igf i and bone metabolism in type 2 diabetes

Báo cáo y học: "A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes"

Ngày tải lên : 25/10/2012, 10:02

... Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes Chest 20 03, 124 :29 7-305 24 Diagnosis and classification of diabetes mellitus Diabetes ... Ghanim H, Assian E, Dandona P: Tumor necrosis factor-alpha inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human ... 17:107- 124 13 Grimble RF: Inflammatory status and insulin resistance Curr Opin Clin Nutr Metab Care 20 02, 5:551-559 14 Marette A: Mediators of cytokine-induced insulin resistance in obesity and other...

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báo cáo hóa học: " Fatness and fitness: how do they influence health-related quality of life in type 2 diabetes mellitus?" docx

Ngày tải lên : 18/06/2014, 19:20

... new findings in this cross-sectional study examining the influence of fatness and fitness on the association of type diabetes with HRQOL in participants with and without type diabetes First, ... Quality of life in type diabetes patients under intensive multitherapy Diabetes Metab 20 07, 33(1):54-60 Quality of life in type diabetic patients is affected by complications but not by intensive ... the study participants In the combined baseline sample there were 21 7 participants, including 98 participants with and 119 participants without type diabetes People with type diabetes were younger...

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Báo cáo y học: "Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3 alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]" ppsx

Ngày tải lên : 09/08/2014, 01:24

... [26 ] Its biological function is still unclear, but findings suggest that COMP may be involved in regulating fibril formation and maintaining the integrity of the collagen network It was initially ... be associated with significant lower CTX-II levels, indicating an effect of HRT on cartilage turnover [47] In the present investigation, CTX-II in the urine decreased significantly within the ... group A regression line is inserted showing the significant inverse association the first year correlated with the change in BMD in the lumbar spine during the whole trial is shown in Fig The short-term...

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Báo cáo y học: "Correction: A prospective observational study of the relationship of critical illness associated hyperglycaemia in medical ICU patients and subsequent development of type 2 diabetes" pdf

Ngày tải lên : 13/08/2014, 21:21

... Gornik et al Critical Care 20 10, 14:444 http://ccforum.com/content/14/5/444 Page of 22 07 patients admitted to medical ICU 385 with a history of DM, IFG or IGT 1 822 27 4 died in hospital 1548 ... 21 1 refused participation - 20 3 terminally ill - 29 receiving corticosteroids 669 436 NORMOGLYCAEMIA HYPERGLYCAEMIA 76 excluded: - newly diagnosed DM, IGT or IFG 669 360 started follow-up 1 02 ... died 154 discontinued follow-up 15 started steroid treatment 389 49 IGF / IFG 14 DM 326 normoglycaemic finished follow-up 66 died 93 discontinued follow-up started steroid treatment 193 47 IGF...

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Báo cáo y học: "Efficiency of vibration exercise for glycemic control in type 2 diabetes patients."

Ngày tải lên : 26/10/2012, 10:04

... (flexibility training) and the strength training group HbA1c increased by % and %, respectively This finding is clearly inconsistent with the outcome of other strength-training related interventions ... exercise training on insuline sensitività and glucose metabolism in lean, obese, and diabetic men J Appl Physiol 1991; 71: 24 02 - 11 Torvinen S, Sievänen H, Järvinen TAH, et al Effect of a 4-min ... 20 03; 24 : 441- Brooks N, Layne JE, Gordon PL, et al Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type diabetes Int J Med Sci 20 07; 4: 19 - 27 ...

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Báo cáo y học: "The association of meat intake and the risk of type 2 diabetes may be modified by body weight"

Ngày tải lên : 31/10/2012, 16:49

... participation during the previous years and provided information on daily activity such as walking, stair climbing, cycling, household activities and daily commuting to and from work (walking and ... glycation and lipo-oxidation end products formed in meat and high fat products through heating and processing have been associated with insulin resistance in mice [24 ] and with diabetes complications ... the Institutional Review Boards of all institutes involved in the study Dietary intake and other exposure information Dietary intake was assessed through an in- person interview using a validated...

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Báo cáo khoa học: Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the 1 level of phosphorylation of IRS1 in type 2 diabetes pot

Ngày tải lên : 07/03/2014, 16:20

... frozen within 10 s, and thawed in boiling water to minimize postincubation signalling modiﬁcations in the cells and protein modiﬁcations during immunoprecipitation [22 ] Equal amounts of cells (i. e ... Deibert DC & DeFronzo RA (1980) Epinephrine-induced insulin resistance in man J Clin Inv 65, 717– 721 34 Rizza RA, Mandarino LJ & Gerich JE (19 82) Cortisolinduced insulin resistance in man: impaired ... described in some obese individuals and relatives of patients with diabetes [19] Animal studies have also indicated a role for IRS1 in insulin resistance in adipose tissue (reviewed in [20 ,21 ]) We aimed...

