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ht2a 5 htt and insr receptor expression in the hippocampus of control and experimental rats

Hypoglycemia induced changes in cholinergic receptor expression in the cerebellum of diabetic rats ppt

Hypoglycemia induced changes in cholinergic receptor expression in the cerebellum of diabetic rats ppt

Báo cáo khoa học

... consequence of insulin therapy in diabetes altered the binding parameters of Muscarinic M1, M3 receptors and gene expression of α7nAchR, AchE, ChAT and GLUT3 in the cerebellum and AchE activity in the ... excitatory and inhibitory control over central and peripheral tissues In the present study, enhanced muscarinic M1 and M3 receptor binding in the cerebellum of insulin induced hypoglycemia in both ... Muscarinic M1 and M3 Receptor Binding Studies in the Cerebellum Muscarinic M1 and M3 receptor binding assays were done using specific antagonists [3H]QNB and [3H]DAMP in the cerebellum of rat...
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báo cáo hóa học: " The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice" pptx

Hóa học - Dầu khí

... cholinotoxicants nicotine and CPF, alone and in combination, showed increased GFAP expression in offspring in the CA1 sub-field of the hippocampus, and white matter and granular cell layer of the ... moleculare-lacunosum and two random areas in stratum oriens of the hippocampus were examined The areas of the captured images were constant Astrocytic cell counts were then performed in the regions of the hippocampus ... GFAP expression [17,18] The effect of dermal application of CPF on GFAP expression in the hippocampus has not been reported The aim of this study was to determine the expression of GFAP in the...
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báo cáo hóa học:" Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival" doc

Hóa học - Dầu khí

... visualized in the left panels and tumors with high expression in the right panels Bars in the middle represent the distribution of positive cases in absolute numbers Nodin et al Journal of Ovarian ... predictor of decreased OCSS in serous tumors The main limitation of this study is the absence of data on residual disease and future studies of AR expression in EOC should incorporate this in any ... proportion of serous carcinomas arise within the fimbrial tubal epithelium [10,17,18] Our findings indicate that malignant transformation could involve a downregulation of AR in certain EOC cases AR expression...
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Báo cáo khoa học: "Changes in orexin-A and neuropeptide Y expression in the hypothalamus of the fasted and high-fat diet fed rats" doc

Báo cáo khoa học

... P12, and P 15 by 14~31% [23] The present study is to investigate the effect of the high-fat diet on the expression of OXA and NPY in the hypothalamus of the induced SD obese rats as well as the ... OXA-IR neurons of the LHA increased at the 24, 36, 48, 60, and 72 hs fastings compared with the fed control On the other hand, at 84 h of fasting, the number of the OXA-IR neurons of the LHA decreased ... Changes in orexin-A and neuropeptide Y expression in the hypothalamus of the fasted and high-fat diet fed rats of the OXA-IR neurons in the LHA of the high-fat (30% fat) diet fed rats increased...
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Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps

Báo cáo khoa học

... (Figure 5C; arrowhead-indicated in (i)) The increase of basal-intermediate (CK14+/CD44+) (Figure 5D) and intermediateluminal (CK14+/CK8+) (Figure 5E) progeny in the PIN and CaP lesions of pCX-shh-IG-injected ... promoter and the GFP tag, but without the Shh insert Therefore, presence of GFP in prostates indicated successful introduction of pCX-shh-IG vector and expression of Hh protein Intraprostatic injection ... magnified in the inlets) (C) The pCX-shh-IG-injected prostate tissue sections were stained strongly for Hedgehog protein in PIN and CaP, in contrast to those of the sham and vehicle controls Scale...
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Báo cáo hóa học: "Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins" ppt

Hóa học - Dầu khí

... from in situ to invasive carcinoma and in a minor percentage brain, liver and pancreas metastases were observed Inactivation of p53 and pRB occurs in the majority of neuroendocrine lung carcinomas ... of Polo-Like Kinase Evaluation of the results obtained in the two systems showed deregulation of the same pathways in human SCLC and in that induced experimentally by the E6/E7 oncoproteins of ... phase gene expression and prevent entry of cells in the S phase [37] Furthermore, other members of aryl hydrocarbon receptor signaling, the inhibitors of cyclin-dependent kinases (p16 and p21),...
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Báo cáo y học: "Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review" pot

