hexosamine flux and the efficacy and safety of glucosamine in the treatment of osteoarthritis
Báo cáo y học: "Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review" pdf
... Annals of General Psychiatry 2009, 8:16 the treatment of acute mania, the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of olanzapine, ... dose at the end of the study was 15.5 mg daily The results suggest that in weeks to and then again at week there is a significant reduction in the MADRS scores in the aripiprazole group in comparison ... which included 66 of the 67 patients who completed the 26-week period Unfortunately only 12 of them (5 in the placebo group and in the aripiprazole group) completed the 74-week treatment period The...
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Báo cáo y học: "A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee" potx
... placebo-controlled clinical study, we sought to evaluate the efficacy and safety of 5-Loxin® in treatment of OA of the knee We assessed the effectiveness of 100 mg/day and 250 mg/ day 5-Loxin® on pain, joint ... symptomatic [3] Clinical manifestations of OA of the knee include pain in and around the joint, stiffness of the joint after rest, crepitating on motion and limited joint motion, among others [4] Current ... regarding the possible molecular mechanisms of action of an anti-inflammatory compound of herbal origin in the treatment of OA We demonstrated that 5Loxin® has potential efficacy in terms of reducing...
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Báo cáo y học: " Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold" doc
... Good Clinical Practices (CPMP/ICH/135/95)5, and the principles of the Declaration of Helsinki, local drug law and standard operating procedures of the investigator, sponsor and CRO involved The ... analyses and coordination of the study, interpretation of data and writing the manuscript All authors read and approved the final manuscript Competing interests The trial was funded by Marinomed ... recording The y axis shows the study day; i indicates the point of inclusion into the study taken within 48 hours of development of common cold symptoms Designed as an exploratory trial, the size of...
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Báo cáo y học: "Efficacy and safety of tiotropium in COPD patients in primary care – the SPiRiva Usual CarE (SPRUCE) study" ppsx
... to initiating the study and a repeat training session was given during the initiation visit Spot checks on the calibration of spirometers were conducted during the monitoring visits and randomly ... authors participated in the design of the study, interpretation of data and the drafting and approval of the final manuscript AL performed the statistical analyses Participating investigators Daryl ... skewing of data was seen in the distribution of the primary endpoint, trough FEV1 response, in both treatment groups, and this has resulted in non-parametric analyses being used for the study The...
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Báo cáo y học: "Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema – a systematic review and meta-analysis" docx
... regarding the methods of implementation and technical characteristics of the ventilation devices (Table 3) and regarding the definition and adequacy of criteria for ETI (Table 3) The analysis of safety ... to answer key clinical questions about the efficacy and safety of CPAP and NPPV in the treatment of patients with ACPE, considering three different outcomes: the need for ETI; in- hospital all ... suggesting the need for a critical analysis of the safety of NPPV and CPAP in the treatment of ACPE A very recent meta-analysis unfortunately addressed only some of the questions to which clinicians...
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Efficacy and safety of pregabalin in the treatment of
... Efficacy and Safety of Pregabalin in GAD There are now placebo-controlled studies in GAD demonstrating robust efficacy of pregabalin for the treatment of both psychic and somatic symptoms of ... taper and follow-up phase Efficacy Analyses The primary efficacy measure was the change from baseline to endpoint in the total score of the 14-item, clinician-rated HAM-A in the pregabalin and ... diazepam (Valium and others), gabapentin (Neurontin and others), imipramine (Tofranil and others), lorazepam (Ativan and others), paroxetine (Paxil, Pexeva, and others), pregabalin (Lyrica), trazodone...
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Báo cáo khoa học: "Tree water relations and climatic variations at the alpine timberline: seasonal changes of sap flux and xylem water potential in Larix decidua Miller, Picea abies (L.) Karst. and Pinus cembra L." ppt
... as the slope of the linear regression of sap flux (Fd) versus the drop in the water potential (Ψ) throughout the day In L decidua data deviated slightly from the regression line, indicating ... #1 and #2 probably due to the position of the probes in the stem This may occur using except for two days after the end of the MWDP In P cembra and P abies HC dropped to minimum values at the ... 215), stabilizing at about -1.9 MPa until the end of August (day 237) Afterwards Ψm again increased, reaching the values of the beginning of the season In this species no close relationship was...
