... 1H,15N-HSQC spectra ofthe M domain of human eRF1 The numbering ofthe residues corresponds to that ofthe full eRF1 protein (A) The Gly region ofthe 15 H, N-HSQC spectrum ofthe M domain of human eRF1 ... implications ofthe behavior of this loop The first is the facilitation ofthe conformational rearrangements andthe maintenance ofthe conformational plasticity for effective binding ofthe protein to the ... at the PTC ofthe large ribosomal subunit [20] The three-domain structure of eRF1, with the shape ofthe protein resembling the letter ‘Y’, partly mimics the ‘L’-shape ofthe tRNA molecule, and...
... have an effect on the estimated value ofthe mutation rate and on the branch length ofthe phylogenetic tree However, they not affect the structure ofthe tree andthe estimates ofthe recombination ... tree obtained using the SNPs ofthe core genome ofthe 44 strains of S pneumoniae, strains of S mitis and strain each of S oralis and S infantis For clarity the clade containing the S pneumoniae ... genes, andthe genome ofthe common ancestor of S pneumoniae and S mitis encoded 2,039 genes For comparison, the average number of genes of S pneumoniae is 2,104, andthe average number of genes...
... contribution ofthe systematic factor andthe regulation to the total timely variation ofthe exposure is 17.24% and, therefore, 82.76% ofthe variation is due to idiosyncratic effects These effects ... disentangle the contributions ofthe systematic factor andofthe regulation One can expect some correlation between the regulatory variables outi (t) and out2i (t) on the one hand, andthe variables ... instance, the duration, andthe weighted sum ofthe positions’ duration is a measure ofthe bank’s exposure to interest rate risk (See, for instance, Sierra and Yeager (2004)) The main problem of these...
... further our knowledge with respect to the mechanisms of action of these proteins, it is crucial that we define the precise boundaries ofthe STI1-homologous domain and compare the structures of these ... [33] The errors of R1 and R2 were estimated from the errors in the single exponential decay fitting, and those ofthe 15N-1H NOEs were obtained from the difference of two independent experiments The ... values of error were adjusted for the proper tensor2 analysis, by increasing ofthe errors from the fitting (1.75 and 2.0 times for the relaxation data of 500 and 600 MHz, respectively), in which the...
... parts comprising mainly the b-strands The loops between strands B and C, known as the ‘hypervariable loop‘, D and E, E and F, F and G, and G and H are particularly tolerant of longer insertions ... exactly the reverse ofthe situation observed for the CCP1single and CCP2single modules and probably reflects the complex interdependence ofthe modules in terms of internal dynamicsand may also ... typically given in terms ofthe square ofthe generalized order parameters, S2, as the rate of physical restriction of NH motion, andof effective correlation time, se, on the ps to ns range Extremely...
... inwards, the arms close andthe tips ofthe arms wrap around the DNA The amplitudes and time scales ofthe intramolecular motions experienced by the protein backbone are commonly determined from the ... additional DNA andthe body ofthe protein [19] In the case of MC1ÆDNA complexes, we know that the protein covers at least 15 bp and that the binding site is composed of two areas of contact separated ... with the DNA-binding b-hairpin arms of HUs, which showed high mobility relative to the core (Fig 2) The b-ribbon arms wrap around the minor groove ofthe DNA and, at the tip of each arm, the conserved...
... depend upon the location ofthe event andthe zenith angle chosen as it represents the vector snm ofthe Earth’s orbital Nuclear and aerial dynamicsofthe Tunguska velocity (30 km s-l) with the comet’s ... cP is the specific heat ofthe gas at constant pressure, y is the ratio of specific heats, c is the speed of sound, (T is the Stefan-Boltzmann constant, pa is the air density and T,, is the temperature ... estimation ofthe mass lost along the comet’s arbitrary path prior to entry into the Earth’s atmosphere However, to specify the orbit ofthe comet demands knowledge of both the comet’s eccentricity and...
... activity of PAF Differences and similarities between the structures of PAF and AFP The common geometrical arrangement ofthe two proteins is the special Greek key fold, in which the Structure anddynamics ... mPAF at the respective concentrations ofand 100 lgÆmL)1 Fig Ribbon diagram ofthe mean PAF structure without disulfide bond constraints the core ofthe protein (Fig 9) As a consequence ofthe highly-twisted ... contributing to the sheet stabilization (Table 2) The b5 strand is the most negativelycharged region of PAF and close to the C-terminus starts at Ala51 Loop (47–50) connects strands b4 and b5 and creates...
