how did the emergency services response to hurricane katrina
Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
Ngày tải lên :
26/10/2012, 09:32
... associated with
the individual’s response to tacrolimus. However, in
order to secure the appropriate administration of ta-
crolimus, both genetic and epigenetic factors must be
taken into account ... at-
tempting to clarify the influence of various factors on
tacrolimus kinetics. However, the results remain con-
troversial with regard to pharmacokinetic and clinical
effect of the studied ... expressed, it may
count for the 50% of the total hepatic CYP3A protein
[5,14].
Macphee et al were the first to detect the effect of
a CYP3A5 polymorphism in the distribution of tacro-
limus...
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Strengthening the Education Sector Response to School Health, Nutrition and HIV/AIDS in the Caribbean Region: A Rapid Survey of 13 Countries pdf
Ngày tải lên :
14/03/2014, 20:20
... to
responding to HIV&AIDS. The inclusion of the
education sector shows the recognition of the
role of the sector in the response. Addresses
sector specific HIV&AIDS issues.
Shows how the sector ... education
sector response to HIV throughout the Caribbean region.
1.5 The Education Sector Response to HIV
in the Caribbean
The Caribbean is the second most-affected region in the world with
respect to ... (CARICOM) recognizes the
education sector as a key partner within the multi-sectoral response
to HIV.
For two decades, similar to patterns of response globally, the
Caribbean response to the HIV/AIDS...
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THE ECB’S RESPONSE TO THE FINANCIAL CRISIS pdf
Ngày tải lên :
22/03/2014, 17:20
... liquidity than
they needed to fi nance their daily transactions.
Chart 7 shows how the increasing recourse to
Eurosystem operations after the implementation
of the changes to the operational ... Facility.
On 10 May the ECB announced the launch of the
Securities Markets Programme. This is the third
element in the ECB’s response to the crisis, the
other two being the series of interest ...
contributed to the revitalisation of the covered
bond market and a decline in covered bond
spreads, although they remained elevated
compared with their levels in the period prior to
the start of the...
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Audit and Accountability in Central Government: The Government’s response to Lord Sharman’s report “Holding to Account” pdf
Ngày tải lên :
29/03/2014, 22:20
... and Industry and the National Audit Office (NAO) should work
together to identify how best the current obstacles to the ability of the C&AG to be
appointed as an auditor under the Companies ... C&AG, the bodies involved, their
regulators,and other auditors should produce protocols for the exercise of these new statutory
powers. The protocols should be prepared to a fixed timetable and ... becomes the statutory
auditor, the management letter will be addressed to the NDPB and the audit certificate will be
addressed to Parliament. Where asked, however, the C&AG will continue to provide
departments...
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Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
Ngày tải lên :
30/03/2014, 03:20
... TRAIL-mediated apoptosis in HCT116 human
colon carcinoma cells by inhibiting the translocation of
Bax from the cytosol to the mitochondria, thereby pre-
venting the release of cytochrome c and progression ... signaling, leading to
the activation of two distinct pathways. One pathway
might lead to increased nuclear localization of BRCA1
and the other to apoptosis. Hypoxia could block the
apoptotic arm (Fig. ... induces apoptosis. The inability of
hypoxia to cause apoptosis was not surprising, consid-
ering the number of reports demonstrating that
hypoxia blocks TRAIL-induced apoptosis. There are
two...
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Báo cáo hóa học: "TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status" pot
Ngày tải lên :
18/06/2014, 16:20
... similarity to p53
and have been shown to share functions with the tumor
suppressor gene p53, but their contributions to the inhi-
bition of tumor formation or to the response to che-
motherapy has ... type.
The association between the expression of TAp73 and
the presence/absence of K-Ras and B-Raf mutations in
response to cetuximab supports thei r possi ble apoptotic
function and helps to understand ... cells are more sensitive to
apoptosis induced by these drugs.
These findings could corroborate the data published by
other authors showing that p73 is a determinant of che-
motherapeutic efficacy...
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Báo cáo sinh học: "The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil" pdf
Ngày tải lên :
18/06/2014, 19:20
... with
the potential to execute necrosis in response to treat-
ments with glycolytic inhibitors. In contrast, the bioener-
getic signature directly correlates with the apoptotic
response to 5-FU ... cells) to both meta-
bolic inhibitors (3Br P and IA) decreased as the bioener-
getic signature of the cells increased. Thus, the lower
the bioenergetic signature of a cell the greater the death
response ... cells and the regressio n of tumor
xenographs, in response to the glycolytic inhibitors 3-
bromopyruvate (3BrP) and iodoacetate (IA), and the
classic chemotherapeutic agent, 5-FU. The small alkylat-
ing...
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báo cáo hóa học: " Wallerian degeneration: the innate-immune response to traumatic nerve injury" potx
Ngày tải lên :
19/06/2014, 22:20
... express the mRNAs of
the inflammatory cytokines TNFa and IL-1a,andthe
TNFa protein. Schwann cells that form close contacts
with axons are the first amongst non-neuronal c ells to
respond to axotomy ... phagocytosis of
degenerated myelin, and production of cytokines and
chemokines). Special attention is given to the orchestra-
tion of these events with respect to their timing and
magnitude, and to ... zed
by the production of the inflammatory cytokines TNFa,
IL-1a,IL1-b,GM-CSFandIL-6.Thesecondphaseis
characterized by the production of IL-10, IL-6, and a
GM-CSF inhibitor molecule, and furthermore,...
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báo cáo hóa học: " Strain-dependent variation in the early transcriptional response to CNS injury using a cortical explant system" doc
Ngày tải lên :
19/06/2014, 22:20
... genetic variation of Nalp1 as a
contributor to in terstrain differences in the inflammatory
response to injured skin [38]. It is important to recognize
that the involvement of multiple genes may ... sectioning. Therefore, the extent of
the measured pro-inflammatory response is predomi-
nantly by resident CNS cells.
Pro-inflammatory cytokines and chemokines expres-
sion are activated in cells of the ... Interestingly, the
abundance of IL-1a and COX-2 mRNA revealed a similar
pattern to the chemokines suggesting these inflammatory
mediators could have a common regulatory mechanism
that is distinct am ong these...
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báo cáo hóa học: " The acute inflammatory response to intranigral a-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation" pptx
Ngày tải lên :
19/06/2014, 22:20
... wished to discover whether the host response to eSNCA would be sufficient to induce significant
cytokine production. In vitro cultured BV-2 microglia were used to determine the basic inflammatory response ... the substantia nigra became comparable to that
induced by the direct injection of LPS into the brain. The injection of albumin into the nigra with a peripheral LPS
challenge did not provoke the ... protein to study the inflammatory
response.
The inflammatory response described in PD is
thought to initially result from the activation of micro-
glia [5]. Traditionally, this has been seen to induce...
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báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc
Ngày tải lên :
19/06/2014, 22:20
... MT-I/II
-/-
mice
compared to wild type mice. In vitro,theaaMF
response has been shown to be much less neurotoxic
than the caMF response which is purported to be due
to the higher production of ... absence of the neuroprotective effects
of MT-I/II in the CNS or the absence of the modulatory
effects that MT-I/II has on the immune system.
The infiltration of neutrophils into CNS injuries is the
most ... infiltrate
the injured CNS and have the potential to be neurotoxic
which makes it difficult to determine if the increased
cell death observe d in the injured brains of MT-I/II
-/-
mice is due to the...
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