nakazato M, Minamino N Peptidomic identification and biological validation of ... DJ, Voustianiouk A, Macgrogan D, Ho L, Suh J, Humala N, Thiyagarajan M, Wang J, Pasinetti GM A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis BMC Neurosci ... hypothesis was rejected at the 0.05 level in all analyses Statistical analysis Results Statistical analyses were performed using SigmaStat (version 3.0, SPSS Inc., Chicago, IL) Independently measured...
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Báo cáo khoa học: " Evidence for a novel gene associated with human influenza A viruses" pptx
Ngày tải lên :
12/08/2014, 04:20
... PB1-F2, that is not translated from the first AUG of the mRNA, rather the PB1-F2 peptide is produced as a result of translation initiating at an alternate start codon in a different reading-frame to ... Talon J, Salvatore M, O'Neill RE, Nakaya Y, Zheng H, Muster T, Garcia-Sastre A, Palese P: Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach Proc Natl Acad Sci USA ... [70]) and internal initiation of translation (e.g Hepatitis C virus F protein [71]) Clearly, some of these mechanisms (those that utilize a normal viral mRNA) are not appropriate for translation...
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Báo cáo khoa học: Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase docx
Ngày tải lên :
30/03/2014, 15:20
... Selva, E (2004) Antibiotic GE23077, a new inhibitor of bacterial RNA polymerase I Taxonomy, isolation and characterization J Antibiot 57, 210–217 20 Plevani, P., Albertini, A. M., Galizzi, A. , Adamoli, ... minor damage to the cell membrane may have far-reaching consequences on cellular activities, and, in particular, on membrane -associated transport systems Although our data suggest that impairment ... In addition, the widespread production of b-lactamase renders M catarrhalis resistant to penicillins [35], as also observed in GE23077-sensitive M catarrhalis strains (E Selva, unpublished data)...
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báo cáo khoa học: " Non-coding RNAs: a key to future personalized molecular therapy?" docx
Ngày tải lên :
11/08/2014, 12:20
... ncRNA, non- coding RNA; PAR, promoter -associated RNA; PASR, promoter -associated small RNA; piRNA, PIWI -associated RNA; pre-miRNA, precursor miRNA; pri-miRNA, primary miRNA; RISC, RNA induced silencing ... Plk1 regulation by miR-100 in human nasopharyngeal cancer Int J Cancer 2009, in press 89 Takeshita F, Patrawala L, Osaki M, Takahashi RU, Yamamoto Y, Kosaka N, Kawamata M, Kelnar K, Bader AG, Brown ... complex; shRNA, small hairpin RNA; siRNA, small interfering RNA; snoRNA, small nucleolar RNA; tel-sRNA, telomere-specific small RNA; UCR, ultraconserved region; UTR, untranslated region Author details...
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Báo cáo y học: " Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during " pps
Ngày tải lên :
14/08/2014, 21:20
... 204508_adh ttacaatttttaCTGTTTCAaaatatttgcaaaatcctaatagaattcgcggagtaaTACTAGAGAAGTAGAAGTCATttgcgggtt TACTAGAGAAGTAGAAGTCATTTGC TACTAGAGAAGTAGAAGTCATT TACTAGAGAAGTAGAAGTCAT ... TACTAGAGAAGTAGAAGTCAT TAGAGAAGTAGAAGTCATTTG TACTAGAGAAGTAGAAGTCA TACTAGAGAAGTAGAAGTC ATACTAGAGAAGTAGAAGTCAT AATACTAGAGAAGTAGAAGTCAT 25 22 21 21 20 19 22 ... 2740490_adh 2740489_adh 2740488_adh 21UR-5525 21UR-6159 2740480_adh 2740476_adh 747154_adh tgaagaaattgaCTGTTTCAtatagttgttttaacaaaacaaattattgcctaataaTTTTGAAAAGCTGACAGGGGGtaattaatt TTTTGAAAAGCTGACAGGGGGTAAT...
