impact of tumor hypoxia src and met signaling in the dissemination of tumor cells
Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating ... hepatocyte swelling [12,13], insulin-induced hepatocyte swelling is registrated by the integrin system, leading to a Src- dependent activation of the p38-type MAPK and thereby inhibition of 5800 autophagic...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain For ... C-terminus Kinase domain and C-terminus SH3 domain and C-terminus SH2 domain and C-terminus SH3, SH2 domain and C-terminus N-terminal, SH3, SH2 domain and C-terminus N-terminal, SH3, SH2, kinase ... types of Src, cellular Src (c -Src) and neuronal Src (n -Src) , are found in neurons n -Src contains a six amino acid insertion in the SH3 domain, and is only expressed in neurons [3] The SH3 and SH2...
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THE HUMANITARIAN IMPACT ON PALESTINIANS OF ISRAELI SETTLEMENTS AND OTHER INFRASTRUCTURE IN THE WEST BANK doc
... The main public authorities identified included the Ministry of Defense and the Israel Defense Forces (IDF) including the Civil Administration; the ministries of Construction and Housing, Interior ... hilltop in Ramallah governorate, commands the surrounding area, including the Palestinian village of ‘Ein Qinya (foreground) Photo by J.C Tordai, 2007 17 Settlements and other infrastructure in the ... government since the beginning of Israel’s occupation following the 1967 Arab-Israeli War.2 In 2007, there are more than 450,000 settlers living in 149 settlements in the West Bank including East...
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Báo cáo y học: "Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury" potx
... determine activation of BMP signaling independently of the expression of one ligand, including secretion and solubility of the ligand(s), its/their binding to matrix molecules, the presence of secreted ... after the operation The asterisk indicates the site of injury (occupied by debris) The dashed line indicates the margin of the injury site level in vivo in a mouse model of joint surface injury ... (injured knee) The patellar dislocation was then reduced and the joint capsule and the skin sutured in separate layers The mice were then allowed to walk freely in standard cages and maintained...
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Báo cáo y học: " Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis" pdf
... mRNA and protein levels This finding would open a new insight in the field of monocyte-lineage cell biology and of the diseases where this lineage cells play a prominent role In the latter part of ... the data and draft of the manuscript HT helped collection and acquisition of the data and draft of the manuscript TA and TK was involved in the interpretation and design of the study, and also ... but does results in the loss of 92 amino acids which correspond to the C-terminal half of the CDC25-like catalytic domain in the signaling protein[1] The second most frequent isoform was variant...
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Báo cáo y học: "Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells" ppt
... upon activation of the insulin and wingless pathways in S2 cells Binding of insulin-like peptides to the insulin receptor in Drosophila cells leads to the activation of dPI3 kinase, which Genome ... Activation of insulin and wingless signaling pathways in Drosophila S2 cells Figure Activation of insulin and wingless signaling pathways in Drosophila S2 cells (a) Schematic representation of the insulin ... activation of a signaling pathway, as well as the corresponding regions in the same intron of the other 11 Drosophila species Motifs were identified using MEME and PHYLOGIBBS software and the specificity...
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Hedgehog signaling in the zebrafish embryo role of kif7 and DZIP1 1
... report the cloning of a kinesin-related gene from Danio rerio zebrafish and propose that it is the first vertebrate Cos2 and is annotated as kinesin family member (Kif7) in the mouse and human ... critical for the differentiation of primary cilia Igu encodes DAZ-interacting protein (Dzip1) with zinc finger and coiled-coil domains and was first thought to play a role in the Hh pathway Further molecular ... de-repression of the Hh pathway in the myotome of the zebrafish embryo Inactivation of Cos2 function induces ectopic Hh signalling in the ventral neural tube Cos2 is epistatic to shh and smo 59...
