in search of the trojan war empire of the hittites
Tài liệu Báo cáo khoa học: Modulation of the enzymatic efficiency of ferredoxin-NADP(H) reductase by the amino acid volume around the catalytic site pptx
... on the si-face of the flavin in FNRs [12]. The single point energies of the flavin–tyrosine system in different conformations were calculated. The arrange-ment of lumiflavin and phenol with the ... inter-action of the nicotinamide of substrate NADP+with the isoalloxazine is modulated by the terminal tyrosine(Y308 in pea FNR) [15,17,18]. During binding of NADP+, the terminal tyrosine should ... the aromatic interaction between the flavin, Y308 and the nicotinamide of NADP+is precisely tuned by selectingamino acids that face the other side of the tyrosinephenol ring. The specific volumes of the...
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religious rivalries in the early roman empire and the rise of christianity apr 2006
... notions of decline in the study of the polis (Models of Decline in the Study of the Polis), before outliningways in which this notion has influenced studies of ancient religious life in this ... origins and the his-tory of other religious groups in the early Roman Empire. In the first chapter of the book, it was proposed that the category of mission be abandoned alto-gether. Neither ... of Decline in the Study of Social-Religious Life). Ithen provide evidence for the continuing vitality of civic life by using the inscriptional evidence for small social-religious groups in the...
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Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc
... total volume of the column(% 12 min). However, as previously found with otherdissociated capsid proteins, the lack of elution of the proteins can be explained by non-specific binding of the denatured ... resides on the surface of the protein and makes noobvious stabilizing interactions with other amino acid side-chains, this part of the protein interacts with genomic RNA[33,41,47]. Such interactions ... different from those of other simple icosahedralviruses [13]. The main chain of the protein subunit foldsinto a five stranded antiparallel b-sheet (strands bC–bG)facing the interior of the phage particle,...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... productive binding of steroid substrates: in the first, a (small) sub population of enzyme bindsdirectly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactiveconformation. ... unusual in havingtwo histidine residues (rather than the His-Asn pairseen in OYE, MR and some of the other memberproteins; Fig. 1B) in the active site for ligand andsubstrate binding. For ... role in the binding of phenolic compounds in the active site [3,26]. Likewise, in MR the counter-part residues His186 and Asn189 form key interactionswith reducing nicotinamide coenzyme and the...
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Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... đbronectin-binding protein [8], the brainprotein a-synuclein together with the related proteinsb-synuclein and c-synuclein [9±12], a nd the brain proteintau [13±16]. In addition to their role ... relies mainly on the evidence outlined above. In view of the c lose similarity of the ROA spectra of the casein, synuclein and tau proteins shown in t his paper, wehave reproduced in F ig. 1 ... aglobular protein c ontaining a similar number o f residues, asobserved in the caseins [3], synucleins [10], tau [14],prothymosin a [7] and the đbronectin-binding protein [8],and also in typical...
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Báo cáo khoa học: Functional studies of crustacean hyperglycemic hormones (CHHs) of the blue crab, Callinectes sapidus – the expression and release of CHH in eyestalk and pericardial organ in response to environmental stress pot
... Thus, we wereinterested in isolating the cDNA of PO-CHH andidentifying the native CHH neuropeptide in the ES,after the recent report of CHH cDNA from the ES[28]. Also, we examined the physiological ... decrease in CHH expres-sion in the ES is in proportion to that of CCAPexpression in the same tissue, as described in Chunget al. [47], but there is no change in CCAP of TG,indicating the tissue-specific ... targeted into the specific sites in which the nerve fibers of the PO innervate the anteriorramifications. On the other hand, as a neurohormone,PO-CHH may be released from the surface of the POand into...
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Báo cáo khoa học: Effect of mutations in the b5–b7 loop on the structure and properties of human small heat shock protein HSP22 (HspB8, H11) pptx
... in the case of the K137E mutant of HSP22 (Fig. 4B); however, in this case, the intensity of the band corresponding to the HSP22 dimer wasmore intense than in the case of the wild-type protein.Thus, ... intact protein at the beginning of tryp-sinolysis and at the fixed time of trypsinolysis) against the time of incubation (Fig. 8D). The apparent rateconstants of trypsinolysis under these conditions ... shock proteins, each of which contains the so-called a-crystallin domain consisting of 80–100 residues and located in the C-terminal part of the molecule. The a-crystallin domain consists of six...
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Tài liệu Fertility, Family Planning, and Reproductive Health of U.S. Women: Data From the 2002 National Survey of Family Growth doc
... attitudes toward the intendedness of pregnancies based on their own reports (13). + Of all births in the 5 years before interview, 55 percent were intended by both the mother and the father (as ... instead of the full phrase, ‘‘not Hispanic white, single race.’’ All characteristics of women reflect the time of interview unless otherwise indicated in the tables. While most tables in ... 80. Number of women 15–44 years of age who were working during the week prior to the interview and have at least 1 child under 13 years of age in the household and percentage using the specified...
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Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt
... produced(Fig. 1D, lane 2). In the presence of lactacystin, a sig-nificant increase in the amount of tBid–GFP present in the extract, both in control conditions and in the pres-ence of FLAG–Itch, was ... protein of the Bcl-2family that is crucial for death receptor-mediatedapoptosis in many cell systems [16,17]. The BH3domain-only proteins are a subfamily of the Bcl-2family involved in the initiation ... apoptosis is critical in the maintenance of a healthy organism, and tipping the equilibrium in one or another direction results in eitherKeywordsapoptosis; Bid; c-Jun N-terminal kinase;epidermal...
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Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx
... of the P-loop main chain (starting at the residue prior to the catalytic cysteine and ending after the conserved arginine) resulted in rmsd values of < 0.75 A˚(supplementary Table S3). In ... upon substratebinding, due to the presence of a small b-barrel domainthat is unique to this protein and is involved in substrate binding [7,8]. No other residues in the proteinwere found to ... [18]. Treatment of PhyAsr with100 lm H2O2resulted in 33% of the enzyme beinginactivated after 10 min of treatment and 65% beinginactivated after 30 min. Incubation of the enzyme forup...
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