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Roles of long non coding RNAs in human embryonic stem cell pluripotency and neural differentiation 1
Ngày tải lên :
09/09/2015, 17:54
... R: ggagccgtagtgagcagttc atgcctcacacggagactgt aagtgggttgtttgcctttg ggcacagttagagccaactaaga ccgagcagcactaacacg gagaggcagctgagatcagaa tgagaatacgatgtctgcaggt gtggagagcaactccgatg tctgcagagctttgatgtcc ... ggcacacacacattaacacactt ggtgtgtgagagcaattctcag aggtggttgaccttcaatgg tttgatttcttccagcattgtg gagtctgcctgttgcagga cagcgtctgacagcgaca aagttcaacaacaactgctaccaa gaagctcgtcatgcagttca ttgctgcctctttaagactagga ... gcccaatacgaccaaatcc tcagctacctgaagcacagc tagtcctggtgcaggctctt tgcctaagatgcccgactt agctgctggctggtgaag aaggacaagaagcgaagcat ttcctgtcatcccctggata aaggcctcatttgaagtatcctc cactcagccctgtctctgc atggaacagagcccctacg...
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Roles of long non coding RNAs in human embryonic stem cell pluripotency and neural differentiation 3
Ngày tải lên :
09/09/2015, 17:54
... 7.2: RNA- seq analysis indicating transcription start and end sites of neuronal lncRNAs (A) The three isoforms of RMST are namely AK056164, AF429305 and AF429306 (B) lncRNA_N1 (AK124684) is a single-exon ... be associated with many lncRNAs (Khalil et al., 2009), and the latter is an important transcription factor that represses neurogenesis and is part of the complex bound by the lncRNA HOTAIR (Naruse ... (Jiang et al., 2008; Loh et al., 2006) In this chapter, it is evident that lncRNAs act as an additional layer of transcriptional control in maintaining stem cell pluripotency LncRNAs are regulated...
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Roles of long non coding RNAs in human embryonic stem cell pluripotency and neural differentiation 4
Ngày tải lên :
09/09/2015, 17:54
... colocalization of the RMST signal and the DAPI stain confirmed that RMST is a nuclear-localized lncRNA (Figure 8.11B) Figure 8.11: RMST is a nuclear-localized lncRNA (A) Cellular RNA was separated ... nuclear and cytoplasmic fractions by RNA fractionation, and abundance of the RNA transcripts in either fraction was assayed by qPCR The nuclear/cytoplasmic ratio was computed presented in the graph ... confirm that RMST is a nuclear transcript, RNA fluorescence in situ hybridization (RNA- FISH) was performed, using a full-length fluorescent probe against RMST 135 As a nuclear-retained lncRNA, RMST...
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Roles of long non coding RNAs in human embryonic stem cell pluripotency and neural differentiation 5
Ngày tải lên :
09/09/2015, 17:55
... et al (2007) RNA maps reveal new RNA classes and a possible function for pervasive transcription Science 316, 1484-1488 Katayama, S., Tomaru, Y., Kasukawa, T., Waki, K., Nakanishi, M., Nakamura, ... Masin, M., and Tartaglia, G.G (2011) Predicting protein associations with long noncoding RNAs Nat Methods 8, 444-445 Bernard, D., Prasanth, K.V., Tripathi, V., Colasse, S., Nakamura, T., Xuan, ... Guttman, M., Huarte, M., Garber, M., Raj, A. , Rivea Morales, D., Thomas, K., Presser, A. , Bernstein, B.E., van Oudenaarden, A. , et al (2009) Many human large intergenic noncoding RNAs associate...
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Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"
Ngày tải lên :
26/10/2012, 10:04
... 1145-9 Tamura N, Ogawa Y, Chusho H, et al Cardiac fibrosis in mice lacking brain natriuretic peptide Proc Natl Acad Sci USA 2000; 97: 4239-44 Mukoyama M, Nakao K, Saito Y, et al Human brain natriuretic ... Japanese Circ Res 2000; 86: 841-5 13 Nakayama T, Soma M, Rahmutula D, Ozawa Y, Kanmatsuse K Isolation of the 5'-flanking region of genes by thermal asymmetric interlaced polymerase chain reaction ... using an automatic electrophoresis system (Agilent 2100 bioanalyzer systemTM; Agilent Technologies, Waldbronn, Germany) Int J Med Sci 2007, Statistical analysis Data are presented as the mean ±...
