huntington apos s disease function and dysfunction of huntingtin in axonal transport pdf
Báo cáo y học: "Phenomenology and management of cognitive and behavioral disorders in Parkinson''''s disease. Rise and logic of dementia in Parkinson''''s disease" pptx
... a place in the classification of nosologists Some have regarded its characteristic symptoms as distinct and different diseases, and others have given its name to diseases differing essentially ... precipitating factors common in these ages, and, finally addressing dementia itself So, the diagnostic process in patients with PD and suspected dementia involves two steps: the diagnosis of dementia and ... the prominent visuospatial dysfunction results from a decrease in central processing resources rather than from a specific visuospatial dysfunction in PD patients In any case, patients with PD...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc
... verification of endogenous expression is difficult to assess in most cell lines as a result of the presumed low levels of protein and a lack of potent antibodies [36] On a subcellular level in the brain, ... West containing interleukin receptor-associated kinase family Many of these kinases have clear roles in the MAPK pathway, and MLK proteins serve as critical mitogen-activated protein kinase kinase ... into families based on sequence similarity of recognizable substructures within the kinase domains, with the expectation that similar kinases may be involved in similar roles in cells LRRK1 and...
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The auditor's loss function and investors' perceptions of audit effectiveness Effects of regulatory change
... are being discussed by regulators and legislators in popular business news publications and in other public forums In addition, both changes used in this study affect the auditor s loss function ... described as the existing standard and the proposed standard For expositional purposes, I refer here to the two standards presented in the experimental setting as AS2 (the existing standard) and ... descriptive statistics are summarized in Table In this study, 57.4% of participants have experience investing in individual stocks in the past years, 71.3% plan to invest in individual stocks in the...
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báo cáo hóa học: " The effects of high frequency subthalamic stimulation on balance performance and fear of falling in patients with Parkinson''''s disease" docx
... Journal of NeuroEngineering and Rehabilitation 2009, 6:13 Background Postural instability is one of the cardinal symptoms of Parkinson 's disease (PD), and persons with PD run an increased risk of ... (60 seconds) is accomplished Best value is registered Time is registered in seconds, and gaitspeed is calculated as meters per second (m /s) A digital stopwatch is used In the study by Smithson ... platform and relax for three minutes in- between the tests (eyes open, eyes closed) The same test order was maintained during the DBS OFF and ON measurements In every test situation, spontaneous sway...
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Báo cáo y học: " Histology of adipose tissue inflammation in Dercum’s disease, obesity and normal weight controls: a case control study" doc
... by the same consultant in internal medicine Diagnosis was based on a systematic physical examination on three separate visits The clinical criteria Page of of the disease used in this study were ... liver disease [29-31] The expanded pool of adipocytes is responsible for the increased production and release of inflammatory mediators such as cytokines An increased density of macrophages has been ... levels of interleukin (IL)-13 and levels of fractalkine were detected In previous reports and studies, an inconsistent picture of the histological appearance of the adipose tissue in DD has been...
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Histology of adipose tissue inflammation in Dercum’s disease, obesity and normal weight controls: a case control study pdf
... by the same consultant in internal medicine Diagnosis was based on a systematic physical examination on three separate visits The clinical criteria Page of of the disease used in this study were ... liver disease [29-31] The expanded pool of adipocytes is responsible for the increased production and release of inflammatory mediators such as cytokines An increased density of macrophages has been ... levels of interleukin (IL)-13 and levels of fractalkine were detected In previous reports and studies, an inconsistent picture of the histological appearance of the adipose tissue in DD has been...
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Tài liệu Tolley’s Basic Science and Practice of Gas Service Gas Service Technology Volume 1 docx
... membership all operatives must be successful in a series of initial gas safety assessments (Nationally Accredited Certification Scheme for Individual Gas Operatives ACS) in the areas of work in which ... talks of ‘strikers’, ‘sweepers’ and ‘back fours’ the gas service man deals with ‘calorific values’, ‘standing pressures’ and ‘secondary aeration’ It is necessary for him to know about these things ... generated causes an increase in the volume of the gas and its products, and results in a sudden increase in pressure and an explosion The larger the container, the faster the flame speed The more...
