identification of the distribution of treatment effects in switching regime models and its confidence sets
Tài liệu Báo cáo khoa học: Bioinformatics of the glycoside hydrolase family 57 and identification of catalytic residues in amylopullulanase from Thermococcus hydrothermalis doc
... that in the future further subfamilies will be identified, owing to the appearance of new members or by subdivision of the existing subfamilies Indeed, there are several GH-57 candidates in the ... domain (SLD2), a threonine-rich region and a putative transmembrane domain [22] Interestingly, the 3D structure of a protein domain, which is clearly homologous to SLD1 and -2 of Q9Y8I8_THEHY, ... the C-terminus of the first b-strand of the catalytic (b/a)7-barrel [16] Interestingly, the three shortest GH-57 members, which include the P furiosus a-galactosidase (Q9HHB5_PYRFU), exhibit the...
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Báo cáo khoa học: Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxis doc
... C-terminal half of the first TM domain through the second intracellular loop of FPRL1 with the corresponding part of FPR (A) Chimera H contains the N-terminus and a segment between the fourth TM and ... pep in the presence of increasing concentrations of unlabeled ligand After incubation cell pellets were collected and measured for c emission The binding data were analyzed with the program LIGAND ... that these regions of FPRL1 play an important role in the FPRL1 response to MMK-1 Based on the deduced amino acid sequences of FPR and FPRL1, the segment spanning the C-terminal half of the first...
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Báo cáo khoa học: "Semantic Retrieval for the Accurate Identification of Relational Concepts in Massive Textbases" ppt
... articles indexed in MEDLINE at the end of 2004 (14,785,094 articles) The following sections explain in detail off-/on-line processing for the text retrieval system for MEDLINE 3.1 Off-line processing: ... original database and the number of entries expanded by name variations Terms in MEDLINE were then identified by the longest matching of entries in this expanded list with words/phrases in MEDLINE ... GENA entry and examine the effects of using predicate argument structures and ontological identifiers The need for the discovery of relational concepts has been investigated intensively in Information...
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Báo cáo khoa học: Identification of domains involved in the allosteric regulation of cytosolic Arabidopsis thaliana NADP-malic enzymes ppt
... of CoA or acetyl-CoA The results are presented as the percentage of activity in the presence of the effectors in relation to the activity measured in the absence of the metabolites for each of ... change in the pKa value of the amino acid residue(s) involved in malate inhibition may occur as a result of interaction with different amino acid residues in the allosteric site The amino acid ... than the other compounds (Fig 6) In this way, amino acid residues of different segments of NADP-ME2 swapped in the construction of the chimeras are involved in the fumarate activation of the pyruvate...
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Báo cáo khoa học: Identification of a domain in the a-subunit of the oxaloacetate decarboxylase Na+ pump that accomplishes complex formation with the c-subunit pot
... eluted with biotin (data not shown) Effect of point mutations in the binding domain of a-2-C on the binding to c¢-2 To elucidate whether single amino acids in the binding domain of a-2-C were particularly ... domain This part of the protein is upstream of the putative linker segment connecting the C-terminal biotin-binding domain with the residual parts of a-2 (Fig 5) For further analyses of the domain ... synthesized subunits ⁄ domains of the OAD-2 from V cholerae As shown in Fig the c-subunits of the OAD-2 and OAD-1 isoforms harbour the Zn2+-binding motif previously identified in the c-subunit of...
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Báo cáo hóa học: " Research Article Blind Identification of FIR Channels in the Presence of Unknown Noise" docx
... studies in the same institute and obtained the Master of Engineering degree in July 2004 She then attended McMaster University pursuing further studies in the Department of Electrical Engineering and ... in Datong, Shanxi Province, China She attended the Nanjing University of Science and Technology and was awarded the degree of Bachelor of Engineering (with distinction) in June 2001 She continued ... edges are the [MK − (K + L)] vectors {ηm } involved in the principal minor Now, since the determinant of the rank deficient matrix P ⊥ Σr (P ⊥ )H H H represents the square of the volume of a collapsed...
