induction of cardiac fibrosis by transforming growth factorβ1
Báo cáo khoa học: Fragile X-related protein FXR1 controls posttranscriptional suppression of lipopolysaccharide-induced tumour necrosis factor-a production by transforming growth factor-b1 doc
... anti-inflammatorycytokine transforming growth factor-b1 (TGF-b1) of the proinflammatory cytokine TNF-a via the induction of FXR1 is the focus of this article.TGF-b1, a member of the large transforming growth factor-b ... two different isoforms of FXR1 were visualized by western blotting with anti-body against FXR1 following the addition of TGF-b1and TGF-b1 ⁄ LPS [39,40].The pattern of FXR1 induction suggests ... also dem-onstrate that this process is regulated by TGF-b1. Induction of FXR1 expression by TGF-b1 leads topost-transcriptional downregulation of TNF-aproteinMany RNA-binding proteins, such...
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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
... localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. Am J Respir CellMol Biol 5, 155–162.153 Broekelmann TJ, Limper AH, Colby TV & McDonaldJA (1991) Transforming growth ... go to only one of thetwo daughter cells, leaving the other relatively clear of such signaling byproducts. A deeper understanding of the role of microtubules in the regulation of Smadtrafficking ... characterized by thedissolution of epithelial cell–cell junctions and reorga-nization of the actin cytoskeleton with the formation of focal adhesions and stress fibers, acquisition of aspindle-shaped...
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Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx
... acombinatory effect of negative feedback and ultrasensitivity[22]. Both of these features have been demonstratedexperimentally. Negative feedback is constituted by thephosphorylation of Sos by ERK, which ... ynergistic ERK phosphorylationcaused by EGF and PMA.DiscussionThe architecture of signal transduction networks i s oftenhighly complex, due to the large number of participatingprotein co mplexes, ... determines the repertoire of targetgenes expressed [16], and also affects the type of cellularresponse that is evoked [17,18]. Activation of ERK isrequired for proliferation of fibroblasts [19] and...
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Báo cáo Y học: Induction of chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI ) gene expression is mediated by ETS factor binding sites doc
... lg)andincreasingamounts(0,0.1,0.2,0.3,0.4,0.5,0.6,0.8and 1.0 lg) of ETS f acto rs. (A) Eect of E ts-2. (B) E ect of E RM. (C)Eect of ETV1 (D) Eect of Spi-1 (E) Eect of PEA3. Representativeexperiments performed ... depend on the availability of these acc essoryfactors.When transfected in HeLa cells, the activity of theCOUP-TFI promoter was a bout the same r egardless of thesize of the s equence used until ... characterizedorphan members of the nuclear receptor superfamily [1].COUP-TFs have been shown to be negative regulators of the transcription of many genes [1,2], but can also act asactivators of gene t ranscription...
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Báo cáo y học: Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-b ppt
... either of the other isoforms were cotransfected (data notshown).Modulation of SeP promoter activity by overexpression of Smad 2, 3, and 4Overexpression of Smad proteins has been ... down-regulation by TGF-b1.DISCUSSIONThe inhibition by TGF-b1 of SeP expression is to date theonly known regulation of this protein by a factor other thanthe availability of selenium. TGF-b1has ... presence of a TGF-b-responsiveelement in the promoter of the SeP gene. In addition, wefound the expression of SeP mRNA being attenuated by overexpression of Smad 3 and 4 which mimics activation of the...
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báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot
... activation of mesenchymal HSCs. Thisinterpretation is strengthened by the findings of a negativecorrelation of serum TGF-β1 with fibrosis score, feature of stable collagen deposition, and by a good ... biopsy-proven diagnosis.Measurements: Serum concentrations of transforming growth factor-beta1 and ferritin.Results: High concentrations of transforming growth factor-beta1 were noticed in patients suffering ... Medical School of Naples, Department of Biochemistry and Medical Biotechnology, Naples, Italy and 4Federico II University Medical School of Naples, Department of Neurosciences, Section of Clinical...
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báo cáo hóa học: " Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised" potx
... obstruction of CSF clearance by meningeal fibrosis [34,35]. Other examples exist of hydrocephalus caused by growth factor-induced fibrosis [36]. The site and mechanism of action of pioglitazone ... degradation of Aβ42. Alsoibuprofen has been shown to reduce plaque-associatedand soluble Aβ42 in mice over-expressing the Swedishmutation of human APP [15,16]. The lack of effect of ibu-profen in ... resolution of injuries by inhib-iting local inflammation, and by stimulating the synthesisand deposition of matrix components leading to thereconstitution of the basal membrane in the final stages of angiogenesis....
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Báo cáo y học: "Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees" potx
... Robbins11Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, ... clinicalapplications of transforming growth factor-beta (TGF-beta). Growth Factors 1993, 8:1-9.3. Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB: Transforming growth factor-beta in ... sequence analysis of simian transforming growth factor-beta cDNA. DNA 1987, 6:239-244.5. Miller DA, Pelton RW, Derynck R, Moses HL: Transforming growth factor-beta. A family of growth regulatory peptides.Ann...
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Báo cáo y học: "Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity" ppsx
... tibia.Figure 3Percentage of cells expressing transforming growth factor (TGF)-beta in medial and lateral tibial cartilagePercentage of cells expressing transforming growth factor (TGF)-beta in ... Heydemann A, Izumi T, Reddi AH: Regulation of theexpression of the type-II collagen gene in periosteum-derivedcells by three members of the transforming growth factor-betasuperfamily. J Orthop ... measurements, analyzedFigure 8Effect of transforming growth factor (TGF)-beta deprivation on intrinsic cartilage repair capacityEffect of transforming growth factor (TGF)-beta deprivation on...
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Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx
... an in vitro measure of the in vivo efficiency of TGF-β1 activationTo examine the ability of SLE patients and control individualsto activate TGF-β1, a ratio of levels of TGF-β1 in freshly ... development of earlyatherosclerosis.Introduction Transforming growth factor (TGF)-β1 is the most potent natu-rally occurring immunosuppressant [1]; it is produced by allcells of the immune ... reaction was stopped by the addition of 50 àlper well of 2 mol/l H2SO4, and the plates were read at 450 nm. Available online http://arthritis-research.com/content/8/3/R81Page 5 of 7(page number...
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Báo cáo y học: "Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts" doc
... levels of activeTGF-β1 have recently been reported in RA synovial fluid inFigure 2mRNA-expression of the transforming growth factor (TGF)-β related genesmRNA-expression of the transforming growth ... Analy-sis of the oligonucleotide microarray dataCentral components of the transforming growth factor (TGF)-β pathway are shown with their scores, as determined by Gene Set Enrichment Analy-sis of the ... Heldin CH, et al.: Enhanced expres-sion of transforming growth factor-beta s and transforming growth factor-beta type II receptor in the synovial tissues of patients with rheumatoid arthritis....
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