Báo cáo khoa học

... action of a single mediator (An in- depth discussion of the mediators involved in EIB and their cellular sources are beyond the scope of this review.) 61 activity in individuals with underlying airway ... hyperresponsiveness.4 The occurrence of EIB in asthmatic persons is common and often signifies suboptimal control of asthma.8 The diagnosis of EIB is confirmed in the laboratory by a drop of 15% or more in forced ... ventilation (exercise intensity), temperature and humidity of the inspired air (climatic conditions), and underlying baseline airway responsiveness are the primary determinants of the degree of EIB a patient...
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Báo cáo y học: "CXCR3/CXCL10 expression in the synovium of children with juvenile idiopathic arthritis" pot

Báo cáo khoa học

... recruitment of T cells at sites of synovial inflammation in JIA An in- depth molecular study of mechanisms regulating overexpression of CXCR3/CXCL10 might help in defining the role of these molecules in ... synovial inflammatory responses, offering new insights into elements controlling the immune response within joints Competing interests 11 12 13 14 15 The author(s) declare that they have no competing ... evaluated the role of CXCR3/CXCL10 interactions in the regulation of T-cell migration into the joints of patients with JIA We have demonstrated the presence of IP-10/CXCL10 in the synovial tissue and...
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Báo cáo y học: " Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma" potx

Báo cáo khoa học

... for LPA receptors in linking lung injury in the murine bleomycin model of pulmonary fibrosis Asthma is a chronic inflammatory disease of the airways involving T-lymphocytes and eosinophils infiltration, ... conform to the principles outlined by the Animal Welfare Act and the National Institutes of Health guidelines for the care and use of animals in biomedical research PCR genotyping of LPA1+/- and LPA2+/- ... remodeling of the bronchoalveolar structures Th1 and Th2 cytokines play a key role in orchestrating inflammatory and structural changes of the airway in asthma by recruiting, activating and promoting...
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Báo cáo y học: "The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever" ppsx

Báo cáo khoa học

... protein kinase, and IFN-γ receptors and This response increased even further on day and remained high throughout the time course of infection We extracted the set of IFN regulated transcripts using ... well as the plasminogen activator inhibitor type of the plasminogen-cleaving serine proteases, increased during days to after infection (Figure 6a,c,d) Expression of transcripts encoding uPA and ... BH3 interacting domain death agonist, BCL-X, and BAK appeared to be induced in the later stages of infection; all of these factors promote apoptosis by inhibiting Bcl-2 Expression levels of IL-1α...
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Báo cáo y học: "The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data" pps

Báo cáo khoa học

... angiogenesis and myofiber remodeling of rabbit skeletal muscle J Clin Invest 1994, 94:277-2 85 Pugh BF: Control of gene expression through regulation of the TATA-binding protein Gene 2000, 255 :1-14 ... value of the training samples in the case of continuous variables The aggregate forest's output is then determined by averaging the regression values of the trees or using a weighted voting process ... applications of LeFE, to gene expression in three breast cancer classes and to in vitro gefitinib sensitivity (see Results), provide further proofs of principle The findings highlight the distinctions...
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Báo cáo y học: "The LeFE algorithm: embracing the complexity of gene expression in the interpretation of microarray data" potx

Báo cáo khoa học

... to the aminoterminal actin-binding and ATPase domain, F45G2.2 is a member of the myosin II class of striated muscle MHCs that includes myo-3 and unc -54 However, the carboxyl-terminal sequence of ... filament-binding protein Afadin F08A8.6 tag-138 - 474 Actin-binding protein SLA2/Huntingtin-interacting protein Hip1 Y66H1B.3 462 784 Actin-binding cytoskeleton protein, filamin Y66H1B.2 119 902 Actin-binding ... Actin-binding cytoskeleton protein, filamin 766 20 Actin-binding protein Coronin, contains WD40 repeats R01H10.3 cor-1 Y105E8B.1 lev-11 53 0 50 8 Actin filament-coating protein tropomyosin F42E11.4...
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báo cáo hóa học: " Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes" pdf

Hóa học - Dầu khí

... 4) The presence of HIF-1-binding sites in the promoter of MCP -5 gene and the observation that the expression of MCP -5 correlated with the levels of HIF-1α suggest that HIF-1α is involved in transcriptional ... poly-lysine The cells were cultured in an atmosphere of 5% CO2/ 95% air at 37°C in D-MEM containing 4 .5 g/L glucose, mM glutamine, 25 μg/ml gentamycin (Invitrogen, Burlington, ON), and 10% fetal bovine ... across the BBB to the sites of axonal injury in the brain [33,37] Both in vitro and in vivo findings suggest that hypoxia/ischemia-induced infiltration of monocytes and macrophages contributes to the...
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Báo cáo khoa học: "Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications" doc

