... alertness, parkinsonism, and visual hallucinations DLB may be difficult to distinguish from Parkinson s disease, but the parkinsonism in DLB differs from Parkinson sdisease by being more often symmetric, ... toward scan interpretation that integrates the visual and quantifying information present inclinical PET scans Visual Assessment Systematic visual examination of a clinical brain PET scan involves ... cognitive functioning Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive to significant cognitive...
... subentities, making a clear definition very difficult The majority of AD researchers assume Risk Factors for Disease Progression inAlzheimer'sDisease a linear slope, but some investigators also suggest ... re-sampled repeatedly, allowing for longitudinal assessment of gene dysregulation at different disease stages This could assist in making diagnoses, tracking the disease course and evaluation of ... a disease modifier exerting its effect on disease risk by influencing age of onset rather than disease risk per se (Serretti et al., 2007) In this hypothesis, APOEe4 genotype modulates disease...
... helps in comparing results across studies and obtaining a global overview of the disease pathogenesis In this paper, we perform a transcriptomebased study by combining the analysis of co-expressed ... meaning co-expressionlinks expressed co-expression at since profiles number We are This of over-represented 6.4% shows biological ID ofin disease- asso- Acknowledgements pcc − mpcc Zscore = spcc ... categories Check for genes associated with Alzheimersdisease and other human diseases WordSpy Identify significant cis-regulatory elements indisease associated genes Figure Steps taken to analyze Alzheimer' s...
... neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based on this review all participants ... role of apolipoprotein E inAlzheimers disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models [In Process Citation] Neurobiol Aging ... repetition of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities and Oddities subtest of...
... complements data from rat tissues showing that calcineurin is also expressed in neurons [14,15] RCAN1 gene expression is significant in several tissues, particularly human brain, spinal cord, kidney, liver, ... control tissues (a representative western blot is shown in Fig 3A) As human brain tissue is difficult to obtain, we focused on the most interesting regions for further studies These regions included ... shown to bind to and inhibit the serine–threonine protein phosphatase calcineurin [5] The brain is an especially interesting organ in which to examine RCAN1 expression, because calcineurin is...
... Cross-talk between calpains and caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation ... Ca2+-mediated apoptosis in astrocytes In this model of astrocyte apoptosis, translocation of the NF-kB p65 subunit to the nucleus is observed These findings indicate that, in this case, NF-jB acts as a death-promoting ... mechanism associated with the proteolysis of several MAPs and leading to neuronal apoptosis in AD Conclusion In summary, the ubiquitous expression of calpains in distinct subcellular compartments at...
... of increased levels of cytokines in the brains ofAlzheimer'sdisease patients, and in transgenic mouse models ofAlzheimer'sdisease [10-12] However, all these reports have focused on a small ... brain slices was assessed using the Bioplex cytokine multi-array system Cytokine levels were not significantly elevated in PS1 brain slices compared to control slices, indicating that the PS1 Page ... brain slice cultures from transgenic mouse models ofAlzheimer's disease, and to further relate this increase to the level of Aβ present in the brain Another purpose of our study was to determine...
... memory loss in a mouse transgenic model ofAlzheimer'sdisease J Neurosci 2002, 22:6331-6335 Selkoe DJ, Schenk D: Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics Annu ... performed on sections processed at the same time Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and C3 activation products reactivity ... numbers of Aβ-positive objects (or the sum of the areas of the Aβ positive objects) for the entire section and dividing by the sum of the areas of all ROIs This analysis was performed blinded...
... di-tyrosine-mediated cross-linking of Ab peptides [16–18] This is consistent with the high di-tyrosine content observed in AD brain tissue [17] Oxidative stress within the AD brain is also closely ... is increased in cerebrospinal fluid inAlzheimersdisease but not Parkinson sdiseaseAlzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper ... Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders Brain Res 738, 265–274 24 Snaedal J, Kristinsson J, Gunnarsdottir S, Olafsdottir Baldvinsson M & Johannesson...
... treating AlzheimersdiseaseIn 1984, the first clinical criteria for the diagnosis ofAlzheimersdisease was published, and the first five AlzheimersDisease Research Centers were established ... disease Frontotemporal and Parkinsonian dementias Huntington sdisease Neuronal ceroid lipofuscinosis Multiple infarct dementia “Binswanger sdisease “Small vessel ischemic disease CADASIL Schizophrenia ... important scientific advances in a single volume Those working in the areas ofAlzheimersdisease and dementia will find this book of interest, including physicians, medical students, psychologists, scientists,...