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Báo cáo khoa học: Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells potx
... aspartyl aminopeptidase was inhibited by EDTA in this study This indicates that the surroundings of the zinc ion in yeast aspartyl aminopeptidase differ from those of the mammalian enzyme The yeast ... PAGE using 15% gels by the methods of Hirano [11] Yhr113wp was identified by peptide mass finger printing using MALDI-TOF MS In- gel digestion and peptide mass fingerprinting The protein band on ... salts The digested peptide substrate was analyzed using MALDI-TOF MS The amount of peptide generated was estimated from the ratio of the height of the product peptide peak versus the sum of the...
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Báo cáo khoa học: Identification of amino acids in antiplasmin involved in its noncovalent ‘lysine-binding-site’-dependent interaction with plasmin pptx
... between plasmin and antiplasmin is of great importance in regulating the fibrinolytic process and keeping the plasmin active in the right place and at the correct time, as fibrin and antiplasmin compete ... lysine-binding-site-mediated interaction between plasmin and antiplasmin Molecular modelling of the C-terminal portion of antiplasmin The amino-acid sequence of the C-terminal 40 residues in antiplasmin ... plasmin In uence of the antiplasmin variants on the plasmin–antiplasmin reaction To study the reaction between the antiplasmin variants and plasmin in the absence of 6-aminohexanoic acid, plasmin...
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Báo cáo khoa học: Increased amylosucrase activity and specificity, and identification of regions important for activity, specificity and stability through molecular evolution doc
... in the B¢ domain (SB2), in the N-terminal domain (SB3), and in the B domain (SB4); alternative oligosaccharide binding sites are found in the B¢ domain (OB2), and in the C domain (OB3) Bound ... the salt bridge and the secondary sucrose-binding site SB2 Other regions are involved in specificity and thermostability, as the loop containing Glu227 in the B domain These findings provide new ... helix and a b strand in the B domain Unlike Asp226, none of the mutated residues in this loop interact with maltotheptaose bound in the active site in (A) However, Asp231 has hydrogen bonding interactions...
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Application of knowledge discovery and data mining methods in livestock genomics for hypothesis generation and identification of biomarker candidates influencing meat quality traits in pigs
... processes and pathways in androstenone biosynthesis and metabolism in terms of individual QTLs, SNPs or candidate genes Two experiments were devised in thesis to demonstrate the use of data mining and ... representation are: breeding, swine, male, female and Sus scrofa The font size of the terms in the figure directly reflects the frequency of occurrence of these MeSH terms in the set of abstracts returned ... used in the field of data compression, but index built using BWT allows indexing and searching of large texts in a memory efficient manner FM index is an indexing algorithm utilizing BWT and allows...
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Báo cáo sinh học: " Identification of gametes and treatment of linear dependencies in the gametic QTL-relationship matrix and its inverse" pptx
... received the first MQTL-allele of its sire and therefore SQ2 = If there is a i one in the first or second row of the first column of Qi the place of this allele in i is the number of that row containing ... [10] therefore combines a special case of the condensing algorithm with gamete identification by parental origin Assuming the QTL in the middle of a certain marker interval and rounding the QTL-transition ... parts: the generation of the index matrix N, the determination of matrix L, the calculation of the condensed gametic relationship matrix G∗ , and finally, the computation of its inverse It is independent...
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Tài liệu Báo cáo khoa học: The cellulosomes from Clostridium cellulolyticum Identification of new components and synergies between complexes ppt
... attributed to the physical proximity of the enzymes in the mini-cellulosomes and to cellulose targeting of the complexes via the CBM of the mini-scaffoldin [21] The most active mini-cellulosome ... percentage of amino acid coverage in the matched proteins; Mpep, the number of unique matched peptides; Upep, the number of unmatched peptides in the MALDI-TOF experiments The function of new proteins ... based on the GH family of the catalytic module and the modular organization of the protein, or on the identity of the catalytic domain with another characterized protein (see text) Protein F1 12...
