... stromaltumorofthe duodenum mimicking a pancreatic head tumor J Hepatobiliary Pancreat Surg 20 05, 12: 324 - 327 Goh BK, Chow PK, Ong HS, Wong WK: Gastrointestinalstromaltumor involving the second and ... appearance ofthe resected specimen The distance to the proximal resection margin was 0.5 cm A great portion ofthetumor was located subserosal The duodenal mucosa was bulged by the sumucosal tumor ... the level ofthe ampulla of Vater P: pancreas, V: ampulla of Vater, T: tumor, J: jejunum http://www.wjso.com/content/6/1/105 Figure Macroscopic appearance ofthe resected specimen Macroscopic...
... density of × 105 cells/ml in the presence of different concentration of ATRA onto Chi et al Journal of Experimental & Clinical Cancer Research 20 10, 29 :165 http://www.jeccr.com/content /29 /1/165 ... observation that, upon creation of a new artificial gap, so called a scratch on a confluent cell monolayer, the cell onthe edge ofthe newly created gap will move toward the opening to close the scratch ... 2Department Chi et al Journal of Experimental & Clinical Cancer Research 20 10, 29 :165 http://www.jeccr.com/content /29 /1/165 of Medical Genome Sciences, Graduate School of Frontier Sciences, the University...
... gastroinestinal stromaltumor (GIST) Proceedings ofThe American Society of Clinical Oncology (ASCO) Annual Meeting: May 31 - June 20 03; Chicago, IL Edited by Proc Am Soc Clin Oncol 20 03, 22 , [abstr 327 5] Chen ... 122 ofthe 346 gastric tumors and only two ofthe 75 small intestinal tumors Ten ofthe 170 gastric tumors and one ofthe 54 small intestinal tumors had a PDGFRA exon 12 mutation One hundred and ... Results ofthe intergroup phase III trial ACOSOG Z9001 Proceedings ofThe American Society of Clinical Oncology (ASCO) Annual Meeting: June 4-8 20 10; Chicago, IL J Clin Oncol 20 10, 28 :15s, [abstract...
... gastroinestinal stromaltumor (GIST) Proceedings ofThe American Society of Clinical Oncology (ASCO) Annual Meeting: May 31 - June 20 03; Chicago, IL Edited by Proc Am Soc Clin Oncol 20 03, 22 , [abstr 327 5] Chen ... 122 ofthe 346 gastric tumors and only two ofthe 75 small intestinal tumors Ten ofthe 170 gastric tumors and one ofthe 54 small intestinal tumors had a PDGFRA exon 12 mutation One hundred and ... Results ofthe intergroup phase III trial ACOSOG Z9001 Proceedings ofThe American Society of Clinical Oncology (ASCO) Annual Meeting: June 4-8 20 10; Chicago, IL J Clin Oncol 20 10, 28 :15s, [abstract...
... smooth-muscle (stromal) tumors: dependence on anatomic site Am J Surg Pathol 1999, 23 : 82- 87 Strickland L, Letson GD, Muro-Cacho CA: Gastrointestinalstromal tumors Cancer Control 20 01, 8 :25 2 -26 1 Yamamoto ... IP, SD and RF participated equally in the design ofthe paper and in the study ofthe clinical and radiological data LM, FDN and SL participated in the study of macroscopic and microscopic features ... function in controlling motility Most GISTs (50–80%) arise because of a mutation in the c- kit gene The c- kit/ CD117 receptor is expressed on ICCs, mast cells, spermatocytes and hematopoietic cells...
... Conclusion The existing data on EGIST is not sufficient to make a significant conclusion ontheprognosisand survival of these patients, but certainly cellularity, mitosis and necrosis ofthe ... Journal of Surgical Oncology 20 08, 6:50 http://www.wjso.com/content/6/1/50 Figure Microscopic imaging ofthetumor at 10×, 20 ×, 40× shown with H&E staining Microscopic imaging ofthetumor at 10×, 20 ×, ... citation purposes) World Journal of Surgical Oncology 20 08, 6:50 http://www.wjso.com/content/6/1/50 colonic adenocarcinoma and another of unknown causes); six were alive and without evidence of...
... in the design ofthe study and collect the clinical data FZ participated in the design ofthe study and collect the clinical data GCP participated in the design ofthe study and collect the clinical ... study and collect the clinical data LR participated in the design ofthe study and collect the clinical data GP participated in the design ofthe study and collect the clinical data AZ participated ... could hypothesize that development of these tumors may involve common carcinogen antigens, making the synchronous occurrence of GIST and other abdominal malignancy not only a coincidence Conclusion...
... therapies in oncology: new concepts of treatment response assessment A collection of cases Int J Oncol 20 08, 33:443-4 52 22 Choi H, Charnsangavej C, Faria SC, Macapinlac HA, Burgess MA, Patel SR, Chen ... Journal of Experimental & Clinical Cancer Research 20 10, 29 :173 http://www.jeccr.com/content /29 /1/173 Figure Inhibition oftumor growth in Rag2-/-; gcommon -/male mice injected s .c with GIST 8 82 by ... Coco P: Combination of PKC4 12 and sirolimus in a metastatic patient with PDGFRA-D842V gastrointestinalstromaltumor (GIST) J Clin Oncol (abstract) 20 08, 26 :20 16 Piovesan C, Fumagalli E, Coco...
