... for DrugDeliverySystemsDrugdeliverysystems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drugdelivery ... numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer DrugDeliverySystems Under Development 15.6.1 Polyketals Polyketal-based drugdeliverysystems are under development ... nanotechnology and biological mimicry to create drugdeliverysystems that penetrate into 15.6 Examples of Biodegradable Polymer DrugDeliverySystems Under Development articular cartilage tissue...
... stability Chemical Aspects of DrugDeliverySystems Table Routes of administration and general classification of drugdeliverysystems ROUTES OF ADMINISTRATION DRUGDELIVERY CLASS ORAL SOLIDS (e.g ... Aspects of DrugDeliverySystems Table Mechanisms and properties influencing drug release from particle carrier systems* MECHANISM OF DRUG RELEASE PROPERTIES INFLUENC~NG DRUG DIFFUSION DRUG RELEASE ... Aspects of DrugDeliverySystems Table 5B Formulation systems for controlled drug release and drug targeting PARENTERAL AND PULMONARY ROUTES ADMINISTRATION ROUTE FORMULATION SYSTEMS INTRAVENOUS...
... Generalities of drugdelivery Liposomes as drugdeliverysystems Polymers and polymeric systems for drugdelivery Dendrimers for drugdelivery GENERALITIES OF DRUGDELIVERYDRUGDELIVERY SYSTEM ... Targeted drugdelivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled-release drugdelivery systems: preprogramed drug release By the route of delivery: ... Topical (local) drugdelivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation Systemic drugdelivery systems: drugs are delivered...
... define drug- deliverysystems of a certain size range Reflecting this trend of size definition, Nanoparticulate DrugDeliverySystems is a worthy attempt to bring together a wide range of drug- delivery ... and their delivery to where they are needed An ever increasing number of drug- and vaccinedelivery systems are being tested clinically, with many already marketed Recently, drug- deliverysystems ... 0‑8493‑9073‑7 (alk paper) Drugdeliverysystems Nanoparticles I Thassu, Deepak II Deleers, Michel III Pathak, Yashwant IV Series [DNLM: DrugDeliverySystems ‑methods Nanostructures Drug Carriers W1 DR893B...
... the widespread application of nanodelivery systems in medicine Design of nanotechnology – based drugdeliverySystems Nanoparticles can be used in targeted drugdelivery at the site of disease ... uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic comparison of untargeted and targeted drugdeliverysystems is shown in Figure ... therapy The effectiveness of drugdeliverysystems can be attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification of drug pharmacokinetics and...
... the molecular transporter in drugdelivery Page 14 of 22 Drugdelivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drugdeliverysystems targeted to the lymphatic ... advantages for tracking and real-time monitoring of drugdelivery efficacy in vivo Intracellular drugdelivery To study the cellular drug delivery, in vitro experiments have unique advantages, ... used in drugdeliverysystems These functionalization methods provided candidate techniques, and there are great possibilities for them to be used in the construction of drugdelivery systems...
... ophthalmic drugdelivery systems, but the knowledge in this field is rapidly expanding Systems range from simple solutions to novel deliverysystems such as biodegradable polymeric systems, corneal ... to provide maximal benefit, improvements in ocular drugdelivery are essential Drugdelivery is no less vital than drug discovery Although many drugs can be safely delivered by eye drops, effective ... Mitra 251 III DrugDeliverySystems A: Conventional Systems Ocular Penetration Enhancers Thomas Wai-Yip Lee and Joseph R Robinson 281 10 Corneal Collagen Shields for Ocular DrugDelivery Shiro...
... (1990) Ocular drugdelivery Pharmacokinetic considerations Clin Pharmacokinet., 18:255 Lang, J C., and Stiemke, M M Biological barriers to ocular delivery In: Ocular Therapeutics and DrugDelivery ... consideration in topical ocular drugdelivery Clin Exp Pharmacol Physiol., 27:558 Schoenwald, R D (1993) Ocular pharmacokinetics/pharmacodynamics, Ophthalmic DrugDeliverySystems (A K Mitra, ed.), ... for extremely hydrophilic drugs Drugs similar in lipophilicity to timolol will be well absorbed systemically, while extremely hydrophilic drugs or extremely lipophilic drugs will be absorbed to...
... increased as the drug diffusivity was reduced Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination halflife, decreased significantly as the drug diffusivity ... changes in the pathophysiology of the eye is the diffusivity of drugs in the vitreous Changes in drug diffusivity will be most significant when drugs of different molecular weight are used to treat different ... by changes to the drug diffusivity However, the time at which the peak concentration occurred increased as the drug diffusivity decreased because the average time required for a drug molecule to...
