investigation of the structural requirements for biological activity
Tài liệu HIGHLIGHTS OF THE AUTHORISATION REQUIREMENTS FOR FUND DISTRIBUTION IN HONG KONG doc
Ngày tải lên :
19/02/2014, 14:20
... Document The Hong Kong Offering Document of a scheme should contain, inter alia, the following information: Constitution of the scheme (e.g the name, registered address, place and date of creation of ... apply [2] Section of the Handbook sets out the overarching principles and requirements that apply across different types of products governed by the Handbook, whilst Section of the Handbook (i.e ... certain provisions of the Handbook by virtue of prior authorization in a regulated jurisdiction Applications for reviewed on the basis that the scheme's structural and operational requirements, and...
- 13
- 537
- 0
Báo cáo sinh học: "Review of the 25th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (now the Society for Immunotherapy of Cancer)" potx
Ngày tải lên :
18/06/2014, 19:20
... opinion leaders in the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) provided ... immediately prior to the Annual Meeting At the Annual Meeting, the NIH took the opportunity to publicly announce the award of the U01 grant that will fund the Cancer Immunotherapy Trials Network ... Correspondence: FMarincola@mail.cc.nih.gov Society for Immunotherapy of Cancer, Milwaukee, WI, USA Full list of author information is available at the end of the article therapies or vaccines to combine with...
- 10
- 474
- 0
báo cáo hóa học:" Review of the 25th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (now the Society for Immunotherapy of Cancer)" pot
Ngày tải lên :
20/06/2014, 03:20
... opinion leaders in the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) provided ... immediately prior to the Annual Meeting At the Annual Meeting, the NIH took the opportunity to publicly announce the award of the U01 grant that will fund the Cancer Immunotherapy Trials Network ... Correspondence: FMarincola@mail.cc.nih.gov Society for Immunotherapy of Cancer, Milwaukee, WI, USA Full list of author information is available at the end of the article therapies or vaccines to combine with...
- 10
- 444
- 0
Báo cáo khoa học: Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases pptx
Ngày tải lên :
16/03/2014, 04:20
... out of the catalytic cleft The angle of approach, calculated in the way described above, has the lowest value for the tetragonal form of the chagasin–cathepsin B complex and the highest for the ... as the result of two factors: (a) the overall similarity of the enzymatic part, and (b) the variability of the angle of approach of the inhibitor relative to the catalytic cleft of the enzyme The ... chagasin–cathepsin L complex (Table 3) The difference of 9° between these complexes may be correlated with the variation of the rate of binding and affinity for chagasin of these enzymes On the other...
- 14
- 517
- 0
Báo cáo khoa học: Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2) potx
Ngày tải lên :
31/03/2014, 09:20
... retention of MRP2 in the ER, so that sorting of MRP2 to the apical membrane is impaired [34] The aim of the present study was to identify structural determinants required for apical sorting of human ... amino-acid identity of only 48% between the laterally localized isoform MRP1 and the apically localized isoform MRP2 [1] hampers the identification of apical sorting signals in the MRP2 sequence ... N-terminus of MRP2 The N-terminus of MRP2 is located on the extracellular side [16], therefore a cDNA was constructed which led to translation of a GFP inserted into the lumen of the ER by the murine...
- 11
- 523
- 0
Báo cáo khoa học: Identification of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinase pdf
Ngày tải lên :
07/03/2014, 00:20
... [18] To assess the role of the S ⁄ Ts in the regulation of GIRK1 via PKA in a manner that is unbiased by the eventual contributions of the other subunits in a heterooligomer, the corresponding ... of relative specific radioactivity of the different constructs are plotted The number of experiments is given in parenthesis above each bar The mean value differs statistically significant at the ... part is unique for GIRK1 among the Kir3.x isoforms Further truncations of the C-terminus revealed a 49 amino acid stretch (amino acids 362–411) that was the most prominent target for phosphorylation...
- 9
- 403
- 0
Báo cáo khoa học: Enzymatic investigation of the Staphylococcus aureus type I signal peptidase SpsB – implications for the search for novel antibiotics ppt
Ngày tải lên :
07/03/2014, 01:20
... as the host for overproduction of SpsB) The importance of the transmembrane segment for optimum activity of the SPases was also conrmed by these results, which revealed a 30-fold reduction in the ... in the Fig SPase recognition sequence and cleavage sites of the SpsB substrates used in the present study: Showing part of the sequence of the IsaA precursor (upper row) and the sequence of the ... amount of preprotein processed at varying pH did not yield sufcient quantitative data, and therefore the FRET assay was used to study the effect of pH on the enzyme The stability of the synthetic...