... involved in the maintenance ofthe long axis ofthe cell Depletion of either MreB or Mbl causes aberrant partitioning ofthe origins of replication and a large fraction of anucleate cells The intermediate ... control the degree of methylation of specific glutamates in the MCPs This resets the signaling state ofthe chemoreceptors and allows them to adapt to the present concentration of attractant and ... pestis XV Color Plates Structure ofthe OmpF porin View ofthe monomer from the side (left) and view ofthe trimer from the top The loop inside the opening narrows the channel H Nikaido 2003, Microbiol...
... sizes of about micron and less The number of theoretical and experimental works on the subjects of microspheres increases every year The most fruitful turns out to be the idea of transition from the ... 2003 and references therein] Despite of high cost of such microspheres, many important and interesting features of wave and quantum effects are already discovered Nevertheless the results ofthe theorists ... questions ofthe theory of classical optics andthe quantum optics ofthe spherical multilayer systems are studied In such systems the spatial scales have order magnitudes ofthe wavelength of radiation...
... inherent in them and influence on the profitability ofthe project, such as the oil price, the royalty rate, the production scheme, the expensed capital investments andthe cost of acquiring ... transfer of rights to the contractor (the contractor bears all the risks and most ofthe rewards) andthe payment of bonuses, royalties and taxes to the state and/ or federal government The most important ... instead ofthe ideally envisioned stabilized piston-like displacement (Figure 1) The GAGD process uses the natural tendency ofthe gas to rise to the top andthe descent ofthe injected water to the...
... case of MZ with mirror-imaging of AC in the literature In this case, we describe the second case of MZ with mirror-imaging of AC and discuss the possible clinical implications First, Helland and ... lack of systematic monitoring and follow-up Therefore, a large percentage of patients with AC are probably undiscovered Mirror images, on the other hand, are present in approximately 25% of MZ Therefore, ... consider that it is mandatory to monitor the counterpart ofthe symptomatic patient with AC as early as possible, irrespective ofthe absence of symptoms Conflict of Interest The authors have declared...
... craniotomy because ofthe proximity ofthe sinus to the orbit andthe anterior skull base [5] The frequency of bilateral absence ofthe frontal sinus has been reported in 3-4% to 10% of several populations ... reliability between observers and was 0.86 Fig Unilateral absence ofthe frontal sinus; on the right, the absence ofthe frontal sinus, and on the left, the limited aeration ofthe frontal sinus; axial ... sinuses, although there is only one frontal sinus ostium The size ofthe sinus and, therefore, its anatomic relationships also depend upon the extent of pneumatization [11] The extent of pneumatization...
... occurrence ofthe tumor corresponded exactly one to the other; and (4) there was a more than one year interval between trauma andthe appearance ofthe tumor As regards the pathogenesis of post-traumatic ... time interval between trauma andthe appearance ofthe tumor of at least year, a longer latent period increasing the likelihood of a causal relationship The presence ofthe tumor must be proved histologically ... at the time ofthe trauma demonstrating significant injury andthe follow-up scans demonstrating tumor at the same site4 With the routine use of CT and magnetic resonance imaging (MRI), some of...
... circumstances In the resolutions ofthe VIth andthe VIIth congresses ofthe Communists Party and those ofthe important meeting ofthe National Assembly, the Government andthe Central Party ... assessment the demand of skilled labor and how to solve the gap between demand and supply of skilled labor for sustainable economic growth in Vietnam Objectives ofthe Study The objectives ofthe study ... building up the whole system It is hoped that these schools (10-15% ofthe sector) will reach the standards ofthe best institutions in the region and gradually those ofthe world While these school...
... component of most management definitions of strategy Strategy is the determination ofthe basic long-term goals and objectives of an enterprises, andthe adoption of courses of action andthe allocation ... features 60 As a rule, then, the lower the price of substitutes, the higher the quality andthe performance, andthe lower the user’s switching costs, the more intense are the competitive pressures ... market conditions in the supplier industry andthe significance ofthe item they supply The competitive fore of suppliers is greatly diminished whenever the item they provide is a standard commodity...