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báo cáo khoa học: " Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes" ppsx

Ngày tải lên : 11/08/2014, 12:20

... non-diabetic insulin-sensitive and insulin-resistant Pima Indians Diabetologia 20 02, 45:1584-1593 Kim JA, Wei Y, Sowers JR: Role of mitochondrial dysfunction in insulin resistance Circ Res 20 08, ... bovine serum albumin (BSA) in TBST Incubation with primary antibody anti-PTBP1 (Polypyri midine tract-binding protein 1; Proteintech Group Inc (Chicago, Illinois, USA) at 1:1,000 in 5% skimmed ... PS, penicillin/streptomycin; PTBP1, Polypyrimidine tract-binding protein 1; qPCR, quantitative real-time PCR; RT, reverse transcription; SAM, significance analysis of microarray; T2D, type diabetes; ...

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basal insulin therapy in type 2 diabetes

Ngày tải lên : 12/08/2014, 20:59

... NJ]), insulins with an intermediate duration of action (NPH insulin and lente insulin [Lente; Eli Lilly and Company]), and long-acting insulins (ultralente insulin and insulin glargine) Short-Acting ... with NPH insulin for improving glycemic control when combined with either oral therapy in patients with type diabetes or with insulin lispro in patients with type diabetes In 426 patients with ... currently available long-acting analog is insulin glargine Insulin Glargine Insulin glargine is an extended-action insulin analog and was created by the recombinant DNA modiﬁcation of human insulin Alterations...

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Probiotics as a novel approach to modulate incretins, insulin secretion and risk factors of type 2 diabetes and complications

Ngày tải lên : 19/11/2015, 16:47

... (PI3K) activity is reduced in the muscles of individuals after a lipid infusion In addition, in these individuals the insulin action in the liver, which has some similarities with the insulin ... al., 20 01; Nauck et al., 1986), resulting in an impaired insulin secretion in response to glucose In particular, the first-phase of insulin secretion (ISR) is diminished in T2D, indicating the important ... 20 09; Roglic et al., 20 05; Wild et al., 20 04) T2D results from decreased insulin sensitivity in combination with insufficient insulin secretion When individuals are insulin-resistant and have...

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Effectiveness of PRECEDE model for health education on changes and level of control of HbA1c, blood pressure, lipids, and body mass index in patients with type 2 diabetes mellitus docx

Ngày tải lên : 05/03/2014, 22:21

... Carlos III (PI 02/ 0567) Author details Fundación Investigación Biomédica Hospital Carlos III SERMAS Madrid Spain 2Unidad de Nutrición Hospital Ramón y Cajal SERMAS Madrid Spain Unidad de Formación ... Medication profile % (95% CI) Thiazolidinediones Alpha glucosidase inhibitors Insulin 14 .2 (10.4-18) 14.4 (10.4-18.4) 0.94 Diuretics 27 .4 (22 .5- 32. 3) 23 .1 (18.3 -27 .9) 0 .23 Beta blockers 12. 9 ... participants HPE: Health Promotion Education Researchers in the experimental group received training in the PRECEDE model before patients were included in the study This specific training involved...

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Long-term Exposure to Traffic-related Air Pollution and Type 2 Diabetes Prevalence in a Cross-sectional Screening-study in the Netherlands pdf

Ngày tải lên : 06/03/2014, 19:20

... unifying hypothesis of type diabetes Endocr Rev 20 02, 23 :599- 622 10 Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM: C-reactive protein, interleukin 6, and risk of developing type diabetes ... statistically significant Sensitivity analyses were done to examine the potential confounding effect of BMI (Additional File Table s2) In these analyses all participants with missing data Dijkema ... [2- 5] In contrast with previous epidemiological studies [2, 3,5] we did not find consistent associations, though despite the limited level of exposure in the population studied, some indications...

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TYPE 2 DIABETES - National clinical guideline for management in primary and secondary care (update) pdf

Ngày tải lên : 08/03/2014, 14:20

... 11.1 11 .2 11.3 11.4 Glucose control: insulin therapy Oral agent combination therapy with insulin Insulin therapy Insulin detemir Insulin delivery devices 125 130 146 146 12 12. 1 12. 2 12. 3 Blood ... following publication in order to provide suggestions of areas for audit in line with the key recommendations for implementation s Structuring and writing the guideline The guideline is divided into ... human insulin in which change of the amino-acid sequence alters duration of action after injection 4 Glossary and definitions Insulin regimen A therapeutic combination of different insulin preparations,...