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Báo cáo y học: " Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease" potx
... design of the study and the interpretation of the study data RL supervised the statistical analysis All authors contributed to the development of the manuscript, and read and approved the final ... Competing interests PWJ has received fees from a number of pharmaceutical companies, including Almirall, for speaking at meetings and for consulting and participating in advisory board meetings, and ... Garcia GE, Ferrer P: Safety and pharmacokinetics of single doses of aclidinium bromide, a novel long-acting, inhaled antimuscarinic, in healthy subjects Int J Clin Pharmacol Ther 2009, 47:460-468...
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Báo cáo khoa học: "Efficacy and safety of a low-flow veno-venous carbon dioxide removal device: results of an experimental study in adult sheep" pps
... changes in ventilatory setting were made during the treatment A bolus of 2,000 UI of heparin was administered intravenously, followed by an infusion titrated to maintain ACT (activated clotting time) ... during the experiment, was maintained even in longer treatments (9 and 12 hours), and was not influenced by CO2 production, as deep anaesthesia was maintained and no significant variations in ... reduction in PaCO2, with respect to the baseline, of 21.9% (7.7%) at 60 minutes, 18.4% (4.4%) at 90 minutes, and 17.3% (9.3%) at 210 minutes from starting treatment After treatment discontinuation and...
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Báo cáo y học: "Drug monitoring in child and adolescent psychiatry for improved efficacy and safety of psychopharmacotherapy" pdf
... psychopharmacology of the three German professional societies and initiated the network based on decisions of the commission MG (head of the TDM laboratory in Würzburg) was involved in the design of the database, ... treatment strategy in third line The lack of evidence for the use of most SSRIs in minors implies the need for further studies on the treatment of Major Depressive Disorders in minors [12] At present ... factors that influence the pharmacology of drugs, a safety system in standard treatment would help to solve the black box of safety and of unknown relationship between the dosage and actions of drugs...
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Tài liệu Osteoarthritis The care and management of osteoarthritis in adults ppt
... people and also at different joints in the same person The majority of the published evidence relates to osteoarthritis of the knee Osteoarthritis: the care and management of osteoarthritis in adults’ ... strain put on the upper limbs if knee osteoarthritis is present and painful Most trials of osteoarthritis therapies have examined efficacy of therapies on a single joint NICE clinical guideline ... clinical guidelines are recommendations about the treatment and care of people with specific diseases and conditions in the NHS in England and Wales This guidance represents the view of the Institute,...
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QUALITY AND SAFETY OF ORGANIC PRODUCTS pdf
... established by the international organizations FAO and WHO contains a set of standards relating to food and food safety, providing a point of reference that is used internationally Inner quality Inner ... to their discriminating eating behaviour The rats are initially cautious when tasting the feed newly presented to them; they then choose whichever they nd most palatable and begin to eat more Their ... foods that retain their order and structure are associated with higher quality Dening the concept of inner quality he Louis Bolk Institute in the Netherlands has deined the term inner quality...
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báo cáo hóa học: " Measuring the impact and distress of osteoarthritis from the patients'''' perspective" potx
... http://www.hqlo.com/content/7/1/37 The aim of the current study was to extend the validity testing of the PIP by (a) assessing the psychometric properties of the PIPP in a sample of patients with OA and (b) exploring the impact ... as the WOMAC [11] and the Lequesne Index [12] they predominately measure pain and function, which has been the focus of the majority of OA research to date However, increasing emphasis is being ... variance this is indicative of redundancy, suggesting the removal of one of the sets of scales This was explored further by assessing the predictive ability of the PIPP scales against other validated...
