i the physiological mechanism of sense perception
Tài liệu Human-Animal Bonds I: The Relational Significance of Companion Animals pdf
Ngày tải lên :
15/02/2014, 13:20
... companions The intentional wording of epithets described the merits of the animal and their owner’s sorrow at their death In the ruins of Pompeii, stretched out beside the remains of a child were the ... of pets in many families of individuals with schizophrenia, who found it easier to establish and maintain a relationship with a pet The loss of the pet often precipitated an episode of severe ... participation in social and athletic activities Children’s early interest in animals is shaped by their families and social environments Children live in a world filled with animalsFreal, symbolic,...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
Ngày tải lên :
19/02/2014, 16:20
... IPU has Asp and/or Glu as the catalytic residues In addition, in the chemical modification experiment IPU was inactivated by N-bromosuccinimide, indicating that a Trp residue is required for IPU ... located in the vicinity of the active site and could form a binding site for a glucosyl unit in subsite )1 (Fig 4B) Together with the observations from the site-directed mutagenesis, Trp402 of IPU ... for binding of Glc +2 of the a-(1fi4)-linked glucose units of pullulan (Fig 4A) IPU is an anomer-inverting enzyme Comparison of the active sites of the model of IPU and Dex49A The active site structures...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
Ngày tải lên :
20/02/2014, 02:21
... generate a highly oxidizing intermediate, indicated as Cpd I In the presence of peroxide excess, the intermediate Cpd III [a superoxide-Fe(III) adduct] can be generated Cpd I is able to oxidize mono-electronically ... superoxide anion could either be free in solution or, more likely, bound to the enzyme and give rise to Cpd III, which is responsible for a reversible inactivation mechanism Cpd III might in turn ... II rather then native LPO This should also explain the higher sensitivity of LPO towards peroxide inactivation with respect to MPO Unanswered is the question: which factors are discriminant in...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
Ngày tải lên :
21/02/2014, 01:21
... essentially the same position in the corresponding active site The same position for the scissile guanidine carbon of the substrates, with respect to the metal ions and conserved, catalytically important ... (1999) Chemical modification and site-directed mutagenesis of human liver arginase: evidence that the imidazole group of histidine-141 is not involved in substrate binding Arch Biochem Biophys 371, ... together with the fact that the positions of other Fig Scheme of the binuclear manganese cluster and the localization of the side-chains of Asp153 and Asn153 in the modelled structures of wild-type...
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Báo cáo khoa học: The catalytic mechanism of dye-decolorizing peroxidase DyP may require the swinging movement of an aspartic acid residue potx
Ngày tải lên :
06/03/2014, 00:20
... The black bars enclosing iron atoms represent porphyrin rings The acid–base catalytic residue is indicated as the imidazole group of histidine In compound I, the plus sign and the black dot indicate ... misunderstanding, only the heme of the native is shown in white The position of the CN carbon mimics the position of the proximal oxygen of H2O2 Double-headed arrows show whether the distance between ... the native The side chain of the catalytic residue of DyP is not located just above the heme iron, unlike in other heme peroxidases Moreover, the side chain of DyP is arranged in parallel rather...
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Báo cáo khoa học: Spectroscopic investigation of the reaction mechanism of CopB-B, the catalytic fragment from an archaeal thermophilic ATP-driven heavy metal transporter potx
Ngày tải lên :
07/03/2014, 00:20
... ligand competition shows that the nucleotide portion of the analogue is responsible for the specic interaction with the protein A titration of the nucleotide binding site under stoichiometric ... groups of the substrate [21] The binding interaction of CopB-B with various adenine nucleotides under stoichiometric conditions was qualitatively veried by gel ltration of the nucleotide protein ... region of the infrared spectrum is indicative of product formation This band was assigned to the symmetric stretching vibration of the c-PO32) group of ATP [25], thus providing information on the...
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Báo cáo khoa học: Transthyretin and familial amyloidotic polyneuropathy Recent progress in understanding the molecular mechanism of neurodegeneration pdf
Ngày tải lên :
07/03/2014, 10:20
... 146 Cecchi C, Baglioni S, Fiorillo C, Pensalfini A, Liguri G, Nosi D, Rigacci S, Bucciantini M & Stefani M (2005) Insights into the molecular basis of the differing susceptibility of varying cell ... model of the mechanism of TTR-induced neurotoxicity is presented (Fig 3) In this model, amyloidogenic mutations in TTR destabilize the native structure of the tetramer and induce dissociation of the ... induce calcium influx The identification of toxic species is more than of academic interest Ultimately, if therapies are to be aimed at inhibiting amyloid deposition, then it will be important to...
