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index the expression of c kit p53 and bcl 2 and the apoptotic count on the prognosis of gastrointestinal stromal tumor

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Báo cáo khoa học: "Segmental resection of the duodenum for gastrointestinal stromal tumor (GIST)" ppt

Báo cáo khoa học

... stromal tumor of the duodenum mimicking a pancreatic head tumor J Hepatobiliary Pancreat Surg 20 05, 12: 324 - 327 Goh BK, Chow PK, Ong HS, Wong WK: Gastrointestinal stromal tumor involving the second and ... appearance of the resected specimen The distance to the proximal resection margin was 0.5 cm A great portion of the tumor was located subserosal The duodenal mucosa was bulged by the sumucosal tumor ... the level of the ampulla of Vater P: pancreas, V: ampulla of Vater, T: tumor, J: jejunum http://www.wjso.com/content/6/1/105 Figure Macroscopic appearance of the resected specimen Macroscopic...
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báo cáo khoa học:

báo cáo khoa học: " All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein" pdf

Báo cáo khoa học

... density of × 105 cells/ml in the presence of different concentration of ATRA onto Chi et al Journal of Experimental & Clinical Cancer Research 20 10, 29 :165 http://www.jeccr.com/content /29 /1/165 ... observation that, upon creation of a new artificial gap, so called a scratch on a confluent cell monolayer, the cell on the edge of the newly created gap will move toward the opening to close the scratch ... 2Department Chi et al Journal of Experimental & Clinical Cancer Research 20 10, 29 :165 http://www.jeccr.com/content /29 /1/165 of Medical Genome Sciences, Graduate School of Frontier Sciences, the University...
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Báo cáo sinh học:

Báo cáo sinh học: " The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting" doc

Hóa học - Dầu khí

... gastroinestinal stromal tumor (GIST) Proceedings of The American Society of Clinical Oncology (ASCO) Annual Meeting: May 31 - June 20 03; Chicago, IL Edited by Proc Am Soc Clin Oncol 20 03, 22 , [abstr 327 5] Chen ... 122 of the 346 gastric tumors and only two of the 75 small intestinal tumors Ten of the 170 gastric tumors and one of the 54 small intestinal tumors had a PDGFRA exon 12 mutation One hundred and ... Results of the intergroup phase III trial ACOSOG Z9001 Proceedings of The American Society of Clinical Oncology (ASCO) Annual Meeting: June 4-8 20 10; Chicago, IL J Clin Oncol 20 10, 28 :15s, [abstract...
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báo cáo hóa học:

báo cáo hóa học:" The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting" docx

Hóa học - Dầu khí

... gastroinestinal stromal tumor (GIST) Proceedings of The American Society of Clinical Oncology (ASCO) Annual Meeting: May 31 - June 20 03; Chicago, IL Edited by Proc Am Soc Clin Oncol 20 03, 22 , [abstr 327 5] Chen ... 122 of the 346 gastric tumors and only two of the 75 small intestinal tumors Ten of the 170 gastric tumors and one of the 54 small intestinal tumors had a PDGFRA exon 12 mutation One hundred and ... Results of the intergroup phase III trial ACOSOG Z9001 Proceedings of The American Society of Clinical Oncology (ASCO) Annual Meeting: June 4-8 20 10; Chicago, IL J Clin Oncol 20 10, 28 :15s, [abstract...
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Báo cáo khoa học: "Extra-gastrointestinal stromal tumor of the greater omentum: report of a case and review of the literature" potx

Báo cáo khoa học

... smooth-muscle (stromal) tumors: dependence on anatomic site Am J Surg Pathol 1999, 23 : 82- 87 Strickland L, Letson GD, Muro-Cacho CA: Gastrointestinal stromal tumors Cancer Control 20 01, 8 :25 2 -26 1 Yamamoto ... IP, SD and RF participated equally in the design of the paper and in the study of the clinical and radiological data LM, FDN and SL participated in the study of macroscopic and microscopic features ... function in controlling motility Most GISTs (50–80%) arise because of a mutation in the c- kit gene The c- kit/ CD117 receptor is expressed on ICCs, mast cells, spermatocytes and hematopoietic cells...
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Báo cáo khoa học:

