health effects of asbestos exposure in humans a quantitative assessment
Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 17)
Ngày tải lên :
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... consisting
of the concentration of an alkyl nitrite on the horizontal axis and peak area on the vertical
axis. e concentration of the analyte in a specimen is calculated using the calibration
curve.
Assessment ... transformation in rats. J Pharm Sci
74:780–782
10) Kielbasa WB, Bauer JA, Fung HL (1999) Analysis of isobutyl nitrite inhalant in rat and human blood: application
for pharmacokinetic investigations. ... mg/mL), and kept airtightly
in a refrigerator. A 5-àL volume of the above solution is placed using a microsyringe in a
glass vial containing 1 mL of dimethyl sulfoxide (DMSO), capped airtightly and...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 67)
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... For quantitative analysis of DAEMS, various concentrations of DAEMS are spiked into
blank serum specimens containing a xed amount of DAEMO (IS) each and extracted
as described before. Since ...
gradually and carefully. If VX itself remains, there is a danger of the secondary exposure for
an analyst; the manipulations including the above evaporation should be done inside a
dra chamber.
f) ... base peaks of DAEMS and DAEMO (IS) equally appear at
m/z 114, the SIM measurements should be made using this single ion to construct a cali-
bration curve for DAEMS consisting of peak area ratio...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 20)
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... GC/MS analysis of ∆
9
-THC-11-oic acid in urine
188 Cannabinoids and their metabolites
GC analysis of cannabinoids in plant specimens
a
Reagents and their preparation
ã Extraction and puri cation ... resin of the cannabis plant. Since the main component of cannabis, ∆
9
-tetrahydrocannabi-
nol ( ∆
9
-THC), has various psychopharmacological e ects including hallucination, the can-
nabis and ... CBD, CBN and 5α-cholestane.
GC analysis of cannabinoids in plant specimens
192 Cannabinoids and their metabolites
e Substance Abuse and Mental Service Administration (SAMSA) in USA set the...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 21)
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... Matsubara K, Fukushima S, Akane A et al. (1992) Increased urinary morphine, codeine and tetrahydropapavero-
line in Parkinsonian patient undergoing L-3,4-dihydroxyphenylalanine therapy: a possible ... for diagnosis of heroin use, because of its relatively long
half-life in the body [4].
For accurate diagnosis of a cause of death in an opiate poisoning case, the ratio of a free
form to a conjugated ... urinalysis: a closer look. J Anal
Toxicol 14:308–310
10) Hasegawa M, Maseda C, Kagawa M et al. (1992) Morphine and codeine being contained in poppy seeds and
poppy seed-containing foods. Eisei Kagaku...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 70)
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... (1987) Cyanosis in infants caused by nitrates in well water. JAMA 257:2788–2792
12) Fan AM, Steinberg VE (1996) Health implications of nitrate and nitrite in drinking water: an update on methe-
moglobinemia ... (1996) A case of severe methemoglobinemia for a newborn baby caused by
well water. Jpn J Pediatr 49:1661–1665 (in Japanese)
4) Saito T, Takeichi S, Osawa M et al. (2000) A case of fatal methemoglobinemia ... methemoglobinemia be-
comes severe, it causes cyanosis, headache, easy fatigability, respiratory and conciousness dis-
turbances and nally death. e fatal methemoglobinemia is rare, but fatal ones a ...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 71 and End)
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... 285, 290
alternative specimens 9
Amanita neoovoidea 480
Amanita pantherina 469
Amanita phalloides 469
Amanita verna 469, 474
Amanita virosa 469, 473
amanitin 473, 477, 479
amido-type local anesthetic ... 137
aldicarb 566
aldrin 529
alkylated adducts 85
alkylated DNAs 85
alkylation 30
alkyl nitrites 153, 655
allobarbital 305, 308
allylesterase 624
allyxycarb 566
alminoprofen 325, 330, 332
alprazolam ... phenomenon that the
absorbance maximum of weakly acidic Met-Hb at 630 nm disappears by addition of cyanide.