... disorders, is representative of a number of inherited diseases The initiation of the disease process depends on the size of polyglutamine tails [32] The cognitive and psychiatric decline is caused ... glucose metabolism in the cytosol of mouse brain The model included the kinetic parameters of the glycolytic enzymes in normal brain tissues as established by ourselves (Table 2) and others (Doc S4 ) ... vulnerable striatal neurones in HD Our studies were performed with brain tissues containing different types of neuronal cells as well as a large excess of glial cells Astrocytes, a sub-type of the...
... neuritic SP (classic/burnt out)) Analyses also investigated SP density in a semi-quantitative manner, dividing SP counts into ‘no SP’, ‘sparse SP’, ‘moderate SP’ and ‘frequent SP’, comprising a scoring ... Affairs of Finland Senile plaques and neurofibrillary tangles SP and NFT assessments were made as previously described [28] A large number (70%) of cases had ‘no SP’ and using this skewed data as ... already have played its part Based on our studies and others’ results, the brains of most middle-aged to elderly persons possess some degree of persistent inflammation as well as SP and NFT It could...
... diagnosis that would be diagnostic aid to probable Alzheimer'sdisease cases such as MRI brain, PET scan and computed tomography single photon SPECT Alzheimer'sdisease was diagnosed clinically based ... This situation was similar to the clinical literature review inAlzheimer'sdisease and in other countries 4.1.1.3 Quality of life of people with Alzheimer'sdisease Assessing the quality of ... level of stress and psychological distress were significantly higher satisfaction and physical health were significantly lower inAlzheimersdisease caregivers than caregivers in other diseases In...
... Suzuki N, Nara K, Suzuki T: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet sdisease Clin Med Res 2006, 4:147-151 ... arthritis (PsA) resembles BD clinically; a further similarity is the presence of neutrophils in SF from PsA patients Increased levels of intra-articular CD15+ neutrophils, CD3+ T cells, and perforin ... inflammatory cells On the other hand, those micro-organisms are also capable of stimulating an immune response in BD Most tissue studies of the pathophysiology of BD are conducted in skin One of the unique...
... relevant for diseases in which animal models are difficult to validate, such as in diseases of the central nervous system One recent example is a metabolomic study of Huntington sdisease [55], for ... expression of genes involved in cytoskeletal maintenance, DNA repair and redox homeostasis Profiling of small molecules (metabolites) is also a promising way to search for new AD biomarkers Concentration ... to its writing Page of Author information MO is a Research Professor of systems biology and bioinformatics His main research areas are metabolomic applications in biomedical research and integrative...
... frequencies of HLA-A alleles between patients and controls or between patients with and without certain clinicalfeatures Statistical calculation was done using SPSS version 17.0 (SPSS Inc., Chicago, ... retrospective studies ofdisease J Natl Cancer Inst 1959, 22:719-748 Higgins JP, Thompson SG, Deeks JJ, Altman DG: Measuring inconsistency in meta-analyses BMJ 2003, 327:557-560 Itoh Y, Inoko ... Katsuyama Y, Pivetti-Pezzi P, Ohno S, Inoko H: Significant associations of HLA-B*5101 and B*5108, and lack of association of class II alleles with Behçet sdiseasein Italian patients Tissue...
... cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses ofclinical samples ... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing ... by crossing PDGF–a-synuclein and APP-SweInd, which led to a 1.6-fold increase in a-synuclein inclusions in comparison with transgenic mice that expressed only wild-type human a-synuclein Similar...
... either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken ... phosphorylate eEF2 in its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272...
... present study was set slightly higher than the previously reported community-based mean values In the present study the cognitive assessment also included the AlzheimersDisease Assessment Scale ... PASW software (former SPSS software, version 17.0.1 for Windows, SPSS Inc., Chicago, IL, USA) Non-parametric tests were used because normal distribution could not be assumed in the groups Spearman ... levels of different MMPs in plasma of AD patients [30] The increased levels of several MMPs in the CSF of individuals with increased risk for AD, as observed in the current study, could be explained...