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Hedgehog signaling in the zebrafish embryo role of kif7 and DZIP1 2
... cilia and some of the mutants displayed situs inversus of the heart The mammalian node is important in determining the left-right asymmetry of organs and the beating of the motile cilia in the ... kinesin-like protein of 1363 amino acids was assembled Like Drosophila Cos2 and other members of the kinesin heavy chain (KHC) superfamily of proteins, the N-terminal and C-terminal regions of ... 1996; Ingham and McMahon, 2001) The processing and nuclear translocation of Ci is regulated by the Hedgehog signaling complex (HSC) in the cytoplasm The HSC is made up of a serine threonine kinsase...
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WNT signaling in the early development of zebrfish swimbladder and xenopus lung
... Wnt and Hh signaling in the swimbladder development 4.7.1 Wnt signaling maintained Hh signaling and is negatively regulated by Hh signaling 4.7.2 Hh signaling might be required to maintain wif1 ... lines, which are engineered for heat-shock-inducible Wnt inhibition, the chemical inhibitor of Wnt signaling, IWR-1, and upregulation of Wnt signaling by knockdown of the Wnt protein inhibitor wif1, ... Induction of GFP-fusion proteins and inhibition of Wnt signaling in the hs:Dkk1-GFP and hs:∆Tcf-GFP transgenic embryos by heat-shock treatment Effects of temporal inhibition of wnt signaling on the...
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Báo cáo y học: Esterified Hyaluronic Acid and Autologous Bone in the Surgical Correction of the Infra-Bone Defects"
... without the application of a membrane in the treatment of infra bone defects, our clinical results are encouraging considering that in a similar study a mean value of the increase of the bone ... factors and cytokines, which promote migration of inflammatory cells, fibroblasts and endothelial cells into the damaged site It has been showed that fibroblasts cultured in presence of increasing ... of bone graft in the damaged site and on the other hand, it creates an environment with a rich content of HA, with all the advantages deriving from the phenomenon The present study’s clinic and...
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Improvement of nutrient removal and phosphorus recovery in the anaerobic/oxic/anoxic process combined with sludge ozonation and phosphorus adsorption
... ozonation) and effluent of the phosphorus adsorption column are shown in Fig During the operation, about 70% of the phosphorus in the sludge was solubilized by ozonation, and a large part of the solubilized ... 2008) The reactivated adsorbent was packed into the column again, and phosphorus was effectively adsorbed Figure Concentration of each type of phosphorus in the influent and effluent of the phosphorus ... daily, was flowed into the system The characteristics of the influent wastewater were as follows: 160–200 mg/L of SS, 55–80 mg/L of TOC, 45–55 mg/L of T-N, and 4.0–5.5 mg/L of T-P In this study,...
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Characteristics of Leachate from Citrus Groves and their Changes in the Collecting Reservoirs in Matsuyama, Japan
... the middle parts of the grove from points Sampling points St.1 and St.2 are in the same stream, and sampling point St.3 is in the other stream The two streams flow together to be one stream and ... and periphery of the Seto Inland Sea The location of the research area and the distribution of the citrus groves in Matsuyama region are shown in Fig Matsuyama is situated in Shikoku Island in ... kind of citrus called Iyokan is mainly cultivated There are two small streams on the upper part of the hill and the streams flow together from 47 m above sea level The water in the stream is the...
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Cadmium Removal by the Hydroponic Culture of Giant Reed (Arundo donax) and Its Concentration in the Plant
... was removed within days in every run Assuming the zero-order kinetics, the average cadmium removal rates within the days calculated from the linear approximations of the plots in Fig were estimated ... like in the case of cadmium was not observed Furthermore, the particular effect of the cadmium addition on the appearance of the plant body was not observed during days in runs to Assimilation of ... cadmium, and is synthesized from glutathione (GSH) Inouhe et al (1994) reported that the cadmium binding complex containing PCs has an important role for the cadmium-tolerance of seedlings of some...