... Ophthalmic DrugDeliverySystems (A K Mitra, ed.), Marcel Dekker, Inc., New York, Chapter 12 17 Zheng, X., Marquart, M E., Mitra, A K., and Hill, J M (2002) Unique ocular drugdeliverysystems In: ... for rational design of drugdeliverysystems for therapeutic agents that are poorly absorbed across the cornea or require delivery to posterior segment of the eye Drugdelivery across the conjunctiva ... non–cross-linked type, thereby prolonging drugdelivery times They concluded that cross-linked collagen shields might be useful ocular drugdelivery devices because they can allow drug concentrations to achieve...
... protein drugs, Adv DrugDelivery Rev., 8:331–339 81 Chiou, G C Y (1994) Systemic delivery of polypeptide drugs through ocular route, J Ocul Pharmacol., 10:93–99 82 Morgan, R V (1995) Delivery ... (1998) Ophthalmic drugdeliverysystems recent advances, Prog Retinal Eye Res., 17:33–58 95 Robinson, J C (1993) Ocular anatomy and physiology relevant to ocular drugdelivery Drugs Pharm Sci., ... J (1995) Review: Deliverysystems for intraocular routes, Adv DrugDelivery Rev., 16:107–123 132 Velez, G., and Whitcup, S M (1999) New developments in sustained release drugdelivery for the...
... future We hope that novel drugdeliverysystems will be developed to deliver potent polypeptide drugs through the ocular route REFERENCES Lee, V H L (1987) Ophthalmic delivery of peptides and ... insulin, Int J Pharm., 62:53 51 Su, K S E (1991) Nasal route delivery of peptide and protein drugdelivery In: Peptide and Protein DrugDelivery V H L Lee (ed.) Marcel Dekker, New York, Chap 13 ... OCULAR DELIVERY OF PEPTIDE AND PROTEIN DRUGS Peptides and proteins may be instilled into the eye for local/topical use Instillation of a topical dose of a drug to the eye leads to absorption of a drug...
... (2000) Bispecific Mab aided liposomal drugdelivery J Drug Target, 8(4):257–266 160 Cristiano, R J., and Roth, J A (1995) Molecular conjugates: a targeted gene delivery vector for molecular medicine ... perform and bypasses the need for complex viral or non viral deliverysystems Subretinal or intravitreal injections are common routes of delivery to the affected area Preparative amounts of neurotrophic ... therapeutically active drugs This is a fascinating technology that has the potential of being a tailor-made delivery system that will improve the therapeutic index of a number of drugs Another modification...
... therapeutics: drugdelivery and targeting Adv DrugDelivery Rev., 18:115–131 167 J W Jaroszewski, and J S Cohen (1991) Cellular uptake of antisense oligodeoxynucleotides Adv DrugDelivery Rev., ... Section 201(p)) New drugs require INDs for conducting clinical investigations and NDAs for marketing approval The terms drug and new drug are inclusive of the drug substance and the drug product It ... for ophthalmic deliverysystems in which a drug is incorporated in a carrier for its pharmacological effect on the human eye and is reviewed as a new drug product by the FDA’s Drug Center (CDER)...
... ophthalmic drugdelivery systems, but the knowledge in this field is rapidly expanding Systems range from simple solutions to novel deliverysystems such as biodegradable polymeric systems, corneal ... to provide maximal benefit, improvements in ocular drugdelivery are essential Drugdelivery is no less vital than drug discovery Although many drugs can be safely delivered by eye drops, effective ... Mitra 251 III DrugDeliverySystems A: Conventional Systems Ocular Penetration Enhancers Thomas Wai-Yip Lee and Joseph R Robinson 281 10 Corneal Collagen Shields for Ocular DrugDelivery Shiro...
... increased as the drug diffusivity was reduced Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination halflife, decreased significantly as the drug diffusivity ... changes in the pathophysiology of the eye is the diffusivity of drugs in the vitreous Changes in drug diffusivity will be most significant when drugs of different molecular weight are used to treat different ... by changes to the drug diffusivity However, the time at which the peak concentration occurred increased as the drug diffusivity decreased because the average time required for a drug molecule to...
... Ophthalmic DrugDeliverySystems (A K Mitra, ed.), Marcel Dekker, Inc., New York, Chapter 12 17 Zheng, X., Marquart, M E., Mitra, A K., and Hill, J M (2002) Unique ocular drugdeliverysystems In: ... for rational design of drugdeliverysystems for therapeutic agents that are poorly absorbed across the cornea or require delivery to posterior segment of the eye Drugdelivery across the conjunctiva ... non–cross-linked type, thereby prolonging drugdelivery times They concluded that cross-linked collagen shields might be useful ocular drugdelivery devices because they can allow drug concentrations to achieve...