hormone action amp signal transduction
Structure and mechanism of hormone perception and signal transduction by abscisic acid receptors
Ngày tải lên :
10/09/2015, 09:26
... if the signals have been there Thus, in the process of conveying a signal, perception of the signal is as important as existence of the signal itself At the cellular level, extracellular signals ... knowledge of ABA signal transduction That is, how the ABA signal is perceived LITERATURE REVIEW The identification of ABA receptors, plant proteins that sense the hormone and relay the signal to other ... identified a ‘gate-latch-lock’ mechanism of hormone binding and signal transduction by the PYL ABA receptor These structural observations were supported by interaction and phosphatase activity assays...
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Báo cáo Y học: Coordinated action of protein tyrosine phosphatases in insulin signal transduction potx
Ngày tải lên :
17/03/2014, 23:20
... insulin signal transduction Structure of several phosphatases implicated in insulin signal transduction rPTP-a, LAR, PTP-1B and SHP-2 are the major phosphatases acting on the insulin signaling ... insulin signaling (Eur J Biochem 269) 1055 Fig Model of coordinated PTP action on the insulin signaling pathway Different PTPs may act on the IR in various compartments within the cell For example, ... recruited to many sites of insulin action However, the role of SHP-2 is mainly to transmit positive signals from the IR How these PTPs coordinate their action on the insulin signaling pathway remains...
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Báo cáo khoa học: Growth hormone/JAK-STAT axis signal-transduction defect A novel treatable cause of growth failure pdf
Ngày tải lên :
23/03/2014, 10:21
... GH ⁄ JAK-STAT axis signal- transduction defect A P Rojas-Gil et al it is important that growth hormone (GH) deficiency has been completely ruled out before ... IFN-b, a cytokine that also signals through the same JAK ⁄ STAT FEBS Journal 273 (2006) 3454–3466 ª 2006 The Authors Journal compilation ª 2006 FEBS GH ⁄ JAK-STAT axis signal- transduction defect A ... necessary to shed light on the possible impact of this defect of GH-mediated signal transduction on other GH-driven actions, besides growth, such as its effect on the metabolism of proteins, lipids...
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The role of small GTPases rap1 and rhoa in growth hormone signal transduction
Ngày tải lên :
16/09/2015, 17:13
... exchange factor GH growth hormone GHBP growth hormone- binding protein GH-N growth hormone normal gene GHR growth hormone receptor GHRH growth hormone releasing hormone GHRP growth hormone releasing peptide ... protein (GHBP) 1.3 Biological effects of growth hormone 11 1.4 Cellular mechanism of growth hormone signal transduction 14 1.4.1 Growth hormone receptor (GHR) and protein tyrosine kinase ... growth hormone molecule 1.1.1 Growth hormone gene and protein structure 1.1.2 Regulation of growth hormone synthesis and secretion .5 1.2 Growth hormone receptor and growth hormone...
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Báo cáo y học: " Low concentration of ethanol induce apoptosis in HepG2 cells: role of various signal transduction pathways"
Ngày tải lên :
31/10/2012, 15:37
... JNK and NFκB signaling in association with a slight activation of the cell death receptor signaling In addition, ethanol also phosphorylated protein kinases belonging to signal transduction pathways ... through the interaction of both pro-apoptotic and anti-apoptotic signaling pathways The pro-apoptotic effect induced by ethanol was demonstrated by a strong inhibition of GPCR signaling pathway ... CDK signaling pathways, including ERK2, RSK2, CDK9, CDK6, CDK7 and RSK1 with values of 50%, 48%, 38%, 35%, 29%, 26% and 26%, respectively Table Effect of mM ethanol on various signaling transduction...
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Tài liệu Báo cáo khoa học: Effects of sequestration on signal transduction cascades docx
Ngày tải lên :
19/02/2014, 07:20
... transient signals However, interpretation of the signal by the signal transduction network requires circuits that respond only to prolonged activation As pointed out by Deshaies & Ferrell [22], such signal ... [17], in which the rise in the signal is delayed but the dropping signal is transduced immediately Finally, we analyse the effect of sequestration on a complex signal transduction cascade, the MAPK ... sequester only limited fractions of MAPK and MAPKK Discussion The function of the signal transduction network is to sense changes in the environment of the organism in the form of signals of physicochemical...