- 13
- 464
- 0
Báo cáo khoa học: Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization pptx
Ngày tải lên :
07/03/2014, 05:20
... than the full length enzyme, whereas the enzymatic activity of USP7 208-1102 was rather similar to the wild-type These results indicate an important role for the C-terminal domain in catalysis The ... products, the cleavage site protected by the presence of ubiquitin was Ser341, located in the ‘fingers’ region of the catalytic core domain involved in the recognition of the ubiquitin core These ... point to further roles for this DUB in the maintenance of cell homeostasis Additional evidence for the crucial role of USP7 is provided by the fact that targeting this enzyme belongs to the strategies...
- 15
- 592
- 0
Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx
Ngày tải lên :
08/03/2014, 08:20
... concentrations of the steroid (Fig 5) Therefore, these results reveal two levels of complexity of the CYP11A1 reaction in yeast On one hand, the content of free ergosta-5-eneol poorly correlates with the ... and the efficient coupling of the SCC and the 3b-HSD activities in yeast require the use of strains lacking this acetylating activity For this reason, the CA10 ATF2 gene was disrupted, yielding the ... present, and the rate of progesterone biosynthesis is only marginally reduced compared to the rate observed for pregnenolone alone Therefore, an efficient coupling of the two first steps of steroidogenesis...
- 13
- 441
- 0
Báo cáo khoa học: The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway pdf
Ngày tải lên :
16/03/2014, 01:20
... requires the formation of an initial enzyme–NAD(P)H complex, whereupon the cofactor is oxidized to NAD(P)+ during the reaction Therefore, the reduced cofactor must be replaced from the solution before ... oxidation of the cofactor may alter the conformation of the RR loop or destabilize the dimer–dimer interface in a manner that allows cofactor exchange In support of this hypothesis, the oligomerization ... important, either in regulation of enzyme activity or as a mechanism to change the oxidation state of bound cofactor There are properties of GMDs, e.g stimulation of catalytic activity by addition of micromolar...
- 15
- 402
- 0
Báo cáo khoa học: " Investigation of the usability of conebeam CT data sets for dose calculation" pptx
Ngày tải lên :
09/08/2014, 09:22
... techniques because of the location of the VOIs within areas of the inhomogeneous dose distribution for the 1F technique For the IMRT technique, the dose deviation was determined by evaluating the dose ... observed for the pelvis, thorax and head patient group The density values of the planning CT were taken as reference for calibration of the CBCT curves The mean regression curve of the CBCT data ... and biological tissue inhomogeneities [29] For the current investigation, we established the HU-DpCT relationship based on the Gammex RMI® Dose calculations in the CBCT of the CATPhan® were performed...
- 13
- 453
- 0
Báo cáo y học: "A proposed adaptation of the European Foundation for Quality Management Excellence Model to physical activity programmes for the elderly - development of a quality self-assessment tool using a modified Delphi process" ppt
Ngày tải lên :
14/08/2014, 08:20
... of the identities of other respondents and are, therefore, freed of personal and social constraints [30] They are also able to complete the Delphi rounds in ways that suit them best because they ... and Key performance results) 10 Discussion The main goal of this study was to describe the development of a quality selfassessment tool for PA programmes for the elderly To the best of our knowledge, ... when assessing the quality of PA programmes for the elderly Because of the heterogeneity of their interests, panel members were able to cover a broad range of topics In addition, they were able...