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Báo cáo Y học: Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis pptx

Ngày tải lên : 08/03/2014, 22:20

... to investigate which residues are important for interactions with IGF1 R, IGF2 R and the IGFBP family Initially, key residues involved in IGF1 R binding were identi®ed in the IGF- I B-domain (Tyr24) ... 0 Time (s) Fig BIAcore analysis of IGF- II and IGF- II analogue binding to highanity recombinant IGF1 R Binding of IGF- II (A), des-(1±6) -IGF- II (B) and Arg6 -IGF- II (C) to rhIGF1R measured by BIAcore ... maintain rhIGF1R-binding af®nities similar to IGF- I Long Gly3 -IGF- I and Long Arg3 -IGF- I also had similar rhIGF1R-binding af®nities to IGF- I (data not shown) The analogues Leu24 -IGF- I, des- (2, 3)-Leu24 -IGF- I, ...

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Báo cáo khoa học: Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated ﬁbroblasts docx

Ngày tải lên : 30/03/2014, 02:20

... quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 24 8 25 4 Martı´ R, Spinazzola A, Tadesse S, Nishino I, Nishigaki Y & Hirano M (20 04) ... A rapid exchange of nucleotides across the mitochondrial inner membrane maintains the cytosolic and mitochondrial compartments in equilibrium We were interested in investigating whether in the ... (20 03) Mammalian 5¢-nucleotidases J Biol Chem 27 8, 46195–46198 Pontarin G, Gallinaro L, Ferraro P, Reichard P & Bianchi V (20 03) Origins of mitochondrial thymidine Thymidine metabolism in TK2-mutated...

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báo cáo hóa học: " A comparison of EQ-5D index scores using the UK, US, and Japan preference weights in a Thai sample with type 2 diabetes" pdf

Ngày tải lên : 18/06/2014, 19:20

... dead = and perfect health = to indicate their preferences for different outcomes The utility score is incorporated into quality-adjusted life-year (QALYs) which combine, in a single index, gains ... clinical populations need investigation Finally, we utilized a simple hypothetical decision tree model to examine the impact of variability in EQ-5D index scores on ICUR Therefore, using real CUA ... review and proposed guidelines J Clin Epidemiol 1993, 46:1417-14 32 16 17 18 19 20 21 22 23 24 25 26 Kaplan RM, Feeny D, Revicki DA: Methods for assessing relative importance in preference based...

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báo cáo hóa học: " Additional impact of concomitant hypertension and osteoarthritis on quality of life among patients with type 2 diabetes in primary care in Germany – a cross-sectional survey" doc

Ngày tải lên : 18/06/2014, 19:20

... diabetes Quality of life (QoL) in patients with diabetes is reduced and patients are impaired in nearly all domains of daily life [2, 3] In addition patients with diabetes are more likely to suffer ... disabling and painful comorbid condition has a stronger impact on QoL than hypertension Individualized care of patients with chronic conditions should consider both improving QoL and controlling ... Outcomes 20 09, 7:19 be kept in mind when dealing with diabetic patients with concomitant osteoarthritis The list of self reported comorbidities used in this survey did not contain any mental conditions...

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báo cáo hóa học: " Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes" docx

Ngày tải lên : 18/06/2014, 22:20

... will deteriorate 13 Injecting insulin is embarrassing 14 Injecting insulin is painful 15 It is difficult to always inject insulin correctly 16 Insulin makes it difficult to fulfil my responsibilities ... the risk of hypoglycaemia Insulin will improve health Insulin will cause weight gain 10 Insulin will be demanding to administer 11 Insulin means I have to give up activities I enjoy 12 Insulin ... that insulin causes weight gain, compared to 23 % in the insulin naïve The highest mean score for insulin-naïve patients was on the item pertaining to the belief that insulin signifies disease...

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báo cáo hóa học:" Factors associated with psychological and behavioral functioning in people with type 2 diabetes living in France" pptx

Ngày tải lên : 20/06/2014, 15:20

... doi:10.1186/1477-7 525 -8- 124 Cite this article as: Boini et al.: Factors associated with psychological and behavioral functioning in people with type diabetes living in France Health and Quality ... 19 20 21 22 23 24 25 26 27 28 Davis RE, Morrissey M, Peters JR, Wittrup-Jensen K, Kennedy-Martin T, Currie CJ: Impact of hypoglycaemia on quality of life and productivity in type and type diabetes ... factors Discussion Psychological and behavioral functioning was measured in a large sample of people with type diabetes who were living in France by using a scale specific to diabetes The original...

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báo cáo hóa học:" Health-related quality of life and self-related health in patients with type 2 diabetes: Effects of group-based rehabilitation versus individual counselling" pot

Ngày tải lên : 20/06/2014, 15:20

... participated in four one-hour sessions of individual counselling with a diabetes nurse specialist, who had a bachelor’s degree in education and was trained in motivational interviewing [19] Using ... low vitality in the SF-36 questionnaire and fatigue in the DSC-R questionnaire This was also found in studies evaluating the questionnaires in both type diabetes patients [8 ,23 ,26 ,27 ] and in the ... and well-being in relation to glycemic control in type II diabetes Diabetes Care 1996, 19 :20 4-10 21 25 26 27 28 29 Testa MA, Simonson DC: Health economic benefits and quality of life during improved...

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