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Tài liệu Báo cáo khoa học: Identification of differentially expressed genes of the Pacific oyster Crassostrea gigas exposed to prolonged thermal stress docx
... upregulated in gills but slightly less and later in mantle One inducible and two constitutive isoforms of HSP70 are synthesized in the gills and mantle of C gigas [26] The expression level of the constitutive ... chaperones, the chaperonin-containing TCP1 (subunit 7, isoform b) presented the same expression pattern in response to heat stress in our study This complex, involved in folding actin, tubulin and cyclin ... expression of organisms subjected to thermal stress are known to involve major adjustments in the expression of ribosomal genes and genes coding for proteins involved in RNA metabolism and protein synthesis...
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Tài liệu Báo cáo khoa học: Suppressed catalytic efficiency of plasmin in the presence of long-chain fatty acids Identification of kinetic parameters from continuous enzymatic assay with Monte Carlo simulation ppt
... resulted in a decrease, of up to two-fold, in the kp of plasmin Considering the recently described reversible nature of the plasmin inhibition by oleic acid [3] and the changes of the kinetic parameters ... identify the site of action of the fatty acids in the plasmin molecule, the amidolytic activity of two truncated plasmin variants was examined (Fig 8) Miniplasmin (des-kringle 1-4 plasmin) contains the ... plasmin inhibitors of the fatty acids, the turbidity effects of which are smaller compared with the free acid and are not in uenced by the plasmin substrate Analytical models of plasmin inhibition...
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Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identification of oscillophores ppt
... each other) The value (the sign) of a cycle is the product of the values (the signs) of its steps The sign of the magnitude of a Ôminus combined autoinfluence path of order pÕ equal those of the ... linearize the system of Eqn (3) in the vicinity of the steady state We this to investigate the stability of this state In this way we obtain the in uence a small change in the concentration of substance ... autoinfluence) The absolute magnitude of a combined autoinfluence path is the product of all the rates divided by the product of all the concentrations of its species Therewith the coefficient of...
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Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt
... quantify the amount of recovered protein owing to the presence of a high molar excess of BSA remaining in the buffer Therefore, a fixed aliquot of the protein was incubated with the indicated ... basic proteins it might be that either methylation of the lysine or specific substitutions in the amino acid sequence, increasing the number of basic residues of lysine, arginine and histidine, could ... One hypothesis may be that these oligomers exert their action by blocking the binding of eEF1A to its ligand in cancer cells, perhaps to zinc finger proteins involved in the modulation of cell...
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Tài liệu Báo cáo Y học: Identification of a set of genes involved in the biosynthesis of the aminonucleoside moiety of antibiotic A201A from Streptomyces capreolus pdf
... implicated in the biosynthesis of the aminonucleoside moiety of A201A Here we report the sequencing of a total of 6946 bp, which include the ata genes most likely implicated in the biosynthesis of this ... which lack this domain, is scant This domain promotes the binding of the acyl-CoA initiation unit to the ketosynthetase domain of the PKSs for polyketide biosynthesis [35] Therefore, AtaPKS1 could ... be implicated in the biosynthesis of the aminonucleoside moiety of puromycin [6–8] Interestingly, their organization is identical to that of the pur cluster, with the exception of pur6, which...
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Báo cáo khoa học: Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms docx
... and in the liver increases under hypoxic conditions in the uterus, resulting in intrauterine growth retardation [15,16] Its mature polypeptide chain consists of 234 amino acids and, as all other ... together with identical aliquots of the untreated proteins (Fig 9A) The degradation process was evaluated on the basis of the ratio between the integrated areas of the intact protein in the treated ... increasing the bioavailability of IGFs by enhancing the proteolytic cleavage as well as for producing the C-terminal domain We have examined the amino acid sequences of the other protein family...
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Báo cáo khoa học: Identification of the structural determinant responsible for the phosphorylation of G-protein activated potassium channel 1 by cAMP-dependent protein kinase pdf
... that the failure of these seven mutations to abolish protein phosphorylation was a result of other protein kinases masking the PKA-catalysed part Indeed, protein kinases other than PKA, including ... GIRK1 subunit was a prominent target for PKA in vitro, after the in vivo treatment of the oocytes with a PKA inhibitor and also in untreated oocytes On the other hand, the in vitro phosphorylation ... observed for the entire C-terminus of GIRK1, when the same mutations were introduced alone or in combination (Fig 2C) Mutation of S385C in combination with a deletion of the last 100 amino acids...
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