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Tài liệu Global Change and the Function and Distribution of Wetlands ppt
... preserved in fine-grained sediments such sandstones, siltstones, mudstones, and volcanic ash, which accumulated in small depressions, floodplains, lakes, swamps, and streams Depending on the type of deposit, ... of deposit Fossil plant assemblages preserved in a particular stratum across a region represent snapshots in time of the dominant species and in some cases changes in the dominant species can ... environments In most cases the alluvial (loose and unconsolidated) sediment deposited in floodplains and swamps is transported by streams and rivers (fluvial) and the information contained in these sediments...
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Tài liệu Robert Kerr''''s General History and Collection of Voyages and Travels, Volume 18 docx
... geography and dimensions of India is curious and accurate Some further insight into these countries was derived from the embassy of Daimachus, to the son and successor of Sandracottus; this terminated ... was occasion, to divide harder substances, they substituted stones sharpened, instead of iron, for iron they had none Their dress consisted of the skins of beasts, and some of the larger kinds ... some of his half-decked vessels, and his quickest sailing transports, ordering at the same time a small part of his army to attend his fleet Considerable difficulties arose, and some loss was sustained...
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Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx
... membranes After successful import, the transit peptide is cleaved off by the stromal processing peptidase (SPP), resulting in the mature form of the protein The entire process is superficially reminiscent ... contains an NADPH binding site and the active site motifs characteristic for SDRs (green) A CaM binding site was located in the extreme C-terminus (blue) Tic40 consists of an N-terminal transmembrane ... overexpression of the other isoform However, analysis of double knockouts of both Hsp93 homologues did not result in the identification of double homozygotes, establishing that Hsp93 function is essential...
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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
... connections indicate binding interactions to the catalytic components (E1 and E3), kinase isoforms (PDK1, PDK2, PDK3, PDK4) and Ca2+-binding of PDP1 in translating and transmitting effector signals, and ... substitution of alanine or glutamine for Glu182 blocks binding of PDP1 and PDP1c to the L2 domain As can be seen in Fig 2A, a distinct pocket exists in the center of this set of residues Binding of PDP1c-Ca2+ ... conditions that meaningfully alter PDC activity Elevating spermidine mimicks insulin activation of PDC in permeabilized adipocytes [4] PDP2 is expressed in fat synthesizing tissues [7] and is probably...
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Coeliac disease - Recognition and assessment of coeliac disease pdf
... (AGA) tests in the diagnosis of coeliac disease 1.1.14 Do not use of self-tests and/ or point -of- care tests for coeliac disease as a substitute for laboratory-based testing 1.1.15 When clinicians request ... gastrointestinal specialists in specific clinical situations) Do not use self-tests and/ or point of care tests for coeliac disease as a substitute for laboratory-based testing Use serological testing for ... test Signs, symptoms and conditions associated with coeliac disease Box A Offer serological testing to children and adults with any of the following signs, symptoms and conditions Signs and symptoms...
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Báo cáo khoa học: Function and regulation of ABCA1 – membrane meso-domain organization and reorganization pptx
... (2004) Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis J Clin Invest 113, 1168–1175 Tamehiro N, Shigemoto-Mogami ... ABCA1 [36] Several protein kinases including protein kinase A (PKA), protein kinase C (PKC), Janus kinase (JAK2) and casein kinase (CK2) are involved in the regulation of ABCA1 activity and stability ... al Function and regulation of ABCA1 Table Possible substrates, localization and related diseases of ABCA subfamily proteins PE, phosphatidylethanolamine; PG, phosphatidylglycerol Possible substrates...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt
... years to 85% at age 70 years in an initial family-based study, but varied in subsequent reports, depending on sample size, study design, inclusion of probands in the analysis and methods of calculation ... healthy controls for some of the carriers This suggests that progressive dopaminergic dysfunction occurs in pre-symptomatic members of the LRRK2 kindred The identification of these individuals could ... pars compacta with the presence of eosinophillic, intracytoplasmic and proteinaceous inclusions termed as Lewy bodies and dystrophic Lewy neurites in surviving neurons [2] For many decades, the...