Báo cáo khoa học

... according to CAR positivity (positive vs negative CAR staining), level of expression (high vs low level of CAR expression) and staining intensity (mild vs moderate and intense CAR staining intensity) ... [4-6] In fact, CAR has been shown to be a docking site for Ad, thus acting as a key receptor for the enhancement of the virus-to-host affinity and the initiation of the virus internalization to the ... immunostaining is presented in Figure The pattern of CAR distribution was both cytoplasmic and membraneous in all positive cases examined High CAR expression was noted in out of 23 ( 35% ) of the positive...
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Báo cáo y học: "Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritsi" potx

Báo cáo khoa học

... plots showing mRNA expression of neurotrophin receptors The scatter plots a to d depict the expression levels of the four neurotrophin receptors receptors (a) Tyrosine kinase (trk)A (b) p 75 (c) trkB ... synovitis of the knee Our data confirm the high expression of both the trkA and p 75 NGF receptors at the Figure mRNA expression of NGF in synovial tissue samples mRNA expression of NGF in synovial ... demonstrates the expression of the pleiotropic NGF and its two receptors in peripheral synovitis of SpA and RA The knowledge of neurotrophin expression on cells from the inflamed synovial compartment in...
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Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt

Báo cáo khoa học

... was supported in part by grants -in- aid from the Ministry of Health, Labor and Welfare, and the Ministry of Education, Science, Sports and Culture, Japan, and the Japanese Ministry of Education, ... molecule expression Finally, we examined the effects of the chemokines on the expression of the cell surface molecules ICOSL, BAFF-R and TACI by peripheral blood B cells of normal donors and sub- ... the four chemokines induced migration of both CD27- and CD27+ B cells (Figure 3a) However, the migration induced by CCL21 was most prominent Comparison of the migratory effects of the chemokines...
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Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus ppt

Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus ppt

Báo cáo khoa học

... affect the function of the GABAAR Increases in α1 mRNA and protein expression during development correspond to increases in BZ binding and altered zinc sensitivity [54 ], while reduced α1 mRNA and ... most of the GABAAR found in the hippocampus, and were chosen based on their relative abundance and their potentially important contributions in GABAAR function When the expression of these proteins ... at 24 hours may indicate greater γ2-containing GABAAR clustering and greater BZ binding potential during the first few hours after injury, therefore providing a widow of initial therapeutic sensitivity...
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Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats potx

Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats potx

Báo cáo khoa học

... hrs after the administration of morning dose of insulin and curcumin The results were expressed in terms of milligram per decilitre of blood Total Dopamine receptor binding studies in the cerebellum ... interest in learning dopamine D2 receptor expression begins with the hypothesis that dopamine D2 receptors are involved in the pathophysiology of schizophrenia and in the mechanism of antipsychotic ... to determine the fold change in expression This was done by normalizing the resulting threshold cycle (CT) values of the target mRNAs to the CT values of the internal control β-actin in the same...
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Báo cáo khoa học: "Central nervous system Toll-like receptor expression in response to Theiler''''s murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains" ppsx

Báo cáo khoa học

... response of the pDCs in the resistant strain of mice Interestingly, pDCs are one of the main therapeutic targets for MS[16], and thus the involvement of TLRs in the processing of self-DNA in these ... cytokines and chemokines) involvement of TLRs in the initiation of TMEV-IDD in C57BL/6 resistant mice following LPS stimulation The involvement of TLRs in the TMEV-IDD is well supported by the ... presence of multiple TLRs in the brain of mice during TMEV-IDD These include TLRs involved in the recognition of the viral genome (TLR3 and TLR7) and multiple other TLRs that could be involved in autoimmune...
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Báo cáo khoa học: " Effect of a povidone-iodine intrauterine infusion on progesterone levels and endometrial steroid receptor expression in mares" pptx

Báo cáo khoa học

... by the release of prostaglandins during an acute inflammatory process [14, 15] may alter the expression of the sex steroid receptors in the endometrium [11] The consequences of povidone-iodine infusions ... eosinophils) were observed in the uterine biopsy sections of a few mares from the control and infused group The anatomical pattern was superficial, involving only the luminal epithelium and the ... IgG, the absence of staining confirmed the high specificity of immunostaining for both receptors (Figure 2) Details of the changes in staining for the different days and treatments are shown in...
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