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Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf
Ngày tải lên :
19/02/2014, 07:20
... gland and overexpressed in prostate cancer STAMP1 and STAMP2 are six transmembrane proteins Whereas STAMP1 is largely specific to prostate for expression, STAMP2 has a wider tissue distribution and ... individual roles it is emerging that there are significant interactions between small GTPase signalling pathways Interesting examples of such interactions are emerging through studies on invasion/cell ... KLK4, STAMP1, and STAMP2 contribute to the normal biology of the prostate cell, as well as prostate cancer progression In addition to these data, the molecular mechanism of antiandrogen action...
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Tài liệu Báo cáo khoa học: Separation of a cholesterol-enriched microdomain involved in T-cell signal transduction doc
Ngày tải lên :
20/02/2014, 03:20
... conditions, and selectively retains signalling molecules such as Lck, Fyn, and LAT The essential TCR-signalling molecules obtained in raft fractions, for example CD3f and Zap70, are not concentrated ... sucrose density gradient and fractionated into 12 fractions from the top Membrane-bound BCh was predominantly detected in fractions three to five (Fig 1) These fractions correspond to one of the ... gradients were fractionated from the top (0.4 mL each; total 12 fractions) The distributions of cholesterol and cell-bound BCh in the gradient fractions were analysed The BCh detected in fractions 10...
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Báo cáo khoa học: Organizing signal transduction through A-kinase anchoring proteins (AKAPs) docx
Ngày tải lên :
06/03/2014, 22:21
... inhibit ERK5 signaling (C) As cAMP levels decrease, the Epac1-mediated inhibition of ERK signaling is lost and mitogenic signaling favors cell growth (D) mAKAP assembles an oxygen-sensitive signaling ... protein kinase, extracellular signal regulated kinase (ERK5) [25,26] This provides a locus for the control of cAMP and mitogenic signaling events (Fig 1A–C) As local cAMP levels increase, the mAKAP-associated ... PDE4D3 to enhance cAMP metabolism [27] This mAKAP–PKA–PDE configuration forms a classic enzyme feedback loop because anchored PKA activity eventually leads to the termination of cAMP signals Interestingly,...
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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot
Ngày tải lên :
07/03/2014, 01:20
... reduced signaling [63–65] The differential signaling outcome of RTK versus TbR signaling by RIN1, however, suggests that Rab5-mediated endocytosis is not inextricably linked to a particular signaling ... of the TGFb signaling pathway Interconnection between TGFb signaling and receptor traffickingregulation by small GTPases Endocytosis has long been considered a way of terminating signaling processes ... modulate their signaling duration [36] Is internalization required for TGFb family signaling? The presence of SARA, Hrs and Endofin in early endocytic compartments questions whether signaling can...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
Ngày tải lên :
07/03/2014, 16:20
... signaling because: (a) interruption of the amphipathic structure of B1wt helix in B1wt and B1KB2 through the presence of a serine in position of V323 leads to a strong attenuation of the IP signal; ... in their capability to activate other additional signaling pathways These potential differences in, for example, the transactivation of growth hormone receptors and in the activation of MAPK cascades, ... preferentially to the same Ga subunit (Gq ⁄ 11) differential signaling is less likely to explain differences in internalization than in two receptors signaling through different G proteins Internalization...
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Plant physiology - Chapter 14 Gene Expression and Signal Transduction potx
Ngày tải lên :
07/03/2014, 21:20
... reactions is called a signal transduction pathway Typically, the end result of signal transduction pathways is to regulate transcription factors, which in turn regulate gene expression Signal transduction ... concentration of cAMP in the cell, which is normally maintained at a low level by the action of cyclic AMP phosphodiesterase, which hydrolyzes cAMP to 5 AMP Nearly all the effects of cAMP in animal ... generation of second messengers, transient secondary signals inside the cell that greatly amplify the original signal For example, a single hormone molecule might lead to the activation of an...
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Báo cáo khoa học: Signal Transduction pot
Ngày tải lên :
16/03/2014, 10:20
... implicated in cell death signaling cascade by TrkA in the absence or presence of DNA damage 135 Abstracts Signal Transduction C1-13 Identification of SIVA and PDCD2 as novel XIAP interaction partners C1-15 ... regulatory proteins Involvment of particular signal transduction pathway was also studied ª 2007 The Authors Journal compilation ª 2007 FEBS Signal Transduction Abstracts C2-48 Sterols and Multi ... both cholinergic signal transduction pathways and apoptotic cell death and presenilin mutations are responsible for both sensitizing neurons to death and altering neuronal signal transduction C2-75...