- 30
- 369
- 0
Báo cáo y học: "Insight into the molecular requirements for pathogenicity of Fusarium oxysporum" pdf
Ngày tải lên :
14/08/2014, 21:20
... number of 1.4 Non-T-DNA was present in 4% of the pathogenicity mutants These numbers are comparable to those of the entire transformant collection (a random subset of 72 out of the 10,290 transformants ... 5% of the mutants There was no correlation between severity of pathogenicity loss and the number of T-DNA insertions (data not shown) In conclusion, the majority of the mutants carried either ... close proximity of each other (
- 18
- 375
- 0
An approximate method for investigation of the stability of motion in the critical case
Ngày tải lên :
08/04/2015, 15:36
... reduction of the system (1), lying on the boundary of the stability, to the equivalent linear form (2 ) we use this assumption, i.e that the motionof theconsi dered, system in the neigbourhood of the ... [108] The question on stability of the zero solution x = y = of system (2) is answered by the sign of the real part of the roots of characteristic equation (3) - ( a + đ ) + a d —bc = For reduction ... can now write the system (1) in the following equivalent linear form: (1 ) * = x + (6 -A )> ', ỷ = (c+ Ằ )x+ dy The condition for the asymptotic stability of the zero solution of system (13)...
- 5
- 237
- 0
Structural characterization of nogo proteins implications for biological functions and moleculedesign of therapeutic applications
Ngày tải lên :
14/09/2015, 12:53
... block the interaction between the ligand and the receptor The peptide NEP1-40, consisting of the first 40 residues of the Nogo-66 loop of Nogo-A , behaves as an antagonist of NogoA to attenuate the ... disease The hallmark of Alzheimer’s disease is a progressive degeneration of the brain caused by the accumulation of amyloid β-peptide (Aβ) The first step in the production of Aβ is the cleavage of ... result in the re-growth and the repair of the injured nerve fibers Since the degeneration of nerve fibers is one of the earliest changes in ALS, stimulating their re-growth may provide a novel therapeutic...
- 189
- 330
- 0
Investigation of the characteristics of ice slurries for energy storage
Ngày tải lên :
08/11/2015, 17:07
... drops and the water, the uneven size and distribution of the drops in the water, the turbulent mixing caused by the passage of the drops through the water, and the lack of knowledge of the heat ... inner diameter of 50mm and an outer diameter of 76mm The height of the glass column is 1m The location of the nozzle used for the experiments would be at the top above the water level The parameters ... knowledge of the mean drop size and the residence time There are several factors affecting the drop size of the coolant and some of the factors are the flow rate, the pressure, the spray angle and the...
- 142
- 172
- 0
An investigation into the structural and semantic features of sentence types in english and vietnamese detergent product advertisements discourse
Ngày tải lên :
06/06/2016, 15:00
... 15/12/2013 Venue : The University of Danang The origin of the thesis is accessible for the purpose of reference at: - The College of Foreign Languages Library, The University of Danang - Information Resources ... (1994) The subject is the principal part of the sentence, expressed by a word or a group of words, which is grammatically independent of the other parts of the sentence and with which the second ... what are often the same organizations, using similar sills” Therefore, advertising is one of the main elements of the marketing 10 mix (A planned mix of the controllable elements of a product's...
- 26
- 603
- 0
Báo cáo y học: "Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functionalization of Amide-Based Monomers"
Ngày tải lên :
25/10/2012, 11:00
... [15] The synthesis of the tetrazine dicarbonic acid derivate was performed as described by [15] The synthesis procedure of the corresponding dansyl derivative was carried out according to the ... of the dansyl derivative and the N-ethyl-diisoproylamine and the dansyl sulfamidoethylamine to the tetrazine product linked with 5-dansyl sulfamidoethylcarboxamide-2-yl For the syntheses of the ... 1665.9) for chemical reaction by the solid phase peptide synthesis (Figure 4) Ligation of the pentamer I with the tetrazine-dicarboxylate 6: One µmol of the pentamer I (Figure 3) and 5.5 µmol of the...
- 10
- 756
- 0
EFFECT OF THE NUMBER OF THE VERTICAL PIPES FOR THE PASSIVE AERATION ON THE COMPOSTING RATE
Ngày tải lên :
05/09/2013, 08:40
... determine the effect of the number of the ventilation pipes on the composting rate, an attempt was made to correlate the composting rate with the number of the perforated pipes for air supply in the ... determine the real enthalpy of the composting reaction, ∆Η , due to a lack of data Therefore, the nutritional energy of the DF about 3500 kcal/kg-DF was assumed as the enthalpy of the reaction ... Temperature profiles The bed temperature profiles of each of the composting runs are shown in Fig At the beginning of the composting, after the raw materials were initially put into the reactor,...
- 8
- 622
- 1