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Tài liệu Báo cáo khoa học: KIPase activity is a novel caspase-like activity associated with cell proliferation doc
Ngày tải lên :
19/02/2014, 13:20
... for caspases and 7; Ac-YVAD-AMC is a substrate for caspase 1; Ac-IETD-AMC is a substrate for caspase and 10; Ac-LEHD-AMC is a substrate for caspases 2, 4, and Ac-DVPD-AMC, Ac-DPSD-AMC and Ac-ESQD-AMC ... duplicate The preferred substrate (bar A) for each was as follows: caspase 1, WEHD-AMC; caspase 2, VDVADAMC; caspase 3, DEVD-AMC; caspase 4, WEHD-AMC; caspase 5, WEHD-AMC, caspase 6, VEID-AMC; caspase ... currently uncharacterized gene Interestingly, a distant relative of the caspases, termed paracaspase, was identified in Homo sapiens using a PSI-BLAST search [39] Paracaspase could be a candidate gene...
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Báo cáo khoa học: Characterization of a novel long-chain acyl-CoA thioesterase from Alcaligenes faecalis docx
Ngày tải lên :
16/03/2014, 13:20
... In an analogous manner, when stearoyl-CoA was used as 2379 Thioesterase of Alcaligenes faecalis P Shahi et al Table Thioesterase catalyzed hydrolysis of acyl-CoA derivatives A solution of acyl-CoA ... is to prevent the abnormal accumulation of intracellular acyl-CoA We have isolated a thioesterase from Alcaligenes faecalis ISH108 and demonstrated its application in FEBS Journal 273 (2006) 2374–2387 ... 8.67 – – 2380 acetate propanoate butanoate hexanoate dodecanoate palmitate stearate FEBS Journal 273 (2006) 2374–2387 ª 2006 IMTECH P Shahi et al Thioesterase of Alcaligenes faecalis Reagent (1 mM)...
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Báo cáo khoa học: A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells potx
Ngày tải lên :
16/03/2014, 23:20
... plasminogen activator Nature 377, 340–344 Hirata A, Yoshida S, Inoue N, Matsumoto-Miyai K, Ninomiya A, Taniguchi M, Matsuyama T, Kato K, Iizasa H, Kataoka Y, Yoshida N & Shiosaka S (2001) Abnormalities ... brain Biochim Biophys Acta 1350, 11–14 11 Ogawa K, Yamada T, Tsujioka Y, Taguchi J, Takahashi M, Tsuboi Y, Fujino Y, Nakajima M, Yamamoto T, Akatsu H, Mitsui S & Yamaguchi N (2000) Localization ... Phe-Phe-Arg-MCA Prosemin acted enzymatically on Pro-Phe-Arg-MCA and Boc-Val-Leu-Arg4919 A novel serine protease in various cancer cells MCA, although it preferentially cleaved Boc-Glu(Obzl) and Gln-Ala-Arg-MCA...
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Tài liệu Báo cáo khoa học: Identification of a novel matrix protein contained in a protein aggregate associated with collagen in fish otoliths pdf
Ngày tải lên :
18/02/2014, 17:20
... TCATCAT-3¢; rOMM-64-IV, 5¢-CGCGGATCCGCCCCT GTTAATGATGGAACC-3¢ and 5¢-CGCCTCGAGCTAA GAAGACTGGGCTGCCAG-3¢; rOMM-64-V, 5¢-CGCGG ATCCAGGCAAGATTTTAAGCATCCA-3¢ and 5¢-CGCC TCCACCTAAGAGGCATCCTTGTCCAC-3¢; ... 5¢-CGCCTCCA CCTAAGAGGCATCCTTGTCCAC-3¢; rOMM-64-II, 5¢CGCGGATCCACCGTAGACACTTATGATATA-3¢ and 5¢-CGCCTCGAGCTAAGAGTCAGCTTGCACGTC-3¢; rOMM-64-III, 5¢-CGCGGATCCGCTGATGTGACCAGT GATGAC-3¢ and 5¢-CGCCTCGAGCTATTTGGGCTCTT ... analysis of Prismalin–14 from the prismatic layer of the Japanese pearl oyster, Pinctada fucata FEBS J 274, 5158–5166 Murayama E, Takagi Y, Ohira T, Davis JG, Greene MI & Nagasawa H (2002) Fish...
