... presentation However, theincreasedriskoflocalrecurrencewithbreastconserving surgery and radiotherapy rather than mastectomy after systemic therapy should be discussed withthe patient Locally advanced ... to the site oflocal excision to patients with early invasive breast cancer and a high riskoflocal recurrence, following breastconserving surgery with clear margins and whole breast radiotherapy ... Radiotherapy Radiotherapy after breastconserving surgery 1.11.1 Patients with early invasive breast cancer who have had breastconserving surgery with clear margins should have breast radiotherapy...
... on the results ofthe present study Our findings are likely to be representative estimates ofthe true effects of passive smoking on theriskof LRI in infancy since they are based on results of ... assessment ofthe relation between amount of exposure and disease risk was included in 26 ofthe 60 papers studied, quantifying exposure in terms ofthe numbers of cigarettes per day smoked by the source ... was updated for the Surgeon General and SCOTH reports [1,4] by the inclusion of papers published to the end of 2001 The number of relevant studies has increased substantially since the original...
... investigated the levels of different MMPs in plasma of AD patients [30] Theincreased levels of several MMPs in the CSF of individuals withincreasedrisk for AD, as observed in the current study, ... [14-20] Apart from these biomarkers, the presence ofthe apolipoprotein E (APOE) ε4 allele is another well-established risk factor for the development of AD dementia [1] The aim of this study was ... define ‘individuals within the control group withincreasedrisk for future AD’ The group difference in the CSF analysis method should therefore not influence the findings ofthe study Moreover, it...
... blot analysis of HO-1, HO-2 and GAPDH mRNAs The intensity ofthe signals representing HO-1 or HO-2 mRNA was normalized with respect to the intensity ofthe 18S rRNA signal The ratio of each normalized ... in the liver [43] HO-2 knockdown increasedthe transient expression of phHOLUC45 through the enhancer region ofthe human HO-1 gene, located between )4.5 kb and )4 kb Theincreased expression of ... normalized with respect to the intensity ofthe b-actin signal The ratio of each normalized value to the control value in siRNA-untreated cells (control) is shown as the relative expression level of...
... spinal cord with EAN nerves and spinal roots These two molecules may be involved in cell migration into the spinal cord in the early stages of EAN Further study ofthe functional role of OPN will ... Counterstained with hematoxylin Scale bars represent 50 µm This is the first study to examine the expression of OPN and its receptor, CD44, in the spinal cord of rats with EAN Many studies of EAN have ... cells in the subarachnoid space (Fig 4, B and C), and was increased in GFAP-positive astrocytes (Fig 4, D and E) The results ofthe immunohistochemical analysis ofthe distribution of OPN and...
... COPD is currently the 4th-leading cause of mortality and the 12th-leading cause of disability, by the year 2020 it will be the 3rd-leading cause of death and the 5thleading cause of disability worldwide ... responsible for theincreased susceptibility of women to cigarette smoke are largely unknown There is now a general consensus that inflammation is at the heart ofthe pathobiology of COPD and that the inflammatory ... both the lung (airways and parenchyma) and the systemic circulation [32-34] The intensity ofthe inflammatory process in the airways and in the systemic circulation is associated with severity of...
... artery catheter was inserted when necessary The type of surgery (on-pump or off-pump surgery) and the number of bypass grafts were determined by the surgeons All patients underwent CABG surgery ... compared withthe use ofthe independent samples t test or the Mann-Whitney U test Categorical variables are presented as number of patients (percentage) Data were compared withthe use ofthe chi-square ... (120 of 123), the initial symptom occurred within the first days after surgery (Figure 2) The median duration of postoperative delirium (that is, the duration between the initial symptom and the...
... duration of surgery and duration of bypass time up until the removal ofthe aortic cross clamp We defined three time points for EAA collection: at the induction of general anesthesia (T1), at the ... excluded from the analysis because of lack of EAA data and patients were excluded because of withdrawal of consent resulting in a sample size of 54 patients Of these 54 participants, the mean age ... this period of endotoxemia represents the first “hit” in a two “hit” model ofrisk Faist et al first used this “two hit” hypothesis to describe theincreasedriskof development of sepsis in...
... material The next strategy, which is the basis ofthe present study, is continued surveillance This necessitates the presence of an ongoing surveillance system which is the case withthe Swedish ... expected number of 16.8, RR = 1.61, 95%CI 1.04-2.34) trimester with an upper confidence limit of 10.5 The authors calculate that in order to rule out a doubling ofthe risk, they would need a ... lower than that during the first period There are two possible explanations The noticed effect of loratadine during the first period could be the result of a synergism with an unknown factor...