Báo cáo khoa học: "A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literature" pot

Báo cáo khoa học

... Conclusion The existing data on EGIST is not sufficient to make a significant conclusion on the prognosis and survival of these patients, but certainly cellularity, mitosis and necrosis of the ... Journal of Surgical Oncology 20 08, 6:50 http://www.wjso.com/content/6/1/50 Figure Microscopic imaging of the tumor at 10×, 20 ×, 40× shown with H&E staining Microscopic imaging of the tumor at 10×, 20 ×, ... citation purposes) World Journal of Surgical Oncology 20 08, 6:50 http://www.wjso.com/content/6/1/50 colonic adenocarcinoma and another of unknown causes); six were alive and without evidence of...
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Báo cáo khoa học:

Báo cáo khoa học: "The synchronous occurrence of squamous cell carcinoma and gastrointestinal stromal tumor (GIST) at esophageal site" ppsx

Báo cáo khoa học

... in the design of the study and collect the clinical data FZ participated in the design of the study and collect the clinical data GCP participated in the design of the study and collect the clinical ... study and collect the clinical data LR participated in the design of the study and collect the clinical data GP participated in the design of the study and collect the clinical data AZ participated ... could hypothesize that development of these tumors may involve common carcinogen antigens, making the synchronous occurrence of GIST and other abdominal malignancy not only a coincidence Conclusion...
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báo cáo khoa học:

báo cáo khoa học: " Preclinical evaluation of KIT/PDGFRA and mTOR inhibitors in gastrointestinal stromal tumors using small animal FDG PET" ppsx

Báo cáo khoa học

... therapies in oncology: new concepts of treatment response assessment A collection of cases Int J Oncol 20 08, 33:443-4 52 22 Choi H, Charnsangavej C, Faria SC, Macapinlac HA, Burgess MA, Patel SR, Chen ... Journal of Experimental & Clinical Cancer Research 20 10, 29 :173 http://www.jeccr.com/content /29 /1/173 Figure Inhibition of tumor growth in Rag2-/-; gcommon -/male mice injected s .c with GIST 8 82 by ... Coco P: Combination of PKC4 12 and sirolimus in a metastatic patient with PDGFRA-D842V gastrointestinal stromal tumor (GIST) J Clin Oncol (abstract) 20 08, 26 :20 16 Piovesan C, Fumagalli E, Coco...
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Báo cáo hóa học:

Báo cáo hóa học: " The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs)" pdf

Hóa học - Dầu khí

... Growth Factor Receptor-1R Pathway for Cancer Therapy Clin Cancer Res 20 10, 16 :25 12- 7 Scotlandi K, Picci P: Targeting insulin-like growth factor receptor in sarcomas Curr Opinion Oncology 20 08, 20 :419- 427 ... P, Picci P, Scotlandi K: Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing’s sarcoma cells Clin Cancer Res 20 01, ... CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic nonsmall-cell lung cancer J Clin Oncol 20 09, 27 :25 16 -25 22 Tarn C, Rink L, Merkel...
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Báo cáo khoa học:

Báo cáo khoa học: "Malignant gastrointestinal stromal tumor presenting with hemoperitoneum in puerperium: report of a case with review of the literature" ppt

