individual and that the human race was created in him
The Human Race to the Future: What Could Happen - and What to Do
... while maintaining the excitement the material deserves … the book can expand your view of the possible.” —33rd Square (www.33rdsquare.com) The Human Race to the Future What Could Happen — and What ... Artists and Designers (3 Pages) About the Author (1 Page) Foreword to The Human Race to the Future Comments by Gil Alterovitz and Brandon H Lee Thinking about the future can be an overwhelming and ... is what the insistent push of these incentives means for the future of living, working, and commuting Chapter Three (6 Pages) Keyboards Yesterday, Mind Reading Tomorrow Keyboards are the classic...
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Báo cáo khoa học: The propeptide of cruzipain ) a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F ppt
... 2), and showed that PCZ exhibits very high potency towards cathepsin F, and is 150-fold less effective in inhibiting cathepsin V Interestingly, the Ki for cathepsin F was in the same range as that ... Cruzipain is shown in green, cathepsin F in magenta, and the other cathepsins in white An arrow indicates the two-residue insertions (highlighted) in the b1p–a3p loops of cathepsin L and K propeptides ... due to the occluding loop in the primed side of the binding site groove Although the prodomains of cathepsins F and W share the same degree of similarity to the prodomain of cruzipain, the similarity...
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Báo cáo y học: " Indications that "codon boundaries" are physico-chemically defined and that protein-folding information is contained in the redundant exon bases" pot
... additional and specific protein folding information: (a) the chaperons (other proteins that assist in the folding of proteins and nucleic acids [4]; and (b) the protein-coding nucleic acid sequences themselves ... from the codon and maintaining the other two (1st+2nd, 1st+3rd, 2nd+3rd) or removing two letters and maintaining only one (1st, 2nd, 3rd) Distinction was made between exons (B and D) and the preceding ... containing 20 amino acids (corresponding to the other amino acids in each co-locating pair) If the codons of the amino acid pairs followed the predefined complementary code, the co-location was...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 2
... sequences that were used for designing the SNP assays To ensure that the location of the SNPs map to the genome as annotated, the flanking sequences were mapped back to the human genome assembly using ... for 20 minutes The supernatant was carefully aspired and discarded The pellet was rinsed with 200µl of 75% ethanol, spun down at 16,000xg for minutes, and once again the supernatant was carefully ... first rinsed in RPMI and re-suspended in 1.5ml of ice-cold freezing medium (see Appendix) They were then kept at -70ºC for a minimum of hours before being stored in liquid nitrogen Remaining cells...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 3
... over 150kb in length fall within this region and are outlined in a black border on the heatmap The positions of the SNPs in the blocks are highlighted in blue These blocks lie within the high LD ... genotypes for these 192 individuals were also determined using sequence-base typing and an integrated SNP-HLA haplotype map was constructed Using this integrated map, the extended and conserved ... were then re-constructed using the program PHASE The phased samples were segregated accordingly into HLA haplotypes and the homozygosity of each SNP within the haplotypes was calculated These single-SNP...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 4
... “rs1611627” was remapped from 29,965,650 to 29,905,761 In both of these cases, the error was in the Illumina annotation, and the error was communicated back to them In total 1877 markers were retained, ... estimate how well the SNPs in this study represent the variation in the MHC, r2 values between the 1877 SNPs used and the remaining HapMap SNPs within the MHC locus, were calculated using the genotype ... cell-lines and the 41 family-chromosomes were not a random sampling of the local Chinese population, these were not included in constructing population LD maps However, genotype information from the...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 5
... in this study onto these sequences, the same 249kb SNP block was derived for these cell lines The two tag SNPs also capture the DR haplotypes in these cell lines, confirming the validity of the ... recombination rates in HapMap populations (International HapMap Consortium, 2005) The other is recombination hotspots identified by genotyping recombinant sperm from random individuals, and there ... validity of the tags and indicating that these tags not only apply to the local Chinese population The DR52 and DR53 haplotype alignments are expanded in Figure 3.24 and illustrate the different resolution...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 6
... dipping in each haplotype The former falls within an intron of the MSH5 gene, while the latter lies in the 5´ UTR of the C6orf10 gene and is less than 300bp away from an Alu transposableelement The ... rs1264420) in A2-B46-DR9 haplotypes, with 65% of the haplotypes carrying the allele ‘G’ and the rest carrying the allele ‘A’ This SNP lies within an intron of the PPP1R10 gene, bordering an AluJb ... 31,838,993 and 32,447,625 These SNP positions correspond to the outliers in the homozygosity plots discussed in the above section, and confirm that these were not artefacts from the in- silico...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 7
... identified and genotyped through re-sequencing, including that fall within the 826bp breakpoint interval The genotypes of the 19 samples are listed in Table 3.13 The data from the telomeric- and centromerichomozygous ... bridging across the hotspot interval, from 31,676,300 to 31,681,324, was re-sequenced in the 16 individuals Using overlapping PCR fragments and 23 sequencing primers, this 5kb was amplified and ... SNP intervals, the crossover windows in the recombinant haplotypes can be accurately determined Using this approach, the crossover window in the TAP2 recombination hotspot can be identified, and...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 8
... certain selective advantage to the individuals carrying them, possibly due to resistance to infectious diseases such as an influenza or cholera pandemic, resulting in the rapid increase in the ... LD in the MHC will further our understanding of the aetiology of autoimmune and infectious diseases With this in mind we successfully genotyped a panel of Singaporean Chinese individuals, and ... towards the northern Chinese The tight correlation in allele frequencies also indicates that in the absence of available variation data in other regions of the genome for the Singaporean Chinese population,...