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A STUDY OF THE RELATIONSHIP BETWEEN CEO COMPENSATION AND FIRM PERFORMANCE IN THE US AIRLINE INDUSTRY 2002 2006
... Aviation Administration and placed under the control of the U.S Department of Transportation (DOT) Beginning in the 1970s, the inefficiency of the government regulated airline industry became of paramount ... that the inherent instability of the airline industry can be traced to the structure of the industry and its economics, including the highly cyclical demand for air travel, high fixed costs, and ... … by diluting and distorting managers’ incentives and thereby hurting corporate performance” (p 72) The authors argue that the inability of the optimal contracting approach in explaining executive...
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Expansion and its realization in the short story “the law of life” by jack london
... parts Part A introduces the reasons for choosing the topic, the aims of the study, the methodology, the scope, and the design of the study Part B, the main part of the thesis, consists of three chapters ... giving, and (ii) demanding” This means there are two roles in exchange: giving and demanding He goes on to analyze the nature of the commodity being exchange into (a) goods and service and (b) information ... features of the text and the intention of the writer In this thesis, the text chosen is the short story The Law of Life” by the famous American writer, Jack London Aims of the study The study...
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Tài liệu Báo cáo khoa học: Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina doc
... activity in crude yeast extract as the untagged protein, indicating that the tag was not interfering with the protein activity The tagged protein was purified and then used for further analysis In the ... nkatÆmg)1 The GLD1 protein was tagged with a histidine tag at the N-terminal end by adding the coding sequence for six histidines to the end of the open reading frame, and then expressed in S cerevisiae ... cerevisiae The tagged protein had a similar activity in the crude extract as the nontagged protein, indicating that the tag did not affect the protein activity The tagged protein was then purified and...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... partitioning of the protein into an aggregated state The effect of copper binding on the secondary structure was determined using CD in the far UV To prepare proteins without Cu2+, part of each protein ... understanding what causes the loss of appropriate metal binding might be crucial for the understanding of the role of amyloidogenic proteins in a number of neurodegenerative disorders Copper binds ... with glycine alone was performed and no binding was observed In our hands, as others [54], the most reproducible data was obtained from injections of the metal into a solution of the protein Typically...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
... localizes in the cytoplasm of human epithelial cells of the gastrointestinal tract and liver, two central organs in the regulation of iron metabolism [20,21] After their synthesis in the endoplasmic ... decrease in the percentage of cells in the S and G2 ⁄ M phases of the cell cycle (Fig 3B) In a total of seven separate determinations, a statistically significant decrease in the percentage of dividing ... phosphatidylserine in the plasma membrane with a third of these cells also expressing CD1d (Fig 6A, left dot-plot) Interestingly, the increase in phosphatidylserine expression by HepG2 cells grown in iron-rich...
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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc
... concerning the kinetics and properties of the enzyme More strikingly, we show a novel role of the PPase enzyme in the development and molting process of A suum larvae in vitro constructed in UniZap ... were determined by incubating the diluted recombinant proteins in the standard reaction mixture in the presence of increasing concentrations of PPi (0.05–0.5 mM) at 55 °C Data were fit to the appropriate ... (CostarÒ) The cultures were incubated at 37 °C in a humidified 5% CO2 incubator in the absence (control) and presence of increasing concentrations of inhibitors for 10 days, and the number of molting...
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Tài liệu ‘Unheard voices’: listening to Refugees and Asylum seekers in the planning and delivery of mental health service provision in London. pptx
... ONE is the INTRODUCTION This includes an outline of the CONTEXT and main themes, the motivation and purpose of the study - the why and how PART TWO is THE REASEARCH - METHODOLOGY and FINDINGS PART ... component in the integration process: The first step towards the integration of refugees must be to identify and help with their most pressing needs Finding and settling them into safe and appropriate ... GUIDE is the last section This provides a discussion of the main themes as they emerged in the service user interviews (as listed above in the ‘Findings’ section) It breaks the themes down into manageable...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25