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Báo cáo khoa học: Bistability from double phosphorylation in signal transduction Kinetic and structural requirements potx
Ngày tải lên :
16/03/2014, 13:20
... multifunction and crosstalk between signal transduction networks, which explains how the same signal transduction pathway can be responsible for the transduction of signals resulting in several different ... is ubiquitous in MAPK and other signal transduction pathways, this article also reports a new putative mechanism that per se explains multistability in signal transduction networks in which feedback ... cycle in a signal transduction network generates, per se, bistable behavior if the following prerequisites are satisfied: (a) one of the modifier enzymes catalyzes the two modification reactions or...
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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx
Ngày tải lên :
16/03/2014, 18:20
... affects signaling amplitude much more than signaling duration Phosphatases control duration of signaling In the model simulation, phosphatases controlled maximum signaling amplitude, signaling ... the amplitude of signaling; the nal intensity of signaling; the duration of signaling and the integral signal intensity (which corresponds to the area-under-the-curve) For MAPK and other signaling ... and phosphatase reactions 252 J J Hornberg et al control these decisive signaling characteristics For two examples of a signal transduction cascade we showed that control of the amplitudes, the...
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Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx
Ngày tải lên :
23/03/2014, 13:20
... post-translational signal transduction mechanism [7,8] Many reports in the last decade have suggested that protein phosphorylation by protein kinase C (PKC) plays a key role in the regulation of the signal transduction ... involvement of PKC in the signal transduction mechanism participating in TCDD-induced cellular responses [14] We also looked for evidence of the involvement of PKC in the signal transduction mechanism ... L-MAT cells induces signal transduction, leading to very rapid activation of PKCh, as a significant translocation of PKCh to the particulate fraction from the cytosolic fraction (Fig 7) was observed...
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Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
Ngày tải lên :
23/03/2014, 15:21
... the tobacco PR-1a promoter is targeted by at least two distinct signal transduction pathways, elicited by SA and by a yet unknown signal produced during the HR, respectively, which mediate PR-1a ... view of the results presented, it seems plausible that two distinct signal transduction pathways could be targeted by SA and by signals released during the HR, respectively, resulting in the independent ... expression by differential interaction of the mutated promoter region with different transcription complexes To seek for support for our model of distinct signal transduction pathways leading to...
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Báo cáo khoa học: Enhanced apoptosis through farnesol inhibition of phospholipase D signal transduction pdf
Ngày tải lên :
23/03/2014, 15:21
... balance of life-and-death signals away from apoptosis Our results predict that farnesol is inhibiting a PLD ⁄ LPP3-generated DAG signaling pool If augmentation of DAG signaling is the key to preventing ... inhibition of PLD signaling augmented farnesol-induced apoptosis, whereas secondary alcohols had no effect on the level of farnesol-induced apoptosis Consistent with the importance of DAG signaling is ... farnesol-induced apoptosis PA, the intermediate in the PLD signaling pathway, was also capable of preventing farnesol-induced apoptosis Our evidence implicated PLD signaling as a key mediator of farnesol-induced...
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Báo cáo khoa học: No evidence for a role in signal-transduction of Na+/K+-ATPase interaction with putative endogenous ouabain potx
Ngày tải lên :
23/03/2014, 17:21
... interaction of a minor fraction of ouabainaltered Na+/K+-ATPase with neighbouring proteins (Src, growth factor receptors and Ras), i.e by protein–protein interaction In myocytes, the events from signal- transduction ... Caution is needed, however, before classifying OLF or even ouabain as normal steroid hormones functioning in signal- transduction pathways under physiological conditions The described individual steps ... sublocalization critical for the observations looking at ouabain as a signal- transducer Experiments pointing to a pivotal role of ouabain in signal- transduction In the following, more details are discussed...
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Báo cáo Y học: Herbaspirillum seropedicae signal transduction protein PII is structurally similar to the enteric GlnK potx
Ngày tải lên :
24/03/2014, 04:21
... Ninfa, A.J (1997) Structure/function analysis of the PII signal transduction protein of Escherichia coli: genetic separation of interactions with protein receptors J Bacteriol 179, 4342–4353 ... Ninfa, A.J & Atkinson, M.R (2000) PII signal transduction proteins Trends Microbiol 8, 172–179 25 Otwinowski, Z & Minor, W (1997) Processing of X-ray diffraction data collected in oscillation mode ... Synchrotron Laboratory (Campinas, Brazil) ˚ The crystal initially diffracted to 1.9 A, but the high resolution reflections gradually decayed during data collection The diffraction data were consistent...
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