Báo cáo khoa học

... Inter J Gynecol Cancer 20 06, 16:884-943 Klein WM, Kurman RJ: Lack of expression of c- kit protein (CD117) in mesenchymal tumors of the uterus and ovary Int J Gynaecol Pathol 20 03, 22 :181-184 Joensuu ... appearance They arise in the muscularis propria, and can grow either exophytically out into the peritoneum, or endophytically into the lumen of the gut [2] Microscopically, GISTs are well-circumscribed ... receptor [14-18] Mutations of c- kit protooncogen seem to produce overexpression of the KIT protein, which is responsible for the pathogenesis of GISTs [2] Also, GISTs are often positive for CD34...
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Báo cáo khoa học:

Báo cáo khoa học: "When is a GIST not a GIST? A case report of synchronous metastatic gastrointestinal stromal tumor and fibromatosis" ppt

Báo cáo khoa học

... http://www.wjso.com/content/7/1/8 Conclusion The long stable disease control, the absence of glucose avidity of pre-operative PET and the absence of the C- KIT mutation in the mesenteric tumor were all features ... absent of Exon 11 C- KIT mutation, was different from the Exon 11 C- KIT mutation positive of the original resected antral GIST Histologically, AF lies on a spectrum of disorders characterized by excess ... disease control Figure resected primary tumor – diffuse c- KIT staining A representative immunohistochemical section of the A representative immunohistochemical section of the resected primary tumor...
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Báo cáo khoa học:

Báo cáo khoa học: "The Merendino procedure following preoperative imatinib mesylate for locally advanced gastrointestinal stromal tumor of the esophagogastric junction" ppsx

Báo cáo khoa học

... States, National Cancer Institute of Canada J Natl Cancer Inst 20 00, 92: 205 -21 6 http://www.wjso.com/content/6/1/37 25 26 27 28 29 Verweij J, Casali PG, Zalcberg J, LeCesne A, Reichardt P, Blay ... systemic therapy using kinase inhibitors J Clin Oncol 20 06, 24 :23 25 -23 31 Perez EA, Livingstone AS, Franceschi D, Rocha-Lima C, Lee DJ, Hodgson N, Jorda M, Koniaris LG: Current incidence and outcomes ... downstaging of a GIST of the GEJ with limited resection and reconstruction by a interposition of a jejunal segment resulted in an R0 resection and excellent functional outcome of the patient Competing...
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Báo cáo khoa học:

Báo cáo khoa học: "Management of gastrointestinal stromal tumours in the Imatinib era: a surgeon''''s perspective" pps

Báo cáo khoa học

... stromal tumors Report of the GIST Consensus Conference of 20 -21 March 20 04, under the auspices of ESMO Ann Oncol 20 05, 16(4):566-578 NICE: 20 04/86 Imatinib for the treatment of unresectable and/ or ... Risk criteria and prognostic factors for predicting recurrences after resection of primary gastrointestinal stromal tumor Ann Surg Oncol 20 07, 14(7) :20 18 -20 27 Publish with Bio Med Central and ... imatinib and endoscopic assisted laparoscopic resection Eur J Surg Oncol 20 07, 33(8):1044-1046 Choi SM, Kim MC, Jung GJ, Kim HH, Kwon HC, Choi SR, Jang JS, Jeong JS: Laparoscopic wedge resection for...
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Báo cáo khoa học:

Báo cáo khoa học: "Gastrointestinal stromal tumor of the stomach with lymph node metastasis" ppsx

Báo cáo khoa học

... cells of Cajal Am J Pathol 1998, 1 52: 125 9- 126 9 Corless CL, Fletcher JA, Heinrich MC: Biology of gastrointestinal stromal tumors J Clin Oncol 20 04, 22 :3813-3 825 NCCN Practice Guidilenes in Oncology ... Brennan MF, Antonescu CR: Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST) Cancer 20 08, 1 12: 608-15 Bucher P, Egger ... significant impact on prognosis [20 -22 ] A practical grading system for GIST after surgical resection was proposed by Bucher et al [22 ] including minor (tumor size ≥5 cm, mitotic index ≥5 Page of...
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báo cáo khoa học:

báo cáo khoa học: " A large gastrointestinal stromal tumor of the duodenum: a case report" doc