... Inter J Gynecol Cancer 20 06, 16:884-943 Klein WM, Kurman RJ: Lack ofexpressionof c- kit protein (CD117) in mesenchymal tumors ofthe uterus and ovary Int J Gynaecol Pathol 20 03, 22 :181-184 Joensuu ... appearance They arise in the muscularis propria, and can grow either exophytically out into the peritoneum, or endophytically into the lumen ofthe gut [2] Microscopically, GISTs are well-circumscribed ... receptor [14-18] Mutations of c- kit protooncogen seem to produce overexpression oftheKIT protein, which is responsible for the pathogenesis of GISTs [2] Also, GISTs are often positive for CD34...
... http://www.wjso.com/content/7/1/8 Conclusion The long stable disease control, the absence of glucose avidity of pre-operative PET andthe absence ofthe C- KIT mutation in the mesenteric tumor were all features ... absent of Exon 11 C- KIT mutation, was different from the Exon 11 C- KIT mutation positive ofthe original resected antral GIST Histologically, AF lies on a spectrum of disorders characterized by excess ... disease control Figure resected primary tumor – diffuse c- KIT staining A representative immunohistochemical section ofthe A representative immunohistochemical section ofthe resected primary tumor...
... States, National Cancer Institute of Canada J Natl Cancer Inst 20 00, 92: 205 -21 6 http://www.wjso.com/content/6/1/37 25 26 27 28 29 Verweij J, Casali PG, Zalcberg J, LeCesne A, Reichardt P, Blay ... systemic therapy using kinase inhibitors J Clin Oncol 20 06, 24 :23 25 -23 31 Perez EA, Livingstone AS, Franceschi D, Rocha-Lima C, Lee DJ, Hodgson N, Jorda M, Koniaris LG: Current incidence and outcomes ... downstaging of a GIST ofthe GEJ with limited resection and reconstruction by a interposition of a jejunal segment resulted in an R0 resection and excellent functional outcome ofthe patient Competing...
... stromal tumors Report ofthe GIST Consensus Conference of 20 -21 March 20 04, under the auspices of ESMO Ann Oncol 20 05, 16(4):566-578 NICE: 20 04/86 Imatinib for the treatment of unresectable and/ or ... Risk criteria and prognostic factors for predicting recurrences after resection of primary gastrointestinalstromaltumor Ann Surg Oncol 20 07, 14(7) :20 18 -20 27 Publish with Bio Med Central and ... imatinib and endoscopic assisted laparoscopic resection Eur J Surg Oncol 20 07, 33(8):1044-1046 Choi SM, Kim MC, Jung GJ, Kim HH, Kwon HC, Choi SR, Jang JS, Jeong JS: Laparoscopic wedge resection for...
... cells of Cajal Am J Pathol 1998, 1 52: 125 9- 126 9 Corless CL, Fletcher JA, Heinrich MC: Biology ofgastrointestinalstromal tumors J Clin Oncol 20 04, 22 :3813-3 825 NCCN Practice Guidilenes in Oncology ... Brennan MF, Antonescu CR: Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinalstromaltumor (GIST) Cancer 20 08, 1 12: 608-15 Bucher P, Egger ... significant impact onprognosis [20 -22 ] A practical grading system for GIST after surgical resection was proposed by Bucher et al [22 ] including minor (tumor size ≥5 cm, mitotic index ≥5 Page of...
... operation Discussion GISTs are the most common mesenchymal tumors ofthegastrointestinal tract [1] They are most commonly found in the stomach and small bowel Uncommon sites include the colon, rectum, ... required The surgical choice depends not only onthe size ofthetumor but also onthe location in the duodenal wall andthe relation to the ampulla of Vater It is not clear what the optimal surgical ... http://www.jmedicalcasereports.com/content/5/1/457 dissection is required since they are very unlikely to be involved [1] The outcome depends onthe pathological features ofthetumorandthe completeness of surgical resection Large tumors...
... prognostic classifications of Fletcher (NIH 20 02) and Miettinen (AFIP 20 06, NCCN 20 07) [27 ,28 ] Data collection and statistical analysis Symptoms were recorded onthe admission and collected by the ... according with tumor size (2- 5 cm) andtumor localization R1 (persistence of microscopic tumor deposits within the resection margins) and R2 (persistence of macroscopic tumor residual) resections, ... interstitial cell of Cajal (ICC), the gut pacemaker ofthe autonomic * Correspondence: laura.lorenzon@uniroma1.it Surgical and Medical Department of Clinical Sciences, Biomedical Technologies and Translational...
... kinase, coded for by the c- kit proto-oncogene Overexpression of this gene is most commonly caused by an activating mutation of exon 11 and is hypothesized to be responsible for GIST oncogenesis ... in the treatment of chronic myelogenous leukemia, which is characterized by the constitutive activation ofthe Bcr-Abl tyrosine kinase http://www.wjso.com/content/7/1/30 Figure Follow up CT scan ... wedge resection of his stomach that included the stalk andtumor en bloc Pathological analysis revealed a tumorof 15 cm in greatest dimension There were extensive areas of ischemic necrosis There...
... en-block resection ofthetumor to avoid rupture and intra-abdominal spillage, as it is rec- Figure The specimen ofthe colorectal adenocarcinoma The specimen ofthe colorectal adenocarcinoma ... gastric cancer, lymphoma and carcinoid [13,15-18] The coexistence of GIST with either synchronous or metachronous colorectal cancer represents a rare Figure (HE 20 0) A) Invasion of submucosa of ... specimen ofthe GIST in Meckel's diverticulum The arrow shows the diverticulum B: Transverse section ofthe specimen ofthe GIST in Meckel's diverticulum andthe proximal part ofthe ileum The...