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Báo cáo khóa học: Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy pptx
Ngày tải lên :
07/03/2014, 15:20
... G(s, h) is the relative proportion of emitter with lifetime s and correlation time h, A0 is the intrinsic anisotropy This analysis starts with an initial model of the G(s, h) distribution as a ... si and b are, respectively, the values of the center and the normalized amplitude of each lifetime peak c Ii are the values of the partial P intensity of the ith component Ii ¼ aisi/ d The ... mechanism, which involves the existence of a CaM-like binding site in addition to the true CaM-binding site [46], can be applied to AC The mosaic distribution of its different functional modules (Fig 1),...
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Báo cáo Y học: Kinetic and biochemical analyses on the reaction mechanism of a bacterial ATP-citrate lyase ppt
Ngày tải lên :
08/03/2014, 22:20
... observed with the enzyme in terms of citrate binding, as well as inhibition by ADP In addition, our results indicate the steps that govern the nucleotide dependency of the enzyme and the inhibition ... cK4 ị S S S where v is the initial velocity of the reaction, Vmax is the maximum velocity, [S] is the concentration of citrate, Ks is the dissociation constant of the enzyme-citrate (ES) complex, ... subunit, as well as stabilizing its structure Examination of the inhibitory effect of ADP As an increased ratio of ADP towards ATP signicantly inhibits Cl-ACL activity, we investigated the effect...
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Báo cáo khoa học: The role of Tyr71 in Streptomyces trypsin on the recognition mechanism of structural protein substrates ppt
Ngày tải lên :
16/03/2014, 00:20
... was digested with NdeI and KpnI The sprT gene in pCR-Blunt II-TOPO was digested with KpnI and HindIII Next, the sot and sprT genes were ligated into the NdeI–HindIII gap of plasmid pACTI2b [23], ... NdeI–HindIII gap of pTONA5a to construct the expression vector The following mutagenic antisense primer, in which the KpnI site (in italic type) was substituted with a silent mutation, was synthesized ... plasmid representing SOT-Y71L was digested with NdeI and ApaI The plasmid representing the partial sot gene was digested with ApaI and HindIII The fragments were ligated into the NdeI–HindIII gap...
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Báo cáo khoa học: Untangling the folding mechanism of the 52-knotted protein UCH-L3 potx
Ngày tải lên :
16/03/2014, 01:20
... population of the hyperfluorescent intermediates decaying as the population of the native state species increased has 12 proline residues, one of which is in a cis conformation in the native state ... (Pro48), it is highly probable that the slow refolding phase (the black phase, giving rise to k2) is caused by a rate-limiting proline isomerization reaction In order to investigate this further, interrupted ... near the N-terminus of the protein) If HyF -I1 ⁄ HyF -I2 are on-pathway intermediates, it is likely that the hydrophobic environment is created by interactions similar to those present in the native...
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Báo cáo khoa học: A mutagenic analysis of the RNase mechanism of the bacterial Kid toxin by mass spectrometry pptx
Ngày tải lên :
16/03/2014, 03:20
... activity, protein synthesis inhibition and in vivo inhibition of Analysis of Kid RNase model cell growth, underlining their relevance to our understanding of the basic activities of this toxin ... toxicity of the Kid protein, its RNase activity and its potential to inhibit protein synthesis Because the RNase activity of the protein is involved in plasmid stability, we can predict that the ... protein (Fig 4), which is consistent with a drastic reduction in RNA binding and RNase activity in this mutant (see Discussion) KidT46G was not able to inhibit protein synthesis, which is consistent...
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A study in the growth mechanism of silicon nanowires with or without metal catalyst
Ngày tải lên :
16/03/2014, 15:09
... supersaturated with Si atoms and excessive Si atoms will then precipitate The precipitated atoms will grow freely with a crystalline structure (Fig 2B b) Since the orientation of b111N in Si lattice has the ... energy, this orientation dominates the growth direction and the final extending direction of SiNW (Fig 3A) In particular, when the nanowire becomes longer, the droplet at the tip will be pushed ... a SiNW [19] Therefore, the diameter and location of the SiNW are determined by the features of the catalyst particle [20] Thus, it is important to control the catalyst size distribution and the...