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báo cáo hóa học:" Effectiveness and Safety of Generic Fixed-Dose Combination of Tenofovir/Emtricitabine/Efavirenz in HIV-1-Infected Patients in Western India" doc
... worsening of an existing clinical condition (infectious or noninfectious) within months of initiation of ART Toxicity was graded according the system mentioned in the WHO ART scale-up guidelines ... from the grading system of Division of AIDS, National Institute of Allergic and Infectious diseases, USA) The regimen was discontinued (substituted with nonoffending ARV drugs) in cases of grade ... compromise the entire NRTI class There are a few limitations in using this regimen as firstline therapy in the developing world TDF/FTC/EFV is the most expensive of the NNRTI-based regimens, and the...
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Báo cáo y học: "Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus" potx
... urticaria during the administration of a 20 mg/kg single dose The infusion was discontinued approximately 40 minutes after initiation, and the urticaria and chest pain resolved with two doses of intravenous ... respiratory tract infection (15%), and joint swelling (15%) The frequency of AEs did not change with increasing doses of belimumab Overall, there was no significant difference in the incidence of specific ... the incidence of AEs was similar in the placebo and belimumab (single and double dose) treatment groups There was no increase in the incidence of infections in the belimumab groups (37% for all...
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Báo cáo y học: "Effectiveness and safety of adalimumab in patients with ankylosing spondylitis or psoriatic arthritis and history of anti-tumor necrosis factor therapy" pdf
... experienced clinically important improvements in their diseases after 12 weeks of adalimumab therapy during these two large, open-label clinical studies The safety profile of adalimumab was similar in patients ... discontinued ≥ months before the first adalimumab injection [18,19] Study design and measures The RHAPSODY and STEREO studies were conducted in accordance with the principles of the Declaration of ... http://arthritis-research.com/content/12/3/R117 whether they had been treated with IFX, ETN, or both, and according to whether the reason for discontinuation of the prior TNF antagonist had been lack of response, loss of response, or intolerance...
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Báo cáo y học: "Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model" ppsx
... and ADAMTS5 in the cartilage and cathepsin K in the subchondral bone, which is in line with the findings of our previous study [6] and supports this hypothesis The anti-inflammatory effects of ... for the monitoring of pain and joint function in OA The present study brings into perspective a possible link between joint structural changes and functional outcomes The level of joint inflammation ... participated in the data interpretation and revised the manuscript DT participated in the conception of the study, provided the test article and placebo, participated in the data interpretation and in the...
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Báo cáo khoa học: "Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment" ppt
... remifentanil infusion had been stopped for 30 The propofol infusion was then down-titrated in decrements of 25% of the initial rate at 10 intervals and, if necessary, discontinued The time to offset of the ... used to determine the offset of the pharmacodynamic effects of remifentanil during the SDTs If the remifentanil infusion had been discontinued according to the SDT, and there were no clinically significant ... was initiated as appropriate In this case, the time to the offset of the pharmacodynamic effects of remifentanil was recorded as the time from the start of the SDT to the time when, in the investigator’s...
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Báo cáo y học: "Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis" pps
... setting, and design; ventilator settings; classification of pleural effusion (exudative vs transudative); technique of drainage, including the use of imaging guidance, the level of training of the ... Page of 14 defined in each study), and the remaining 3% had indeterminate biochemical findings Methodological quality There were no randomized or non-randomized controlled trials of effusion drainage ... positioning and inhaled nitric oxide The effect of thoracentesis alone was unclear [48] In the remaining five studies, the timing of gas exchange measurements, volume of drainage, ventilator settings,...
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A study of quality and safety of herbal medicine adulteration and herb drug interactions
... after a single intravenous administration of aspirin Most of the pharmacokinetic parameters of aspirin and salicylic acid after a single intraperitoneal administration of aspirin remained unchanged ... well as the mechanisms and clinical interpretations involved in the interactions Although systematic clinical studies are now also beginning to appear in the literature, the mechanisms of these ... needed to confirm and assess the clinical significance of the potential herb-drug interactions Despite the absence of reliable data and uncertainty of the mechanism and extent of these interactions,...
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