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Báo cáo khoa học: A novel prokaryotic L-arginine:glycine amidinotransferase is involved in cylindrospermopsin biosynthesis potx
Ngày tải lên :
06/03/2014, 22:21
... DNA Isolation Kit (MoBio, Carlsbad, CA, USA), according to the manufacturer’s instructions PCR amplification of cyrA was performed using primers cyrA-F (5¢-CATATGCAAACAGAATTGTAAATAGCT3¢) and cyrA-R ... Mutat Res 472, 155–161 Li R, Carmichael WW, Brittain S, Eaglesham GK, Shaw GR, Mahakhant A, Noparatnaraporn N, Yongmanitchai W, Kaya K & Watanabe MM (2001) Isolation and identification of the cyanotoxin ... cyanobacterial species have so far been shown to produce the toxin; they are Aphanizomenon ovalisporum, Umezakia natans, Rhaphdiopsis curvata, Aphanizomenon flosaquae and Anabaena bergii [4,14–18]...
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Báo cáo khoa học: SAF-3, a novel splice variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation pptx
Ngày tải lên :
07/03/2014, 02:20
... splice acceptor 1A 75 ATCTTCCAGgtaacaac 625 cacctcagGGTCACGCC 1C 87 CCATTCCAGgtgagtag 84 ctccgcagGCCGCGCCG 851 CTTCTCCCGgtgtgcac 403 gtccccagGCCGGATCA 64 AATGTGAGgtaggaag 277 ctcctcagAAATGTGAG 172 ... cells SAF-3 antibody was prepared against the N-terminal epitope (MDPSNWSSFIFQ peptide) that is absent in the SAF-1 and SAF-2 isoforms Ray A & Ray BK (1998) Isolation and functional characterization ... post-translational modification, including phosphoryla- Fig SAF-3 expression is detected in human arthritic tissues Total RNA was isolated from representative normal, OA and RA synovium tissues and...
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Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx
Ngày tải lên :
07/03/2014, 05:20
... Nucleic Acids Res 32, 1325– 1334 Nakahata S, Kotani T, Mita K, Kawasaki T, Katsu Y, Nagahama Y & Yamashita M (2003) Involvement of Xenopus Pumilio in the translational regulation that is specific ... compilation ª 2008 FEBS C Papin et al Zealand), followed by affinity purification The antibody against Xenopus CPEB is an affinity-purified rabbit polyclonal antiserum [20] The RPA and AuroraA antibodies ... regulated mRNAs Although cytoplasmic polyadenylation is regulated by a protein complex at the 3¢-end of the mRNA, PAP is the only known enzyme capable of elongating the poly (A) tail This activity...
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Báo cáo khóa học: SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast docx
Ngày tải lên :
07/03/2014, 15:20
... CTTTTTAGAACGACATGCAGCTGAAGCTTCGTA CGC-3¢ and disRAS1rev CAAAACCATGTCATAT CAAGAGAGCAGGATCATTTTCAACAAATTATGC ATAGGCCACTAGGGATCTG-3¢ YEp351-SUT2 was constructed to contain SUT2 as the only open reading frame present ... CGCTGGCTTCCAAACCCTTATCGATACCGTCGA CCC-3¢ and SUT-GFPrev 5¢-AACAATTTCACACACA GGAAACAGCTATGACCATGATTACGCTATAGG GCGAATTGGGTA-3¢, respectively YEp351-SUT2 was linearized with SphI and co-transformed ... The cassette was amplified from the plasmid pUG27 [13] using the primers disSUT2fwd 5¢-TGACGCTCACCAAGCTATTGGTTT GTTTGGATCAATCGTCAGATATGAAGGCATAG GCCACTAGTGGATCTG-3¢ and disSUT2rev 5¢-TAT TAATATTCCTATATTTTACATAGGAGGAAATTA...
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