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A linkage disequilibrium map of the human major histocompatibility complex in singapore chinese conserved extended haplotypes and ancestral blocks 1
... America, 45 Han Chinese individuals from China and 45 individuals from Japan From these data the common DNA variation within the populations were analysed and compared They reported that the non-African ... Mapping Recombination Hotspots in the Human Genome In general there are methods of mapping recombination hotspots in the human genome; analysis of pedigrees, genotyping of recombinant sperm and ... singe-strand tails that are up to 1kb long (Step III in Figure 1.3) DNA strand exchange proteins including the RecA homologs Rad51 and Dmc1 bind to the 3´ tails, forming helical nucleo-protein...
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Báo cáo khoa học: "Exploring and Exploiting the Limited Utility of Captions in Recognizing Intention in Information Graphics∗" pdf
... with the minimum value and in the caption of graphics pear on the bars and sometimes next to them, and the heading for the dependent axis appears in the empty white space of the graphic instead ... focuses on the decades of increasing immigration and the caption strengthens increasing trend in immigration as the intended message of the graphic If we not include the caption, our system hypothesizes ... (increasing, decreasing, or stable), where the change in trend occurred, the end of the second trend, and the slope of the second trend If there was disagreement between the coders on either the...
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báo cáo hóa học:" MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells" ppt
... dead cell discrimination Finally, the samples were run directly on the FACS and counted according to the strength of staining The Hoechst dye was excited with the UV laser at 350 nm and its fluorescence ... expression in ovarian cancer cells showed an increase in HER2 expression and colocalization, suggesting that MUC4 is involved in the stabilization of HER2 protein There is emerging evidence that small ... for 60 minutes at room temperature Then cells were washed (4 × minutes each washing) with PBS containing 0.05% Tween-20 (PBS-T) and then incubated with FITC-conjugated anti-mouse (green) and Texas...
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Báo cáo toán học: "Enumerating all Hamilton Cycles and Bounding the Number of Hamilton Cycles in 3-Regular Graphs" ppsx
... the smallest index in {i, , n} such that vj is passive Then P = (vk , , vj ) where vk is the source of the incoming diagonal of vj Thus P is uniquely determined and we have the following ... which of the outgoing edges of vi to include Remark 2.2 v1 and v2 are active (since they can not have an incoming diagonal) whereas vn−1 and are passive (since they can not have an outgoing diagonal) ... which contain a given set of forced edges In each step it recursively deletes some edges and marks others as “forced” and then continues with the resulting, new graph n Iwama and Nakashima [7]...
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Báo cáo y học: "A critical review of the research literature on Six Sigma, Lean and StuderGroup''''s Hardwiring Excellence in the United States: the need to demonstrate and communicate the effectiveness of transformation strategies in healthcare" pdf
... improvements in care and ever increasing capacity for continuing improvement Improving evaluation and understanding of the implementation and outcomes of such changes are essential to sustaining ongoing ... zation-wide training and leadership behavior modeling to bring about significant cultural change and quality and financial gains In contrast to the number of transformational strategies originating in manufacturing, ... causal inference because with the implementation of the intervention, the outcome measure changes direction The outcome measure was a performance index created by the authors that was the percent...
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báo cáo khoa học: " A critical review of the research literature on Six Sigma, Lean and StuderGroup''''s Hardwiring Excellence in the United States: the need to demonstrate and communicate the effectiveness of transformation strategies in healthcare" pot
... improvements in care and ever increasing capacity for continuing improvement Improving evaluation and understanding of the implementation and outcomes of such changes are essential to sustaining ongoing ... zation-wide training and leadership behavior modeling to bring about significant cultural change and quality and financial gains In contrast to the number of transformational strategies originating in manufacturing, ... causal inference because with the implementation of the intervention, the outcome measure changes direction The outcome measure was a performance index created by the authors that was the percent...
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Báo cáo y học: " Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease" doc
... cells and eosinophils also synthesize interleukin-5, indicating that autocrine production of interleukin-5 may contribute to the chronicity of inflammation [41,42] The interleukin-5 receptor is in ... autophosphorylation Like interleukin-3 and GM-CSF, interleukin-5 induces rapid tyrosine phosphorylation of several proteins, further indicating that tyrosine kinases are involved in the cellular activation ... the interleukin-5-induced hyperreactivity was abated by blocking the activity of interleukin-1, and interleukin-1β mRNA and protein levels are increased by interleukin-5 Interleukin-5 may contribute...
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isolation and selection the thermophilic keratin degradation bacteria in dong thap province
... For that reason, the thesis "Isolation and selection thermophilic keratin degradation bacteria in Dong Thap province" was conducted to select the thermophilic keratinolytic bacteria strains which ... keratin-containing wastes Total of 18 aerobic keratinolytic bacteria strains were isolated of five soil and two wastewater samples from animal and poultry processing plants The result showed that ... can raise highly and inhibit almost activities of the useful bacteria Therefore, the thesis was carried out for isolation and selection the thermophilic keratinolytic bacteria strains which have...
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Mafias, machines and mobilization the sources of local power in three districts in north sumatra, indonesia
... Tans during the New Order, operated a party machine in North Maluku, notwithstanding the prevailing view that the local influence of political parties was in decline.20 In addition, the literature ... from winning the district election But after the district was subdivided into three new districts in 2008, the machine won the 2010 election and took control of the executive branch Finally, in ... patronage and the cost of maintaining the coalition, except in election years Popular elections strain the coalition in two ways First, national election law requires that all candidates obtain nomination...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25