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Báo cáo khoa học: Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis potx
Ngày tải lên :
22/03/2014, 21:21
... Arg173 Fig Cross-eye stereo view of the active site of CNS from Neisseria meningitidis (blue) with CDP (yellow) in the active site (PDB 1EYR) showing the residues highlighted previously in the literature ... Asp247 Fig Cross-eye stereo-view of the residues of interest (blue) in the active site of the CNS from Neisseria meningitidis containing CDP (yellow) (PDB 1EYR) [12] superimposed with their equivalent ... part of the enzyme active site [12] and the neighbouring Gln163 plays a role in controlling the position of residue 165 because the residue in position 164 is proline Gln163 is, in turn, positioned...
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The transmission mechanism of monetary policy docx
Ngày tải lên :
29/03/2014, 01:20
... purpose of this paper is to describe the MPC’s view of the transmission mechanism The key links in that mechanism are illustrated in the figure below First, official interest rate decisions affect ... interlinking of many of the effects mentioned There is also a discussion of the role of monetary aggregates in the transmission mechanism Part II provides some broad quantification of the effects of ... on the component of overall inflation that is imported Part I of this paper describes in more detail these and other links from official interest rate decisions to economic activity and inflation...
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seeing doing and knowing a philosophical theory of sense perception apr 2005
Ngày tải lên :
11/06/2014, 10:44
... Thus, the deictic element is missing VI Seeing Individuals 319 The impossibility of pictorial deixis makes identification of particular individuals in pictures visually impossible The exception is ... Colourist Intuition 183 Intuitively, a person with colour vision experiences a visual image that pixel by pixel is different from that of a colour-blind individual This intuition is questioned The ... be invoked It is doubtful that this would explain anything Additional principles are required II Similarity and Its Woes 129 Explanations of similarity are vitiated by vagaries in the logic of...
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Báo cáo khoa học: "The physiological status of Douglas fir seedlings and the field performance of freshly lifted and cold stored stock Conor." ppt
Ngày tải lên :
08/08/2014, 14:21
... stock Discussion There are two main aspects to the results of the study First, information is provided on the physiological status of Douglas fir seedlings during the period spanning the lifting ... noted high root MI during the winter months in Douglas fir, with a rapid rise in activity occurring in January Winter root activity may have implications for the storability of Douglas fir [19], ... this may be the most useful parameter for describing the physiological status of Douglas fir growing in Ireland (see below) Cold hardiness is routinely used in the monitoring of the physiological...
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Báo cáo y học: "The molecular mechanism of osteoclastogenesis in rheumatoid arthritis" pptx
Ngày tải lên :
09/08/2014, 06:22
... patients AntiIL-17 antibody significantly inhibited osteoclast formation induced by conditioned media of the cultures of RA synovial tissues in cocultures Immunostaining of the synovial tissues ... detected in the synovial fluids from RA patients The ratio of the concentration of soluble RANKL to that of OPG was significantly higher in the synovial fluids of RA patients than in those of patients ... molecule of IFN-γ is TNF receptor-associated factor (TRAF6) The degradation of TRAF6 by IFN-γ leads to the inhibition of osteoclastogenesis The inhibitory action of IL-18 on osteoclast differentiation...
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NVESTIGATING THE MOLECULAR MECHANISM OF PHOSPHOLAMBAN REGULATION OF THE Ca2+-PUMP OF CARDIAC SARCOPLASMIC RETICULUM
Ngày tải lên :
24/08/2014, 11:06
... concentration giving half-maximal inhibition KMUS N-[-maleimidoundecanoyloxy]sulfosuccinimide ester PKA cAMP-dependent protein kinase CaMKII calmodulin kinase II TG thapsigargin Pi inorganic phosphate ... concentration increases to micromolar levels, Ca2+ ions bind to the troponin C subunit of the regulatory troponin complex, initiating a conformational change that relieves inhibition of the actin/myosin ... decreases the apparent Ca2+ affinity of SERCA2a by slowing the isomeric transition that follows binding of the first Ca2+ ion, enabling cooperative binding of the second Ca2+ ion According to this model,...
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The Molecular Mechanism of Break Induced Replication
Ngày tải lên :
24/08/2014, 13:24
... (antisense/orientation2) into intergenic region 3' of THR4 on CHRIII P2 to confirm integration of ura3-‐29 (antisense/orientation2 into intergenic region 3' of THR4 ... initiation of DNA replication and post replication repair is also required for BIR Therefore, almost all proteins in S-‐phase replication initiation are involved in ... (Revised 9/10) PURDUE UNIVERSITY GRADUATE SCHOOL Research Integrity and Copyright Disclaimer Title of Thesis/Dissertation: The Molecular Mechanism of Break Induced Replication For the degree of...
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