... measure of bone strength BMD measurements have been shown to correlate strongly withthe load bearing capacity ofthe hip and spine and withtheriskof fracture In patients with osteoporosis, there ... cells ofthe bone marrow, fill in the area of resorption with type collagen [47] Type I collagen ultimately becomes mineralized, probably as a function ofthe osteoblasts, thereby completing the ... the cessation of linear growth (till the third decade of life) Even after bone accumulation has ended, there is a constant state of remodeling with repeated cycles of resorption followed by the...
... coincides with Pablo Shmerkin’s estimate We have Main result Main Theorem Let µ be the 5−fold convolution ofthe standard Cantor measure, then the lower extreme value ofthelocal dimension of µ is ... Thanh et al / VNU Journal of Science, Mathematics - Physics 25 (2009) 57-68 65 From (13), (14) and (15), the assertion ofthe corollary follows 2.2 The proof ofthe main theorem Lemma Let x = (x1 ... Corollary and Proposition 2, we have Theorem Let µ is the 5−fold convolution ofthe standard Cantor measure, then the lower extreme value ofthelocal dimension of µ is √ √ arccos 427 59 145 log...
... time task, but withthe provision of c o n t e x t s w h i c h are f e l i c i t o u s w i t h one or other ofthe two versions of their examples thewiththe to NP) In the case ofthe n o n - m ... a u s e ofthe i n c r e a s e d n u m b e r of t h e s e v i o l a t i o n s It w o u l d appear, then, that much ofthe evidence cited in the literature concerning the resolution oflocal syntactic ... one of them but not ofthe other "MINIMAL INFERENCING" A policeman was questioning two women He had his d Q u b t $ a b o u t one of t h e m but not a b o u t the other RELATIVE CLAUSE TARGET The...
... in which the reducing end ofthe substrate are connected to subsite i and i + 1, respectively Fig shows the structure ofthe program The supposed number of subsites and the position ofthe cleavage ... the subsite binding energy ofthe subsite i + 1, DGX is the subsite binding energy ofthe subsite x, and Pi and Pi+1 are the bond cleavage frequencies ofthe product which are produced from the ... were based on the action pattern of PPA on three different series of b-maltooligosaccharide glycosides and they confirmed the theory of five subsites [8] However, the crystal structure of PPA isozyme...
... (2008) 767–771 withthe catalyst This results in formation of only a few of SiNWs The reaction temperature is usually decided withthe consideration ofthe catalyst type According to the binary phase ... [19] Therefore, the diameter and location ofthe SiNW are determined by the features ofthe catalyst particle [20] Thus, it is important to control the catalyst size distribution and the delicate ... absorption of vaporphase silicon atoms The continuous absorption induces the supersat- uration ofthe formed liquid alloy with silicon atoms, which leads to nucleation and growth of a SiNW [19] Therefore,...
... Experiment These two examples not suggest any kind of proof, but they well illustrate the recognition power of even the least powerful automaton in the {LeA(i)} family To get another point of view, ... level, but their cll~:ctiveness suffers from the rather free word/constituent order Finally, a comment about the computational efficiency ofthe LCA(k) automaton The time complexity of checking ... define the LCA(I) automaton The table is actually the union ofthe SCr(t,l) sets for all t in T, and it is derived directly from the graph: $< $< $< det det Note that for a sentence of length k, the...
... establish a connection between the Quillen K-theory of certain local fields and the de Rham-Witt complex of their rings of integers with logarithmic poles at the maximal ideal The fields K we consider ... )q ; p), ON THE K-THEORY OFLOCAL FIELDS and again Waldhausen’s approximation theorem allows us to identify the first two terms on the left withthe topological cyclic homology ofthe exact categories ... the identification ofthe E -term is a consequence ofthe celebrated theorem of Suslin, [43], that ⊗(t/2) ¯ Kt (K, Z/pv ) = µpv e For K a finite extension of Qp , the p-adic homotopy type of the...
... oxidation with MnO2 [34] For the synthesized retinoids, the retinals were the forms of storage Synthesis of 7-cis-retinol, 9-cis-retinol and 11-cisretinol were performed by reduction ofthe corresponding ... procedure was employed with 500 000 iterative cycles, allowing free movement ofthe rotatable bonds ofthe ˚ substrate and ofthe v angles ofthe residues inside a A radius from the docked substrate, ... the distinct location ofthe substrate in the binding pocket of ADH4 is the reason for the low activity observed with this retinal isomer The interaction of 11-cis-retinal with ADH1B1 was also...