Báo cáo khoa học

... operation Discussion GISTs are the most common mesenchymal tumors of the gastrointestinal tract [1] They are most commonly found in the stomach and small bowel Uncommon sites include the colon, rectum, ... required The surgical choice depends not only on the size of the tumor but also on the location in the duodenal wall and the relation to the ampulla of Vater It is not clear what the optimal surgical ... http://www.jmedicalcasereports.com/content/5/1/457 dissection is required since they are very unlikely to be involved [1] The outcome depends on the pathological features of the tumor and the completeness of surgical resection Large tumors...
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báo cáo khoa học:

báo cáo khoa học: "Gastrointestinal stromal tumors: correlation between symptoms at presentation, tumor location and prognostic factors in 47 consecutive patients" pot

Báo cáo khoa học

... prognostic classifications of Fletcher (NIH 20 02) and Miettinen (AFIP 20 06, NCCN 20 07) [27 ,28 ] Data collection and statistical analysis Symptoms were recorded on the admission and collected by the ... according with tumor size (2- 5 cm) and tumor localization R1 (persistence of microscopic tumor deposits within the resection margins) and R2 (persistence of macroscopic tumor residual) resections, ... interstitial cell of Cajal (ICC), the gut pacemaker of the autonomic * Correspondence: laura.lorenzon@uniroma1.it Surgical and Medical Department of Clinical Sciences, Biomedical Technologies and Translational...
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Báo cáo khoa học:

Báo cáo khoa học: "Maspin expression in gastrointestinal stromal tumors" pot

Báo cáo khoa học

... overexpression n Age, yr Page of 35/19 cm ≥ 12 42 5≥ 22 32 Yes (n = 27 ) (% 50) P value 0,769 cm < 12 6 cm ≥ 42 21 21 0, 525 5< 22 15 5≥ 32 20 12 Risk Group (compared with high risk group and others) ... Hendrix MJC: The paradoxical expression of maspin in ovarian carcinoma Clin Cancer Res 20 02, 8 :29 24 -29 32 Maass N, Hojo T, Ueding M, Luttges J, Kloppel G, Jonat W, Nagasaki K: Expression of the tumor ... pancreatic cancers Clin Cancer Res 20 01, 7:8 12- 817 Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson JK, Giordano TJ, Misek DE, Hanash S: Molecular profiling of pancreatic adenocarcinoma and...
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Báo cáo khoa học:

Báo cáo khoa học: "Dramatic response of a gastrointestinal stromal tumor to neadjuvant imatinib therapy" pptx

Báo cáo khoa học

... kinase, coded for by the c- kit proto-oncogene Overexpression of this gene is most commonly caused by an activating mutation of exon 11 and is hypothesized to be responsible for GIST oncogenesis ... in the treatment of chronic myelogenous leukemia, which is characterized by the constitutive activation of the Bcr-Abl tyrosine kinase http://www.wjso.com/content/7/1/30 Figure Follow up CT scan ... wedge resection of his stomach that included the stalk and tumor en bloc Pathological analysis revealed a tumor of 15 cm in greatest dimension There were extensive areas of ischemic necrosis There...
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Báo cáo khoa học:

Báo cáo khoa học: "Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor in Meckel''''s diverticulum; an unusual association" pps

Báo cáo khoa học

... en-block resection of the tumor to avoid rupture and intra-abdominal spillage, as it is rec- Figure The specimen of the colorectal adenocarcinoma The specimen of the colorectal adenocarcinoma ... gastric cancer, lymphoma and carcinoid [13,15-18] The coexistence of GIST with either synchronous or metachronous colorectal cancer represents a rare Figure (HE 20 0) A) Invasion of submucosa of ... specimen of the GIST in Meckel's diverticulum The arrow shows the diverticulum B: Transverse section of the specimen of the GIST in Meckel's diverticulum and the proximal part of the ileum The...
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