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Hughes, Mansel & Webster''''s Benign Disorders and Diseases of the Breast pdf
... benign breast disorders as well as malignant disease in his monograph, Illustrations of Diseases of the Breast,6 published in 1829 Among the conditions discussed are cystic disease, pain and fibroadenoma ... outstanding French physician of his time, deeply engrossed in research and study of his patients, as well as research using animals and corpses He was more interested in these than in publicizing his ... his answer in a paper to the American Surgical Association He described his practice of giving systematic instruction in surgical diseases using museum specimens with associated pamphlets setting...
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TOLLEY’S BASIC SCIENCE AND PRACTICE OF GAS SERVICE Volume 1 pptx
... varied inversely as the square root of the densities of gases Or: Diffusion rate ∝ √ density Thus a light gas will diffuse twice as quickly as a gas of four times its density (see section on Specific ... vapour so that the liquid formed requires much less storage space The material is therefore normally stored and distributed in the liquid phase, in pressurised containers and systems, and is finally ... permissions@elsevier.com Alternatively you can submit your request online by visiting the Elsevier web site at http://elsevier.com/locate/permissions, and selecting Obtaining permission to use Elsevier...
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Báo cáo khoa học: Active-site-specific chaperone therapy for Fabry disease Yin and Yang of enzyme inhibitors pptx
... Fabry disease, small molecules capable of specifically rescuing misfolded enzyme proteins have been identified for Gaucher disease [20,21], Tay-Sachs and Sandhoff disease [22] (details for Gaucher and ... center of the b strands in the (b ⁄ a)8 barrel, whereas domain contains antiparallel b strands The galactose ligand is shown in yellow and red (B) Fabry disease- causing point mutations are shown ... disorders [35] Despite the widespread occurrence of protein misfolding, supported by the fact that individual cases of misfolding exist in a variety of diseases, the significance of protein misfolding...
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báo cáo hóa học: "Measuring patient''''s expectation and the perception of quality in LASIK services" pdf
... this study [33] The results of this research demonstrated that the SERVQUAL instrument is a useful measurement tool in assessing and monitoring service quality in LASIK service, and enabling staff ... drafting, statistic and interpretation, and manuscript submission AB served as a LASIK consultant, assisted with data collection and assisted with methodology design CYH was responsible for statistic ... the nonresponded bias Free gifts such as sun glasses and facial cosmetics could be used in the future, in response to a patient 's response and could bolster patients impressions quite cost effectively...
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Opal''''s Site Organization and Development of Russian Business_1 docx
... companies: Members and nonmembers of business associations Indicators of financial standing of joint-stock companies and membership in business associations Types of support rendered to authorities and ... Share of business groups (BGs) in number of companies and in employment 8.2 Instruments to solve the agency problem in Russian BG subsidiaries 9.1 Gains from joining business groups (BGs) according ... Sberbank financial undertakings Asset structure of Sberbank Definitions, descriptive statistics, and sources of variables used in the empirical analysis Results of regression analysis on enterprises...
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Opal''''s Site Organization and Development of Russian Business_2 pptx
... rights in its relationships with state-owned and mixed enterprises The concluding chapter summarizes the major findings in this study and discusses the remaining issues and agenda for future research ... established relative overstatement of costs and prices in some industries determined, to a large extent, the scale of competitive weakness of enterprises in these industries in Russia after prices in ... activities, and to resort to state capture and rent seeking in their relations with governments using the weakness of public institutions and the remaining soft budget constraint The causes of such...
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