Met-Hb concentration can be easily determined as the ratios of the absorbance changes in-
duced...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 22)
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... for urine sampled 0–1 h a er cocaine inhalation; the ratio was 10.6 on average for
urine sampled 0–8 h a er the inhalation. e ratios increased according to the increase in time
interval between ... fatal
levels of cocaine in literature probably due to the above factors. e fatal doses are, of course,
di erent according to administration routes. Usually, the oral fatal dose for humans ... USA, but in Japan the number of
such cases is limited. e author et al. experienced a fatal cocaine poisoning case and measured
concentrations of cocaine and its metabolites in body uids and...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 23)
Ngày tải lên :
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... concentration in the horizontal axis and peak area ratio of pentazocine to IS in the
vertical axis. e peak area ratio of a test specimen is applied to the calibration curve to
obtain its pentazocine ... Determination of pentazocine in human plasma by high performance liquid
chromatography. Pharmazie 46:464–465
8) Seno H, Kumazawa T, Ishii A et al. (2000) Determination of pentazocine in human whole ... and phencyclidine in human plasma using capillary gas chromatography. Method Find Exp
Clin Pharmacol 12:193–196
4) Hattori H, Suzuki O, Seno H et al. (1993) Sensitive determination of pentazocine...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 24)
Ngày tải lên :
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... tract is rapid and distinct visual hallucination takes place
45 min–1 h a er oral intake of about 20 àg of LSD [1]. e hallucination becomes most marked
2–3 h a er the intake and lasts for ... powerful hallucinogenic
drugs of abuse. LSD was explosively abused in U.S .A. in the latter half of the 1960s. In Japan,
the amount of seizure of LSD is much smaller than that of methamphetamine. ... Albert Hofmann who did synthesize the compound; the pharmaco-
logical activity can be obtained by oral administration of as small as 2075 àg of LSD. e ab-
sorption of LSD from the digestive tract...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 25)
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... H, Nakajima K, Nishikawa M et al. (1991) Determination of methamphetamine and amphetamine
in urine by headspace gas chromatography/mass spectrometry. Anal Sci 7:19–22
25) Shima N, Kamata T, ... intestinal tract and reaches its peak concentration in plasma about
2 h a er oral administration [21, 22]. e doses of 50, 75 and 125 mg in the usual “recreational”
range for healthy human ...
discrimination, TFA derivatization followed by GC/MS is applicable (
> Fig. 7.3).
e quantitative analysis data for MDAs in many kinds of clandestine tablets encountered
in Japan are summarized...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 26)
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... respectively.
-Hydroxybutyric acid
244 Phencyclidine
Center. At admission, he stared straight ahead, following commands but not responding
verbally; the levels of serum creatinin kinase and aspartate aminotransferase ... Ishii and Yoshinao Katsumata
Introduction
Phencyclidine ( PCP) (> Fig. 8.1), a synthetic arylcyclohexylamine hallucinogen, had been
rst applied as an anaesthetic to animals and then to humans ... urine samples in cases of alleged sexual assault: case
history. In: Salamore SJ (ed) Benzodiazepines and GHB: Detection and Pharmacology. Humana Press, Totowa,
pp 127–144
11) Takahara J, Yunoki...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 27) ppt
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... MO, USA). Pure powder of perazine and clospi-
razine was donated by Mitsubishi Welpharma, Osaka, Japan; that of upentixol by Takeda
Chem. Ind. Ltd., Osaka, Japan; that of thioproperazine by ... construct a calibration curve, consisting of drug concentration on
the horizontal axis and of peak area ratio of a drug to IS on the vertical axis. e above peak
area ratio obtained from a specimen ... Yoshinao Katsumata
Introduction
Phenothiazine drugs, including chlorpromazine and levomepromazine, have been being
widely used as neuroleptics ( major tranquilizers), antiparkinsonian drugs and...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 28) pptx
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... peak area ratios of haloperi-
dol or bromperidol to IS are plotted against various concentrations of the test compound
spiked to blank blood or urine to draw a calibration curve. A peak area ratio ... 13) Igarashi K, Kasuya F, Abe T et al. (1995) Simultaneous determination of haloperidol and its neurotoxic metabo-
lite in plasma and brain tissue from schizophrenic patients treated with haloperidol ... dimethylsilyl coating, because trace amounts of drugs are
easily adsorbed to their surfaces, causing variation of results.
References
1) Seno H, Suzuki O, Kumazawa T et al. (1989) Rapid isolation with...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 29) ppt
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... tricyclic and tetracyclic antidepressants and carbamazepine obtained by
HPLC-UV. A: carbamazepine, B: desipramine, C: maprotiline, D: nortriptyline, E: amoxapine,
F: setiptiline, G: mianserin, H: ...
by Takeda Chem. Ind. Ltd., Osaka, Japan; dosulepin by Kaken Pharmaceutical Co., Ltd.,
Tokyo, Japan; lofepramine by Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan; and setip-
tiline by Mochida ... the reuptake of norepinephrine and
serotonin and by accerelating the release of them at synaptic terminals of neurons in the brain.
As characteristic structures of such drugs showing antidepressive...
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Tài liệu Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 30) doc
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... concentrations
290 Benzodiazepines
Mass chromatograms of triazolam, 4-hydroxytriazolam, α-hydroxytriazolam and alprazolam (IS).
A 100-ng aliquot each of triazolam, 4-hydroxytriazolam and α-hydroxytriazolam ... diazepam, udiazepam,
urazepam, prazepam, utoprazepam, dipotassium clorazepate, medazepam, chlordiazepoxide,
unitrazepam, alprazolam, midazolam, etizolam and brotizolam for both blood and ... cloxazolam,
mexazolam, utazolam and haloxazolam having oxazolo rings in their structures [1]. In such
cases, the relatively low injection temperature and the use of a wide-bore capillary...
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